Meng Qi

First Affiliated Hospital of Zhengzhou University

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Jing Chen

Peking University

Xingjie Yang

Beijing HuiLongGuan Hospital

Huai‐Qiang Ju

State Key Laboratory of Oncology in South China

Steven J. Armstrong

University of Lincoln

Suo-Yuan Zhang

Beijing HuiLongGuan Hospital

Zexian Liu

Guizhou University

Shuang‐Jiang Zhou

Peking University

Rui‐Hua Xu

Sun Yat-sen University

Lan Gao

University of Oklahoma

Liduan Zheng

Huazhong University of Science and Technology

Cooperative Institutions

Sun Yat-sen University

Sun Yat-sen University Cancer Center

State Key Laboratory of Oncology in South China

Chinese Academy of Sciences

Peking University

John Wiley & Sons (United States)

Hudson Institute

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Huazhong University of Science and Technology

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Promotive and prohibitive ethical voice in groups: the effect of faultlines and role ambiguity

Humanities and Social Sciences Communications (2024)

Meng Qi Fei Liu

Abstract Despite the role of ethical voice in promoting ethics in working units, scant attention has been devoted to the emergence and boundary conditions of collective ethical voice. In accordance with the integration between regulatory focus theory and social identity theory, this research explores the antecedents and moderators of promotive ethical voice and prohibitive ethical voice in working units. Hierarchical regression analysis of field data on 632 employees and 62 leaders at three Chinese organizations supports the hypotheses. Faultlines negatively relate to promotive ethical voice and prohibitive ethical voice in groups. Role ambiguity moderates the effect of two forms of ethical voice on citizenship behaviors and task performance in groups. Based on regulatory focus and social identity theory, this study contributes to existing research by revealing faultlines to be barriers of collective promotive and prohibitive ethical voice. Additionally, this research provides a novel lens to understand the underlying interaction mechanisms through which role ambiguity regulates the effect of ethical voice on performance in groups.

10.1057/s41599-024-02799-8

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LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

Molecular Cancer (2019)

Yun Wang Jia-Huan Lu Qi-Nian Wu Ying Jin De‐Shen Wang

Abstract Background Long noncoding RNAs (lncRNAs) play nonnegligible roles in the epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that promotes the colorectal cancer (CRC) progression and could be a potential therapeutic target. Methods We screened highly expressed lncRNAs in human CRC samples compared with their matched adjacent normal tissues. The proteins that interact with LINRIS (Long Intergenic Noncoding RNA for IGF2BP2 Stability) were confirmed by RNA pull-down and RNA immunoprecipitation (RIP) assays. The proliferation and metabolic alteration of CRC cells with LINRIS inhibited were tested in vitro and in vivo . Results LINRIS was upregulated in CRC tissues from patients with poor overall survival (OS), and LINRIS inhibition led to the impaired CRC cell line growth. Moreover, knockdown of LINRIS resulted in a decreased level of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), a newly found N 6 -methyladenosine (m 6 A) ‘reader’. LINRIS blocked K139 ubiquitination of IGF2BP2, maintaining its stability. This process prevented the degradation of IGF2BP2 through the autophagy-lysosome pathway (ALP). Therefore, knockdown of LINRIS attenuated the downstream effects of IGF2BP2, especially MYC-mediated glycolysis in CRC cells. In addition, the transcription of LINRIS could be inhibited by GATA3 in CRC cells. In vivo experiments showed that the inhibition of LINRIS suppressed the proliferation of tumors in orthotopic models and in patient-derived xenograft (PDX) models. Conclusion LINRIS is an independent prognostic biomarker for CRC. The LINRIS -IGF2BP2-MYC axis promotes the progression of CRC and is a promising therapeutic target.

10.1186/s12943-019-1105-0

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Whole-transcriptome sequencing (RNA-seq) analyses of the zebrafish liver cell line, ZFL, after acute exposure to Cu2+ ions

Metallomics (2020)

