Objective:To observe the effect of complex Zaofan pill on preventing platelet depression caused by gemcitabine and cisplatin(GP) combination chemotherapy.Methods:Thirty-nine cancer patients receiving GP combination chemotherapy for 1 cycle were divided into treatment group(20 cases) and control group(19 cases).Two groups were all intravenously treated with gemcitabine 1.0 g·m-2 for the fi rst and eighth day and cisplatin 25 mg·m-2 for the first three days.At the same time,the treatment group was also orally treated with complex Zaofan pill 1.6 g three times a day for 8 days.While the control group was treated with GP chemotherapy only.The occurrence of platelet depression and the total platelet count were evaluated after the chemotherapy for 14 days.Results:The extent of platelet depression was lower in treatment group than in control group and the total platelet count was higher in treatment group than in control group after the chemotherapy for 14 days,which showed signifi cant difference between two groups(P0.05).Conclusion:Complex Zaofan pill can lighten the platelet depression caused by GP combination chemotherapy.
Abstract Hearing loss has been associated with cognitive decline in the elderly and is considered to be an independent risk factor for dementia. One of the most common causes for acquired sensorineural hearing loss is exposure to excessive noise, which has been found to impair learning ability and cognitive performance in human subjects and animal models. Noise exposure has also been found to depress neurogenesis in the hippocampus. However, the effect is mainly attributed to the oxidant stress of noise on the cognitive brain. In the present study, young adult CBA/CAJ mice (between 1.5 and 2 months of age) were briefly exposed a high sound level to produce moderate-to-severe hearing loss. In both the blood and hippocampus, only transient oxidative stress was observed after noise exposure. However, a deficit in spatial learning/memory was revealed 3 months after noise exposure. Moreover, the deficit was correlated with the degree of hearing loss and was associated with a decrease in neurogenesis in the hippocampus. We believe that the observed effects were likely due to hearing loss rather than the initial oxidant stress, which only lasted for a short period of time.
Children with burns often have uncooperative behaviors such as crying and struggling when changing dressing because of pain and fear, which affects dressing change of medical staff and increases the psychological burden of the family members of children and dressing change personnel. In order to solve the above problems, the author's team designs and makes the mobile soothing screen for pediatric dressing change. Dressing change personnel are isolated from the children's sight through the screen's shielding function, and the children's favorite program showed on the tablet computer attracts the children's attention. The wound dressing change is completed by using the disposal window on the screen, which has good clinical application effects.小儿烧伤换药时因疼痛、恐惧常出现哭闹、挣扎等不配合行为，从而影响医护人员换药，增加患儿家属及换药人员的心理负担。为解决上述问题，笔者团队设计制作小儿换药用移动式安抚屏风，通过屏风的遮挡作用将换药人员隔离在小儿视线之外，平板电脑播放患儿喜爱的节目，转移其注意力，同时利用屏风上的处置窗口完成创面换药，临床应用效果较佳。.
Abstract In general, the method of conventional motion compensation for inverse synthetic aperture radar (ISAR) imaging is divided into translational motion compensation (TMC) and rotational motion compensation (RMC) in sequence. TMC is the premise of rotational compensation and the most critical procedure is range alignment. However, the deviation of echo correlation results in the poor performance of range alignment under low signal-to-noise ratio (SNR). Therefore, a new high-resolution ISAR imaging and azimuth scaling method under low SNR using parameterized compensation and calibration is proposed in this paper. Firstly, the target motion is modeled, in which translational motion is modeled as formula of the polynomial coefficient vector. In addition, entropy minimization corresponding to echo signal with compensation term based on coefficients is taken as objective function. Moreover, the particle swarm optimization (PSO) algorithm is utilized to search the global optimal parameters to be estimated precisely and efficiently to implement joint motion compensation and azimuth scaling. The experimental results from both simulated and real data verify the effectiveness and robustness of the method.
Almost all kinds of proton pump inhibitors (PPI), especially Omeprazole, have been reported to inhibit the antiplatelet activation of clopidogrel in the therapy of coronary artery disease and were associated with a higher risk of major cardiovascular events ranging from a 24.3% with lansoprazole to a 29.2% with pantoprazole in the increased risk. But recently, two clinical trials give us a paradoxical result from the above in nearly 13,800 patients with ACS. So, what the true influences of PPI on clopidogrel activation are still unclear. And especially, it has not been reported before in ACS group through PCI in Chinese patients. Objectives: To assess the effects of omeprazole on clopidogrel efficacy in patients with ACS through PCI in Chinese patients.
