The authors reportd that FUYANNING,as a basic composition of rerersal membrane model therapeutic method,was used to treat 100 case of dermatosis,including ache,Seborrbeie dermatitis and rosaeea.The results showed that FUYANNING had signifieiently better effect than other regular ehugs.
In this work, we carried out an overlay-aware variation study on Flip FET (FFET) considering the impact on RC parasitics induced by the lithography misalignment in backside processes, and benchmarked it with CFET in terms of the power-performance (PP) and variation sources. The iso-leakage frequency degrades up to 2.20% with layout misalignment of 4 nm. It's found that the Drain Merge resistance degrades significantly with misalignment increasing and is identified as the major variation source. Through careful DTCO with design rule optimization, the variation can be greatly suppressed, while the resistance fluctuation of the DM also drops substantially. Monte Carlo random experiments were also conducted, validating the variation reduction. Comparing with the CFET featuring self-aligned gate and much less overlay induced misalignment, fortunately, FFET's PP is still better except when misalignment reaches 8 nm, which is out of spec and nearly impossible. Considering the variabilities induced by the high aspect ratio processes, CFET still faces big challenges compared with FFET.
Nirmatrelvir/ritonavir (N/R) is the first drug to receive emergency authorization for the treatment of COVID-19 infection. We aimed to develop a population pharmacokinetic (PopPK) model to evaluate the effects of potential covariates and explore dosing regimen.
Objective
To analyze the value of chest digital radiography (DR) in the initial diagnosis of secondary cases of COVID-19.
Methods
The radiological data from Beijing information and resource management platform COVID-19 image database were retrospectively analyzed. Twenty confirmed cases, including 14 males and 6 females (32-80 years old, mean 51.2±15.1 years old), who performed chest computed tomography (CT) scan and DR during his/her first visit to clinic were included. The interval times between CT and DR examination were from 1 to 53 hours, (mean 25.4±22.8 hours). According to the results of CT scan, the diagnostic ability of DR was analyzed. McNemar’s test was used to analyze the agreement between the diagnoses based on the CT and DR findings. Bland-Altman or Kappa analysis was used to analyze the consistency in number, distribution, and morphological features of the lesions identified on the CT and DR.
Results
COVID-19 was identified in 19 of 20 cases by using CT (107 lesions), and 17 of 20 cases by using DR (54 lesions), respectively. The diagnostic accuracy of CT and DR was 95%, 85%, respectively. There was no statistical significance in diagnostic ability between DR and CT (P=0.5). For the determination of bilaterally distributed lesions, patterns of distribution among different lobes, diffused distribution and the morphological features of the lesions, the consistencies between the results of DR and CT were well (κ>0.6, respectively). The consistency between DR and CT is poor when recognizing multiple lesions(≥5). DR diagnosed two cases as normal, both presented as single pure ground glass opacity on CT, and the longest orthogonal diameters were 0.8 cm (≤1 cm) and 1.9 cm (1~3 cm).
Conclusion
Chest DR can be used to diagnose patients with if combined with the epidemic hsitory. However, it is difficult for DR to identify single lesion with lower density in patients with mild symptom. A CT scan in time will provide additional information.
Key words:
COVID-19; Tomography, X-ray computed; Digital radiography
ZY-1 02D is China’s first civil hyperspectral (HS) operational satellite, developed independently and successfully launched in 2019. It can collect HS data with a spatial resolution of 30 m, 166 spectral bands, a spectral range of 400~2500 nm, and a swath width of 60 km. Its competitive advantages over other on-orbit or planned satellites are its high spectral resolution and large swath width. Unfortunately, the relatively low spatial resolution may limit its applications. As a result, fusing ZY-1 02D HS data with high-spatial-resolution multispectral (MS) data is required to improve spatial resolution while maintaining spectral fidelity. This paper conducted a comprehensive evaluation study on the fusion of ZY-1 02D HS data with ZY-1 02D MS data (10-m spatial resolution), based on visual interpretation and quantitative metrics. Datasets from Hebei, China, were used in this experiment, and the performances of six common data fusion methods, namely Gram-Schmidt (GS), High Pass Filter (HPF), Nearest-Neighbor Diffusion (NND), Modified Intensity-Hue-Saturation (IHS), Wavelet Transform (Wavelet), and Color Normalized Sharping (Brovey), were compared. The experimental results show that: (1) HPF and GS methods are better suited for the fusion of ZY-1 02D HS Data and MS Data, (2) IHS and Brovey methods can well improve the spatial resolution of ZY-1 02D HS data but introduce spectral distortion, and (3) Wavelet and NND results have high spectral fidelity but poor spatial detail representation. The findings of this study could serve as a good reference for the practical application of ZY-1 02D HS data fusion.
