Junguang Jiang

Chinese Academy of Sciences

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Hongda Wang

Changchun Institute of Applied Chemistry

Mingjun Cai

Changchun Institute of Applied Chemistry

Jing Gao

Shanghai Institute of Materia Medica

Shaojun Dong

Hefei National Center for Physical Sciences at Nanoscale

Haijiao Xu

Chinese Academy of Sciences

Xian Hao

Nanchang University

Lulu Zhou

Southern University of Science and Technology

Xin Shang

Dalian Institute of Chemical Physics

Erkang Wang

Changchun Institute of Applied Chemistry

Yuping Shan

Affiliated Hospital of Qingdao University

Cooperative Institutions

Chinese Academy of Sciences

Changchun Institute of Applied Chemistry

University of Chinese Academy of Sciences

University of Science and Technology of China

Jilin University

Northeast Agricultural University

Shanghai Jiao Tong University

Sun Yat-sen University

Jilin Medical University

Fudan University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Protein Transduction System Based on Tryptophan-zipper against Intracellular Infections via Inhibiting Ferroptosis of Macrophages

ACS Nano (2023)

Yuxin Fang Ling Li Mingrui Sui Qianzhi Jiang Na Dong

Cells penetrating molecules in living systems hold promise of capturing and eliminating threats and damage that can plan intracellular fate promptly. However, it remains challenging to construct cell penetration systems that are physiologically stable with predictable self-assembly behavior and well-defined mechanisms. In this study, we develop a core–shell nanoparticle using a hyaluronic acid (HA)-coated protein transduction domain (PTD) derived from the human immunodeficiency virus (HIV). This nanoparticle can encapsulate pathogens, transporting the PTD into macrophages via lipid rafts. PTD forms hydrogen bonds with the components of the membrane through TAT, which has a high density of positive charges and reduces the degree of membrane order through Tryptophan (Trp)-zipper binding to the acyl tails of phospholipid molecules. HA-encapsulated PTD increases the resistance to trypsin and proteinase K, thereby penetrating macrophages and eliminating intracellular infections. Interestingly, the nonagglutination mechanism of PTD against pathogens ensures the safe operation of the cellular system. Importantly, PTD can activate the critical pathway of antiferroptosis in macrophages against pathogen infection. The nanoparticles developed in this study demonstrate safety and efficacy against Gram-negative and Gram-positive pathogens in three animal models. Overall, this work highlights the effectiveness of the PTD nanoparticle in encapsulating pathogens and provides a paradigm for transduction systems-anti-intracellular infection therapy.

Transduction (biophysics)

Cell membrane

Intracellular parasite

10.1021/acsnano.3c00765

Cite

Citations (7)

Correlative dual-color dSTORM/AFM reveals protein clusters at the cytoplasmic side of human bronchial epithelium membranes

Nanoscale (2020)

Lulu Zhou Jing Gao Huili Wang Yan Shi Haijiao Xu

Localizing two distinct specific proteins within the topography of a cell membrane by correlative dSTORM/AFM microscopy.

Correlative

10.1039/c9nr10931e

Cite

Citations (13)

Electrochemical behavior and assembly of tetranuclear Dawson-derived sandwich compound [Cd4(H2O)2(As2W15O56)2]16− on 4-aminobenzoic acid modified glassy carbon electrode

Analytica Chimica Acta (2005)

Lihua Bi Yan Shen Junguang Jiang Erkang Wang Shaojun Dong

Glassy carbon

Aminobenzoic acid

10.1016/j.aca.2004.11.040

Cite

Citations (20)

Enhanced dSTORM imaging using fluorophores interacting with cucurbituril

Science China Chemistry (2016)

Min Zhang Jing Gao Junling Chen Mingjun Cai Junguang Jiang

Cucurbituril

Fluorescence-lifetime imaging microscopy

Two-photon excitation microscopy

10.1007/s11426-015-0535-0

Cite

Citations (9)

Recording force events of single quantum-dot endocytosis

Chemical Communications (2011)

Yuping Shan Xian Hao Xin Shang Mingjun Cai Junguang Jiang

We applied force spectroscopy based on atomic force microscope (AFM) to demonstrate the possibility of measuring the interaction force between single quantum-dots (QDs) and living cells at single particle level under native conditions. In the force–distance cycle, we recorded the events of cellular uptake of single QDs and single QD detachment from the cell.

Force Spectroscopy

Particle (ecology)

10.1039/c1cc00040c

Cite

Citations (37)

Super-resolution imaging of STAT3 cellular clustering during nuclear transport

RSC Advances (2016)

Jing Gao Feng Wang Junling Chen Jianzhong Wang Mingjun Cai

STAT3 cellular clustering revealed by super-resolution fluorescence microscopy.

10.1039/c6ra09591g

Cite

Citations (4)