Xiaoran Zhao

Peking University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Xinjing Tang

Peking University

Jianfeng Wang

Jilin University

Shigen Ye

Dalian Ocean University

Jing Wang

Shanghai Ninth People's Hospital

Xinli Fan

Xi'an University of Science and Technology

Dongyang Guo

Second Affiliated Hospital of Zhejiang University

Xuming Deng

Jilin University

Hongen Li

Ministry of Water Resources of the People's Republic of China

Xiaodi Niu

Jilin University

Xingxing Liang

State Key Laboratory of Natural and Biomimetic Drugs

Cooperative Institutions

Peking University

Dalian Ocean University

Jilin University

Chinese Academy of Sciences

State Key Laboratory of Natural and Biomimetic Drugs

First Hospital of Jilin University

Ministry of Agriculture and Rural Affairs

Zhejiang University

Central South University

Shanghai Jiao Tong University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Inhibition of sortase A by chalcone prevents Listeria monocytogenes infection

Biochemical Pharmacology (2016)

Hongen Li Yutao Chen Bing Zhang Xiaodi Niu Meng Song

Chalcone

Sortase A

Sortase

Isothermal Titration Calorimetry

10.1016/j.bcp.2016.01.018

Cite

Citations (37)

Anticytotoxin Effects of Amentoflavone to Pneumolysin

Biological and Pharmaceutical Bulletin (2016)

Xiaoran Zhao Bowen Liu Shui Liu Lin Wang Jianfeng Wang

Pneumolysin (PLY) is a devastating bacterial protein toxin of Streptococcus pneumoniae that punctures the cytomembrane, leading to pathological reactions, such as cell disruption and inflammation. Drugs capable of closely impacting the toxin are considered advantageous in the treatment of bacterial infections. Amentoflavone (AMF) is a chemical substance extracted from traditional Chinese herbs. Previous studies have demonstrated that AMF has multiple pharmacological effects and mentioned without attenuating pneumolysin-mediated cytotoxicity. This work focuses on the influence of AMF on inhibitory hemolytic mechanisms. AMF interacts with the toxin at Ser254, Glu277, Arg359, and effectively weakens the oligomerization of wild-type PLY and provides considerable protection against pneumolysin-mediated human alveolar epithelial (A549) cell damage. The results of our study demonstrate that AMF could be a candidate against pneumolysin-related injury.

Pneumolysin

Amentoflavone

10.1248/bpb.b16-00598

Cite

Citations (18)

The complete mitochondrial genome sequence of the Metschnikowia bicuspidata (Metschnikoff, 1884), an emerging pathogen of ‘milky disease’ in Chinese mitten crab

Mitochondrial DNA Part B (2022)

Jiannan Liu Jieying Yu Senting Pu Xinran Shi Yihao Li

The outbreak of milky disease of Chinese mitten crab caused by M. bicuspidata seriously restricted the development of the crab industry. In this study, the mitochondrial genome sequence of M. bicuspidata was assembled, annotated, and further analyzed. The results indicated that the complete mitochondrial genome of M. bicuspidata was 75,095 bp, which contained two rRNAs, 23 tRNAs, and 13 protein-coding genes. The phylogenetic tree of 13 yeasts based on the complete mitochondrial genome was constructed which showed that M. bicuspidata (accession number OK514652) and M. bicuspidata (accession number MW147605.1) were clustered in a clade. To sum up, our research results would further provide essential data for the systematics and evolution study of M. bicuspidata.

10.1080/23802359.2022.2097025

Cite

Citations (1)

Comparison of whole genome sequences of three Bacillus cereus strains reveals the food safety risks of Apostichopus japonicus in China

Aquaculture Reports (2021)

Xiaoran Zhao Ruijun Li Huifeng Dang Luo Wang Songzhe Fu

Sea cucumber (Apostichopus japonicus) is considered to be an important food and nourishing ingredient in Asian cuisine, but consumers are vulnerable to food safety risks because of eating customs and breeding conditions. Three isolates (CH, HB, and WH) of Bacillus cereus were obtained from sea cucumbers in three coastal aquaculture areas in northeastern China. We performed whole genome sequencing and the complete genome of each isolate was composed of one circular chromosome, which was further analyzed. COG functional categories, pathogenic bacteria virulence factors and evolutionary relationships were investigated. Virulence factor database (VFDB) analysis demonstrated that all three B. cereus isolates possessed multiple potential virulence factors, which indicates the urgent need to improve microbial detection in aquatic products to ensure seafood security in China.

