X-W Ren

Viva Biotech (China)

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Fang Hu

Southern Medical University

L-R Zhang

Center for Translational Molecular Medicine

Yaping Li

Shanghai Institute of Materia Medica

G-W Feng

S.‐L. Ye

Fudan University

W W Shang

First Affiliated Hospital of Zhengzhou University

X Ye

UConn Health

Jianqiang Guo

Changzhou University

Min Liang

First Affiliated Hospital of GuangXi Medical University

Hong Ma

Union Hospital

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Viva Biotech (China)

Sun Yat-sen University

Peking University

Huazhong Agricultural University

Southern Medical University

Jiangxi Academy of Environmental Sciences

Jiangxi Provincial Institute of Water Sciences

Fifth Affiliated Hospital of Sun Yat-sen University

South China Agricultural University

Shaoguan University

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Simvastatin-induced myopathy with concomitant use of cyclosporine: case report

International Journal of Clinical Pharmacology and Therapeutics (2011)

W-H Yang Z-S Zeng X-W Ren Yaping Li W W Shang

Simvastatin has been shown to play an important role in reducing the risk of cardiovascular events caused by atherosclerosis. To promote the understanding of the potential toxicity of simvastatin and individualized treatment in genetic factors, we report a case of a renal transplant in a female patient who had developed acute myopathy after taking simvastatin.By PCR restriction fragment length polymorphism (PCR-RFLP) and allele-specificity polymerase chain reaction (AS-PCR) and direct sequencing. The genotypes of CYP3AP1, CYP3A5, CYP3A4 and SLCO1B1 were analyzed.The patient was identified to have mutant genotypes of CYP3AP1*3/*3 (-44G > A), CYP3A5*3/*3 (6986A > G) and wild genotype of CYP3A4*1/*1 and SLCO1B1*1/*1, which finally led to the elevation of her cyclosporine level except the SLCO1B1*1/*1 genotype and the acceleration of simvastatin-induced acute myopathy.Genetic factors have partly contributed to the development of simvastatin-induced myopathy with concomitant use of cyclosporine, and provided information on the adverse reactions of statins. What is different from other studies is that the SNP of SLCO1B1*5 does not take part in this adverse reaction.

SLCO1B1

Concomitant

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10.5414/cp201623

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A tumor-specific conditionally replicative adenovirus vector expressing TRAIL for gene therapy of hepatocellular carcinoma

Cancer Gene Therapy (2005)

X-W Ren Min Liang Xianfeng Meng X Ye Hong Ma

Heterologous

10.1038/sj.cgt.7700868

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Citations (24)