Mahtab Norouzi

École de Technologie Supérieure

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Seyyed Mojtaba Nekooghadam

Shahid Beheshti University of Medical Sciences

Farshad Mirzavi

Birjand University of Medical Sciences

Amir R. Afshari

Islamic Azad University, Mashhad

Farzad Rahmani

Islamic Azad University, Science and Research Branch

Sasan Shafiei

Shahid Beheshti University of Medical Sciences

G H Noroozinejad

Qom University of Medical Science and Health Services

Shahin Fahiminia

Imam Khomeini Hospital

Kaiwen Zhang

Jilin Province Science and Technology Department

M Ashtian

Mounir Elgharabawy

Concordia University

Cooperative Institutions

Mashhad University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Islamic Azad University, Mashhad

Imam Khomeini Hospital

Payame Noor University

Ghaem Hospital

Gonabad University of Medical Sciences

North Khorasan University of Medical Sciences

Islamic Azad University, Science and Research Branch

Islamic Azad University Medical Branch of Tehran

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Relationship between Cognitive Deficits and Self-care Instrumental Activities Daily Living in Schizophrenic Patients in Qom's Psychiatric Ward, 2010

V Akbari G H Noroozinejad M Ashtian Mahtab Norouzi

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The Effectiveness of Mindfulness Therapy by VR (Virtual-Reality) With a Focus on Death Anxiety in a Patient With Cerebellar Cancer (Case Report)

International Clinical Neuroscience Journal (2019)

Shahin Fahiminia Afshin Salahiyan Mahtab Norouzi

Background: Cancer has many potential physical, psychological and social consequences for the patient. This single case study explored the efficiency of mindfulness therapy with the aid of virtual reality (VR) focusing on minimizing anxiety especially death anxiety in a patient with cerebellar cancer. Methods: In this case study research the patient met and consulted 3 times in the first week, and the aim of these meetings was to break the patient’s resistance through meditation and psychological treatment. After that, 8 sessions each one 2 hours were planned at the patient’s home. In the second week, a subsidiary device called VR (large eye crystal capable of playing 3D film) was used as a method to assist the patient. Results: The data collected from the pre/posttest of Beck anxiety showed significant progress in blood pressure, heart rate and body temperature, and increased up to its normal levels. In addition, the sense of satisfaction expressed by the patient during the sessions was noticeably significant. Conclusion: According to results mindfulness therapy by VR with a focus on anxiety reduction as a complementary therapy has remarkable efficacy on improving quality of life in the cancer patient.

Beck Anxiety Inventory

Death anxiety

10.15171/icnj.2019.07

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Effects of some anti-diabetic herbal extracts on the insulin-degrading enzyme in human colon cancer Caco-2 cell line.

DOAJ (DOAJ: Directory of Open Access Journals) (2022)

Mahtab Norouzi Hossein Saghi Reza Mohebbati Farshad Mirzavi Amir R. Afshari

Type 2 diabetes mellitus (T2DM) is a condition characterized by insufficient insulin production or insulin resistance. The insulin-degrading enzyme (IDE) is responsible for degrading insulin and is a potential drug target for T2DM treatment. Numerous activities have been proposed for plant extracts, but research on the effects of plant extracts on IDE expression and activity is riddled with drawbacks.We investigated the effect of Phaseolus vulgaris, Allium cepa, Portulaca oleracea, Cinnamomum verum, and Citrullus colocynthis extracts on the expression and activity of IDE in the Caco-2 cell line.Findings of RT-PCR showed that IDE gene expression was reduced following treatment with P. vulgaris, C. colocynthis, and C. verum extracts. The results of IDE activity with fluorogenic peptide substrate V also indicated that P. vulgaris, C. colocynthis, and P. oleracea extracts reduced IDE activity in a significant and dose-dependent manner.The hydroalcoholic extracts studied, except for A.cepa, can prevent insulin degradation by reducing the expression and activity of the IDE enzyme. This new insight into the effects of herbal medicines on IDE activity can help future studies.

