Xinmei Li

Northwest A&F University

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Fei Sun

Institute of Biophysics

Wei Wang

Northwest A&F University

Susan C. Olson

Portland State University

Zhuohui Li

Northwest A&F University

Yunyu Liang

Guangzhou University of Chinese Medicine

Xiangmin Zhao

Gansu Agricultural University

Di‐Yun Ruan

University of Science and Technology of China

Yu Jiang

Northwest A&F University

Huili Wang

Hefei University of Technology

Anguo Liu

University of Maryland, Baltimore

Cooperative Institutions

Northwest A&F University

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Fudan University

Shanghai Institute of Materia Medica

Shanghai Jiao Tong University

Peking University

Sun Yat-sen University

Zhejiang University

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Single-nucleus transcriptomes reveal the underlying mechanisms of dynamic whitening in thermogenic adipose tissue in goats

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology (2025)

Manman Li Ning Ma Shujie Luo Yao Lu Xiang Yan

Thermogenic adipose tissue, both beige and brown, experiences whitening as animals are exposed to warmth and age, but the potential mechanisms are not fully understood. In this study, we employed single-nucleus RNA-seq to construct a cell atlas during whitening progression and identified the characteristics of thermogenic adipocytes. Our histological studies and bulk transcriptome gene expression analysis confirmed that both perirenal and omental adipose tissues (pAT and oAT) exhibited progressive whitening in goats. Compared to the classic brown adipocytes in mice, goat thermogenic adipocytes were more closely related in gene expression patterns to human beige adipocytes, which was also confirmed by adipocyte type- and lineage-specific marker expression analysis. Furthermore, trajectory analysis revealed beige- and white-like adipocytes deriving from a common origin, coexisting and undergoing the transdifferentiation. In addition, differences in gene expression profiles and cell communication patterns (e.g., FGF and CALCR signaling) between oAT and pAT suggested a lower thermogenic capacity of oAT than that of pAT. We constructed a cell atlas of goat pAT and oAT and descripted the characteristics of thermogenic adipocytes during whitening progression. Altogether, our results make a significant contribution to the molecular and cellular mechanisms behind the whitening of thermogenic adipocytes, and providing new insights into obesity prevention in humans and cold adaptation in animals.

10.1186/s40104-025-01157-1

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Overexpression of BnGA2ox2, a rapeseed gibberellin 2-oxidase, causes dwarfism and increased chlorophyll and anthocyanin accumulation in Arabidopsis and rapeseed

Plant Growth Regulation (2020)

Jindong Yan Fujiang Xiang Piao Yang Xin Li Ming Zhong

Silique

Plant Physiology

10.1007/s10725-020-00665-6

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Citations (16)

Angiotensin type 1 receptor is linked to inhibition of nitric oxide production in pulmonary endothelial cells

Regulatory Peptides (2005)

Xiangmin Zhao Xinmei Li Sandra Trusa Susan C. Olson

BAPTA

10.1016/j.regpep.2005.09.010

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Citations (24)

Relativistic multichannel treatment of the autoionization Rydberg series 3ds(¹D₂)np²P^o_1/2of scandium

Journal of Physics B Atomic Molecular and Optical Physics (2010)

Fan Shi-Lin Xinmei Li Feng-Dong Jia Jianguo Wang Yi-Zhi Qu

In the framework of multichannel quantum defect theory, the energy levels of autoionization Rydberg series of 3ds(1D2)np (n = 13–21) 2Po1/2 of scandium (Sc) are calculated from first principles by relativistic multichannel theory, and these calculations are at four levels of approximation, i.e. frozen core approximation, including dipole polarization effects, quadrupole polarization effects and both dipole polarization and quadrupole polarization effects, respectively. The present calculations show that both dipole polarization and quadrupole polarization effects play an important role. The calculation that includes both dipole polarization effects and quadrupole polarization effects agrees well with the experimental data. Furthermore, two perturbed states related to quadrupole polarization effects are found in the energy region of autoionization Rydberg series of of Sc and assigned based on our calculation.

Autoionization

10.1088/0953-4075/43/13/135002

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Heart Failure Is Closely Associated With the Expression Characteristics of Type I Interferon‐Related Genes

Clinical Cardiology (2024)

Jianfeng Zhuo Yan Zhong Xiaojuan Luo Sijie Qiu Xinmei Li

The association between the expression of type I interferon related genes (TIIRGs) and EFrHF is not well understood. This study aimed to investigate the correlation between the expression patterns of TIIRGs and EFrHF using bioinformatics analysis.

