Bing Liao

The First Affiliated Hospital, Sun Yat-sen University

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Junhang Luo

Sun Yat-sen University

Shuling Chen

The First Affiliated Hospital, Sun Yat-sen University

Luyao Zhou

The First Affiliated Hospital, Sun Yat-sen University

Qian Zhou

Nanjing University

Sui Peng

The First Affiliated Hospital, Sun Yat-sen University

Qinghua Cao

The First Affiliated Hospital, Sun Yat-sen University

Stanley H. Appel

Houston Methodist

Yong Fang

The First Affiliated Hospital, Sun Yat-sen University

Jun Lü

Shanghai Academy of Environmental Sciences

Yinghua Chen

Jiangxi Maternal and Child Health Hospital

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Sun Yat-sen University

238

The First Affiliated Hospital, Sun Yat-sen University

197

Massachusetts General Hospital

Harvard University

Key Laboratory of Guangdong Province

Clinical Research Institute

Fudan University

Nanchang University

Central South University

Sun Yat-sen University Cancer Center

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The first case of ischemia-free organ transplantation in humans: A proof of concept

American Journal of Transplantation (2017)

Xiaoshun He Zhiyong Guo Qiang Zhao Weiqiang Ju Dongping Wang

Ischemia and reperfusion injury (IRI) is an inevitable event in conventional organ transplant procedure and is associated with significant mortality and morbidity post-transplantation. We hypothesize that IRI is avoidable if the blood supply for the organ is not stopped, thus resulting in optimal transplant outcomes. Here we described the first case of a novel procedure called ischemia-free organ transplantation (IFOT) for patients with end-stage liver disease. The liver graft with severe macrovesicular steatosis was donated from a 25-year-old man. The recipient was a 51-year-old man with decompensated liver cirrhosis and hepatocellular carcinoma. The graft was procured, preserved, and implanted under continuous normothermic machine perfusion. The recipient did not suffer post-reperfusion syndrome or vasoplegia after revascularization of the allograft. The liver function test and histological study revealed minimal hepatocyte, biliary epithelium and vascular endothelium injury during preservation and post-transplantation. The inflammatory cytokine levels were much lower in IFOT than those in conventional procedure. Key pathways involved in IRI were not activated after allograft revascularization. No rejection, or vascular or biliary complications occurred. The patient was discharged on day 18 post-transplantation. This marks the first case of IFOT in humans, offering opportunities to optimize transplant outcomes and maximize donor organ utilization. Ischemia and reperfusion injury (IRI) is an inevitable event in conventional organ transplant procedure and is associated with significant mortality and morbidity post-transplantation. We hypothesize that IRI is avoidable if the blood supply for the organ is not stopped, thus resulting in optimal transplant outcomes. Here we described the first case of a novel procedure called ischemia-free organ transplantation (IFOT) for patients with end-stage liver disease. The liver graft with severe macrovesicular steatosis was donated from a 25-year-old man. The recipient was a 51-year-old man with decompensated liver cirrhosis and hepatocellular carcinoma. The graft was procured, preserved, and implanted under continuous normothermic machine perfusion. The recipient did not suffer post-reperfusion syndrome or vasoplegia after revascularization of the allograft. The liver function test and histological study revealed minimal hepatocyte, biliary epithelium and vascular endothelium injury during preservation and post-transplantation. The inflammatory cytokine levels were much lower in IFOT than those in conventional procedure. Key pathways involved in IRI were not activated after allograft revascularization. No rejection, or vascular or biliary complications occurred. The patient was discharged on day 18 post-transplantation. This marks the first case of IFOT in humans, offering opportunities to optimize transplant outcomes and maximize donor organ utilization.