Man Long Kwok Xue Lei Hu Meng Qi King Ming Chan

Abstract All cells require Cu as a cofactor, but Cu2+ induces toxicity and oxidative damage. A strict system is thus needed to maintain Cu homeostasis. Using the ZFL zebrafish liver cell line as a model, we studied the cellular responses after exposure to Cu2+, using whole-transcriptome shotgun sequencing (RNA-seq) to screen nearly all transcriptomes in cell samples and identify changes in gene expression. ZFL cells were treated with 100, 200, or 400 μM CuCl2 and harvested after 4 and 24 h. RNA was then extracted and subjected to RNA-Seq and qPCR validation. Exposure to 400 μM CuCl2 for 4 h and 24 h led to the regulation of 5993 and 4235 genes, respectively. In a gene ontology enrichment analysis, Cu2+ exposure enriched the nitrogen compound metabolic process and antioxidant activity but did not significantly affect cellular copper, zinc, iron and calcium ion homeostasis. In a KEGG pathway enrichment analysis, anti-oxidative stress induced the glutathione metabolism pathway. Furthermore, Cu2+ also induced genes related to apoptosis and arrested the cell cycle in the G2 phase. This study was based on the full gene expression profile combined with pathway analysis details, providing a full cellular response picture for Cu.

KEGG

RNA-Seq

10.1039/d0mt00005a

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Depression, Anxiety, and Suicidal Ideation in Chinese University Students During the COVID-19 Pandemic

Frontiers in Psychology (2021)

Shuang‐Jiang Zhou Leilei Wang Meng Qi Xingjie Yang Lan Gao

Coronavirus disease-2019 (COVID-19) pandemic has seriously threatened the global public health security and caused a series of mental health problem. Current research focuses mainly on mental health status and related factors in the COVID-19 pandemic among Chinese university students. Data from 11133 participants was obtained through an online survey. The Patient Health Question-9 (PHQ-9) was used to assess depressive symptoms, the Social Support Rate Scale (SSRS) was used to assess social support. We also used 7-item Generalized Anxiety Disorder Scale (GAD-7) to assess anxiety symptoms. Totally, 37.0% of the subjects were experiencing depressive symptoms, 24.9% anxiety symptoms, 20.9% comorbid depressive and anxiety symptoms, and 7.3% suicidal ideation. Multivariable logistic regression analysis revealed an increased presence of mental health problems in female students, graduate students, and those with personal COVID-19 exposure. Awareness of COVID-19, living with family were protective factors that reduced anxiety and depression symptoms. In addition, male, personal COVID-19 exposure, depressive and anxiety symptoms were risk factors for suicidal ideation. Social support, COVID-19 preventive and control measures, prediction of COVID-19 trends, living with family and graduate students are protective factors for reducing suicidal ideation.

Patient Health Questionnaire

Depression

10.3389/fpsyg.2021.669833

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Citations (67)

Mechanism of 17β-estradiol degradation by Rhodococcus equi via the 4,5-seco pathway and its key genes

Environmental Pollution (2022)

Kejian Tian Meng Qi Shuaiguo Li Menghan Chang Fanxing Meng

Steroid estrogens have been detected in oceans, rivers, lakes, groundwaters, soils, and even urban water supply systems, thereby inevitably imposing serious impacts on human health and ecological safety. Indeed, many estrogen-degrading bacterial strains and degradation pathways have been reported, with the 4,5-seco pathway being particularly important. However, few studies have evaluated the use of the 4,5-seco pathway by actinomycetes to degrade 17β-estradiol (E2). In this study, 5 genes involved in E2 degradation were identified in the Rhodococcus equi DSSKP-R-001 (R-001) genome and then heterologously expressed to confirm their functions. The transformation of E2 with hsd17b14 reached 63.7% within 30 h, resulting in transformation into estrone (E1). Furthermore, we found that At1g12200-encoded flavin-binding monooxygenase (FMOAt1g12200) can transform E1 at a rate of 51.6% within 30 h and can transform E1 into 4-hydroxyestrone (4-OH E1). In addition, catA and hsaC genes were identified to further transform 4-OH E1 at a rate of 97-99%, and this reaction was accomplished by C-C cleavage at the C4 position of the A ring of 4-OH E1. This study represents the first report on the roles of these genes in estrogen degradation and provides new insights into the mechanisms of microbial estrogen metabolism and a better understanding of E2 degradation via the 4,5-seco pathway by actinomycetes.

