Surya Kant Tripathi

King George's Medical University

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Bijesh K. Biswal

National Institute of Technology Rourkela

Munmun Panda

National Institute of Technology Rourkela

Kamal Pandey

University of Arkansas at Little Rock

Rajeev Kumar Sahoo

National Institute of Technology Rourkela

Sonali Trivedi

Loma Linda University

Gotthelf Wolmershäuser

University of Kaiserslautern

Hardev Singh

Kurukshetra University

Sundeep Salvi

Symbiosis International University

Hari Prasad Devkota

Kumamoto University

Rekha Gahtori

Kumaun University

Cooperative Institutions

University of Washington

Institute for Health Metrics and Evaluation

Indian Council of Medical Research

All India Institute of Medical Sciences

Public Health Foundation of India

Institute of Medical Sciences

Universidad Complutense de Madrid

Medical University of Vienna

King George's Medical University

Government of India

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Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2023)

Atif Khurshid Wani Nahid Akhtar Tahir ul Gani Mir Rattandeep Singh Prakash Kumar Jha

10.17615/asch-qv66

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Citations (0)

CCDC 739452: Experimental Crystal Structure Determination

The Cambridge Structural Database (2011)

S. Nair V. K. VERMA C.S. Verma T.A. Jain Surya Kant Tripathi

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccstg9b

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Current and future therapeutic approaches of CFTR and airway dysbiosis in an era of personalized medicine

Journal of Family Medicine and Primary Care (2024)

Kirti Upadhyay Nitu Nigam Surbhi Gupta Surya Kant Tripathi Amita Jain

A BSTRACT Cystic fibrosis (CF) is a life-threatening genetic disorder caused by mutations in the CFTR gene. This leads to a defective protein that impairs chloride transport, resulting in thick mucus buildup and chronic inflammation in the airways. The review discusses current and future therapeutic approaches for CFTR dysfunction and airway dysbiosis in the era of personalized medicine. Personalized medicine has revolutionized CF treatment with the advent of CFTR modulator therapies that target specific genetic mutations. These therapies have significantly improved patient outcomes, slowing disease progression, and enhancing quality of life. It also highlights the growing recognition of the airway microbiome’s role in CF pathogenesis and discusses strategies to modulate the microbiome to further improve patient outcomes. This review discusses various therapeutic approaches for cystic fibrosis (CFTR) mutations, including adenovirus gene treatments, nonviral vectors, CRISPR/cas9 methods, RNA replacement, antisense-oligonucleotide-mediated DNA-based therapies, and cell-based therapies. It also introduces airway dysbiosis with CF and how microbes influence the lungs. The review highlights the importance of understanding the cellular and molecular causes of CF and the development of personalized medicine to improve quality of life and health outcomes.

Personalized Medicine

Dysbiosis

10.4103/jfmpc.jfmpc_1085_23

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Antioxidant activity of biogenic silver nanoparticles on cells

AIP conference proceedings (2021)

Harmandeep Kaur Sanjay Pathania Archana Bhatnagar Surya Kant Tripathi

Nanoparticles have found applications in varied technologies ranging from chemical to medicinal and environmental to electrical. Metal nanoparticles especially silver have emerged with leading contributions in all these applications. Silver nanoparticles are also found in a wide range of commercially available consumer products. Synthetic methods for producing silver nanoparticles usually call for potentially hazardous chemicals and can produce environmentally unsafe byproducts. Therefore the novel biogenic synthesis of nanoparticles has gained importance and it is imperative to fully analyze biological activities and potential toxic effects of silver nanoparticles. The objective of present study is to check the effect of green tea synthesized metal (Silver) nanoparticles on the antioxidant activity in cells. Nanoparticles synthesized via green tea extract as reducing as well as stabilising agent have been used for this purpose. Biochemical assays were performed to study ROS production and level of reduced glutathione (GSH) in cells. To study the effect of Ag nanoparticles on B cell (lymphoma), cells were treated with two different concentrations of Ag nanoparticles and green tea extract. Results were obtained after 18 hours of incubation. Study revealed decrease in the ROS production in cells after nanoparticle treatment.

Silver nanoparticle

10.1063/5.0055660

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Exposure of piperlongumine attenuates stemness and epithelial to mesenchymal transition phenotype with more potent anti-metastatic activity in SOX9 deficient human lung cancer cells

Naunyn-Schmiedeberg s Archives of Pharmacology (2024)

Surya Kant Tripathi Rajeev Kumar Sahoo Bijesh K. Biswal

Ex vivo

10.1007/s00210-024-02965-4

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SOX9 promotes epidermal growth factor receptor-tyrosine kinase inhibitor resistance via targeting β-catenin and epithelial to mesenchymal transition in lung cancer

Life Sciences (2021)

Surya Kant Tripathi Bijesh K. Biswal

Viability assay

10.1016/j.lfs.2021.119608

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Citations (10)

Pterospermum acerifolium (L.) wild bark extract induces anticarcinogenic effect in human cancer cells through mitochondrial-mediated ROS generation

Molecular Biology Reports (2018)

Surya Kant Tripathi Bijesh K. Biswal

Acridine orange

DAPI

Viability assay

MTT assay

Trypan blue

10.1007/s11033-018-4390-6

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Citations (15)

Plumbagin engenders apoptosis in lung cancer cells via caspase-9 activation and targeting mitochondrial-mediated ROS induction

Archives of Pharmacal Research (2020)

Surya Kant Tripathi Kannan R. R. Rengasamy Bijesh K. Biswal

Plumbagin

Caspase-9

Intrinsic apoptosis

10.1007/s12272-020-01221-6

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Citations (54)

CCDC 706265: Experimental Crystal Structure Determination

The Cambridge Structural Database (2010)

V. K. VERMA A.A. Asatkar T.A. Jain Surya Kant Tripathi Rajender Singh

10.5517/ccrpxr2

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Posterior mediastinal mass diagnosed as schwanomma with concomittant tuberculosis

BMJ Case Reports (2014)

Surya Kant Tripathi Ashwini Kumar Mishra Ajay Verma Ved Prakash

A 21-year-old non-smoker, non-hypertensive male without diabetes was referred to our pulmonary medicine department with suspected malignant intrathoracic mass. The clinicoradiological evaluation revealed that it could be a posterior mediastinal mass. The same diagnosis was confirmed on performing CT and MRI. Benign posterior mediastinal schwanomma was suspected as it is the most common posterior mediastinal mass. It was completely resected. Histopathological examination confirmed the same. The mass was also sent for culture for mycobacterium which came out to be positive. The patient recovered from the surgery and postoperative X-ray showed complete clearance. He was treated with antitubercular treatment and responded very well.

Mediastinal mass

Mediastinal tumor

Histopathological examination

10.1136/bcr-2014-205799

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Citations (1)