Datong Zhang

Shandong University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Jianwu Wang

Central South University

Ruibing An

Shandong First Medical University

Weiren Xu

Tianjin Institute of Pharmaceutical Research (China)

Peng Wei

Donghua University

Tang Li-da

Jiangsu University

Guilong Zhao

Shanghai Institute of Materia Medica

Yue‐Zhi Cui

Qilu University of Technology

Yaling Zhu

Anhui Medical University

Gong He

Binzhou Medical University

Yuntong Ma

Qilu University of Technology

Cooperative Institutions

Shandong University

Chinese Academy of Sciences

Qilu University of Technology

Shandong Academy of Sciences

Fudan University

University of Chinese Academy of Sciences

Shandong First Medical University

Zhejiang University

Tianjin Institute of Pharmaceutical Research (China)

Shanghai Institute of Materia Medica

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

mTOR Signaling in T Cell Immunity and Autoimmunity

International Reviews of Immunology (2014)

Yu Liu Datong Zhang Xinguang Liu

The mammalian target of rapamycin (mTOR), a phosphoinositide-3-kinase-related protein kinase, acts as a rheostat capable of integrating a variety of environmental cues in the form of nutrients, energy, and growth factors to modulate organismal processes and homeostasis. Recently, there is a growing appreciation of mTOR in adaptive immunity for its crucial roles in keeping a proper balance between T cell quiescence and activation. Under steady-state circumstances, mTOR is subtly inhibited by multiple mechanisms to maintain normal T cell homeostasis. Antigen recognition by naïve T cells leads to mTOR activation, which subsequently promotes the differentiation of these cells into distinct effector T cell subsets. This review focuses primarily on the recent literature with respect to the regulatory effects and mechanisms of mTOR signaling in dictating T cell fate, and discusses the therapeutic implications of mTOR modulation in T-cell-mediated autoimmunity.

RPTOR

mTORC2

Phosphoinositide 3-kinase

10.3109/08830185.2014.933957

Cite

Citations (77)

Synthesis and preliminary antibacterial evaluation of hydroxamic acid and N-formyl hydroxylamine derivatives bearing oxazole ring

Medicinal Chemistry Research (2012)

Datong Zhang Lingyan Huo Laichun Lu Qiong Yu Jianwu Wang

Oxazole

Hydroxylamine

Hydroxamic acid

Hydroxylamine Hydrochloride

Isoxazole

10.1007/s00044-012-0141-8

Cite

Citations (2)

Aromatic β-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists

Bioorganic & Medicinal Chemistry (2010)

Yongli Du Qunyi Li Bing Xiong Hui Xin Xin Wang

Progesterone receptor

Carboxamide

Ligand binding assay

10.1016/j.bmc.2010.04.092

Cite

Citations (16)

The influence of furanyl monomer on the self‐healing polyurethanes by reverse Diels‐Alder cross‐link

Polymers for Advanced Technologies (2018)

Yunlin Pan Xi Yu Pengfei Yang Junying Li Datong Zhang

In this work, several furanyl diols with amide, imide, or amine groups were synthesized, each diol was subsequently polymerized with 4,4′‐dicyclohexylmethane diisocyanate and polytetramethylenene ether glycol to prepare polyurethanes. Bis(4‐maleimidophenyl) methane was then added as a cross‐linker to give self‐healing polyurethanes. DSC and DMA analysis were used to measure the DA/rDA temperature of these polyurethanes with different chemical structures. It was demonstrated that the polyurethane prepared from amide furanyl diol had the highest DA/rDA temperature, followed with the order of amide > imide > amine. This expands the versatility of monomers that have different self‐healing activity, which is expected to have the application for preparing various polyurethane coatings.

Amide

Imide

Diethylene glycol

10.1002/pat.4507

Cite

Citations (5)

Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma

Organic & Biomolecular Chemistry (2013)

Kai Liu Datong Zhang Jeremy E. Chojnacki Yuhong Du Haian Fu

In our efforts to develop effective treatment agents for human multiple myeloma (MM), a series of hybrid molecules based on the structures of thalidomide (1) and curcumin (2) were designed, synthesized, and biologically characterized in human multiple myeloma MM1S, RPMI8226, U266 cells, and human lung cancer A549 cells. The biological results showed that two hybrid compounds, 5 and 7, exhibited significantly improved lethal effects towards all three human MM cell models compared to 1 or 2 alone, as well as the combination of 1 and 2. Furthermore, mechanistic studies in U266 cells demonstrated that 5 and 7 can induce the production of reactive oxygen species (ROS) and cause G1/S arrest, thus leading to apoptosis and cell death. Additionally, they exhibited inhibitory effects on NFκB activation in A549 cells. Collectively, the results obtained from these hybrid compounds strongly encourage their further optimization as new leads to develop effective treatment agents for human MM.

