The Sinovac enterovirus 71 (EV71) vaccine has been given to children aged 6-35 months with good safety, immunogenicity, and efficacy. Further exploration is needed for the application of Sinovac EV71 vaccine in older children.A phase III, double-blind, single-center, randomized, controlled, non-inferiority, and bridging-designed trial enrolled 300 participants aged 6-35 months and 600 participants aged 36-71 months. Non-inferiority and superiority analyses were made to determine the immunogenicity of Sinovac EV71 vaccine in older children (Older-S group), comparing with that of control EV71 vaccine in the same age group (Older-C group), or comparing with that of Sinovac EV71 vaccine in younger children (Younger-S group).The seroconversion rate of anti-EV71 in Older-S group (95.5%) was superior to that of Older-C group (86.0%), and non-inferior to that of Younger-S group (98.5%). For baseline seronegative participants, the geometric mean titer of Older-S group (370.0) was non-inferior to that of Older-C group (296.2) and superior to that of Younger-S group (176.5). Incidence of adverse reactions in Older-S group (47.0%) was similar to that of Older-C group (44.8%), or Younger-S group (49.8%).This study showed good safety and immunogenicity of Sinovac EV71 vaccine in children aged 36-71 months.NCT03909074.https://clinicaltrials.gov/ct2/show/NCT03909074?term=NCT03909074&draw=2&rank=1.
Objective To study the stability of cefoselis sulfate injection mixed with omeprazole sodium.Methods The concentrations of cefoselis and omeprazole were determined by RP-HPLC at different temperature within eight hours,and the appearance and pH values were investigated.Results The contents of cefoselis sulsate and omeprazole sodium were stable within eight hours and the mixed solutions were clear.Their pH values were also stable at 4 ℃ for eight hours,25 ℃ for three hours and 37 ℃ for one hour.While the content variation of omeprazole sodium was more than 5% after putting two hours at 37 ℃.Conclusion Cefoselis sulfate with omeprazole sodium were stable at high temperature within one hour,but the stability of mixture was poor after two hours.
The funding project numbers were omitted from the published Funding statement. The correct Funding is:
This work was supported by the grants from the Ministry of Science and Technology of China (2009ZX10004-903, 2008ZX10001-016, 2008ZX10001-004 and 2009DFB30420). The funders had no role in study design, data collection and analysis, desicion to publish, or preparation of the manuscript.
Accurate earthquake location is of primary importance in studying the seismicity of reservoir area. The well known program Velest was used to inverse the minimum 1-D velocity,hypocenter location and station correction simultaneously.We selected 529 earthquakes,which were recorded at least by 10 stations each and whose max azimuth gap was less than 180°,to re-determine the velocity model and station corrections with three different initial models used by different researchers before.Using the 1-D minimum velocity model and station correction,we relocated 2138 earthquakes in the Three Gorges area.The average focal depth changes remarkably in different areas,as 5.6km in the area near Xiannvshan Fault,2.9km in the Xietan area and 2.6km in the Badong area.Divided by the depth of 5km,the b values are different,as 1.07,1.16 and 0.90 for all,shallower and deeper events respectively. The frequency of shallower or deeper events per 15 days increases with impounding.But that of the shallower ones drops quickly and the deeper attenuates slowly when water lever keeps stable.
The effects of four fungicides on the hypha growth of Flammulina velutiper and Trichderma viride were studied.The results showed that the different kinds and treatment concentrations of fungicides on the hypha growth of Flammulina velutiper and Trichderma viride had significant difference.The Bavistin at concentration of 0.833 g/L gave completely controlling effect on mycelial growth of both Flammulina velutiper and Trichderma viride.It was proved that Thiram and Copperh hydroxide at each concentration of 0.375-0.188 g/L and 0.963-0.418 g/L had almost no inhibitions on the growth of Flammulina velutiper and had stronger effects on the growth of Trichderma viride.Therefore,Thiram and Copperh hydroxide could be used in Flammulina velutiper cultivation.
Abstract Aims MNDA (myeloid nuclear differentiation antigen) has been considered as a potential diagnostic marker for marginal zone lymphoma (MZL), but its utility in distinguishing MZL from other B-cell non-Hodgkin lymphomas (B-NHLs) and its clinicopathologic relevance in diffuse large B-cell lymphoma (DLBCL) are ambiguous. We comprehensively investigated MNDA expression in a large series of B-NHLs and evaluated its diagnostic value. Methods MNDA expression in a cohort of 1293 cases of B-NHLs and 338 cases of reactive lymphoid hyperplasia (RLH) was determined using immunohistochemistry and compared among different types of B-NHL. The clinicopathologic relevance of MNDA in DLBCL was investigated. Results MNDA was highly expressed in MZLs (437/663, 65.9%), compared with the confined staining in marginal zone B-cells in RLH; whereas neoplastic cells with plasmacytic differentiation lost MNDA expression. MNDA expression was significantly higher in mantle cell lymphoma (MCL, 79.6%, p = 0.006), whereas lower in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL, 44.8%, p = 0.001) and lymphoplasmacytic lymphoma (LPL, 25%, p = 0.016), and dramatically lower in follicular lymphoma (FL, 5.2%, p < 0.001), compared with MZL. 29.6% (63/213) of DLBCLs were positive for MNDA. The cases in non-GCB group exhibited a higher rate of MNDA positivity (39.8%) compared to those in GCB group (16.3%) ( p < 0.001), and MNDA staining was more frequently observed in DLBCLs with BCL2/MYC double-expression (50%) than those without BCL2/MYC double-expression (24.8%) ( p = 0.001). Furthermore, there was a significant correlation between MNDA and CD5 expression in DLBCL ( p = 0.036). Conclusions MNDA was highly expressed in MZL with a potential utility in differential diagnosis between MZL and RLH as well as FL, whereas its value in distinguishing MZL from MCL, CLL/SLL is limited. In addition, MNDA expression in DLBCL was more frequently seen in the non-GCB group and the BCL2/MYC double-expression group, and demonstrated a correlation with CD5, which deserves further investigation. The clinical relevance of MNDA and its correlation with the prognosis of these lymphomas also warrant to be fully elucidated.
Objective:To understand the characteristic of mental disorders due to mushroom poisoning. Method:Thirty two patients with mental disorders due to mushroom poisoning were retrospectively analyzed. Results:Patients with mental disorders due to mushroom poisoning were more common in young adults and rural residents with lower education levels. Most psychiatric symptoms were hallucination and delusion,and the patients would gain therapeutic efficacy well. Conclusion:Patients with mental disorders due to mushroom poisoning can be well effectively cured.
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