Methods
In this randomised controlled trial, all patients (n=186) with ACS and elective PCI who received aspirin (loading dose 300 mg before PCI, followed by maintaining dose 100 mg/day) and clopidogrel (loading dose 600 mg before PCI, followed by maintaining dose 75 mg/day) were randomised to receive omeprazole (20 mg/day) or placebo for 7 days. Residual platelet activity and platelet activation inhibition rate in ADP pathway were detected in the third day after PCI with modified thrombelastograpy-mapping (TEG-mapping) in ADP induced method.
Results
Between the two groups with and without omeprazole, the mean platelet activation inhibition rate with ADP induced method is 63.52%±23.11% vs 67.26±24.17 (p=0.2895) detected with TEG, respectively. But when we divided the patients into 5 levels according to the clinical meaning of platelet activation inhibition rate, the frequency distribution in these 5 levels in the tow groups showed significant difference (p=0.0062), especially the decrease of frequency in higher platelet activation inhibition rate with omeprazole. But without any changes can be seen in the distribution of highest or lowest inhibiting levels group.
Conclusion
Without any significant effects of omeprazole on clopidogreal in total strength of inhibition rate to platelet can be observed in patients with ACS through PCI taking clopidogrel with 600 mg loading dose and aspirin with 300 mg loading dose. But omeprazole decrease the frequency distribution of higher platelet inhibition rate induced by clopidogrel significantly without increasing clopidogrel non-responds rate.
Steel bars play an important role in modern construction projects and their quality enormously affects the safety of buildings. It is urgent to detect whether steel bars meet the specifications or not. However, the existing manual detection methods are costly, slow and offer poor precision. In order to solve these problems, a high precision quality inspection system for steel bars based on machine vision is developed. We propose two algorithms: the sub-pixel boundary location method (SPBLM) and fast stitch method (FSM). A total of five sensors, including a CMOS, a level sensor, a proximity switch, a voltage sensor, and a current sensor have been used to detect the device conditions and capture image or video. The device could capture abundant and high-definition images and video taken by a uniform and stable smartphone at the construction site. Then data could be processed in real-time on a smartphone. Furthermore, the detection results, including steel bar diameter, spacing, and quantity would be given by a practical APP. The system has a rather high accuracy (as low as 0.04 mm (absolute error) and 0.002% (relative error) of calculating diameter and spacing; zero error in counting numbers of steel bars) when doing inspection tasks, and three parameters can be detected at the same time. None of these features are available in existing systems and the device and method can be widely used to steel bar quality inspection at the construction site.
To evaluate the effectiveness and safety of rhubarb-based Chinese herbal formulae (RCHF), which are widely used to treat hepatic encephalopathy (HE) in China. Nine online databases were searched from inception to November 22, 2016. Eligible studies were randomized controlled trials of Traditional Chinese Medicine (TCM) treatment for adult patients (≥ 18 years old) with HE. Outcomes such as mortality rate, clinical response rate, blood ammonia level, and alanine aminotransferase were evaluated between TCM group and control group. Thirty studies involving 2661 HE patients were analyzed. Most studies used RCHF treatment. Compared with conventional treatment as usual, lactulose, and vinegar, RCHF were associated with significant improvement in clinical response rate [risk ratio (RR) = 1.33, 95% confidence interval (CI) = 1.25, 1.43, I2 = 0%; RR = 1.26, 95% CI = 1.14, 1.38, I2 = 22%; and RR = 1.19, 95% CI = 1.06, 1.33, I2 = 0%, respectively] and significant reductions in levels of blood ammonia and alanine aminotransferase. Only minor RCHF-associated adverse events, such as abdominal pain (0.3%), anal tenesmus (0.3%), and diarrhea (2.3%), were reported, and there were no significant differences in these events between the treatment group and the three types of control group. The findings suggest that RCHF may be an alternative treatment option for HE patients. More rigorous multicenter studies with larger samples and longer observational periods are needed to confirm these findings.
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