Proof of concept

10.1111/ajt.14583

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Citations (134)

MiR-216b inhibits cell proliferation by targeting FOXM1 in cervical cancer cells and is associated with better prognosis

BMC Cancer (2017)

Shanyang He Bing Liao Yalan Deng Chang Su Jiuling Tuo

Our previous study showed FOXM1 expression was significantly up-regulated in cervical cancer, and was associated with poor prognosis. To clarify miRNAs-FOXM1 modulation pathways, in this study, we investigated the relationships between miR-216b and FOXM1 and the role of miR-216b in cell proliferation and prognosis of cervical cancer patients. Western blotting and qPCR were used to determine expression of FOXM1, cell cycle related factors and miR-216b level. MiR-216b overexpression and inhibited cell models were constructed, and siRNA was used for FOXM1 silencing. Cell proliferation was analyzed by MTT and colony formation assay. Dual luciferase reporter assay system was used to clarify the relationships between miR-216b and FOXM1. Kaplan-Meier survival analysis was used to evaluate prognosis. MiR-216b was down-regulated in cervical cancer cells and tissues, and its ectopic expression could decrease cell proliferation. Western blotting analysis showed miR-216b can inhibit cell proliferation by regulating FOXM1-related cell cycle factors, suppressing cyclinD1, c-myc, LEF1 and p-Rb and enhancing p21 expression. Repressing of miR-216b stimulated cervical cancer cell proliferation, whereas silencing FOXM1 expression could reverse this effect. Western blotting and luciferase assay results proved FOXM1 is a direct target of miR-216b. Survival analysis showed higher level of miR-216b was associated with better prognosis in cervical cancer patients. FOXM1 expression could be suppressed by miR-216b via direct binding to FOXM1 3′-UTR and miR-216b could inhibit cell proliferation by regulating FOXM1 related Wnt/β-catenin signal pathway. MiR-216b level is related to prognosis in cervical cancer patients and may serve as a potential prognostic marker.

FOXM1

Ectopic expression

10.1186/s12885-017-3650-5

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Citations (41)

Activating transcription factor 6 contributes to cisplatin‑induced ototoxicity via regulating the unfolded proteins response

Biomedicine & Pharmacotherapy (2024)

Yuchen Liu Xue Bai Bing Liao Xu-Bo Chen Lihua Li

Ototoxicity

Nephrotoxicity

10.1016/j.biopha.2024.117025

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EIF5A2 predicts outcome in localised invasive bladder cancer and promotes bladder cancer cell aggressiveness in vitro and in vivo

British Journal of Cancer (2014)

J-H Wei J-Z Cao D. Zhang Bing Liao W-M Zhong

EIF5A2, eukaryotic translation initiation factor 5A2, is associated with several human cancers. In this study, we investigated the role of EIF5A2 in the metastatic potential of localised invasive bladder cancer (BC) and its underlying molecular mechanisms were explored. The expression pattern of EIF5A2 in localised invasive BC was determined by immunohistochemistry. In addition, the function of EIF5A2 in BC and its underlying mechanisms were elucidated with a series of in vitro and in vivo assays. Overexpression of EIF5A2 was an independent predictor for poor metastasis-free survival of localised invasive BC patients treated with radical cystectomy. Knockdown of EIF5A2 inhibited BC cell migratory and invasive capacities in vitro and metastatic potential in vivo and reversed epithelial–mesenchymal transition (EMT), whereas overexpression of EIF5A2 promoted BC cells motility and invasiveness in vitro and metastatic potential in vivo and induced EMT. In addition, we found that EIF5A2 might activate TGF-β1 expression to induce EMT and drive aggressiveness in BC cells. EIF5A2 stabilized STAT3 and stimulated nuclear localisation of STAT3, which resulted in increasing enrichment of STAT3 onto TGF-β1 promoter to enhance the transcription of TGF-β1. EIF5A2 overexpression predicts tumour metastatic potential in patients with localised invasive BC treated with radical cystectomy. Furthermore, EIF5A2 elevated TGF-β1 expression through STAT3 to induce EMT and promotes aggressiveness in BC.

