Yuxin Feng

First Hospital of China Medical University

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Yan Zhu

Tianjin University of Traditional Chinese Medicine

Yi Zheng

Cincinnati Children's Hospital Medical Center

SA Khan

Combined Military Hospital

Kelli Cole

New York University

Shuang He

Tianjin University of Science and Technology

Xiumei Gao

Tianjin University of Traditional Chinese Medicine

Guangxu Xiao

Tongji University

Ting Shang

Tongren University

Xuan Zhou

Second Affiliated Hospital of Nanjing Medical University

Yuefei Wang

Tianjin University of Traditional Chinese Medicine

Cooperative Institutions

Tianjin University of Traditional Chinese Medicine

Tianjin International Joint Academy of Biomedicine

Cincinnati Children's Hospital Medical Center

City of Hope

Beckman Research Institute

University of Cincinnati

University of Cincinnati Medical Center

Baylor College of Medicine

City Of Hope National Medical Center

Chinese Academy of Medical Sciences & Peking Union Medical College

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Ixazomib suppresses human dendritic cell and modulates murine graft-versus-host disease in a schedule-dependent fashion

Experimental Hematology (2016)

Ahmad Samer Al-Homsi Austin Goodyke Kelli Cole Marlee Muilenburg Michael J. McLane

Ixazomib

10.1016/j.exphem.2016.12.002

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Citations (10)

MECHANISM OF ESTROGEN RECEPTOR-ALPHA ACTION AND THE CONSEQUENCE OF ITS CONDITIONAL DELETION ON MAMMARY GLAND DEVELOPMENT AND FUNCTION

Yuxin Feng

Estrogen receptor alpha

Alpha (finance)

Mechanism of Action

Source

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Citations (1)

Bortezomib for the prevention and treatment of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Experimental Hematology (2016)

Ahmad Samer Al-Homsi Yuxin Feng Ulrich Duffner Monzr M. Al Malki Austin Goodyke

10.1016/j.exphem.2016.05.005

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Citations (23)

Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-α-positive human cells

Environmental Research (2005)

David W. Singleton Yuxin Feng Jun Yang Alvaro Puga Adrian V. Lee

Estrogen receptor alpha

FOXA1

10.1016/j.envres.2005.05.004

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Citations (62)

The combination of four main components in Xuebijing injection improved the preventive effects of Cyclosporin A in acute graft-versus-host disease mice by protecting intestinal microenvironment

Biomedicine & Pharmacotherapy (2022)

Ting Shang Yue Guo Xiurong Li Zhengcan Zhou Yubo Qi

Acute graft-versus-host disease (aGVHD) is a major life-threatening complication after Allogeneic Hematopoietic Stem Cell Transplant (allo-HSCT). Although a series of immunosuppressant agents are routinely used as the first-line prevention, the morbidity and mortality rate remains high in allo-HSCT recipients. Our previous work indicated that combining Xuebijing (XBJ) with Cyclosporin A (CSA) is superior to CSA alone in preventing aGVHD. However, it was not clear which compounds in XBJ may prevent aGVHD. Whether the effective compounds in XBJ can be safely combined with CSA to prevent GVHD remain to be evaluated. Here, we accessed whether the combination of four main components in XBJ (C0127) had the same efficacy as XBJ in preventing aGVHD. In addition, the effectiveness of a novel combination therapy (C0127 + CSA) on aGVHD prophylaxis was evaluated using 16 s rRNA sequencing and RNA sequencing approaches in vitro and in vivo. In aGVHD mice, C0127 enhanced the preventive effects of CSA including decreasing mortality, maintaining weight, reducing GVHD score and reducing the expression of IL-6 and TNF-α in serum. Fatal GVHD is a frequent consequence of intestinal tract damage. We found combining C0127 with CSA alleviated the gut damage and maintained the normal physiological function of intestine by H&E staining, intestinal permeability and short chain fatty acid (SCFA) assays. Next, 16 S sequencing analysis of feces showed the combination treatment maintained the intestinal microbial diversity, normalized the intestinal microorganism and prevented flora disorder by reducing the relative abundances of Escherichia coli and Enterococcus. Further, RNA-seq analysis of colonic epithelium revealed C0127 combined with CSA chiefly regulated chemokines and cytokines in IL-17 signaling pathway. The combination treatment reduced the expression of G-CSF and its effector STAT3 (an axis that aggravated gut inflammation and flora disorder) in gut epithelium on mRNA and protein level. These findings indicated that C0127 improved the prevention of CSA in aGVHD mice partially by protecting the gut from damage through normalizing G-CSF signaling, which regulates the intestinal microbiota and the integrity of the epithelial barrier.

