Xianling Liu

Central South University

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Chunhong Hu

Second Xiangya Hospital of Central South University

Larry D. Sanford

Eastern Virginia Medical School

Xiangdong Tang

Sichuan University

Chaoyuan Liu

Second Xiangya Hospital of Central South University

Fang Wu

Central South University

Linghui Yang

Sichuan University

Tao Hou

Guizhou Provincial People's Hospital

Yurong Peng

Central South University

Zhongming Li

Sichuan University

Yinzhang Ding

Nanjing Medical University

Cooperative Institutions

Central South University

184

Second Xiangya Hospital of Central South University

136

Chinese Academy of Sciences

Nanjing Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Huazhong University of Science and Technology

University of Chinese Academy of Sciences

Shanghai Jiao Tong University

Xiangya Hospital Central South University

Sichuan University

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Fear-conditioned suppression of REM sleep: relationship to Fos expression patterns in limbic and brainstem regions in BALB/cJ mice

Brain Research (2003)

Xianling Liu Xiangdong Tang Larry D. Sanford

Dorsal raphe nucleus

Locus coeruleus

Tegmentum

Extended amygdala

c-Fos

Freezing behavior

10.1016/j.brainres.2003.07.003

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Citations (50)

Differential Effects of Controllable and Uncontrollable Footshock Stress on Sleep in Mice

SLEEP (2010)

Larry D. Sanford Linghui Yang Laurie L. Wellman Xianling Liu Xiangdong Tang

Inescapable shock (IS), an uncontrollable stressor, and presentation of fearful contexts associated with IS produce prominent reductions in REM sleep. We compared sleep in animals trained with IS to that in animals trained with escapable shock (ES), a controllable stressor, in a paradigm in which animals always received shock but could terminate it by their actions.Male BALB/cJ mice were implanted with telemetry transmitters for recording EEG and activity. After recovery from surgery, baseline sleep recordings were obtained for 2 days. The mice were then randomly assigned to receive ES (n=9) or IS (n=9). ES mice could escape a footshock (20 trials; 0.5 mA; 5.0 sec maximum duration; 1.0 min intervals) by moving to the unoccupied chamber in a shuttlebox. Yoked-control IS mice in a separate shuttlebox received identical footshock. The mice received 2 days of shock training (ST1; ST2) and were re-exposed to the shuttlebox without footshock (context alone).NA.NA.NA.On each training and test day, the mice were returned to their home cages, and EEG and activity were recorded for 20 h. Freezing was scored in the context alone. Compared to baseline, ES mice showed significantly increased REM, and IS mice showed significantly decreased REM after ST1, ST2, and context alone. Total NREM was decreased after shock training only in IS mice. Contextual freezing was enhanced in both ES and IS mice.The directionally opposite changes in REM suggest that stressor controllability is an important factor in the effects of stress and stressful memories on sleep.

Stressor

Sleep

Differential effects

10.1093/sleep/33.5.621

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Citations (86)

Newly found variations of the right posterior portal vein identified radiologically in 1,003 Chinese patients: a cross-sectional study

Annals of Translational Medicine (2022)

Jinyu Li Weidong Dai Jixiong Hu Jiangsheng Huang Xianling Liu

The anatomy of the right posterior portal vein (RPPV) plays an important role in planning hepatic resection, living transplantation and interventional radiological procedures, yet the incidence of variations of RPPV without a common trunk in Chinese persons is still unclear. Therefore, we conducted this study and discussed its clinical implications.A retrospective analysis of multidetector computed tomography (MDCT) scans was performed in 1,933 patients with various abdominal pathologies between September 28, 2018 through May 23, 2019. After excluding 930 patients, a total of 1,003 patients were included in this study. Variations of the RPPV without a common trunk were classified according to classification standards.A total of 1,003 patients were included. RPPV without a common trunk was found in 216 (21.54%, 216/1,003) patients. Among them, we identified three variations of the origin from the right portal vein (RPV): first separate origin of P6, P7, or simultaneous separate origin of P6 and P7, and the incidences of these three variations were 1.50% (15/1,003), 6.58% (66/1,003) and 13.46% (135/1,003), respectively. Among 1,003 patients included in this study, 787 patients (78.46%, 787/1,003) showed that RPPV normally divided into P6 and P7 branches.Variations of the RPPV without a common trunk were not rare in Chinese population. Knowledge of this anatomic variation of the RPPV is extremely important for hepatic and transplant surgeons and interventional radiologists.

