OBJECTIVE :To investigate level changes in serum and synovial fluid of IL1,IL6 and
TNFa in osteoarthritis patients and the influences of sodium hyaluronate. METHODS :22
patients with osteoarthritis having hydrops in knee joint cavity were randomized to receive 2 ml
sodium hyaluronate intraarticular injection once 10d for 5 times or functional training plus NSAI
therapy for 50 days.In both arms,the level changes in serum and synovial fluid of IL1,IL6,and
TNFa were measured by ELISA before and after therapy.In statistical analysis the t test between
2 factors and lineal relative recurrence were adopted. RESULTS :In both arms,the titers of
IL1,IL6 and TNFa in synovial fluid before therapy were higher than the corresponding titers in
serum (P0.01).In active arm,the titers of IL1,IL6,and TNFa in synovial fluid after therapy were
lower than before therapy but no change in control arm.In active arm,the serum titers of IL1 and
IL6 after therapy were lower than before therapy,but no change in TNFa titer. CONCLUSION :The
pathogenesis of osteoarthritis is linked to higher titers in serum and synovial fluid of IL1,IL6
and TNFa secreted by articular synovial cells.Titers in synovial fluid of IL1,IL6 and TNFa;and
titers in serum of IL1 and IL6 can be decreased by intraarticular injection of sodium hyaluronate
and the immunopathological lesion progress can be inhibited.
To explore the efficacy and safety of Rivaroxaban in preventing catheter related thrombosis (CRT) in patients with breast cancer who are undergoing central venous catheter chemotherapy, and provide basis for making standardized prevention and treatment strategies.
With the accelerated process of urbanization and a rising degree of urban mobility, urban traffic problems arouse more social concern. There is a consensus on giving priority to the development of public transport which is an important move to implement scientific concepts and construct a resource-saving and environment-friendly society. It is also an important aspect to build a harmonious society. Based on an analysis of existing problems in city traffic, the paper puts forward urban traffic principles and basic contents of sustainable development, and analyzes and discusses the urban traffic costs. Last it puts forward a proposal on the sustainable development of urban traffic from a people-centered concept.
Objective To investigate the characteristics of lymph nodes metastasis in papillary thyroid carcinoma (PTC) and to discuss surgical approach.Methods All patients underwent total thyroidectomy,central lymph nodes and lateral lymph nodes dissection in Department of Thyroid Surgery,the First Hospital of the Jilin University,from Dec.2011 to Dec.2012.Results With the increase of the number of positive central lymph nodes,lateral cervical lymph node metastasis rate increased as well and accompanied multi region metastasis trend.In 102 cases of lateral positive cervical lymph node patients,55 cases were in level Ⅱ,accounting for 53.92％,62 cases were in level Ⅲ,accounting for 60.78％,76 cases were in level Ⅳ,accounting for 74.51％,and 17 cases were in level V,accounting for 16.67％.In lateral lymph nodes metastasis,we found level Ⅳ was the most vulnerable area,followed by level Ⅲ,level Ⅱ and level Ⅴ.Conclusions Prophylactic central lymph node dissection should be performed in PTC patients.Patients with central lymph node metastasis especially with the number of positive lymph nodes ＞ 3 should be performed ipsilateral level Ⅱ-Ⅴ lymph node dissection.
Key words:
Papillary thyroid carcinoma; Lymph node metastasis; Neck dissection
This paper introduce the professor WU Lian-zhong's clinical experience in acupuncture treatment for facial paralysis. Professor WU emphasizes the treatment based on syndrome differentiation. The appropriate theory, method, prescription and acupoints should be applied according to observing the subtle details of syndromes and differentiating the state of diseases development, so as to obtain effectiveness, to shorten the duration of treatment course and to reduce sequelae. The concrete methods of prognosis diagnosis for facial paralysis and three effective cases are introduced.
