Zilin Wei

Hebei University of Engineering

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i-10 index

Research Trends

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Co-Authors

Tianhui Wang

Tianjin University of Sport

Jùnwén Lǐ

Chinese Academy of Agricultural Sciences

Yingkai Qin

Academy of Military Medical Sciences

Min Jin

Academy of Military Medical Sciences

Aili Wei

Taiyuan Normal University

Shuqing Zhou

East China University of Science and Technology

Aili Wei

Academy of Military Medical Sciences

Dong Yang

Quantum (Australia)

Miaomiao Yang

Academy of Military Medical Sciences

Danyang Shi

Academy of Military Medical Sciences

Cooperative Institutions

Academy of Military Medical Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Tianjin University

Shanghai Jiao Tong University

Chinese Academy of Sciences

Tianjin University of Sport

Tianjin Hospital

Fudan University

Peking University

Huazhong University of Science and Technology

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Design of Simulation System to Semi-automatic Tracing-target Aiguille of Some Bomb-disposing

Jisuanji fangzhen (2009)

Zilin Wei

Due to a great deal of parameters of semi-automatic tracing-target aiguille which was the key part of some bomb- disposing equipment, and the factor of cost and time, a real-time simulation system of the aiguille was designed. Based on the model of aiguille, the scheme of system was proposed. The designs of software and hardware were described. Experiment results on the simulation system were given, the results show that the system can create a favorable real-time simulation environment. Designer can test the control software and function of semi-automatic tracing-target aiguille in the laboratory easily and reducing the developmental cost of time and money.

Tracing

Source

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Multi-objective Optimizing with Random Variable Coefficients Based on Interactive Fuzzy Satisfying Method

Yuan De-guo Zilin Wei Donggen Yuan Tingjin Lu

Focus on multi-objective linear optimizing problems with random variable coefficients in objective functions and/or constraints. Using the probability maximization model to maximize the probability that each objective function becomes a certain value under chance constrained conditions, the stochastic programming problems are transformed into deterministic ones. Assuming that the decision maker has a fuzzy goal for each of the objective functions, having determined the fuzzy goals of the decision maker, we present an interactive fuzzy satisfying method to derive a satisfying solution for the decision maker by updating the reference membership levels. An illustrative numerical example is provided to demonstrate the feasibility of the proposed method.

Decision maker

Maximization

Expected value

10.1109/wcica.2008.4594164

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MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation

Frontiers in Endocrinology (2023)

Yuejun Zheng Zilin Wei Tianhui Wang

Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c) is a mitochondrial-derived peptide composed of 16 amino acids encoded by the 12S rRNA region of the mitochondrial genome. The MOTS-c protein is transferred to the nucleus during metabolic stress and directs the expression of nuclear genes to promote cell balance. Different tissues co-expressed the protein with mitochondria, and plasma also contained the protein, but its level decreased with age. In addition, MOTS-c has been shown to improve glucose metabolism in skeletal muscle, which indicates its benefits for diseases such as diabetes, obesity, and aging. Nevertheless, MOTS-c has been used less frequently in disease treatment, and no effective method of applying MOTS-c in the clinic has been developed. Throughout this paper, we discussed the discovery and physiological function of mitochondrial-derived polypeptide MOTS-c, and the application of MOTS-c in the treatment of various diseases, such as aging, cardiovascular disease, insulin resistance, and inflammation. To provide additional ideas for future research and development, we tapped into the molecular mechanisms and therapeutic potentials of MOTS-c to improve diseases and combined the technology with synthetic biology in order to offer a new approach to its development and application.

