Jianfeng Guo

Suzhou Municipal Hospital

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i-10 index

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Sifang Chen

First Affiliated Hospital of Xiamen University

Guowei Tan

First Affiliated Hospital of Xiamen University

Xiongjie Zhuang

Eighth Affiliated Hospital of Sun Yat-sen University

Chunquan Zhang

Nanchang University

Chengkun Han

First Affiliated Hospital of Xiamen University

Youbin Deng

Tongji Hospital

Ping Zhou

Northwestern Polytechnical University

Ying Gu

Affiliated Hospital of Guizhou Medical University

Jinli Sun

Shanghai Jiao Tong University

Qing Zhou

Beijing Chao-Yang Hospital

Cooperative Institutions

Huazhong University of Science and Technology

First Affiliated Hospital of Xiamen University

Nanjing Medical University

Union Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Chinese Academy of Sciences

Jilin University

Sichuan University

Amsterdam University Medical Centers

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Tei index and tissue Doppler imaging combined with N-terminal proBNP in evaluation of acute radiation induced right heart injury

Zhongguo yixue yingxiang jishu (2012)

Jianfeng Guo

Objective To explore the value of Tei index,tissue Doppler imaging(TDI) combined with N-terminal proBNP(NT-proBNP) in evaluating acute radiation induced right heart injury.Methods NT-proBNP and echocardiography were performed in 21patients underwent thoracic radiotherapy(RT) at the timepoint of before RT,1day and 1month after RT.The following echocardiographic parameters were obtained : ①Tei index;②Conventional parameters,including the deceleration time of E wave,peak early filling velocity(E),late diastolic filling velocity(A),E/A ratio and deceleration time of E peak,as well as right ventricular end diastolic diameter,right atrium end systolic diameter,right ventricular fractional area change and tricuspid annular plane systolic excursion;③TDI parameters : Mitral annulus peak velocities in systole(Sa),early diastole(Ea),late diastole(Aa).Then the mitral inflow E velocity to tissue Doppler Ea(E/Ea) was calculated.Results Compared with data before RT,NT-proBNP increased 1day after RT but declined to a low level a month later(P0.05),while Sa and Ea decreased,Tei index,Aa and E/Ea increased,but conventional parameters had no significant changes(all P0.05).Conclusion After RT,TDI,Tei index and NT-proBNP can provide valuable information for evaluating acute radiation induced right heart injury.

Doppler imaging

Systole

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Use of a high b-value for diffusion weighted imaging of peritumoral regions to differentiate high-grade gliomas and solitary metastases

Journal of Magnetic Resonance Imaging (2014)

Chengkun Han Shumin Huang Jianfeng Guo Xiongjie Zhuang Haiwei Han

To determine whether apparent diffusion coefficient (ADC) values obtained using a b-value of 3000 s/mm(2) can be used to differentiate high-grade glioma (HGG) from solitary metastases (SM).Forty patients underwent conventional magnetic resonance imaging (MRI) and standard and high b-value diffusion-weighted imaging (DWI). Minimum, maximum, and mean ADC values (ADCMIN , ADCMAX , and ADCMEAN , respectively) were measured from ADC maps obtained for the two b-values for each subject. ADC ratios were also measured. A receiver operating characteristic (ROC) curve analysis was used to determine the cutoff ADC value for distinguishing between HGG and SM.All ADC values for the peritumoral region of the HGGs examined were lower than those for the SM. Furthermore, a larger statistical difference was observed for ADCMIN , ADCMAX , and ADCMEAN values at a b-value of 3000 s/mm(2) versus 1000 s/mm(2) (P < 0.0001, P = 0.0010, and P = 0.0001 versus P = 0.0001, 0.0030, and 0.0002, respectively). A discriminant analysis identified the greatest log likelihood for the ADCMIN values obtained at a b-value of 3000 s/mm(2) , and the cutoff value for differentiating HGG and SM was 0.890 × 10(-3) mm/s(2) .ADC values from DWI using a high b-value were found to distinguish HGG and SM. The lowest degree of overlap was obtained when an ADCMIN value was obtained at a b-value of 3000 s/mm(2) .

