Manish Kumar

Chacha Nehru Bal Chikitsalaya

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Kirtisudha Mishra

Chacha Nehru Bal Chikitsalaya

Diganta Saikia

Assam Medical College

G. J. Naga Raju

Jawaharlal Nehru Technological University, Kakinada

S. Bhuloka Reddy

Sher-i-Kashmir Institute of Medical Sciences

Pankaj Hari

All India Institute of Medical Sciences

Aditi Sinha

Tata Main Hospital

Arvind Bagga

All India Institute of Medical Sciences

V. Vijayan

Sri Balaji Vidyapeeth University

Priyanka Khandelwal

All India Institute of Medical Sciences

P. Sarita

GITAM University

Cooperative Institutions

University of Birmingham

568

NIHR Birmingham Biomedical Research Centre

451

ESCP Business School

369

ESCP Business School

360

National University of Avellaneda

354

Collaborative Group (United States)

Yorkshire Cancer Research

Urology Foundation

Institut de Virologie

All India Institute of Medical Sciences

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Respiratory Distress Syndrome in a tertiary centre over ten year period - A descriptive study

University journal of medicine and medical specialities (2020)

Abhilipsa Acharya MintooTergestina ShanuChandran Manish Kumar Santhanam Sridhar

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Status of Metabolic Bone Disease in Pediatric Steroid Resistant Nephrotic Syndrome: Study from North India

Zenodo (CERN European Organization for Nuclear Research) (2018)

Shikha Sharma Pradeep Kumar Dabla Manish Kumar

Metabolic bone disease

10.5281/zenodo.8285720

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STIMULATORY ACTIVITY OF BARK EXTRACTS OF ANTHOCEPHALUS INDICUS ON PROTEIN PROFILE IN ALBINO RATS

THE SCIENTIFIC TEMPER (2010)

Paramjit Singh Seema Kumari Manish Kumar Anil Gupta A. P. Vajpeyi

This study was designed to investigate, stimulatory effect of Anthocephalusindicus (Family: Rubiaceae) alcoholic bark extract on protein profile (e.g. totalprotein, albumin, total globulins and A/G ratio) in albino rat. Male albino ratswere administered with bark extract of Anthocephalus indicus at the dose of 50mg/kg body weight for 7, 15, 30, and 60 days showed significantly increase inserum total protein (P<0.001), albumin (P<0.01), total globulins (P<0.001) and A/Gratio (P<0.05). These data suggest that the anabolic activity of alcoholic bark extractof Anthocephalus indicus

10.58414/scientifictemper.2010.01.1.18

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Fatal Paint thinner ingestion-A case report

Journal of Indian Academy of Forensic Medicine (2016)

Jitendra Singh Tomar Pradeep Kr Mishra Mandar Ramchandra Sane Divyesh Saxena Manish Kumar

Household poisons can cause serious damage to the health of children. Turpentine is a volatile hydrocarbon used in polishes, solvents, paints and textile industry. It is capable of causing serious toxicity, whether ingested or inhaled. When hydrocarbons are aspirated into the lung, they cause chemical pneumonitis, acute respiratory distress syndrome (ARDS), and rarely pneumatoceles and pneumothorax. We report a case of accidental ingestion of turpentine oil by a 13 year old female child brought to SAMC and PGI, Indore, leading to aspiration pneumonitis and ultimately causing death after 6 days of hospitalization.

10.5958/0974-0848.2016.00124.x

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Goat lung surfactant for treatment of respiratory distress syndrome among preterm neonates: a multi-site randomized non-inferiority trial

Journal of Perinatology (2019)

Kajal Jain Sushma Nangia Vishnu Bhat Ballambattu Venkataseshan Sundaram M. Jeeva Sankar

Abstract Objective To investigate the safety and efficacy of goat lung surfactant extract (GLSE) compared with bovine surfactant extract (beractant; Survanta®, AbbVie, USA) for the treatment of neonatal respiratory distress syndrome (RDS). Study design We conducted a double-blind, non-inferiority, randomized trial in seven Indian centers between June 22, 2016 and January 11, 2018. Preterm neonates of 26 to 32 weeks gestation with clinical diagnosis of RDS were randomized to receive either GLSE or beractant. Repeat dose, if required, was open-label beractant in both the groups. The primary outcome was a composite of death or bronchopulmonary dysplasia (BPD) at 36 weeks postmenstrual age (PMA). Interim analyses were done by an independent data and safety monitoring board (DSMB). Result After the first interim analyses on 5% enrolment, the “need for repeat dose(s) of surfactant” was added as an additional primary outcome and enrolment restricted to intramural births at five of the seven participating centers. Following second interim analysis after 98 (10% of 900 planned) neonates were enroled, DSMB recommended closure of study in view of inferior efficacy of GLSE in comparison to beractant. There was no significant difference in the primary outcome of death or BPD between GLSE group ( n = 52) and beractant group ( n = 46) (50.0 vs. 39.1%; OR 1.5; 95% CI 0.7–3.5; p = 0.28). The need for repeat dose of surfactant was significantly higher in GLSE group (65.4 vs. 17.4%; OR 9.0; 95% CI 3.5–23.3; p < 0.001). Conclusions Goat lung surfactant was less efficacious than beractant (Survanta®) for treatment of RDS in preterm infants. Reasons to ascertain inferior efficacy of goat lung surfactant requires investigation and possible mitigating strategies in order to develop a low-cost and effective surfactant.

