Ying Zhou

Chongqing Medical University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Maolin Pang

Guangxi Normal University

Sainan Liu

Changchun Institute of Applied Chemistry

Lihan Cai

Dalian University

Chunling Hu

Shihezi University

Zhendong Liu

University of Science and Technology of China

Wen Song

Hainan University

Yuan Xiong

Huazhong University of Science and Technology

Tao Wan

Zhejiang University

Shujun Song

Wuhan University of Science and Technology

Jing Kuang

Second Affiliated Hospital of Zhengzhou University

Cooperative Institutions

Chinese Academy of Sciences

Wuhan University of Science and Technology

Chongqing Medical University

Changchun Institute of Applied Chemistry

University of Science and Technology of China

University of Chinese Academy of Sciences

Dalian Medical University

Second Affiliated Hospital of Chongqing Medical University

Jilin University

Sun Yat-sen University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Theoretical Study of the 1CF2 + 3O2 Reaction on the Singlet Potential Surface

Advanced materials research (2013)

Cong Yun Shi Jia Yu Xing Zhong Liu Yan Yang Lin Wu

A detailed singlet potential energy surface survey on the 1 CF 2 + 3 O 2 reaction is carried out in order to clarify the reaction mechanisms of the singlet difluorocarbene ( 1 CF 2 ) with oxygen ( 3 O 2 ) at the B3LYP/6-311++G(d,p) level. To determine the accurate energies of all stationary points, the QCISD/6-311++G(d,p) single-point calculations are done by using the B3LYP/6-311++G(d,p) optimized geometric structures. The title reaction is important in high temperature processes. Four product channels, P 1 (F 2 + CO 2 ), P 2 (F 2 O + CO), P 3 (2F + CO 2 ) and P 4 (FCO + FO), have been found in the 1 CF 2 + 3 O 2 reaction. P 1 (F 2 + CO 2 ) and P 3 (2F + CO 2 ) have comparable contributions to the title reaction and they are more favorable than the other two thermodynamically and kinetically.

Difluorocarbene

10.4028/www.scientific.net/amr.641-642.140

Cite

Citations (0)

SeisGPT: A Physics-Informed Data-Driven Large Model for Real-Time Seismic Response Prediction

arXiv (Cornell University) (2024)

Shiqiao Meng Ying Zhou Quanle Zheng Bingxu Liao Mushi Chang

Accurately predicting the dynamic responses of building structures under seismic loads is essential for ensuring structural safety and minimizing potential damage. This critical aspect of structural analysis allows engineers to evaluate how structures perform under various loading conditions, facilitating informed design and safety decisions. Traditional methods, which rely on complex finite element models often struggle with balancing computational efficiency and accuracy. To address this challenge, we introduce SeisGPT, a data-driven, large physics-informed model that leverages deep neural networks based on the Generative Pre-trained Transformer (GPT) architecture. SeisGPT is designed to predict, in real-time the dynamic behavior of building structures under seismic forces. Trained on a diverse corpus of seismic data and structural engineering principles, it instantly generates predictive responses, including displacement, acceleration, and inter-story drift, with high accuracy and computational efficiency. Its adaptability across various building typologies and seismic intensities makes this framework a valuable tool for designing robust structures and assessing seismic risk. Through comprehensive validation, this approach exhibits superior performance, offering engineers and researchers a powerful tool for assessing seismic response and informing resilient design strategies. This innovative framework represents a significant advancement in seismic engineering practice, with potential applications in mitigating seismic hazards and enhancing structural resilience.

10.48550/arxiv.2410.20186

Cite

Citations (0)

A Robust Oxygen-Carrying Hemoglobin-Based Natural Sonosensitizer for Sonodynamic Cancer Therapy

Nano Letters (2021)

Meng Yuan Shuang Liang Ying Zhou Xiao Xiao Bin Liu

The development of novel sonosensitizers with outstanding reactive oxygen (ROS) generation capacity and great biocompatibility poses a significant challenge for the clinical practice of sonodynamic therapy (SDT). In this work, hemoglobin (Hb) with natural metalloporphyrin was first shown to possess great potential as a sonosensitizer. Compared with traditional organic sonosensitizers, Hb had satisfactory sono-sensitizing efficiency because four the porphyrin molecules were separated by four polypeptide chains. This effectively avoided the problem of low ROS quantum yield caused by the stacking of hydrophobic porphyrins. Meanwhile, Hb is an efficient and safe oxygen carrier that may release O2 at hypoxic tumors site, which improved tumor oxygenation and subsequently enhanced SDT efficacy. Therefore, Hb was integrated with zeolitic imidazolate framework 8 (ZIF-8) to form a nanoplatform that demonstrated a potent suppression effect on deep-seated tumors under ultrasound irradiation.