Citrullus colocynthis

Insulin-degrading enzyme

Caco-2

10.22038/ajp.2022.19982

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The Greed Trap: Uncovering Intrinsic Ethereum Honeypots Through Symbolic Execution

Mahtab Norouzi Mounir Elgharabawy Kaiwen Zhang

Smart contracts are computer programs that run on blockchain networks, enabling secure, transparent, and decentralized transactions. However, the security of smart contracts has always been a critical issue in the blockchain community. One major concern in recent years is the proliferation of honeypots - malicious contracts that deceive users into depositing funds, only to discover that they cannot withdraw their money and have lost their original deposit. In this research, we present a novel classification of honeypots and introduce a new type of contract that allows for the development of a future-proof method for detecting honeypots based on the contract owner and cash flow. We implement this method in a detection tool called HoneyVader, which uses symbolic execution to identify real-world honeypot contracts. Our tool analyzes over 2 million contracts deployed on the Ethereum network, detecting 139 honeypots. By using HoneyVader, we are able to uncover previously unknown zero-day honeypots and new techniques used by attackers, in addition to the ones identified in previous works.

Honeypot

Trap (plumbing)

Smart contract

10.1109/bcca58897.2023.10338870

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Paraneoplastic acute eosinophilic pneumonia due to carotid angiosarcoma: A rare case

Clinical Case Reports (2023)

Elham Paraandavaji Homa Hadidi Mahtab Norouzi Maryam Azaddehghan Mohadeseh Khodaparasti

Key Clinical Message This case report emphasizes that we should analyze a patient's signs and symptoms as a whole rather than relying exclusively on a common pattern to diagnose the condition and indicates that thorough histological investigation and sample collection are needed to accurately diagnose this malignancy. Abstract Angiosarcoma is a rare, fatal, and poorly understood malignant tumor of vascular endothelial cells which is a challenging disease to diagnose in the clinical settings and requires early diagnosis to achieve a favorable prognosis. Paraneoplastic syndromes associated with angiosarcoma can include hypercoagulability, thrombocytopenia, anemia, fever, weight loss, and night sweats. In some cases, the paraneoplastic syndrome can be the first sign of the underlying malignancy. Here, we present a 47‐year‐old individual with angiosarcoma over the right scapula accompanied by hemoptysis and other pulmonary complaints whom at first was thought to be metastatic polmunary involvement. However, the patient's dramatic response to corticosteroids, in addition to further imaging and paraclinical studies, led us to an acute eosinophilic pneumonia (AEP) diagnosis which is an eosinophilic infiltrations of alveolar spaces. The patient received chemotherapy for angiosarcoma and radiation, since the brachial nerve network was disrupted, leaving the tumor unresectable. After 3 years of continuous follow‐up, the patient is now completely cured.

Hemangiosarcoma

10.1002/ccr3.7348

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Therapeutic potency of heat-shock protein-70 in the pathogenesis of colorectal cancer: current status and perspectives

Biochemistry and Cell Biology (2018)

Atena Soleimani Elnaz Zahiri Sajad Ehtiati Mahtab Norouzi Farzad Rahmani

Heat-shock protein-70 (HSP70) is critical to the folding, stability, and activity of several client proteins including many responsible for cancer cell proliferation, apoptosis, drug toxicity, and metastasis. Up-regulation of HSP70 is positively associated with increased tumorigenicity as well as poor survival in colon cancer patients, supporting the diagnostic, prognostic, and therapeutic potencies of HSP70 in colorectal cancer. The administration of specific pharmacological inhibitors or gene knock-down for HSP70 suppresses tumor progression and enhances tumor cell chemosensitivity. This review summarizes the different tumorigenic properties of HSP70 and the potential therapeutic potency of HSP70 inhibitors in terms of a novel strategy for colorectal cancer therapy, for a better understanding, and hence better management of this disease.

Pathogenesis

10.1139/bcb-2018-0177

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Citations (17)