Biotransformation

Metabolic pathway

10.1016/j.envpol.2022.120021

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Citations (19)

Improving On-Shelf Availability and Out-of-Stocks in Non-food Retail

Supply Chain Forum an International Journal (2012)

Meng Qi David Grant J. D. Fernie

On-shelf availability (OSA) and out-of-stocks (OOS) are two important business criteria in the retail sector, particularly from a customer service and profitability perspective. However, most retailers in the non-food or grocery sector have paid little attention to OSA compared to food retailers. This article replicates a study by Grant and Fernie (2008) to further explore how non-food retailers measure OSA and solve OOS problems, critical factors to conduct in-store replenishment, and the impact of rapidly increasing e-commerce activities in the retail market. Findings supported the Grant and Fernie (2008) study and additional findings emerged about Internet and online concerns.

Customer Service

Food sector

Food service

10.1080/16258312.2012.11517302

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Identification of a novel pyridine derivative with inhibitory activity against ovarian cancer progression in vivo and in vitro

Frontiers in Pharmacology (2022)

Lulu Si Tianjiao Lai Jun-Ru Zhao Yuxi Jin Meng Qi

Ovarian cancer is the second leading cause of death of female gynecological malignant tumor patients worldwide. Although surgery and chemotherapy have achieved dramatic achievement, the mortality remains high, resulting in the demand for new specific drug discovery. Disrupting ovarian cancer growth via histone deacetylase (HDAC) inhibition is a strategy for cancer therapy or prevention. In this work, we synthesized a novel pyridine derivative named compound H42 and investigated its anti-cancer activity in vivo and in vitro. We found that compound H42 inhibited ovarian cancer cell proliferation with IC50 values of 0.87 μM (SKOV3) and 5.4 μM (A2780). Further studies confirmed that compound H42 induced apoptosis, intracellular ROS production, and DNA damage. Moreover, compound H42 downregulated the expression of histone deacetylase 6 (HDAC6) with a distinct increase in the acetylation of α-tubulin and heat shock protein 90 (HSP90), followed by the degradation of cyclin D1, resulting in cell cycle arrest at the G0/G1 phase. Importantly, ectopic expression of HDAC6 induced deacetylation of HSP90 and α-tubulin, while HDAC6 knockdown upregulated the acetylation of HSP90 and α-tubulin. However, in the nude xenograft mouse study, compound H42 treatment can inhibit ovarian cancer growth without obvious toxicity. These findings indicated that compound H42 inhibited ovarian cancer cell proliferation through inducing cell cycle arrest at the G0/G1 phase via regulating HDAC6-mediated acetylation, suggesting compound H42 could serve as a lead compound for further development of ovarian cancer therapeutic agents.

HDAC6

Ectopic expression

10.3389/fphar.2022.1064485

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Citations (2)

Whole-transcriptome sequencing (RNA-seq) study of the ZFL zebrafish liver cell line after acute exposure to Cd2+ ions

Aquatic Toxicology (2020)

Man Long Kwok Meng Qi Xue Lei Hu Chun Ting Chung King Ming Chan

KEGG

RNA-Seq

10.1016/j.aquatox.2020.105628

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Citations (15)

Chapter 2. Where on the Mountain? Patterns of Bronze Age– Transhumant Pastoralism in the Western Tianshan Region of Xinjiang, China

Berghahn Books (2024)

Alison Betts Peter Weiming Jia Dexin Cong Michael Spate Duo Tian

Pastoralism

10.1515/9781805396734-004

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Professional Identity of Chinese Medical Students During the COVID-19 Pandemic

Research Square (Research Square) (2021)

Xingjie Yang Lan Gao Suo-Yuan Zhang Libin Zhang Ligang Zhang

Abstract Background: Although professional identity is a strong predictor of career choice, only a few studies report on career attitudes of medical students during a public health emergency. This study investigates the changes in medical students’ professional identity and career attitude during the COVID-19 pandemic, evaluates their mental health and social support system under stress, and explores the relationship between their career attitude and other factors. Method: An online survey of 6226 Chinese medical students was conducted to collect information on demographics, professional identity, and career attitudes. The collected data were assessed using the Patient Health Questionnaire, the Generalized Anxiety Disorder Scale, and the Social Support Rating Scale. Results: The results revealed that most participants had their professional identity strengthened, did not change their career attitude, and preferred to participate in the frontline during the COVID-19 pandemic. Low social support, depressive symptoms, male gender, and senior year residency were factors that affected career attitude negatively. Conclusions: After the outbreak of the pandemic, it was necessary to carry out diversified professional identity research to support medical students, especially those with low social support and depressive symptoms.

Pandemic

Demographics

10.21203/rs.3.rs-144141/v1

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Citations (1)