Cut-off

Value (mathematics)

10.1002/jmri.24747

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STREPTOZOTOCIN-SENSITIVE PANCREAS ISLET CELLS EXPRESS HUNTINGTIN ASSOCIATED PROTEIN 1

Chieh P'ou Hsueh Pao (2006)

Jingjing Liu Yinghua Chen Xiaowei Chen Jianfeng Guo Xing‐Xing Chen

Objective To investigate the localization of huntingtin-associated protein 1(HAP1) in the pancreas islet of the rat.Methods To replicate rat model of diabetes through selectively destroying B cells of pancreas islet by one peritoneal injection of large dose of streptozotocin;the immunreactivities of HAP1 and insulin in the pancreas islet were showed by ABC method of immunohistochemistry.Results In the pancreas of normal rat,it was found that HAP1 expressed selectively in the islets.HAP1-containing cells were arranged as short cords or groups,mainly located in the center of each pancreas islet,having similar distributive pattern to that of pancreas islet B cell.No HAP1-immunoreactive cell was detected in the exocrine portion of the pancreas.The HAP1-containing cells in the diabetic rats decreased in number as early as 3 days after injection of streptozotocin and further progressively decreased as the rats survived longer,only a few of cells with weak HAP1-immunoreactivity remaining in the islets 4 weeks after streptozotocin injection.It was also noted that the effect of streptozotocin on the expression of HAP1 was similar to that on the expression of insulin in the islet.ConclusionHAP1 also exists in the pancreas islet,mainly located in streptozotocin-sensitive B cells.

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Gail Model Improves the Diagnostic Performance of the Fifth Edition of Ultrasound BI-RADS for Predicting Breast Cancer: A Multicenter Prospective Study

Academic Radiology (2020)

Luying Gao Yang Gu Jiawei Tian Hai-Tao Ran Weidong Ren

BI-RADS

Breast imaging

Breast ultrasound

Microcalcification

10.1016/j.acra.2020.12.002

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Application of intraoperative near-infrared indocyanine green videoangiography and analysis of fluorescent intensity in cerebral aneurysm surgery

Zhonghua shenjing waike zazhi (2011)

Sifang Chen Zhanxiang Wang Guowei Tan Jianfeng Guo Dong-han Chen

Objective To study the application of intraoperative near - infrared indocyanine green videoangiography and visual analysis of blood flow dynamics in cerebral aneurysm clipping surgery,and analyze the advantages and limitations.Methods 47 patients with 51 intracranial aneurysms were treated by microsurgical clipping.Intraoperative ICG videoangiography was performed before or/and after clip application.The infrared fluorescence module integrated into the surgical microscope was used to visualize fluorescent areas in surgical field and permitted the recording of a video of the emitted fluorescent light.The recorded video signal was then constantly analyzed by an integrated analytical visualization tool for rapid interpretation of the fluorescence video sequences with intensity diagram.Results All of the images provided high resolution allowing real time assessment of the blood flow of parent artery,arterial branches or small perforators.Incomplete clipping of 4 anearysms were detected by using ICG angiography.Perforating arteries arising closed to or from aneurysmal neck were identified in the surgical eid of 15 aneurysms and the ICG angiography allowed real time assessment of the blood flow.The intensity diagram of ICG angiography provided important imformation in three cases.Conclusions ICG video angiography could provide high resolution images allowing real time assessment of the blood flow of parent artery,arterial branches or small perforators to improve the outcome of intracranial aneurysm surgery.The intensity diagram function is useful as an adjunct to ICG video angiography for documenting the blood flow. Key words: Intracranial aneurysm; Indocyanine green; Angiograpny; Microsurgery

Indocyanine Green

Clipping (morphology)

Perforating arteries

10.3760/cma.j.issn.1001-2346.2011.12.005

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Research of hemorheology and heat shock protein change law in patients with malignant tumor

China Modern Medicine (2012)

Jianfeng Guo

Objective To investigate the alteration of hemorheology and heat shock protein in patient with malignant tumors. Methods Seventy nine patients with malignant tumors were enrolled from August 2009 to December 2010 in oncology department of our hospital, 82 health persons were also enrolled as control group. The hemorheology was analyzed in both groups. Results The whole blood viscosity, the blood plasma viscosity, the erythrocyte sedimentation rate, the red blood cell press the product, the red blood cell rigid index, the red blood cell accumulation index and the fibrinogen level of malignant tumor patients showed significant higher than the controls, P0.05 or 0.01. In 79 patients with malignant tumor patients, the shift in 46 patients, accounted for 58.2%, not the shift in 33 patients, accounted for 41.8%; Whole blood viscosity, plasma viscosity, red blood cell deposited, fibrinogen in transfer group were significantly higher than not transfer group, P0.05; According to pathological results, all patients with malignant tumors were divided into poorly differentiated group (n=2, accounted for 2.5%), moderately differentiated group (n=34, accounted for 43.0%) and well differentiated group (n=43, accounted for 54.5%). The positive rate of heat shock protein in three groups were 83.7%, 67.6% and 0.0, P0.05. Conclusion The higher the degree of malignant tumor, the more notable the hemorheology changing and the higher heat shock protein content is.