10.3389/fendo.2023.1120533

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Contamination sources of the enteric virus in recreational marine water shift in a seasonal pattern

The Science of The Total Environment (2020)

Zilin Wei Jing Miao Zhongwei Yang Danyang Shi Hai-Yan Wu

Enteric virus

Bathing

10.1016/j.scitotenv.2020.140641

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Citations (9)

Visual Light Flicker Stimulation: Promoting Central Fatigue Recovery in Sleep-Deprived Rats

Kun Wang Kang Chen Zilin Wei Tianhui Wang Aili Wei

Fatigue and sleepiness are among the primary causes of human errors and workplace accidents. The application potential of light flicker, as a strong environmental stimulus, in combatting fatigue is considerable. The present study aimed to investigate the anti-central fatigue effect of light flicker (specifically, 40 Hz and 20-30 Hz light flickers) on sleep-deprived rats. Both C-FOS-positive cell distribution and in vivo electrophysiology were utilized to assess the effects of light flicker stimulation on neural networks. The Y maze test was employed to assess the spontaneous activity and exploratory ability of sleep-deprived rats influenced by visual light flicker stimulation. Additionally, changes in cortisol and serotonin levels in the blood were examined to investigate the animals' physiological state. The results indicate that light flickering has significant effects on various brain regions, such as the thalamus and hippocampus, that are associated with alertness. Moreover, visual flickering at 20-30 Hz induced an enrichment of beta and gamma neural activity while suppressing low-frequency theta neural activity, indicating enhanced brain activity. Furthermore, light flickering facilitated the recovery of cortisol and serotonin levels in sleep-deprived rats, improving their autonomous activity and exploratory capabilities in the Y maze test. These findings suggest that light flicker promotes central fatigue recovery in sleep-deprived rats.

Sleep

10.2139/ssrn.4623206

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Nicotinamide Mononucleotide: Mitigating Myocardial Injury Post-High-Intensity Exercise

Ran Liu Kang Chen Kun Wang Zilin Wei Yingkai Qin

Nicotinamide mononucleotide (NMN) is recognized for its antiaging properties and potential in ameliorating cardiac injuries. This study explores NMN’s protective effect against myocardial injury induced by high-intensity exercise. Rats underwent a 4-week NMN intervention, resulting in a significant extension of exercise endurance. Postexercise, NMN-treated rats exhibited markedly lower serum concentrations of myocardial injury markers (cardiac troponin I, creatine kinase isoenzyme MB, N-terminal pro-brain natriuretic factor) and showed improvements in myocardial cell dysfunction and inflammatory infiltration. NMN intervention modulated proinflammatory and anti-inflammatory factors, suggesting a cardioprotective role. Notably, NMN significantly increased nicotinamide adenine dinucleotide (NAD+) concentration in cardiomyocytes, mitigated mitochondrial structural damage, and attenuated oxidative stress markers (reactive oxygen species, malondialdehyde) while enhancing antioxidant enzyme activities (superoxide dismutase, catalase, glutathione peroxidase). Additionally, NMN significantly upregulated the expression of Sirt1, Nrf2, and HO-1, activating the Sirt1/Nrf2/HO-1 signalling pathway. Our findings provide compelling evidence that NMN exerts cardioprotective effects following high-intensity exercise by boosting NAD+ levels in cardiomyocytes and activating the Sirt1/Nrf2/HO-1 pathway to alleviate oxidative stress. These results underscore NMN’s potential in sports applications, highlighting its role in preventing exercise-induced myocardial injury and enhancing exercise capacity.

Nicotinamide mononucleotide

Intensity

10.2139/ssrn.4692790

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Fabrication and characterization of biomorphic 45S5 bioglass scaffold from sugarcane

Materials Science and Engineering C (2008)

Junmin Qian Yahong Kang Zilin Wei Wei Zhang

Orthorhombic crystal system

Thermogravimetry

Bioactive Glass

10.1016/j.msec.2008.11.004

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Citations (79)

Housing Cost Prediction from the Perspective of Grey Fractional-Order Similar Information Priority

Fractal and Fractional (2024)

Zilin Wei Lifeng Wu

In order to predict the cost of construction projects more accurately for cross-sectional data such as housing costs, a fractional heterogeneous grey model based on the principle of similar information priority was proposed in this paper. The advantages of the proposed model are proved by the stability analysis of the solution. The similarity between predicted samples and existing samples was analyzed, and the priority order of cross-sectional information was distinguished according to the similarity of the index information. The factors affecting the cost of construction projects were sorted by similarity, and the samples with high similarity to predicted samples were ranked first. Since projects with similar influence factors tend to produce similar project costs, such a ranking method can effectively utilize the information of similar projects and help improve prediction accuracy. In addition, compared with the prediction results of other models, it is verified that the method of prioritizing similar information can obtain more accurate prediction results.

