Jing Zhao

Peking University People's Hospital

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Co-Authors

Zhengyu Jiang

State Key Laboratory of Natural Medicine

Qidong You

China Pharmaceutical University

Mengchen Lu

Soochow University

Yingni Li

Peking University

Bingyuan Zhang

Liaocheng University

Hongyan Wang

Anhui Agricultural University

Manting Hou

Chinese PLA General Hospital

Zhaofang Bai

Chinese PLA General Hospital

Xiaohong Xiang

Chongqing Medical and Pharmaceutical College

Kaixin Ding

Shandong First Medical University

Cooperative Institutions

Peking University

Qingdao University

Chinese Academy of Sciences

Huazhong University of Science and Technology

Chinese PLA General Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

Affiliated Hospital of Qingdao University

Shanghai Jiao Tong University

Peking University People's Hospital

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Frontiers in Oncology (2024)

Yimeng Qian Zhi Zheng Jing Ai Lin‐Woo Kang Gang Qiu

Intestinal obstruction, a rare manifestation of immunotherapy-related gastrointestinal adverse events, can be severe and even life-threatening with intestinal perforation. We present a 64-year-old man with HCC and currently under the therapy with Pembrolizumab, who was admitted in our hospital with abdominal distension. Radiologic findings were consistent with small bowel ileus. After conservative treatment, the patient underwent colonoscopy where no cause of ileus was discovered. The patient received high-dose prednisone due to the side effects of immune checkpoint inhibitor therapy. This resulted in a gradual improvement of symptoms.

Ileus

Perforation

10.3389/fonc.2024.1415117

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Citations (3)

Protective Effect of Procyanidin B2 on Acute Liver Injury Induced by Aflatoxin B 1 in Rats.

PubMed (2020)

Zhi Jie Deng Jing Zhao Feng Huang Gui Li Sun Wei Gao

Malondialdehyde

Liver function

10.3967/bes2020.033

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Citations (16)

Antitumor effects of human ribonuclease inhibitor gene transfected on B16 melanoma cells

The International Journal of Biochemistry & Cell Biology (2005)

Junxia Chen Ying Gao Jiwei Liu Yuxiang Tian Jing Zhao

Angiogenin

Angiogenesis inhibitor

10.1016/j.biocel.2004.11.020

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Citations (26)

Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-β signaling

Cancer Letters (2015)

Chengqin Wang Chenggang Wang Zhimin Wei Yujun Li Wenhong Wang

10.1016/j.canlet.2015.07.037

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Citations (30)

A survivin double point mutant has potent inhibitory effect on the growth of hepatocellular cancer cells

Cancer Biology & Therapy (2008)

Rui Zhang Tao Wang Kai-Nan Li Wei-Wei Qin Rui Chen

AbstractSurvivin is an attractive target in cancer therapy. Previous studies have demonstrated that survivin dominant-negative mutants T34A and C84A were able to induce apoptosis in cancer cells. Given that they had different mechanisms in inducing apoptosis, our study was undertaken to determine whether a survivin double point mutant (TC34,84AA) could achieve more potent inhibitory effect on the growth of hepatocellular cancer cells. Adenoviruses expressing survivin mutants were constructed and transduced into hepatocellular cancer cells. The inhibitory effect of the survivin mutants on cancer cell growth was measured. Transduction of cancer cells with all three survivin mutants resulted in significant apoptosis. Compared with survivin mutants T34A or C84A alone, the cancer killing effect of survivin TC34,84AA was much stronger. In addition, the survivin mutants were more sensitive than wild type survivin to the degradation in the ubiquitin-proteasome pathway. Our results suggest that adenovirus-delivered dominant-negative survivin TC34,84AA promotes apoptosis-mediated hepatocellular carcinoma suppression, and could potentially be a promising candidate for cancer therapies.

