Min Yang

Zhengzhou Children's Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Jianmin Chang

Chinese Academy of Medical Sciences & Peking Union Medical College

Yu Fu

Ocean University of China

Wan Liu

Shanghai Institute of Nutrition and Health

Xiaoman Gao

Chinese Academy of Medical Sciences & Peking Union Medical College

Kailv Sun

Chinese Academy of Medical Sciences & Peking Union Medical College

Yingqiu Bao

Guangzhou Institute of Dermatology

Jian-Min Chang

Chinese Academy of Medical Sciences & Peking Union Medical College

Gao Xiaoman

Chinese Academy of Medical Sciences & Peking Union Medical College

Bao Ying-qiu

Beijing Hospital

Dong‐Lai Ma

Chinese Academy of Medical Sciences & Peking Union Medical College

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Beijing Hospital

Peking University

Peking Union Medical College Hospital

Capital Medical University

Zhengzhou University

Shanghai Jiao Tong University

Chinese Academy of Sciences

Wuhan University

Zhengzhou Children's Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Epidemiology of primary Sjögren's syndrome: a systematic review and meta-analysis

Annals of the Rheumatic Diseases (2014)

Bao‐Dong Qin Jiaqi Wang Zaixing Yang Min Yang Ning Ma

Objective

Epidemiological studies of primary Sjögren9s syndrome (pSS) are crucial for describing the burden to society and the public medical system and for shedding light on aetiology. Previous reports of the epidemiology of pSS show variable outcomes. We conducted a systematic review of the epidemiology of pSS to assess the prevalence rates (PRs) and incidence rates (IRs), and to investigate possible geographic variations in pSS.

Methods

A systematic literature search of PubMed and Embase (updated to 22 October 2013) was performed to identify all published reports on the epidemiology of pSS. The incidence and prevalence rates of pSS were summarised with IRs or PRs and 95% CIs.

Results

The literature search yielded 1880 related citations. Only 21 fulfilled the inclusion criteria. According to a random-effects model, the pooled IR for pSS was 6.92 (95% CI 4.98 to 8.86) per 100 000 person-years. The overall PR was 60.82 (95% CI 43.69 to 77.94) cases per 100 000 inhabitants with a slightly lower estimate of Baodong Qin is BDQ, Jiaqi Wang is JQW, Zaixing Yang is ZXY, Renqian Zhong is RQZ. 43.03 (25.74 to 60.31) cases per 100 000 inhabitants when only considering population-based studies. The female/male ratio in incidence data was 9.15 (95% CI 3.35 to 13.18). The female/male ratio in prevalence data was 10.72 (95% CI 7.35 to 15.62). The overall age of pSS patients was 56.16 years (95% CI 52.54 to 59.78).

Conclusions

Incidence and prevalence rates of pSS vary widely around the world. The results help us better understand the global epidemiology of pSS. Large population-based studies combining meticulous case-finding and case-ascertainment strategies are needed.

Etiology

10.1136/annrheumdis-2014-205375

Cite

Citations (702)

Effect of a blended learning design in an undergraduate nursing electrocardiogram course: A quasi‐experimental study

Nursing Open (2023)

Li Jiang Duoduo Wang Jie Yan Min Yang

Abstract Aim The study aimed to explore learning achievement and students' satisfaction with a blended learning (BL) electrocardiogram (ECG) education programme in undergraduate nursing education. Design This was a quasi‐experimental post‐test design. Methods The study was conducted during semester one of the academic year 2020/2021. Participants were divided into two groups: the BL group and face‐to‐face (FTF) group. The BL group received the newly designed BL programme. The FTF group received the traditional learning methods. Post‐test measures of the study variables such as knowledge, study time and satisfaction were conducted. Chi‐square ( χ 2 ) test was used to evaluate categorical variables. The Mann–Whitney test was used to analyse continuous variables. Results Participants in BL group had significantly higher scores in ECG interpretation and total score. No significant differences in foundational knowledge between the two groups were found. Study time was significantly longer in the BL group. Regarding satisfaction, significant differences were found in structure rationality and promotion of self‐learning.