Tumor initiation

10.1038/bjc.2014.52

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Citations (59)

The combination of conventional ultrasound and shear-wave elastography in evaluating the segmental heterogeneity of liver fibrosis in biliary atresia patients after Kasai portoenterostomy

Pediatric Surgery International (2021)

Wenying Zhou Xiaoju Li Nan Zhang Bing Liao Xiaoyan Xie

Aspartate transaminase

10.1007/s00383-021-04920-3

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Citations (9)

Does chromophobe renal cell carcinoma have better survival than clear cell renal cell carcinoma? A clinical-based cohort study and meta-analysis

International Urology and Nephrology (2015)

Hui-Ming Jiang Jinhuan Wei Zhi-Ling Zhang Yong Fang Bang-Fen Zhou

Chromophobe cell

Univariate analysis

10.1007/s11255-015-1161-3

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Citations (19)

Electrographic Patterns In Patients With Posterior Reversible Encephalopathy Syndrome(PRES) And Seizures (P2.088)

Neurology (2015)

Rahul Shah Carlos Kamiya Matsuoka Bing Liao Sudhakar Tummala

OBJECTIVE:To look for correlation between MRI lesions and origin of electrographic dysfunction in patients with PRES and seizures. BACKGROUND:PRES is a clinico-neuroradiological entity with characteristic radiographic findings, presenting with headaches, altered mental status (AMS), seizures and visual disturbances. Although the association between PRES and seizures is known, not much is known about the pathophysiological correlation between the two, or the relation between MRI and EEG findings in this subset of patients. DESIGN/METHODS:In a retrospective review, we looked at the clinical, radiographic and electroencephalogram (EEG) records of 46 cancer patients at MD Anderson Cancer Center between 2007 and 2012 diagnosed with PRES, presenting with seizures. RESULTS: Average age at presentation was 49.9+/-19.72 years. 34(73.9[percnt]) patients were women and 12(26.1[percnt]) were men. 22(47.8[percnt]) patients had primary hematological malignancies and 24(52.1[percnt]) patients had other solid tumors. 33(71.7[percnt]) patients had received some form of chemotherapy while 13(28.2[percnt]) had not. Mean systolic Blood pressure(SBP) at baseline was 99.8+/-9.36 mmHg, mean SBP at onset of symptoms was 123.6+/-15.7 mm Hg with a mean difference of 23.7+/-16.4 mm Hg. On MRI, out of 46 patients, 34(73.9[percnt]) had predominant lesions in the parieto-occipital region while 12(26.08[percnt]) had a fronto-parieto-occipital predominance. 33(71.7[percnt]) had abnormal EEG findings. Of these 15 showed diffuse slowing and 18 showed focal dysfunction including 3 patients with Non Convulsive Status Epilepticus. 4(8.6[percnt]) patients had focal dysfunction originating from areas with no corresponding MRI lesion. 13(28.2[percnt]) had normal EEG findings. CONCLUSIONS:Not much is known about the exact mechanism of seizures in patients with PRES. Origin of seizures seen on scalp EEG may not correlate with radiographic abnormalities. Seizures associated with PRES do not necessarily follow typical localization principles raising the possibility of greater degree of dysfunction which may exist beyond those areas seen on the diagnostic MRI. Study Supported by:

10.1212/wnl.84.14_supplement.p2.088

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Citations (0)

A Rare Cause of Liver Fibrosis in Adulthood

Gastroenterology (2021)

Weiqiang Gan Bing Liao Xinhua Li

10.1053/j.gastro.2021.08.048

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Citations (4)

Effect of immune protection of heart allograft in mice induced by immune escape mechanism of trichinella spiralis

Zhonghua shiyan waike zazhi (2015)

