It is a highly desirable but still a challenging task to find a simple, fast and straightforward method to greatly improve the electrochemical properties of a Co3O4 electrode for pseudocapacitors.
The accurate prediction of undrained shear strength is of significant importance in areas such as slope stability, earthquake resistance, and pile foundation design. Therefore, enhancing the accuracy of undrained shear strength prediction is crucial. The research results indicate that employing the KMR model can improve the computational accuracy by 4.4% to 18.9%. Furthermore, compared to conventional empirical formulas, the KMR model evidently processes data more rapidly and can predict relevant parameters more accurately. This method provides a new research idea to some extent for addressing the issue of low prediction accuracy of traditional machine learning models for geotechnical parameters.
Abstract The method for coating Fe3O4 with V-doped TiO2 was presented. On the base of characterizing composition, morphology and properties, the prepared nano-sized Fe3O4@V/TiO2 composites were used as a heterogeneous photocatalyst to catalyze the synthesis of 2-substituted benzimidazoles under light. The photocatalyst Fe3O4@V/TiO2 composites showed the enhanced photocatalytic activity compared to no V-doped Fe3O4@TiO2, being able to yield various 2-substituted benzimidazoles in moderate to good yield with recyclability and stability. A possible photocatalysis mechanism was investigated. It was evident that holes, singlet oxygen and ∙O2̄ radical played important roles in the synthesis of 2-substituted benzimidazole. Moreover, some of the obtained products were proved to have excellent antibacterial activity.
Abstract Background The clinical outcome of B-cell lymphoma has improved dramatically due to hematopoietic stem cell transplantation (HSCT) and biological agents. However, treatment of high-risk B cell lymphoma in the elderly remains a challenge because of their ineligibility for HSCT, high mortality and relapse rates. Maintenance therapy to improve the prognosis of B cell lymphoma in the elderly might be feasible. Methods We analyzed the efficacy of a combination of human recombinant granulocyte-macrophage colony-stimulating factor (rhGM-CSF) with the R2 regimen in maintenance therapy in high-risk B cell lymphoma in the elderly of our center. A total of 83 elderly patients, who were ineligible for auto-HSCT and had a response after 6 cycles of induction therapy above a partial response, were divided into two groups: observation (n = 44) and R2 + GM-CSF (n = 39) by enrollment time. Results The clinical data, survival outcome, and the number of peripheral blood mononuclear cells were analyzed and compared. The numbers of lymphocytes (1.19 × 10 9 /L vs . 1.03 × 10 9 /L, P = 0.0062) and leukocyte (6.46 × 10 9 /L vs . 4.85×10 9 /L, P = 0.0048) increased after receipt of maintenance therapy, particularly the number of natural killer cells (0.131 × 10 9 /L vs . 0.061 × 10 9 /L, P = 0.0244). Patients receiving R2 + GM-CSF for maintenance had longer-term remission (duration of response (DOR): 18.9 months vs . 11.3 months, P = 0.001), and longer-term progression free survival (PFS) (not reached (NR) vs . 31.7 months, P = 0.037), and overall survival (OS) (NR vs . NR, P = 0.015). The new R2 regimen was safe and well tolerated. The elderly, high-risk, and high tumor burden seemed to have tendency to be independent prognostic factors for a better PFS ( P = 0.060, 0.012, 0.005). Conclusions The new R2 regimen prolonged progression-free survival and overall survival among elderly patients with high-risk B cell lymphoma, appeared to lead to improve response without compromising its tolerability profile in elderly patients who are ineligible to receive HSCT. The number of patients in this trial was limited and the conclusions should be verified in larger, prospective, multicenter studies. Retrospectively registered: The ethical committee of Huadong Hospital (approval number: 2021K186).
The objective of the review was to assess the relationship between insulin resistance and cognitive impairment. Medline, Embase, Web of Science and Cochrane Library were searched. Two independent authors selected studies and extracted data. Quality of included studies was assessed by NOS (Newcastle-Ottawa quality assessment scale). A random-effects model with its 95% confidence intervals (CIs) was considered for meta-analysis. Eight articles including 1,399 subjects were included in this meta-analysis. The article showed a negative association between insulin resistance and cognition (R = - 0.262; 95% CI-0.309, - 0.215). There is evidence that insulin resistance may be a mechanism of cognitive impairment. Key Words: Insulin resistance, Insulin, Cognition, Cognitive impairment, Systematic review, Alzheimer's disease.
Rigidity of a crystal structure has a simple and imaginable meaning, although its quantitative expression has not been established. A widely accepted approach is to select the Debye temperature as a measurement of rigidity, yet it overlooks the site differences within a unit cell. In this work, the correlation between polyhedron distortion and rigidity of the corresponding crystallographic site is explored in a series of garnet-type compounds. The polyhedron distortion is characterized by determining to what extent the real polyhedron differs from its best fitted ideal one. The smaller octahedron and tetrahedron are much closer to the ideal shapes than the larger dodecahedron. Nevertheless, the dodecahedron has the least variation percentage change, indicating that the 24c site has the smallest deformation on component changing. This observation could explain the excellent thermal luminescence resistance in Ce3+-doped garnet phosphors, in which Ce3+ is accommodated in the dodecahedral site. This new interpretation sheds light on understanding the rigidity of crystal structure and will promote its quantitative characterization for wider applications.
Abstract Influenza A viruses in animal reservoirs repeatedly cross species barrier to infect humans. Once an animal-borne virus with novel antigenicity acquired the efficient human to human transmissibility, it will become epidemic in the population. Dogs are the closest animal companions to humans and canine respiratory tract expresses both SAα2,3-(avian type) and α2,6-Gal (human type) receptors. However, the role of dogs in the ecology of influenza viruses is unclear. H3N2 avian influenza viruses transmitted to dogs around 2006 and have formed stable lineages. The long-term epidemic of avian-origin H3N2 virus in canine offers the best models to investigate the effect of dogs on the evolution of influenza viruses. Here, we carried out a systematic and comparative identification of the biological characteristics of H3N2 canine influenza viruses (CIVs) isolated in the worldwide over 10 years. We found that during the adaptation of H3N2 CIVs to dogs, H3N2 CIVs became to recognize the human-like SAα2,6-Gal receptor, gradually increased HA acid stability and replication ability in human airway epithelial cells, and acquired a 100% transmission rate via respiratory droplet in ferret model, which were essential hallmarks of being adapted to humans. We also identified that the frequency of substitutions related to human adaptation has gradually increased in H3N2 CIVs, and determined four cumulative molecular changes responsible for the increased airborne transmission ability in ferrets. Our results suggested that canine may serve as an intermediate for the adaptation of avian influenza virus to human. Continuous surveillance coordinated with risk assessment for CIVs is necessary.
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