Jiangfeng Li

First Affiliated Hospital Zhejiang University

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Xiangyi Zheng

First Affiliated Hospital Zhejiang University

Xiao Wang

First Affiliated Hospital of Wenzhou Medical University

Yufan Ying

First Affiliated Hospital Zhejiang University

Liping Xie

First Affiliated Hospital Zhejiang University

Xueyou Ma

Zhejiang University

Ben Liu

Zhejiang University

Xin Xu

Zhejiang University

Haiyun Xie

Sir Run Run Shaw Hospital

Guangfu Yin

Sichuan University

Ke Jin

Hunan Children's Hospital

Cooperative Institutions

Zhejiang University

First Affiliated Hospital Zhejiang University

Chinese Academy of Sciences

Sichuan University

Army Medical University

Nanjing Medical University

Sun Yat-sen University

Air Force Medical University

University of Chinese Academy of Sciences

Huazhong University of Science and Technology

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Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1⁺ Macrophages for Infectious Bone Defect Regeneration

ACS Nano (2024)

Hao Wu Changcheng Chen Jiangfeng Li Dongmei Yu Xun Wu

Infectious bone defects pose significant clinical challenges due to persistent infection and impaired bone healing. Icam1+ macrophages were identified as crucial and previously unrecognized regulators in the repair of bone defects, where impaired oxidative phosphorylation within this macrophage subset represents a significant barrier to effective bone regeneration. To address this challenge, dual-responsive iron-doped barium titanate (BFTO) nanoparticles were synthesized with magnetic and ultrasonic properties. These nanoparticles were further loaded with the anti-inflammatory agent curcumin and coated with engineered mesenchymal stem cell membranes (EMM) modified with γ3 peptide, creating BFTO-Cur@EMM nanoparticles specifically designed to target Icam1+ macrophages. These nanoparticles were shown to disrupt bacterial biofilms under alternating magnetic fields (AMF) and to activate oxidative phosphorylation and osteogenic immune responses in Icam1+ macrophages via low-intensity pulsed ultrasound (LIPUS). Transcriptomic sequencing and validation experiments demonstrated that this approach activates oxidative phosphorylation (OXPHOS) by stimulating the JAK2-STAT3 pathway and inhibiting the MAPK-JNK pathway, thereby promoting the polarization of Icam1+ macrophages toward a pro-reparative phenotype and enhancing the secretion of pro-angiogenic and osteogenic cytokines. These nanoparticles were subsequently integrated into quaternized chitosan (QCS) and tricalcium phosphate (TCP) to create a bioink for three-dimensional (3D) printing anti-infection QT/BFTO-Cur@EMM bone repair scaffolds. In vivo studies indicated that these scaffolds significantly improved the healing of infectious bone defects without causing thermal damage to surrounding tissues. This work highlights the potential of this material and the targeting of Icam1+ macrophages as an effective strategy for simultaneously controlling infection and promoting bone regeneration.

10.1021/acsnano.4c13562

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Transperineal versus transrectal prostate biopsy in the diagnosis of prostate cancer: a systematic review and meta-analysis

World Journal of Surgical Oncology (2019)

Jianjian Xiang Huaqing Yan Jiangfeng Li Xiao Wang Hong Chen

Because conventional prostate biopsy has some limitations, optimal variations of prostate biopsy strategies have emerged to improve the diagnosis rate of prostate cancer. We conducted the systematic review to compare the diagnosis rate and complications of transperineal versus transrectal prostate biopsy. We searched for online publications published through June 27, 2018, in PubMed, Scopus, Web of Science, and Chinese National Knowledge Infrastructure databases. The relative risk and 95% confidence interval were utilized to appraise the diagnosis and complication rate. The condensed relative risk of 11 included studies indicated that transperineal prostate biopsy has the same diagnosis accuracy of transrectal prostate biopsy; however, a significantly lower risk of fever and rectal bleeding was reported for transperineal prostate biopsy. No clue of publication bias could be identified. To conclude, this review indicated that transperineal and transrectal prostate biopsy have the same diagnosis accuracy, but the transperineal approach has a lower risk of fever and rectal bleeding. More studies are warranted to confirm these findings and discover a more effective diagnosis method for prostate cancer.

