This article investigates the use of a model-based neural-network for the traffic reconstruction problem using noisy measurements coming from probe vehicles. The traffic state is assumed to be the density only, modeled by a partial differential equation. There exist various methods for reconstructing the density in that case. However, none of them perform well with noise and very few deal with lagrangian measurements. This paper introduces a method that can reduce the processes of identification, reconstruction, prediction, and noise rejection into a single optimization problem. Numerical simulations, based either on a macroscopic or a microscopic model, show good performance for a moderate computational burden.
We report on two microfluidic elastomeric autoregulatory devices—a diode and a rectifier. They exhibit physically interesting and complex nonlinear behaviors (saturation, bias-dependent resistance, and rectification) with a Newtonian fluid. Due to their autoregulatory properties, they operate without active external control. As a result, they enable increased microfluidic device density and overall system miniaturization. The demonstrated diode and rectifier would also be useful components in future microfluidic logic circuitry.
In the present study, an attempt was made to examine the nature and persistence of bilateral transfer of a throwing skill for a large sample of male and female children. One hundred sixty children ages 6, 8, 10, and 12 years were randomly assigned to either an experimental or control group with an equal number of boys and girls in each group. The experiment lasted 2 days and consisted of a pretest, a practice phase, an immediate transfer test, and a delayed transfer test. On the pretest, each participant performed 10 trials of a novel one-hand throwing task. Following the pretest, participants in the experimental group practiced the skill with the hand opposite the one used during the pretest until they had successfully reached a designated criterion for their age. Participants in the control group performed a balancing activity. Following the practice phase, all participants performed immediate (10 min later) and delayed (24 hr later) transfer tests under the same conditions as the pretest. The results revealed no group differences on the pretest but significantly higher throwing accuracy for the experimental group than the control group on both transfer tests. In addition, boys' throwing accuracy was significantly superior to the girls. It was concluded that bilateral transfer of throwing accuracy can be both a temporary and relatively persistent phenomenon for children and the superior throwing accuracy for boys is consistent with similar gender differences in throwing distance and throwing velocity (Thomas & French, 1985).
Introduction. This paper applies a unique citation-based method to analyse the development trajectory of bibliographic coupling research from 1963 to 2020. Method. Main path analysis is applied to a citation network created based on bibliographic data retrieved from the Science Citation Index Expanded and Social Sciences Citation Index of the Web of Science. Analysis. The analysis incorporated two major phases of basic bibliometrics (publication and citation trends, highly cited authors and core journals) and main path analysis. Results. A total of 223 papers on bibliographic coupling by 461 authors were identified. The papers were cited 5,575 times across ninety-three journals. The main paths, consisting of twenty-six documents, were further divided into emergence, opening, and consolidation periods on the basis of their publication date. Conclusions. This paper is the first to present the development trajectory of bibliographic coupling research. It not only emphasises how current state-of-the-art bibliographic coupling developed but also highlights critical studies in the field.
The aim of this study was to develop a robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantifying dacarbazine levels in the plasma of advanced melanoma patients, followed by an assessment of its analytical capabilities. The research encompassed the design of a high-performance liquid chromatography (HPLC) system, with the quantitative analysis performed using the multiple reaction monitoring (MRM) techniques and specific ion transition: 181.0 > 152.5 for dacarbazine and 187.1 > 158.6 for the internal standard (IS), dacarbazine-D6. The validation of the method involved an evaluation of parameters including linearity, detection limit, precision, and accuracy. Notably, the linear range extended from 10 to 1,000 µg/L for dacarbazine, and the method exhibited a detection limit of 10 µg/L. The method's precision, indicated by within-run and between-run coefficients of variation (CV), both being ≤4.2% and ≤8.3%, respectively. Furthermore, the accuracy of measurements, ranging from 86.1% to 99.4%, underscored the method's reliability. In clinical application, the dacarbazine levels of healthy control (n = 20) were 0.6 ± 0.02 μg/L; 770.9 ± 203.2 μg/mL in early-stage-melanoma patients (n = 22), and 588.7 ± 153.2 μg/mL in advanced melanoma patients (n = 25). The results serve as clinical evidence showing that long-term dacarbazine treatment affects the metabolism of dacarbazine.
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