Human lung

10.1039/c3ob40595h

Cite

Citations (49)

Synthesis of Sulfonylhydrazone‐ and Acylhydrazone‐Substituted 8‐Ethoxy‐3‐nitro‐2H‐chromenes as Potent Antiproliferative and Apoptosis Inducing Agents

Archiv der Pharmazie (2014)

Datong Zhang Yuntong Ma Yu Liu Zhao‐Peng Liu

3‐Nitro‐2 H ‐chromenes have recently been identified as a novel class of potent antitumor agents. In view of the favorable effects shown by sulfonylhydrazones and acylhydrazones, we designed and synthesized a series of sulfonylhydrazone‐ and acylhydrazone‐substituted 8‐ethoxy‐3‐nitro‐2 H ‐chromene derivatives, and evaluated their cell growth inhibition activities against A549, KG‐1, A2780, and K562 cells. All the tested compounds exhibited more potent antiproliferative activity than BENC‐511 against KG‐1 cells. These compounds displayed IC 50 values in the nanomolar range against A2780 cells. Compound 7d showed prominent cytotoxicity against K562 cells with an IC 50 of 0.11 µM, which was comparable to that of BENC‐511. Compound 7d arrested K562 cells at the G1 phase at high concentrations and induced apoptosis in K562 cells. Furthermore, 7d increased the levels of cleaved caspase‐3, decreased the expression of bcl‐2 and induced the cleavage of poly(ADP‐ribose) polymerase in K562 cells. Thus, this study provides the development of a series of novel compounds as effective antitumor agents with apoptotic death ability.

K562 cells

IC50

10.1002/ardp.201400082

Cite

Citations (39)

Docking studies of Nickel-Peptide deformylase (PDF) inhibitors: Exploring the new binding pockets

Biophysical Chemistry (2006)

Qiang Wang Datong Zhang Jianwu Wang Zhengting Cai Weiren Xu

Docking (animal)

Side chain

10.1016/j.bpc.2006.02.009

Cite

Citations (7)

A Facile Convergent Synthetic Procedure for 3-Deoxydapagliflozin as SGLT2 Inhibitor

Chinese Journal of Organic Chemistry (2014)

Zhigang Gao Datong Zhang Wei Peng Zhe Wang Xie Yafei

赵桂龙 * ,a,b ( a 齐鲁工业大学化学与制药工程学院济南 250353) ( b 天津药物研究院天津市新药设计与发现重点实验室天津 300193) ( c 山东中医药大学第一临床医学院济南 250014) 摘要 3-脱氧达格列净(1)是一个高选择性的强效钠依赖性葡萄糖转运子 2 (SGLT2)抑制剂.本研究发现了一条以廉价的 α-D-甲基吡喃葡萄糖(2)为起始原料的简便的 3-脱氧达格列净(1)的汇聚式合成路线, 共 13 步, 总产率 38%.在此过程中系统研究了 4,6-O-苄叉-α-D-甲基吡喃葡萄糖苷(3)中 2-OH 和 3-OH 的选择性保护策略, 使用 NOE (nuclear overhauser effect)技术对区域异构体进行了结构鉴定, 并对区域异构体的相对比例和相对极性提出了合理解释; 在此过程中对 4,6-O-苄叉-2-O-叔丁基二苯基硅基-α

10.6023/cjoc21404007

Cite

Citations (0)

Recent Advances in BTK Inhibitors for the Treatment of Inflammatory and Autoimmune Diseases

Molecules (2021)

Datong Zhang Gong He Fancui Meng

Bruton’s tyrosine kinase (BTK) plays a crucial role in B-cell receptor and Fc receptor signaling pathways. BTK is also involved in the regulation of Toll-like receptors and chemokine receptors. Given the central role of BTK in immunity, BTK inhibition represents a promising therapeutic approach for the treatment of inflammatory and autoimmune diseases. Great efforts have been made in developing BTK inhibitors for potential clinical applications in inflammatory and autoimmune diseases. This review covers the recent development of BTK inhibitors at preclinical and clinical stages in treating these diseases. Individual examples of three types of inhibitors, namely covalent irreversible inhibitors, covalent reversible inhibitors, and non-covalent reversible inhibitors, are discussed with a focus on their structure, bioactivity and selectivity. Contrary to expectations, reversible BTK inhibitors have not yielded a significant breakthrough so far. The development of covalent, irreversible BTK inhibitors has progressed more rapidly. Many candidates entered different stages of clinical trials; tolebrutinib and evobrutinib are undergoing phase 3 clinical evaluation. Rilzabrutinib, a covalent reversible BTK inhibitor, is now in phase 3 clinical trials and also offers a promising future. An analysis of the protein–inhibitor interactions based on published co-crystal structures provides useful clues for the rational design of safe and effective small-molecule BTK inhibitors.

10.3390/molecules26164907

Cite

Citations (47)

Microwave‐Assisted Facile Synthesis of a New Class of Asymmetrical Diheteroarylmethanes Bearing Imidazopyridine Moieties under Solvent‐Free Condition.

ChemInform (2007)

Guiyun Duan Yawei Sun Junzhi Liu Guilong Zhao Datong Zhang

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Imidazopyridine

10.1002/chin.200722140

Cite

Citations (1)