Prostate biopsy

Rectal examination

10.1186/s12957-019-1573-0

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Citations (216)

In vivo confocal microscopy of sub-basal corneal nerves and corneal densitometry after three kinds of refractive procedures for high myopia

International Ophthalmology (2022)

Chenting Hou Jiangfeng Li Jinjian Li Hui Peng Qing Wang

Densitometry

LASIK

Scheimpflug principle

Microkeratome

10.1007/s10792-022-02494-0

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Citations (8)

A prospective multi-center randomized comparative trial evaluating outcomes of transrectal ultrasound (TRUS)-guided 12-core systematic biopsy, mpMRI-targeted 12-core biopsy, and artificial intelligence ultrasound of prostate (AIUSP) 6-core targeted biopsy for prostate cancer diagnosis

World Journal of Urology (2022)

Xiao Wang Yanqi Xie Xiangyi Zheng Ben Liu Hong Chen

Prostate biopsy

10.1007/s00345-022-04086-0

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Citations (12)

Developmental regulation of CYP3A4 and CYP3A7 in Chinese Han population

Drug Metabolism and Pharmacokinetics (2016)

Hang He Yali Nie Jiangfeng Li Xiang‐Gao Meng Wei-Hong Yang

10.1016/j.dmpk.2016.08.008

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Administration of polysaccharide from Panax notoginseng prolonged the survival of H22 tumor-bearing mice

OncoTargets and Therapy (2016)

Tong Chen Yuanyuan Zhong Yajuan Chen Lei Zhang Annie R. Zhang

Polysaccharides from various sources are being considered potential sources for the treatment of liver cancer. The aim of this study was to investigate the impact of polysaccharide isolated from Panax notoginseng (PPN) on the proliferation of H22 liver cancer cells and the survival of the tumor-bearing mice transplanted with H22 cells.Polysaccharide from PPN was added to the culture medium of mouse hepatoma H22 cells at different doses. Cell proliferation was assayed with a standard MTT assay. Survival rates of tumor-bearing mice were recorded. Peripheral blood lymphocytes were assayed by flow cytometry. Serum interleukin-2 levels in peripheral blood were measured by enzyme-linked immunosorbent assay.Polysaccharide from PPN inhibited the growth of H22 cells and significantly prolonged the survival of tumor-bearing mice. The increase in activated CD4(+) T-cells and the elevation of serum interleukin-2 may contribute to the antitumor activity of PPN.PPN has potential antitumor activity for the treatment of liver cancer.

Panax notoginseng

MTT assay

Liver Cancer

10.2147/ott.s79427

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Citations (39)

Research hotspots of prostate cancer at the international conferences on urology in 2022

Journal of Zhejiang University (Medical Sciences) (2023)

Jiahe Yi Jiangfeng Li Liping Xie

The American Urological Association (AUA), European Association of Urology (EUA) and International Urological Society (SIU) annual meetings were held in 2022. Studies on prostate cancer reported in the meetings mainly focus on the advances of diagnostic biomarkers (such as α-2, 3-1inked sialylation of terminal

Prostate biopsy

10.3724/zdxbyxb-2022-0712

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The impacts of gold mining on the welfare of local farmers in Asutifi-North District in Ghana: A quantitative and multi-dimensional approach

Resources Policy (2021)

Adator Stephanie Worlanyo Sikpaam Issaka Alhassan Jiangfeng Li

10.1016/j.resourpol.2021.102458

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Citations (26)

Topology Scaffolds-Enhanced Paracrine of Bmscs Through Mechanotransduction-Related Metabolism Modulation for Burn Wounds Healing

Qingrong Zhang Jiangfeng Li Jiezhi Jia Shuning He Ailian Mei

Mechanotransduction

Modulation (music)

10.2139/ssrn.5128725

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Wide-range adjustment technique of playback wavelength of MBDCG Lippmann hologram

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2003)

Jianhua Zhu Guang‐Xing Dong Jiangfeng Li Jinglei Du

In this paper, a new technique is presented for adjusting the playback wavelength of Lippmann holograms recorded in methylene-blue sensitized dichromated gelatin (MBDCG). The main feature of this technique is introducing a water-soluble organic reagent into MBDCG photosensitive layer as preswelling reagent and wavelength adjuster. This method has wide wavelength adjustment range and high signal-to-noise ratio, can be applied to adjust the playback wavelength of reflection hologram quantitatively by changing the concentration of preswelling reagent. Its possible applications include color image display, holographic optical elements, and optical anti-counterfeiting.

Gelatin

Reflection

Feature (linguistics)

SIGNAL (programming language)

10.1117/12.504411

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Citations (1)