Clinical Significance

10.21037/atm-22-4837

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Comparison of Clinical Features in Octogenarian and Non-octogenarian Adults with Severe COVID-19 Pneumonia

Research Square (Research Square) (2020)

Chang Shu Xianling Liu Bilian Yu Lizhen Yang Hong Zhang

Abstract Background: Aged people is more susceptible and vulnerable to COVID-19 pneumonia. As the “super-elderly” group, octogenarian COVID-19 patients is not rare in current world-wide common healthy event. Object: To describe clinical features in octogenarian with severe COVID-19. And try to find out the differences with other non-octogenarian adult patients. Materials and Methods: We studied a small cohort of octogenarian COVID-19 patients at a hospital in Wuhan from 10 February to 15 March. We recorded interested clinical data including chest CT in the octogenarian patients. In order to know the differences of clinical characteristics between octogenarian and other adult patients, we included the number of non-octogenarian patients cohort as ratio of 1:3. Result: For octogenarian patients, the age is 83.33±3.08 and 4 are female (4/6,66.7%). For non-octogenarian patients, the age is 60.72±8.28 years and 5 are female(5/18, 27.8%). and 59% were men. Compared non-octogenarian patients, octogenarian patients’ hospital stay duration is significantly longer ( p =0.0052*). WBC is obvious elevated in octogenarian( p =0.0494*). BUN ( p =0.0377*) and Cr ( p =0.0112*) is with obvious differences between two group patients. No obvious differences in CT findings between two groups. Conclusion: The severe COVID-19 pneumonia octogenarian may have more chance to combined with bacterial infection. Octogenarian has worse baseline kidney function than non-octogenarian. In individual cases, the broader lesion and more lesion types may be found in octogenarian CT image.

10.21203/rs.3.rs-18587/v1

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Effect of Gemcitabine Combined with Cisplatin on Recurrent and Metastatic Breast Cancer

Zhongliu fangzhi yanjiu (2011)

Xianling Liu Zeng Hui-ai Fang Ma Nong Yang

Objective To analysis the toxicities and efficacy of gemcitabine combined with cisplatin on metastatic breast cancer(MBC).Methods Thirty-three MBC patients,who pretreated with anthracycline-and Taxane-based chemotherapy,received gemcitabine(1000 mg/m2 by intravenous infusion on d1~d8) and cisplatin(25 mg/m2 by intravenous infusion on d1~d3) every 3 weeks.Response evaluation was performed every second cycle and toxicity was observed every week.Results A complete response(CR) was seen in 3 patients(9.7%),partial response(PR) was seen in 10 patients(32.3%),stable disease(SD) was seen in 7 patients(22.6%) and progressive disease(PD) was seen in 11 patients(35.4%).The response rate(RR) was 42%.The median progression-free survival(PFS) was 4.8 months(range,1~11.8 months).The most frequent side effects were hematologic and gastrointestinal adverse events.No treatment related death occurred.Conclusion The combination of gemcitabine and cisplatin appears to be effective and is safe and tolerable for patients with anthracycline-and taxane-pretreated MBC.

Taxane

Combination chemotherapy

10.3971/j.issn.1000-8578.2011.09.021

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Autophagy-dependent ferroptosis as a potential treatment for glioblastoma

Frontiers in Oncology (2023)

Yangchun Xie Tao Hou Jinyou Liu Haixia Zhang Xianling Liu

Glioblastoma (GBM) is the most common malignant primary brain tumor with a poor 5-year survival rate. Autophagy is a conserved intracellular degradation system that plays a dual role in GBM pathogenesis and therapy. On one hand, stress can lead to unlimited autophagy to promote GBM cell death. On the other hand, elevated autophagy promotes the survival of glioblastoma stem cells against chemotherapy and radiation therapy. Ferroptosis is a type of lipid peroxidation-mediated regulated necrosis that initially differs from autophagy and other types of cell death in terms of cell morphology, biochemical characteristics, and the gene regulators involved. However, recent studies have challenged this view and demonstrated that the occurrence of ferroptosis is dependent on autophagy, and that many regulators of ferroptosis are involved in the control of autophagy machinery. Functionally, autophagy-dependent ferroptosis plays a unique role in tumorigenesis and therapeutic sensitivity. This mini-review will focus on the mechanisms and principles of autophagy-dependent ferroptosis and its emerging implications in GBM.

GPX4

10.3389/fonc.2023.1091118

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Citations (9)

Rat strain differences in sleep after acute mild stressors and short-term sleep loss

Behavioural Brain Research (2004)

Xiangdong Tang Xianling Liu Linghui Yang Larry D. Sanford

Sleep

Stressor

10.1016/j.bbr.2004.11.015

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Citations (45)

Study on direct economic cost of five kinds of nosocomial infection in a 3A-grade hospital in Anhui Province

Zhonghua Jibing Kongzhi Zazhi (2016)

Lin Zhang Xianling Liu Jinfeng Wu Wenyi Wang Qiong Zou

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Elevated uric acid to serum albumin ratio: a predictor of short-term outcomes in Chinese heart failure patients

Frontiers in Nutrition (2024)

Xianling Liu Anna Chu Xiahao Ding

The prognostic value of the uric acid to albumin ratio (UAR) in heart failure (HF) remains underexplored. The objective of this research was to investigate the link between UAR and short-term outcomes in Chinese HF patients.

10.3389/fnut.2024.1481155

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Association of Blood Heavy Metal Exposure with Atherosclerotic Cardiovascular Disease (ASCVD) Among White Adults: Evidence from NHANES 1999–2018

Biological Trace Element Research (2022)

Kai Wang Yukang Mao Zheng Liu Yansong Li Zhongming Li

Quartile

Atherosclerotic cardiovascular disease

10.1007/s12011-022-03537-4

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Citations (7)