Objective: To investigate the effect of perioperative care bundle in pediatric patients undergoing minimally invasive digestive endoscopy. Methods: This was a retrospective study using clinical records of pediatric patients who underwent minimally invasive digestive endoscopy surgery at Hebei Children’s Hospital from May 2020 to October 2023. Patients were divided into Care bundle group and Conventional care group based on the treatment received and matched for age, gender, and body mass index in 1:1 ratio. Perioperative vital signs, postoperative recovery, incidence of complications, and family members’ satisfaction with nursing care were analyzed. Results: A total of 98 pediatric patients were included, with 49 patients in each group. After surgery, diastolic blood pressure (DBP), systolic blood pressure (SBP), heart rate (HR), and mean arterial pressure (MAP) of both groups increased compared to preoperative values and were significantly lower in the Care bundle group compared to the Conventional care group (P<0.05). The time for anal exhaust, time for defecation, time to first out-of-bed activity, time to start eating after surgery, and length of hospital stay were shorter in the Care bundle than the Conventional care group (all P<0.05). The incidence of complications in the Care bundle group (4.08%) was lower than the Conventional care group (16.32%) (P<0.05). The overall family members’ satisfaction with the nursing care was considerably higher in the Care bundle group (93.88%) compared to the Conventional care group (81.63%) (P<0.05). Conclusions: Perioperative care bundle in pediatric patients undergoing minimally invasive digestive endoscopy was shown to be more efficacious than the conventional perioperative care. doi: https://doi.org/10.12669/pjms.41.2.11369 How to cite this: Wang L, Zheng L, Zhao X, Gong X, Su Z, Gong S. Perioperative care bundle versus conventional perioperative care in pediatric patients undergoing minimally invasive digestive endoscopy. Pak J Med Sci. 2025;41(2):399-403. doi: https://doi.org/10.12669/pjms.41.2.11369 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background Boswellic acids (BAs) showed promising effects in cancer treatment, immune response regulation, and anti-inflammatory therapy. We aimed to assess the roles of alpha-BA (α-BA) in treating acute wound healing. Methods In vivo wound-healing models were established to evaluate the therapeutic effects of α-BA. Cell assays were conducted to assess the impact of α-BA on cellular biological functions. Western blot analysis was employed to validate the potential mechanisms of action of α-BA. Results Animal models indicated that wound healing was notably accelerated in the α-BA group compared to the control group (P < 0.01). Hematoxylin and eosin (HE) staining and enzyme-linked immunosorbent assay (ELISA) assay preliminarily suggested that α-BA may accelerate wound healing by inhibiting excessive inflammatory reactions and increasing the protein levels of growth factors. Cell function experiments demonstrated that α-BA suppressed the proliferation and migration ability of human hypertrophic scar fibroblasts (HSFBs), thereby favoring wound healing. Additionally, α-BA exerted a significant impact on cell cycle progression. Mechanistically, the protein levels of key genes in nuclear factor kappa beta (NF-κB) signaling pathway, including cyclin D1, p65, IκBα, and p-IκBα, were downregulated by α-BA. Conclusions α-BA demonstrated the ability to counteract the abnormal proliferation of skin scar tissues, consequently expediting wound healing. These findings suggest its potential for development as a new agent for treating acute wound healing.
Pericarpium Citri Reticulatae (Chenpi in Chinese) has been widely used as an herbal medicine in Korea, China, and Japan. Chenpi extracts are used to treat indigestion and inflammatory syndromes of the respiratory tract such as bronchitis and asthma. This thesis will analyze chemical compositions of Chenpi volatile oil, which was performed by comprehensive two-dimensional gas chromatography with high-resolution time-of-flight mass spectrometry (GC × GC-HR-TOFMS). One hundred and sixty-seven components were tentatively identified, and terpene compounds are the main components of Chenpi volatile oil, a significant larger number than in previous studies. The majority of the eluted compounds, which were identified, were well separated as a result of high-resolution capability of the GC × GC method, which significantly reduces, the coelution. β -Elemene is tentatively qualified by means of GC × GC in tandem with high-resolution TOFMS detection, which plays an important role in enhancing the effects of many anticancer drugs and in reducing the side effects of chemotherapy. This study suggests that GC × GC-HR-TOFMS is suitable for routine characterization of chemical composition of volatile oil in herbal medicines.
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