Blended Learning

Promotion (chess)

Categorical variable

10.1002/nop2.1688

Cite

Citations (4)

Disorders Resulting from Physical Factors

Springer eBooks (2018)

Dong‐Lai Ma Bo Li Cheng Li Feng Li Ruzhi Zhang

10.1007/978-981-10-8037-1_8

Cite

Citations (1)

The versatile multi-functional substance NMN: its unique characteristics, metabolic properties, pharmacodynamic effects, clinical trials, and diverse applications

Frontiers in Pharmacology (2024)

Bin Yu Xiaotong Jing Lina Jia Maoru Wang Liying Liu

β-nicotinamide mononucleotide (NMN) is a naturally occurring biologically active nucleotide widely present in organisms and an inherent substance in the human body. As a critical intermediate in synthesizing coenzyme I (NAD+), it widely participates in multiple biochemical reactions in the human body and is closely related to immunity, metabolism, and other factors. In recent years, NMN has rapidly developed and made significant progress in medicine, food, and healthcare. However, there is currently a lack of comprehensive reports on the research progress of NMN, as well as exploration and analysis of the current research achievements and progress of NMN. Therefore, this review is based on retrieving relevant research on NMN from multiple databases at home and abroad, with the retrieval time from database establishment to 20 May 2024. Subsequently, literature search, reading, key information extraction, organization, and summarization were conducted with the aim of providing a comprehensive and in-depth analysis of the characteristics, metabolic pathways, pharmacological effects, progress in human clinical trials, and wide applications of NMN in drug development and food applications. Furthermore, it offers personal insights into NMN’s potential future developments and advancements to present the current development state and existing challenges comprehensively. Ultimately, this review aims to provide guidance and serve as a reference for the future application, innovation, and progression of NMN research.

Nicotinamide mononucleotide

10.3389/fphar.2024.1436597

Cite

Citations (1)

Melatonin Inhibits OGD/R-Induced H9c2 Cardiomyocyte Pyroptosis via Regulation of MT2/miR-155/FOXO3a/ARC Axis

International Heart Journal (2022)

Rui Chen Min Yang

Emerging literature suggests that pyroptosis plays a critical role in ischemia/hypoxia (I/R) -induced myocardial injury. Melatonin has been implicated in attenuating I/R-induced injury of cardiomyocytes. Nevertheless, whether melatonin inhibits I/R-induced pyroptosis of cardiomyocytes and the underlying molecular mechanisms remain unexploited.H9c2 cardiomyocytes were cultured under oxygen-glucose deprivation/reperfusion (OGD/R) condition to establish a myocardial pyroptosis model in vitro. OGD/R-induced pyroptosis was evaluated by CCK-8 assay, IL-1β and IL-18 release, and western blotting. Luciferase reporter assay was utilized to validate the association between miR-155 and Forkhead box O3a (FOXO3a).Melatonin could inhibit OGD/R-induced pyroptosis of H9c2 cells and upregulation of FOXO3a contributed to the antipyroptotic effect of melatonin. Melatonin reduced miR-155 expression, which led to FOXO3a upregulation and inhibition of pyroptosis in OGD/R-exposed H9c2 cells. miR-155 inhibitor enhanced the antipyroptotic effect of melatonin in OGD/R-exposed H9c2 cells. Melatonin-induced downregulation of miR-155 and upregulation of FOXO3a were reversed by melatonin receptor 2 (MT2) siRNA. Melatonin treatment also led to an increased level of apoptosis repressor with caspase recruitment domain (ARC), which was inhibited by FOXO3a siRNA. Moreover, silencing ARC by siRNA significantly blocked the antipyroptotic actions of melatonin, whereas ARC overexpression enhanced the antipyroptotic actions of melatonin in OGD/R-exposed H9c2 cells.Our findings demonstrated that melatonin prevented OGD/R-induced pyroptosis via regulating the MT2/miR-155/FOXO3a/ARC axis in cardiomyocytes.

Pyroptosis

Hypoxia

10.1536/ihj.21-571

Cite

Citations (7)

Stellate spontaneous pseudoscars

Linchuang pifuke zazhi (2006)

Min Yang

Hepatic stellate cell

Source

Cite

Citations (0)

Targetoid hemosiderotic hemangioma (hobnail hemangioma): typical clinical and histological presentation

Chinese Medical Journal (2013)