Gengguo Deng Xinjun Lu Yi Ma Bing Liao Yinghua Chen

Objective To observe the effect of immune protection of heart allograft in mice induced by immune escape mechanism of trichinella spiralis,and explore new and potential ways against acute rejection in clinic. Methods The heterotopic cardiac transplantation models were divided into three groups: rejection group, treatment group,and isograft group.Mean survival time was measured.Twenty- eight days before transplantation, recipients(C57BL/6)of rejection group were orally infected with 300 muscle larvae,and donors were untreated.Hearts in each group were harvested on the day 7 post- transplantation for pathological observation.Proportion of CD4+,CD8+ T cells and regulatory T cells(Tregs)was detected by flow cytometry. Results As compared with rejection group(11 days),survival of allografts was significantly prolonged in treatment group(24 days)(P<0.01),alleviated pathologic signd were observed,and proportion of CD8+ T cells(36.6%)was reduced(48.8%, P<0.01), but there was no significant difference in CD4+ T cells between treatment group and rejection group.Meanwhile, proportion of Tregs in treatment group(16.9%)was significantly higher than in rejection group(10.8%,P<0.05). Conclusion Trichinella spiralis infection lowered the proportion of CD8+ T cells,augmented Tregs frequency,and alleviated acute rejection of heterotopic cardiac transplantation in mice, which immunologically protected mice heart allograft. Key words: Trichinella spiralis; Immune escape; Cardiac transplantation

Trichinella spiralis

Isograft

10.3760/cma.j.issn.1001-9030.2015.03.041

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Clinical characteristic and prognosis of primary renal sarcoma in adults

Zhonghua miniao waike zazhi (2019)

Yiming Tang Yun Cao Yan Guo Wei Chen Wenfang Chen

Objective To investigate the clinical manifestations, imaging and pathological features and treatment prognosis of primary renal sarcoma in adults. Methods A retrospective analysis was performed on the clinical data of 48 patients with primary renal sarcoma from January 2009 to December 2018 in the first affiliated hospital and cancer center of Sun Yat-Sen university. There were 30 males and 18 females. Their aged ranged from 27 to 76 yrs with an average age of 50 yrs. A total of 24 patients presented with lumbar and abdominal pain. Abdominal mass was found in 2 cases. Gross hematuria was noticed in 4 cases. Febrile was recorded in 2 cases and 21 cases were diagnosed by physical examination. 31 tumors located in the left kidney and 17 tumors located in the right kidney. The tumor diameter ranged from 3 to 16 cm with an average diameter of 8 cm.All patients underwent ultrasound or CT/MRI examination of the urinary system before surgery. The ultrasound showed the undistributed echo inside the tumor with the undistinguished border. The image of necrosis and liquefaction could be seen in some cases. The CT/MRI examination showed the lesion site with the necrosis, liquefaction or cystic changing. The mass exhibited the unregular enhancement with undistinguished border line. The mean diameter of liposcarcoma was 10.2 cm. CT scan demonstrated the relative low density of tumor, which was hard to be identified with AML. The average diameter of leiomyosarcoma was 6.5 cm. The enhanced CT scan showed the low density of tumor, compared with renal parenchyma. 46 patients underwent radical nephrectomy, 2 patients underwent renal tumor biopsy. And postoperative follow-up was performed. Results Pathological diagnosis revealed that 19 cases with liposarcoma, 9 cases with leiomyosarcoma and 4 cases with synovial sarcoma, especially 4 cases with Ewing’s sarcoma and 12 cases with other sarcoma. 36 cases were followed up and survived for 4 to 64 months. The average survival time was 28 months. The longest mean survival time was seen in patients with liposarcoma, which was 32 months (ranging 11 to 64 months). The mean survival time of synovial sarcoma group was 25 months (ranging 5-58 months). The mean survival time of Ewing's sarcoma group was 22 months(ranging 12-46 months). and the survival time of leiomyosarcoma group was the shortest 20 months (ranging 4-36 months). Conclusion Renal sarcoma is rare and highly malignant. It needs to be diagnosed with clinical manifestations, imaging and pathological data together. Key words: Kidney neoplasm; Sarcoma; Diagnosis; Clinical

10.3760/cma.j.issn.1000-6702.2019.05.011

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