Hemorheology

Erythrocyte sedimentation rate

Erythrocyte aggregation

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Clipping of large and giant internal carotid artery aneurysms assisted by retrograde suction decompression

Zhonghua shenjing waike zazhi (2011)

Sifang Chen Zhanxiang Wang Guowei Tan Jianfeng Guo Dong-han Chen

Objective To present our experience with retrograde suction decompression in clipping of large and giant internal carotid artery aneurysms and analyze its advantages and pitfalls.Methods A retrospective analysis of 26 large and giant intracranial aneurysms treated by suction decompression assisted clipping between November 2005 and February 2010 was present.The surgical techniques and the outcome of patients were reviewed.Results All aneurysms were successfully clipped, and postoperative 3D - CTA or DSA revealed no major branch occlusion or residual aneurysm.There was no surgical mortality in both giant and large aneurysm groups.Conclusions Retrograde suction decompression is a successful adjunct to clipping of large and giant internal carotid artery aneurysms. Key words: Aneurysm; Internal carotid artery; Retrograde suction decompression

Clipping (morphology)

10.3760/cma.j.issn.1001-2346.2011.08.013

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Epidemiology and antibiotic resistance of pulmonary infections in Neurosurgical Intensive Care Unit Survey

Chin J Neurotrauma Surg(Electronic Edition) (2017)

Xi Chen Jinli Sun Sifang Chen Jianfeng Guo Guowei Tan

Objective To investigate the species of pathogens causing pulmonary infections in Neurosurgical Intensive Care Unit (NSICU) and their antibiotic resistance, and offer reference for the prevention and control of pulmonary infections in NSICU. Methods The species and resistance pattern of bacterial isolates in NSICU of The First Affiliated Hospital of Xiamen University from June 2014 to August 2017 were collected and analyzed retrospectively. Bacterial identification and antibiotic susceptibility tests were carried out by using VITEK2 automatic system, the data was analyzed by WHONET5 software. Results Totally 217 strains of pathogens causing pulmonary infections were isolated, including 44 strains of Gram-positive cocci, 173 strains of Gram-negative bacilli. The top 4 isolated pathogens were Pseudomonas aeruginosa (P. aeruginosa) (22.12%), Klebsiella pneumonia (K. pneumonia) (21.20%), Staphylococcus aureus (S. aureus) (17.51%) and Acinetobacter baumannii (A. baumannii) (16.59%). The susceptible rates of S. aureus to all the antibiotics were less than 65.0% except Vancomycin (100.0%), Linezolid (100.0%), Tigecycline (100.0%), Nitrofurantoin (100.0%), Quinupristin/ Dalfopristin (100.0%) and Sulfamethoxazole (94.7%). The susceptible rates of P. aeruginosa to all the antibiotics were less than 65.0% except Amikacin (95.8%), Tobramycin (89.6%), Gentamycin (83.3%), Cefepime (77.1%) and Ceftazidime (75.0%). The susceptible rates of K. pneumonia were high in Amikacin (91.3%), Meropenem (91.3%), Pipercillin/sulbactam (91.3%), imipenem (89.1%) and Cefotetan (89.1%). while to other common antibiotics, the susceptible rates were more than 60.0% except Ampicillin (0.0%), Piperacillin (2.2%) and Nitrofurantoin (21.7%). The susceptible rates of A. baumannii to all the antibiotics were less than 30.0% except Tobramycin (33.3%). Conclusion The pathogens causing pulmonary infections in NSICU present a trend as highly centralize and multidrug-resistant. To emphasize on the recognition of the pulmonary infections and the antibiotic resistance of NSICU, it is important to take certain preventive measures so as to control and reduce pulmonary infections. Key words: Neurosurgical Intensive Care Unit; Pulmonary infection; Pathogen; Antibiotic resistance

Amikacin

Linezolid

Tigecycline

Cefepime

Acinetobacter baumannii

10.3877/cma.j.issn.2095-9141.2017.06.005

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MEBO for treating 31 children with wounds after exclusion et prepuce penis adhesion

The Chinese Journal of Burns Wounds & Surface Ulcers (2007)

Jianfeng Guo

Objective:To investigate the method of application of MEBO in the treatment of wounds after exclusion of pediatric prepuce penis adhesion.Method:31 cases of this disease were treated locally with MEBO.Result:The average wound healing time was 4 days.Conclusion:MEBO is very efficacious and reliable in treating wounds after exclusion of ped- iatric prepuce penis adhesion.

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Application of balanced turbo field-echo technique for renal arteries MR angiography

Jiangsu Medical Journal (2008)

Jianfeng Guo

Objective To evaluate the feasibility of the balanced turbo field echo(B-TFE)sequence to perform renal arteries magnetic resonance angiography(MRA).Methods Fourty-five patients underwent MR angiography with B-TFE technique and the results were analyzed.Results Renal MRA with B-TFE accurately depicted the status of renal arteries in all cases with high contrast-to-noise ratios (CNR) and fine quality.Conclusion Multislab balanced turbo field-echo imaging is a valuable MRA technique for depicting normal and diseased renal arteries.

Magnetic resonance angiography

Turbo

Fast spin echo

Echo (communications protocol)

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