Apostichopus japonicus

Cereus

Bacillus (shape)

10.1016/j.aqrep.2021.100649

Cite

Citations (3)

Sediment Microbial Fuel Cell with Double-Anode Arrangement for Enhanced Oxygen Reduction Reaction

International Journal of Electrochemical Science (2018)

Qinzheng Yang Dexue Luo Jing Yang Wenrui Shen Xin Liu

10.20964/2018.03.19

Cite

Citations (4)

Gastrodin relieves Vibrio harveyi infection by blocking hemolysin active centers

Aquaculture (2021)

Xiaoran Zhao Yi Guo Jiale He Jianuo Liu Shigen Ye

Vibrio harveyi

Gastrodin

10.1016/j.aquaculture.2021.737056

Cite

Citations (5)

Triton modified polyethyleneimine conjugates assembled with growth arrest-specific protein 6 for androgenetic alopecia transdermal gene therapy

Materials Today Bio (2023)

Xinli Fan Xiaoran Zhao Jianfei Xu Jing Wang Qian Wang

Androgenetic alopecia is an androgen-dependent skin disorder that commonly affects hair follicle growth and hair loss. Gene therapy that can promote the proliferation and survival of hair follicle cells can be a potential choice for its cure. While transdermal application of therapeutic functional nucleic acids across the stratum corneum is quite difficult. Here, we first develop a transdermal agent for functional nucleic acid delivery using Triton X-100-modified low molecular weight polyethyleneimine (PEI-Triton-N, N = 6 or 8). In vitro cell experiments demonstrate that the PEI-Triton-N conjugates can stably encapsulate and efficiently deliver plasmid DNA to hard-to-transfect keratinocyte HaCaT cells. Further mouse model studies show that PEI-Triton-6 can encapsulate and deliver growth arrest-specific protein 6 (Gas6) plasmid through transdermal administration. The transfected Gas6 prolongs the anagen status, inhibits the apoptosis of hair follicle cells, and further promotes the proliferation and differentiation of hair follicle cells. The PEI-Triton-6/pDNAGas6 complexes can obviously alleviate hair loss in androgenetic alopecia mice and provides a promising strategy for gene therapy via transdermal administration.

HaCaT

10.1016/j.mtbio.2023.100575

Cite

Citations (1)

Morin Moderates the Biotoxicity of Pneumococcal Pneumolysin by Weakening the Oligomers’ Formation

Chemical and Pharmaceutical Bulletin (2017)

Xiaoran Zhao Yonglin Zhou Guizhen Wang Dongxue Shi Yonghong Zha

Streptococcus pneumoniae (pneumococcus) is an important causative agent of acute invasive and non-invasive infections.Pneumolysin is one of a considerable number of virulence traits produced by pneumococcus that exhibits a variety of biological activities, thus making it a target of small molecule drug development.In this study, we aimed to evaluate the effect of morin, a natural compound that has no antimicrobial activity against S. pneumonia, is a potent neutralizer of pneumolysin-mediated cytotoxicity and genotoxicity by impairing oligomer formation, and possesses the capability of mitigating tissue damage caused by pneumococcus.These findings indicate that morin could be a potent candidate for a novel therapeutic or auxiliary substance to treat infections for which there are inadequate vaccines and that are resistant to traditional antibiotics.

Pneumolysin

Morin

Pneumococcal pneumonia

10.1248/cpb.c16-00999

Cite

Citations (5)

Co-infection of H9N2 subtype avian influenza virus and QX genotype live attenuated infectious bronchitis virus increase the pathogenicity in SPF chickens

Veterinary Microbiology (2024)

Qinghua Huang Xiao Yang Xiaoran Zhao Xiaoxia Han Shouli Sun

Specific-pathogen-free

10.1016/j.vetmic.2024.110163

Cite

Citations (2)

Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers

Molecular Pharmacology (2015)

Xiaoran Zhao Hongen Li Jianfeng Wang Yan Guo Bowen Liu

Pneumolysin (PLY), an essential virulence factor of Streptococcus pneumoniae (pneumococcus), can penetrate the physical defenses of the host and possesses inflammatory properties. The vital role PLY plays in pneumococcus pathogenesis makes this virulence factor one of the most promising targets for the treatment of pneumococcal infection. Verbascoside (VBS) is an agent that does not exhibit bacteriostatic activity but has been shown to inhibit PLY-mediated cytotoxicity. The results from molecular dynamics simulations and mutational analysis indicated that VBS binds to the cleft between domains 3 and 4 of PLY, thereby blocking PLY's oligomerization and counteracting its hemolytic activity. Moreover, VBS can effectively alleviate PLY-mediated human alveolar epithelial (A549) cell injury, and treatment with VBS provides significant protection against lung damage and reduces mortality in a pneumococcal pneumonia murine model. Our results demonstrate that VBS is a strong candidate as a novel therapeutic in the treatment of Streptococcus pneumoniae infection.

Pneumolysin

Virulence factor

Pneumococcal infections

Verbascoside

Pneumococcal pneumonia

10.1124/mol.115.100610

Cite

Citations (53)