The zwitterionic 1:1 intermediates generated by addition of alkyl isocyanides to acetylenic esters are trapped by 3-methyl-5,5-diaryl-2-thioxoimidazolidin-4-ones to yield dialkyl 2-[(alkylimino)(3-methyl-4-oxo-5,5-diaryl-2-thioxoimidazolidin-1-yl)methyl]but-2-enedioates in good yields.
A series of some new spiro-1,4-dihydropyridine derivatives have been synthesized in good yields in a four component, and solvent-free process by condensation of isatins, primary amines, ethyl cyanoacetate and cyclohexanone on solid support montmorillonite K10
Water soluble compoundes were attached to single-walled carbon nanotubes (SWNTs) to form water- soluble nano dyes. functionalized SWNTs were then characterized by Fourier Transform Infrared spectroscopy (FT- IR), Raman spectroscopy, scanning electron microscopy (SEM) and UV analysis. The product can be dissolved in water and High-resolution transmission electron microscope images showed that the SWNTs were efficiently functionalized, thus the p-stacking interaction between aromatic rings and COOH of SWNTs was considered responsible for the high solubility and High transmission electron in singlewall nanotubes.
The vibrational wavenumbers and corresponding vibrational assignments of 2,2'-Ethylene bis(nitrilomethylidene) diphenol are examined theoretically using the Gaussian03 set of quantum chemistry codes. Comparison of the observed IR spectra with the calculated results by HartreeFock and B 3 lyp method is found in agreement with the experimental data. Theoretical infrared and Raman intensities are reported. The atomic orbital compositions of the frontier molecular orbital for SalenH 2 molecule is shown by the following figure.
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In this letter, an efficient synthesis of an array of poly-substituted quinolines from 2-aminoaryl ketones and β-ketoester, β-diketones and α-methylene ketones using KAl(SO 4 ) 2 •12H 2 O-SiO 2 (Alum-SiO 2 ) under solvent-free conditions is described.Compared with the classical Friedländer synthesis this new synthetic method has the advantage of excellent yields (90-98%), shorter reaction time, and reusability of the catalyst.Quinolines are an important class of heterocyclic compounds having remarkable biological activities such as antimalarial, antibacterial, antiasthmatic, antibacterial, antihypertensive, anti-inflammatory and tyrosine kinase PDGF-RTK inhibiting agents. 1,2In addition, they are also applied for the preparation of nano-structures and polymers that combine enhanced electronic, optoelectronic or non-linear optical properties with excellent mechanical properties. 3Thus, the synthesis of quinolines is an important and useful task in organic chemistry.Various methods such as the Skraup, 4 Friedländer, 5 Pfitzinger, 6 Combes, 7 and Conrad-Limpach-Knorr 8 have been developed for the synthesis of quinoline derivatives.However, the Friedländer annulation is one of the most simple and straightforward methods that is employed to produce poly-substituted quinolines.This method involves the acid or base catalyzed or thermal condensation (150-220 °C) between a 2-aminoaryl ketone and a second carbonyl compound possessing a reactive α-methylene group followed by cyclodehydration. 9-12Subsequent works showed that acid catalysts are more effective that base catalysts for the Friedländer annulation.Several acids such as p-toluenesulphonic acid, 13 SnCl 2 , 14 Bi(OTf) 3 ,15 AuCl 3 , 16 NaAuCl 4 •2H 2 O, 17 HCl, 18 NH 2 SO 3 H, 19 Sc(O 3 SOC 12 H 25 ) 3 , 20 silica sulfuric acid, 21 and ionic liquids 22 have also recently been utilized for this synthesis.
Abstract 2′,3′‐Di‐O‐benzoyl‐uridin (Ia) kann mit Methyl‐chlormethyl‐äther in das Acetal (Ib) übergeführt werden, während mit Vinylacetat das Halbacetal (Ic) entsteht.
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