Abstract The particle size of the oxidizer used by the solid rocket propellant has a great impact on the combustion performance of the grain. In order to study the influence law of the oxidizer used for the jet milling, the jet milling process test system is constructed. The influence of the main process parameters on the average particle size was studied by single-factor test.The orthogonal test was designed, and the prediction model of the relationship between particle size and milling pressure, milling chamber material mass and classification wheel speed was established using multiple linear regression method, and the significance analysis and the prediction test were conducted.The results show that the particle size prediction model is significant, and the classification wheel speed affects the average particle size the most, followed by milling pressure and milling chamber material mass.The conclusion is that the deviation of the milling average particle size under the prediction model acquisition process parameters is between 1.79%∼5.88%, and the prediction model acquisition process parameters can be obtained to mill the AP with the average particle size requirements of different specifications.
Objective: To analyze the differences of clinical characteristics and outcomes between relapsing and monophasic patients with anti-leucine-rich glioma-inactivated 1 (anti-LGI1) encephalitis. Methods: Medical records of confirmed anti-LGI1 encephalitic patients who underwent immunotherapy were retrospectively collected from January 2015 to January 2019 in the first affiliated hospital of Zhengzhou University. Clinical data, treatment methods, duration of treatment and outcomes were analyzed between the relapsing and monophasic groups. Results: Among the 33 anti-LGI1 encephalitic patients, there were 12 and 21 cases in the relapsing and monophasic groups, respectively. No difference was found in age, sex, precipitating factors, intensive care unit (ICU) admission, symptoms and modified Rankin Scale (mRS) score in the acute phase (P>0.05). As to the lab test and image examination, no statistic difference was found in serum and cerebral spinal fluid (CSF) positive rate, hyponatremia, abnormal rate of electrocardiogram (ECG), electroencephalogram (EEG), CSF and magnetic resonance imaging (MRI) and lesion locations (P>0.05). No difference was found in time to diagnose the disease between the 2 groups (P>0.05). The median immunotherapy period was 102.5 days in relapsing group and 194.0 days in monophasic group, with a statistic difference (P=0.001). No patients had bad outcomes in the monophasic group at the last follow-up, while 6 patients had poor outcomes in the relapsing group (4 patients died). The patients in relapsing group had a worse prognosis compared to those in the monophasic group (P=0.007). Conclusions: Relapse is common in anti-LGI1 encephalitis. Patients in the relapsing group received a shorter term of immunotherapy and had worse outcomes than those in the monophasic group.目的： 比较抗富亮氨酸胶质瘤失活1蛋白（LGI1）脑炎复发组与单病程组临床特征、检查、诊断治疗及预后差异。 方法： 收集郑州大学第一附属医院2015年1月至2019年1月确诊抗LGI1脑炎并给予免疫治疗患者，分为复发组与单病程组。回顾性分析患者临床资料、治疗方法、治疗时间及预后。 结果： 33例抗LGI1脑炎患者中，复发组12例，单病程组21例，两组随访时间差异无统计学意义（P>0.05）。两组患者在性别、年龄、起病诱因、重症监护、临床表现、急性期改良Rankin量表（mRS）评分差异无统计学意义（均P>0.05）。两组患者血、脑脊液（CSF）检测阳性率、低钠血症、心电图、脑电图、CSF、磁共振异常率及病灶累及部位方面差异无统计学意义（均P>0.05）。复发组及单病程组患者确诊时间差异无统计学意义（P>0.05）。复发组患者中位免疫治疗时间为102.5 d，单病程组为194.0 d，两组相比差异有统计学意义（P=0.001）。单病程组患者最后随访预后差0例（mRS>2分）；复发组患者预后差6例，其中死亡4例。与单病程组患者相比，复发组患者预后差（P=0.007）。 结论： 复发在抗LGI1脑炎中很常见。复发组患者较单病程组接受免疫治疗时间短，预后差。.
Quetiapine exhibits notable pharmacokinetic and pharmacodynamic (PK/PD) variability, the origins of which are poorly understood. This systematic review summarizes published population PK/PD studies and identifies significant covariates accounting for this variability to inform precision dosing.
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