Ying Liu

Chengdu University

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Junling Pang

Chinese Academy of Medical Sciences & Peking Union Medical College

Bolun Li

Chinese Academy of Medical Sciences & Peking Union Medical College

Meiyue Song

Harbin Medical University

Xianmei Qi

Chinese Academy of Medical Sciences & Peking Union Medical College

Yuchao Luo

East China Jiaotong University

Yanjiang Xing

Chinese Academy of Medical Sciences & Peking Union Medical College

Ming He

Nanchang University

Jing Wang

Chinese Academy of Medical Sciences & Peking Union Medical College

Li Zhang

University of California, San Francisco

Jia Yuan

Guangzhou University

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Chinese Academy of Medical Sciences & Peking Union Medical College

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Chinese Academy of Sciences

Harbin Medical University

Nanjing Medical University

Capital Medical University

Shandong University

Fudan University

Peking Union Medical College Hospital

Huazhong University of Science and Technology

Sichuan University

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The effect of nitrogen concentration and its interaction with light intensity on population dynamics and polysaccharide content ofMicrocystis aeruginosa

Journal of Freshwater Ecology (2011)

Wei Wang Ying Liu Linlin Geng Zhou Yang Yafen Chen

Cultures of Microcystis aeruginosa were inoculated into media with different nitrogen concentrations (5%, 10%, 25%, 100% N of standard BG-11 media) and cultured under two light intensities for 35 days. The populations of M. aeruginosa tended to increase with decreased nitrogen concentrations in both the high light intensity and the low light intensity. Cell densities in high light intensity were significantly higher than those in low light intensity under lower nitrogen concentrations (5%, 10%, 25% N), whereas the result was reversed under the high nitrogen concentration (100% N). A four-parameter logistic model fitted all the population dynamics well. Soluble extracellular polysaccharide content of M. aeruginosa cultured in the 100% N media was significantly higher than in M. aeruginosa cultured in the lower nitrogen media; however, the bound polysaccharide and total polysaccharide of M. aeruginosa cultured in 5% N media were significantly higher than those of M. aeruginosa cultured in all other nitrogen concentration media. Significant differences in bound polysaccharide and total polysaccharide were also detected between the high light intensity and the low light intensity. There was a statistically significant interaction between light intensity and nitrogen concentration on the soluble extracellular polysaccharide content but not on bound polysaccharide or total polysaccharide.

Microcystis aeruginosa

Light intensity

Extracellular polysaccharide

10.1080/02705060.2011.555205

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[Effect of delayed preconditioning induced by Sini decoction on myocardial cell apoptosis and its mitochondrial mechanism].

Ying Liu Wei-Kang Wu Chen Chen Xin-feng Duan

To investigate the mechanism of myocardial cell apoptosis during delayed preconditioning induced by Sini decoction (SND).

Intrinsic apoptosis

Decoction

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Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance

International Journal of Molecular Sciences (2018)

Chong Xue Huanyu Lu Ying Liu Jianbin Zhang Jiye Wang

Trans-ferulic acid-4-β-glucoside (C16H20O₉, TFA-4β-G) is a monomer extracted from the Chinese medicine called radix aconiti carmichaeli (Fuzi). To date, research on this substance is lacking. Here, we found that trans-ferulic acid-4-β-glucoside effectively promoted cold acclimatization in mice via increased heat production and alleviation of oxidative stress in a cold environment. Thus, our work indicates that ferulic acid-4-β-glucoside is a potential therapeutic candidate for prevention and treatment of cold stress injury.

Glucoside

Cold stress

10.3390/ijms19082321

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In vitro cytotoxicity and oxidative damage of mesoporous Nano-SiO2 on RAW 264.7 macrophages.

Ying Liu Weihua Li Gaku Ichihara Ding Xuncheng Weimin Song

[Objective] To study the in vitro cytotoxicity and oxidative damage of mesoporous nano-SiO2 on RAW264.7 macrophages.[Methods] The RAW 264.7 cells were treated with different concentrations of mesoporous nano-SiO(22.5,10,50,100 μg/mL)and saline control for 24 h.MTT assays were applied for testing macrophage cytotoxicity in vitro,which were based on mitochondrial activity evaluation.Total protein(TP),lactate dehydrogenase(LDH),nitrogen monoxide(NO),glutathion(GSH),superoxide dismutase(SOD)and malondialdehyde(MDA)in supernatant and intra-cellular fluid were determined.The morphologic change of RAW 264.7 was also observed.[Results] Compared with saline control,the viability of RAW264.7 cell was decreased significantly after exposed to mesoporous nano-SiO2.The levels of TP,LDH,NO and MDA in exposed groups of 50 μg/mL and 100 μg/mL dosage were higher,while GSH and SOD levels were lower than in the saline control group,which were in accordance with the morphologic change on RAW264.7 cell exposed to mesoporous nano-SiO2.[Conclusion] Mesoporous nano-SiO2 can induce cytotoxicity and oxidative demage on RAW264.7 macrophage.

Malondialdehyde

Viability assay

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Literature analysis on efficacy and safety of chloroquine phosphate in infectious diseases

Ying Liu

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Inhibition of Immunoglobulin E Attenuates Pulmonary Hypertension

Research Square (Research Square) (2021)

Ting Shu Ying Liu Yitian Zhou Zhou Zhou Peiran Yang

Abstract Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by pathological vascular remodeling in the lung. Immunoglobulin E (IgE) is known to participate in aortic vascular remodeling, but whether IgE mediates pulmonary vascular remodeling in PH is unknown. Here, we found serum IgE elevation in PAH patients, hypoxia-induced PH mice and monocrotaline (MCT)-induced PH rats. Combining animal model of PH with single-cell RNA sequencing, we found IgE production in the lung tissues of PH mice. Neutralizing IgE with an anti-IgE antibody was effective in preventing PH development in mice and rat models. The IgE receptor FcεRIα was also upregulated in PH lung tissues and Fcer1a deficiency prevented the development of PH in mice. Single-cell RNA-seq revealed that FcεRIα was mostly expressed in mast cells, and mast cell-specific Fcer1a knockout protected against PH in mice. Further mechanistic experiments revealed that IgE-activated mast cells produced interleukins IL6 and IL13, which subsequently promoted vascular muscularization. Clinically approved IgE antibody Omalizumab alleviated the progression of established PH in rats. Using genetic and pharmacological approaches, we have demonstrated that blocking IgE- FcεRIα signaling may hold potential for the treatment of PAH.

Hypoxia

10.21203/rs.3.rs-1036422/v1

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A Review of Clinical Researches on the Treatment of Diabetic Peripheral Neuropathy by Acupuncture and Moxibustion

Journal of Inner Mongolia University for the Nationalities (2010)

Ying Liu

In this article,the authors review clinical treatment of DPN by acupuncture and moxibustion in recent five years from simple therapies,comprehensive therapies and clinical researches. Clinical practice demonstrates that acu-moxibustion therapies are effective in the treatment of DPN and more researches are needed.

Moxibustion

Clinical Practice

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HIPPOCAMPUS-SPECIFIC LOSS BRPF1 MURINE MODEL EXHIBITS ATTENUATED EXCITATORY SYNAPTIC TRANSMISSION AND IMPAIRED SPATIAL AND FEAR MEMORY

IBRO Neuroscience Reports (2023)

Baicheng Zhao Hang Zhang Ying Liu Linya You

10.1016/j.ibneur.2023.08.200

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Programmed death-ligand 1 triggers PASMCs pyroptosis and pulmonary vascular fibrosis in pulmonary hypertension