10.1016/j.biopha.2022.112675

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Citations (6)

The toxicity and safety of Chinese medicine from the bench to the bedside

Journal of Herbal Medicine (2021)

Hongyan Zhu Xintong Wang Xiaoming Wang Guixiang Pan Yan Zhu

Anthraquinones

Tripterygium wilfordii

Toxicodynamics

10.1016/j.hermed.2021.100450

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Citations (15)

Impairment of Connexin 43 may initiate cilia decline in syringomyelia

Experimental Neurology (2023)

Xinyu Wang Chuan Jiang Chunli Lu Longbing Ma Yuxin Feng

Ependymal Cell

Ependyma

10.1016/j.expneurol.2023.114430

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Citations (1)

Correction: Effects of long-term and incremental exposure to toxic pollutants on the current generation and microbial communities of electrochemically active bacteria

Environmental Science Water Research & Technology (2023)

Yue Yi Yuxin Feng Baoguo Wang Haoran Nan Zikai Hao

Correction for ‘Effects of long-term and incremental exposure to toxic pollutants on the current generation and microbial communities of electrochemically active bacteria’ by Yue Yi et al. , Environ. Sci.: Water Res. Technol. , 2024, https://doi.org/10.1039/D3EW00522D.

10.1039/d3ew90051g

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Paeoniflorin Resists H2O2-Induced Oxidative Stress in Melanocytes by JNK/Nrf2/HO-1 Pathway

Frontiers in Pharmacology (2020)

Jinping Yuan Yansong Lu He‐Xiao Wang Yuxin Feng Shi‐Bin Jiang

Paeoniflorin (PF) possesses multiple biological functions including anti-oxidization. PF is the major bioactive ingredient of total glycosides of paeony (TGP), which could promote re-pigmentation of vitiligo. The study was sought to investigate the effects and potential signaling pathways of PF on hydrogen peroxide (H2O2)-induced oxidative stress in melanocytes. The results showed that pretreatment with 50 µM PF significantly inhibited cell apoptosis, enhanced cell viability, and suppressed reactive oxygen species (ROS) accumulation by enhancing the productions of superoxide dismutase (SOD) and antioxidant enzymes catalase (CAT). Furthermore, PF activated c-Jun amino terminal kinase (JNK) and the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway to counteract H2O2-induced oxidative damage in PIG1 and PIG3V. Taken together, our study firstly demonstrates that PF resists H2O2-induced oxidative stress in melanocytes probably by activating JNK/Nrf2/HO-1 signaling, suggesting a potential therapeutic application of PF on vitiligo.

Paeoniflorin

Viability assay

Vitiligo

10.3389/fphar.2020.00536

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Citations (57)

RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance

Stem Cell Reports (2017)

Ming Liu Zheng Zhang Leesa Sampson Xuan Zhou Kodandaramireddy Nalapareddy

RHOA, a founding member of the Rho GTPase family, is critical for actomyosin dynamics, polarity, and morphogenesis in response to developmental cues, mechanical stress, and inflammation. In murine small intestinal epithelium, inducible RHOA deletion causes a loss of epithelial polarity, with disrupted villi and crypt organization. In the intestinal crypts, RHOA deficiency results in reduced cell proliferation, increased apoptosis, and a loss of intestinal stem cells (ISCs) that mimic effects of radiation damage. Mechanistically, RHOA loss reduces YAP signaling of the Hippo pathway and affects YAP effector epiregulin (EREG) expression in the crypts. Expression of an active YAP (S112A) mutant rescues ISC marker expression, ISC regeneration, and ISC-associated Wnt signaling, but not defective epithelial polarity, in RhoA knockout mice, implicating YAP in RHOA-regulated ISC function. EREG treatment or active β-catenin Catnblox(ex3) mutant expression rescues the RhoA KO ISC phenotypes. Thus, RHOA controls YAP-EREG signaling to regulate intestinal homeostasis and ISC regeneration.

Cell polarity

Small GTPase

RhoC

Hippo signaling pathway

10.1016/j.stemcr.2017.10.004

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Citations (36)