Min Yang Jian-Min Chang

To the editor: Targetoid hemosiderotic hemangioma (THH), also known as Hobnail Hemangioma (HH) is characterized by a violaceous to brown targetoid lesion. The classic histological presentation of THH is that of ectatic vascular lumina mainly in the superficial and mid-dermis lined by a single layer of endothelial cells with hobnail appearance. We report here a case of THH in China with distinctive clinical features. A 71-year-old woman presented with a seven-day history of a solitary lesion on her abdominal wall. This initial lesion was a red and asymptomatic papule, surrounded by a violaceous area that gradually expanded peripherally and developed a bruiselike rim. The patient denied a history of previous trauma to the area. Examination revealed on the abdominal wall there was a 1.5 cm×1 cm firm red papule with a surrounding pale area and peripheral ecchymotic halo, resulting in a targetoid appearance (Figure 1A).Figure 1.: The clinical manifestation and pathologic findings of the patient. A: A red/purple targetoid lesion on the abdomen. B: Histology of a papular lesion showing dilated vessels filled with a large number of erythrocytes in the superficial and mid-dermis. a single layer of hobnail endothelial cells lining by vascular lumina were found to protrude into the lumen of the vessels and intraluminal papillary projections are also obviously seen (Hematoxylin-eosin staining, original magnification×400).Histology of the central papule revealed that in the upper and mid-dermis, there was a proliferation of dilated vascular lumens mostly filled with a large number of congested erythrocytes and a mild infiltration of inflammatory cells. Under higher magnification, a single layer of hobnail endothelial cells lining by vascular lumina were found to protrude into the lumen of the vessels and intraluminal papillary projections are also obviously seen (Figure 1B). THH is a rare benign vascular neoplasm, which was first described by Santa Cruz and Aronburg in 1988.1 Clinically THH appears as an asymptomatic small, solitary, red, purple, and/or brown papule that is typically encircled by a pale area and peripheral ecchymotic ring giving a targetoid appearance. Over time, the ecchymotic rim expands peripherally and ultimately disappears, leaving the central papule. The ring is, however, not a constant feature.2 The main histopathological feature of THH is a dermal vascular proliferation with biphasic growth patterns. In the papillary dermis, the ectatic vascular spaces are often lined with a single layer of prominent plump endothelial cells protruding into the lumen of the vessels. There are occasional intraluminal papillary projections. The histopathologic differential diagnosis of THH includes patch stage Kaposi's sarcoma and retiform hemangioendothelioma (RHE).3 The etiology of THH is unknown, one well-accepted mechanism is that of THH developing from trauma to a pre-existing hemangioma. Some patients with THH have been reported in whom the lesions changed periodically during menstruation, but immunohistochemical staining failed to demonstrate either estrogen or progesterone receptors in these cases.4 Trindade claimed that THH is better considered as a lymphatic malformation but not a lymphatic neoplasm on the basis of the WT1 negativity.5 Our old patient developed a typical purple targetoid lesion for a short time. The histopathology was characterized by a single layer of hobnail endothelial cells and intraluminal papillary projections. She denied a history of previous trauma. Min YANG Jian-min CHANG Department of Dermatology, Beijing Hospital, Beijing 100730, China (Yang M and Chang JM)

Papule

Histology

Pallor

10.1097/00029330-201309050-00044

Cite

Citations (17)

PP01.116 Utilization of extended-interval, fixed-dosing of durvalumab, every 4 weeks, in U.S. patients with unresectable stage III NSCLC following concurrent chemoradiation

Journal of Thoracic Oncology (2024)

Reina Haque Eric C. McGary Min Yang R. Liu Jennifer M. Suga

Durvalumab

10.1016/j.jtho.2024.05.341

Cite

Citations (0)

data of patients with painful DPN

Figshare (2014)

Chenlong Liao Wenchuan Zhang Min Yang Qiufeng Ma Guowei Li

Data of VAS, 2-PD, BDI-DPN, NCV, SCA

10.6084/m9.figshare.1112399

Cite

Citations (0)

Identification of Hub Genes Associated With Clinical Characteristics and Potential Therapy of Diabetic Nephropathy by Bioinformatics Analysis.

Research Square (Research Square) (2020)

Si Xu Xiaoning Li Sha Wu Min Yang

Abstract Background: To provide theoretical basis for the molecular mechanism of the development of diabetic nephropathy and targeted molecular therapy by screening expressed genes based on bioinformatic analysis. Methods: We analyzed diabetic nephropathy microarray datasets derived from GEO database. Perl and R programming packages were used for data processing and analysis and for drawing. STRING online database and Cytoscape software were utilized for protein-protein interaction network analysis and screened for hub genes. Also, WebGestalt was used to analyze the relationship between genes and microRNAs. Nephroseq online tool was used to visualize the correlation between genes and clinical properties. Results: We found 91 differentially expressed genes between diabetic nephropathy tissues and normal control tissues. Protein-protein interaction network analysis screened out 5 key modules and a total of 14 hub genes were identified by integration, also11 microRNAs were associated with hub genes. Especially mir29 could regulate COL6A3 and COL15A1. Conclusions: The internal biological information in diabetic nephropathy can be revealed by integrative bioinformatical analysis, providing theoretical basis for further research on molecular mechanism and potential targets for diagnosis and therapeutics of diabetic nephropathy.

Identification

10.21203/rs.3.rs-120610/v1

Cite

Citations (0)