Bronchopulmonary Dysplasia

Interim analysis

Interim

10.1038/s41372-019-0472-0

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Enhanced Liver Fibrosis Score: Is It Useful for Evaluation of Fibrosis Severity in Chronic Hepatitis C Infection?

Cureus (2022)

Manish Kumar Roshan George Venkatesh Vaithiyam Puja Sakhuja Amol Dahale

The assessment of liver fibrosis is important in patients with chronic hepatitis C (CHC). In recent years, non-invasive tests like enhanced liver fibrosis (ELF) have been developed as an alternative to liver biopsy for estimating the severity of liver fibrosis. Therefore, we aimed to assess whether the ELF score can be used for fibrosis severity estimation using liver biopsy as the gold standard.Forty-nine patients with CHC were enrolled in this study. Liver biopsy, ELF assessment, and transient elastography (TE) were performed in all patients, and severity of fibrosis on histopathology was assessed by meta-analysis of histological data in viral hepatitis (METAVIR) score. In addition, the diagnostic performance of ELF was evaluated by receiver operator characteristic curve (ROC) analyses, and liver biopsy histopathology was taken as the gold standard for the severity of liver fibrosis.The area under receiver operator characteristic curve (AUROC) for significant fibrosis of ELF score was 0.64 (95% confidence interval {CI}, 0.48-0.79) and of TE was 0.85 (95% CI, 0.73-0.96). The AUROC for advance fibrosis of ELF was 0.77 (95% CI, 0.57-0.97) and TE was 0.98 (95% CI, 0.94-1.0). The calculated cut-offs of ELF overestimated fibrosis in 53.06% (26/49) of patients and underestimated fibrosis in 6.12% (3/49) patients. AUROC of TE was significantly better than ELF for diagnosis of significant fibrosis (p=0.004) and advanced fibrosis (p=0.034).The ELF score can be used for estimating the severity of fibrosis but it is inferior to TE in estimating liver fibrosis severity.

Transient elastography

Histopathology

Gold standard (test)

Hepatitis C

Hepatic fibrosis

10.7759/cureus.21168

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Trace elemental analysis of adenoma and carcinoma thyroid by PIXE method

Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms (2002)

S. Bhuloka Reddy M. John Charles Manish Kumar B. Seetharami Reddy Ch. Anjaneyulu

10.1016/s0168-583x(02)01292-2

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The role of kinesin superfamily proteins in hepatocellular carcinoma

Medical Oncology (2024)

Zahraa Sabah Ghnim Morug Salih Mahdi Suhas Ballal Mamata Chahar Rajni Verma

Kinesin

Hematology

10.1007/s12032-024-02497-0

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Effect of radiation therapy on trace elemental concentrations of hair samples of cervical cancer patients?PIXE technique

X-Ray Spectrometry (2004)

M. Charles S. Bhuloka Reddy G. J. Naga Raju Manish Kumar B. Seetharamireddy

Abstract Trace elemental analysis of hair samples from subjects suffering with cervical cancer before radiation therapy and at successive intervals during radiation therapy was carried out using the PIXE technique. A 2 MeV proton beam was employed. The elements Cl, K, Ca, Ti, Cr, Mn, Fe, Ni, Cu, Zn and Pb were identified and their relative concentrations were estimated. The concentrations of Cl, K, Ca, Ti, Cr, Mn, Fe, Ni and Zn were found to be lower in hair samples of cervical cancer patients before radiation therapy than those from controls, whereas the concentration of Cu showed the opposite trend. The concentrations of Cl, K, Ca, Ti, Mn, Fe, Cu, Zn and Pb showed a definite trend of variation with successive intervals of radiation therapy, which indicates that these elements are affected during radiation therapy. The Cu/Zn ratio also decreases with successive radiation therapy. Copyright © 2004 John Wiley & Sons, Ltd.

10.1002/xrs.739

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Clinico-Etiologic Profile of Macroscopic Hematuria in Children: A Single Center Experience.

PubMed (2022)

Kirtisudha Mishra Manish Kumar Ankita Patel Lavleen Singh Komal Dattatrya Zanak

Microscopic hematuria

Etiology

Gross hematuria

Macroscopic hematuria

Tertiary care

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