Dilated Cardiomyopathy

10.1002/clc.70063

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Theoretical study of the Rydberg series energy levels of ns2S1/2,np2P1/2,3/2, nd2D3/2,5/2 and nf2F5/2,7/2 for alkali-metal Li, Na, K, Rb, Cs and Fr

Acta Physica Sinica (2012)

Xinmei Li Ya-Ping Ruan Zhi-Ping Zhong

In the frame work of multi-channel quantum defect theory, the energy levels of Rydberg series of ss2S1/2, np2P1/2, np2P3/2, nd2D3/2, nd2D5/2, nf2F5/2 and nf2F7/2 of alkali-metal atom are calculated by the relativistic multi-channel theory, in five different approximations, i.e., frozen core approximation, with consideration of l=-1 dipole polarization effect, l=+1 dipole polarization effect, l = 1 dipole polarization effect, stretch effect, and both dipole polarization effects and stretch effect, respectively. The present calculations show that electron correlation effect plays an important role in the energy level of Rydberg series. In summary, dipole polarization effect is more important than the stretch effect, and the l = + 1 dipole polarization effect is more important than l = - 1 dipole polarization effect. However, stretch effect is more important for energy levels of both Rydberg series ns2S1/2,(nd2D3/2,nd2D5/2) of Na, and Rydberg series (np2P1/2,np2P3/2) of Li.

Rydberg constant

Rydberg atom

Rydberg matter

Quantum defect

10.7498/aps.61.023104

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Citations (1)

Absorption, distribution, metabolism, and excretion of [14C]Mefuparib (CVL218), a novel PARP1/2 inhibitor, in rats

Cancer Chemotherapy and Pharmacology (2022)

Xinmei Li Yuandong Zheng Yifan Zhang Xia‐Juan Huan Chen Yang

10.1007/s00280-022-04485-5

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Citations (2)

Antidepressant exposure as a source of disinfectant resistance in waterborne bacteria

Journal of Hazardous Materials (2023)

Hai‐Bei Li Xinmei Li Tianjiao Chen Zhongwei Yang Danyang Shi

Disinfectant

Efflux

Ethidium bromide

Sodium hypochlorite

10.1016/j.jhazmat.2023.131371

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Citations (5)

Structural elucidation of rat biliary metabolites of corynoxeine and their quantification using LC‐MSⁿ

Biomedical Chromatography (2014)

Wei Wang Xinmei Li Yaping Chen Masao Hattori

ABSTRACT Corynoxeine (COR) is one of 4 bioactive oxindole alkaloids in Uncaria species. In this work two phase I metabolites, namely 11‐hydroxycorynoxeine (M1) and 10‐hydroxycorynoxeine (M2), and two phase II metabolites, namely 11‐hydroxycorynoxeine 11‐ O‐β ‐ d ‐glucuronide (M3) and 10‐hydroxycorynoxeine 10‐ O‐β ‐ d ‐glucuronide (M4), were detected in rat bile after oral dose of COR (0.105 mmol/kg), by optimized high‐performance liquid chromatography–tandem mass spectrometry (LC‐MS n ) with electrospray ionization in positive ion mode. Structures of M1–4 were determined by LC‐MS n , nuclear magnetic resonance, circular dichroism and high‐resolution MS spectra. COR and its metabolites in rat bile were quantified by LC‐MS n . The LC‐MS n quantification methods for COR and its metabolites yielded a linearity with coefficient of determination ≥0.995 from 5.0 × 10 −10 to 5.0 × 10 −7 m . The recoveries of stability tests varied from 96.80 to 103.10%. Accuracy ranged from 91.00 to 105.20%. Relative standard deviation for intra‐day and inter‐day assay was <5.0%. After the oral dose 0.14% of COR was detected in rat bile from 0 to 8 h, in which in total 97.8% COR biotransformed into M1–4. M1 and M2 yielded 48.1 and 49.7%, which successively glucuronidated to M3 and M4 at 47.2 and 43.8%, respectively. Copyright © 2014 John Wiley & Sons, Ltd.

Glucuronide

10.1002/bmc.3149

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Citations (12)

Calcium promotes differentiation in ameloblast-like LS8 cells by downregulation of phosphatidylinositol 3 kinase /protein kinase B pathway

Archives of Oral Biology (2019)

Jianghong Gao Zhen Gao Fan Dang Xinmei Li Hao Liu

Viability assay

10.1016/j.archoralbio.2019.104579

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Citations (5)