Survivin

Liver Cancer

Inhibitor of apoptosis

10.4161/cbt.7.4.5484

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Citations (30)

Brain Network Study of Attentional Cognitive Impairment in Children with Bronchial Asthma

Research Square (Research Square) (2021)

Kaihua Jiang Lin Zhu Y. Ge Qiuling Shangguan Yi Chen

Abstract Bronchial asthma is a common clinical disease in pediatrics. It affects brain function and causes cognitive impairment due to long-term hypoxia in the brain. Studies have shown attention deficits in asthma children, but lack the basis for brain studies. Functional magnetic resonance imaging (fMRI) based on functional connectivity analysis was used in this study, and 31 asthma children and typically developing children (TDC) were compared in degree centricity (DC), voxel-mirrored homotopic connectivity (VMHC) and continuous performance test (CPT). The study found that the correct number of CPT in the asthma group was significantly lower than the TDC group. And the reaction time in the asthma group was significantly longer than the TDC group. Compared with TDC group, asthma children exhibited lower DC value in the right superior frontal gyrus (after FDR correction, P<0.05). Meanwhile, asthma children exhibited lower VMHC value in bilateral superior frontal gyrus and bilateral superior parietal lobule (after FDR correction, P<0.05). The study found that the impaired functions of superior frontal gyrus and superior parietal lobule were related to the attention deficit of asthma children which were the key nodes of the default network and the dorsal attention network. This study will provide objective indicators for the evaluation of attention in asthma children and provide scientific basis for early clinical intervention.

Inferior parietal lobule

Middle frontal gyrus

Superior frontal gyrus

Attention network

10.21203/rs.3.rs-969991/v1

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Citations (1)

CircRNA_0026344 via miR-21 is involved in cigarette smoke–induced autophagy and apoptosis of alveolar epithelial cells in emphysema

Cell Biology and Toxicology (2021)

Jing Zhao Haibo Xia Wu Yan Lu Lu Cheng Cheng

10.1007/s10565-021-09654-5

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Citations (17)

Tumoral Calcinosis in the Larynx

Ear Nose & Throat Journal (2023)

Lianlian Liu Jing Zhao Hong Liu Jinrang Li

Tumoral calcinosis is a rare benign disease defined as calcium salt deposits in the periarticular soft tissue region. Tumoral calcinosis is rare in the neck and larynx. In this case, we described a 58-year-old man who had numerous calcified nodules in the larynx.

Tumoral calcinosis

10.1177/01455613231166586

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Citations (1)

Anatomy of the Skull of Saanen Goat. An anesthesiology and Stereology Approach

International Journal of Morphology (2021)

Xiangyang Wang Anjun Liu Jing Zhao Fathy Elshaer Diaa Massoud

The Saanen goat is known as the greatest milk producer among small ruminat breeds. However, its morphometric features still remain unclear. Therefore, the present work aimed to investigate the functional anatomy of the upper and lower jaws as well as the volumetric properties of the male and female Saanen goat for clinical applications. The heads of 20 adult animals (10 males and 10 females) were included. Totally, 22 morphometric parameters were measured on three dimensional computed tomographic images using RadiAnt DICOM Viewer software and some parameters were measured on hot macerated sample. The mean volume of paranasal sinuses as well as conchal sinuses were estimated using stereological method. Based on the results, the differences between males and females were not significant (p>0.05) in all desired parameters.The frontal and lacrimal sinuses were the largest and smallest paranasal sinus in both sexes. Also, the dorsal and middle conchal sinuses were the largest and smallest ones, respectively. The common nasal meatus was the smallest and ventral meatus was the largest meatus in the nasal cavity. In conclusion, these findings provide a basic data that would be useful in blocking terminal branches of the cranial nerves in this breed for surgical purpose or teeth injuries treatment.

Meatus

Sinus (botany)

Frontal sinus

10.4067/s0717-95022021000200423

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Citations (9)

miR-155-5p is Involved in Regulating Autism-Like Behaviour, Pain Sensitivity and Inflammatory Response in Brain Tissue via the Wnt/β-Catenin Pathway in Valproic Acid Rat Model of Autism Spectrum Disorder

Pakistan Journal of Zoology (2024)

Jing Zhao

Valproic Acid

10.17582/journal.pjz/20230802054154

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Citations (0)