10.3390/fractalfract8120704

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Effects of Aerosols on Climate, Human Health, and Plant and Mitigation Strategies

Highlights in Science Engineering and Technology (2024)

Zilin Wei

With the increasing global air pollution, aerosols have received increased attention from researchers. Aerosols have been shown to have critical impacts on Earth’s climate, human health, and plant photosynthesis. In this context, this paper briefly introduces the composition of aerosols, the effects on Earth, and mitigation strategies. Aerosols scatter sunlight, as well as trap heat in the atmosphere, affecting Earth’s surface temperatures and reducing visibility. Besides, particulate matter can enter deeply into lungs, causing serious respiratory and cardiovascular diseases and spreading infective diseases. Meanwhile, by scattering sunlight, aerosols facilitate plant photosynthesis and protein expression. Because of the adverse effects of aerosols on climate and humans, several mitigation strategies, based on primary pollution sources, are proposed and discussed. To reduce vehicle aerosol emissions, implementing traffic restrictions is a potential strategy if practical and feasible for local communities. Encouraging the switch to electric vehicles is another strategy suggested and is more widely applied. For industry, a cap-and-trade system serves as another mitigation strategy to limit industrial emissions and provide incentives to reduce emissions.

10.54097/b0sw0j28

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Simulated Gastric Acid Promotes the Horizontal Transfer of Multidrug Resistance Genes across Bacteria in the Gastrointestinal Tract at Elevated pH Levels

Microbiology Spectrum (2023)

Haiyan Wu Zilin Wei Danyang Shi Hai‐Bei Li Xinmei Li

The assessment of factors that can promote the transmission of antibiotic resistance genes (ARGs) across bacteria in the gastrointestinal tract is in great demand to understand the occurrence of infections related to antibiotic-resistant bacteria (ARB) in humans. However, whether acid-resistant enteric bacteria can promote ARG transmission in gastric fluid under high-pH conditions remains unknown. This study assessed the effects of simulated gastric fluid (SGF) at different pH levels on the RP4 plasmid-mediated conjugative transfer of ARGs. Moreover, transcriptomic analysis, measurement of reactive oxygen species (ROS) levels, assessment of cell membrane permeability, and real-time quantitative assessment of the expression of key genes were performed to identify the underlying mechanisms. The frequency of conjugative transfer was the highest in SGF at pH 4.5. Antidepressant consumption and certain dietary factors further negatively impacted this situation, with 5.66-fold and 4.26-fold increases in the conjugative transfer frequency being noted upon the addition of sertraline and 10% glucose, respectively, compared with that in the control group without any additives. The induction of ROS generation, the activation of cellular antioxidant systems, increases in cell membrane permeability, and the promotion of adhesive pilus formation were factors potentially contributing to the increased transfer frequency. These findings indicate that conjugative transfer could be enhanced under certain circumstances in SGF at elevated pH levels, thereby facilitating ARG transmission in the gastrointestinal tract. IMPORTANCE The low pH of gastric acid kills unwanted microorganisms, in turn affecting their inhabitation in the intestine. Hence, studies on the factors that influence antibiotic resistance gene (ARG) propagation in the gastrointestinal tract and on the underlying mechanisms are limited. In this study, we constructed a conjugative transfer model in the presence of simulated gastric fluid (SGF) and found that SGF could promote the dissemination of ARGs under high-pH conditions. Furthermore, antidepressant consumption and certain dietary factors could negatively impact this situation. Transcriptomic analysis and a reactive oxygen species assay revealed the overproduction of reactive oxygen species as a potential mechanism by which SGF could promote conjugative transfer. This finding can help provide a comprehensive understanding of the bloom of antibiotic-resistant bacteria in the body and create awareness regarding the risk of ARG transmission due to certain diseases or an improper diet and the subsequent decrease in gastric acid levels.

Horizontal Gene Transfer

Human gastrointestinal tract

Digestive tract

10.1128/spectrum.04820-22

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Citations (6)