Sonodynamic therapy

Biocompatibility

Imidazolate

10.1021/acs.nanolett.1c01220

Cite

Citations (119)

Mitochondria-targeted high-load sound-sensitive micelles for sonodynamic therapy to treat triple-negative breast cancer and inhibit metastasis

Materials Science and Engineering C (2021)

Xiao Han Zeyu Song Ying Zhou Yujing Zhang Yulin Deng

Sonodynamic therapy

Triple-negative breast cancer

Breast cancer metastasis

10.1016/j.msec.2021.112054

Cite

Citations (23)

A covalent organic framework-based multifunctional therapeutic platform for enhanced photodynamic therapy via catalytic cascade reactions

Science China Materials (2020)

Lihan Cai Chunling Hu Sainan Liu Ying Zhou Maolin Pang

Biocompatibility

Covalent organic framework

Bioorthogonal Chemistry

10.1007/s40843-020-1428-0

Cite

Citations (48)

Copper-Doped Nanoscale Covalent Organic Polymer for Augmented Photo/Chemodynamic Synergistic Therapy and Immunotherapy

Bioconjugate Chemistry (2020)

Chunling Hu Lihan Cai Sainan Liu Ying Liu Ying Zhou

Due to the specific tumor microenvironment (TME) and immunosuppressive state of cancer cells, conventional antitumor therapies face severe challenges, such as high rates of recurrence and metastasis. Herein, Cu-PPT nanoparticles were synthesized based on copper acetate, p-phenylenediamine, and 5,10,15,20-tetra-(4-aminophenyl)porphyrin via oxidative coupling reaction for the first time, and the resultant product was used for synergistic photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT). The polymer nanoparticles exhibited excellent photodynamic and photothermal effect with a photothermal conversion efficacy of 40.1% under 650 and 808 nm laser irradiation, respectively. Encapsulated Cu(I)/Cu(II) ions permitted Cu-PPT with glutathione (GSH) peroxidase-mimicking, catalase-mimicking, and Fenton-like activity to regulate TME. Depletion of overexpressed GSH would reduce antioxidant capacity, generated O2 could relieve hypoxia for enhancing PDT, and hyperthermia from PTT could promote the yield of ·OH. This multifunctional nanosystem with cascade reactions could inhibit tumor growth and activate immune responses effectively. By further combining with antiprogrammed death-ligand 1 (anti-PD-L1) checkpoint blockade therapy, distant tumor growth and cancer metastasis were successfully suppressed.

Tumor Hypoxia

10.1021/acs.bioconjchem.0c00209

Cite

Citations (70)

Activating Innate Immunity by a STING Signal Amplifier for Local and Systemic Immunotherapy

ACS Nano (2022)

Wen Song Shujun Song Jing Kuang Hang Yang Tao Yu

The number of patients who benefit from acquired immunotherapy is limited. Stimulator of interferon genes (STING) signal activation is a significant component to enhance innate immunity, which has been used to realize broad-spectrum immunotherapy. Here, M@P@HA nanoparticles, as a STING signal amplifier, are constructed to enhance innate immunotherapy. Briefly, when M@P@HA was targeted into tumor cells, the nanoparticles decomposed with Mn2+ and activated the release of protoporphyrin (PpIX). Under light irradiation, the generated reactive oxygen species disrupt the cellular redox homeostasis to lead cytoplasm leakage of damaged mitochondrial double-stranded (ds) DNA, which is the initiator of the STING signal. Simultaneously, Mn2+ as the immunoregulator could significantly increase the activity of related protein of a STING signal, such as cyclic GMP-AMP synthase (cGAS) and STING, to further amplify the STING signal of tumor cells. Subsequently, the STING signal of tumor-associated macrophages (TAM) is also activated by capturing dsDNA and Mn2+ that escaped from tumor cells, so as to enhance innate immunity. It is found that, by amplifying the STING signal of tumor tissue, M@P@HA could not only activate innate immunity but also cascade to activate CD8+ T cell infiltration even in a tumor with low immunogenicity.

Sting

10.1021/acsnano.2c03509

Cite

Citations (45)

Novel combination strategy of high intensity focused ultrasound (HIFU) and checkpoint blockade boosted by bioinspired and oxygen-supplied nanoprobe for multimodal imaging-guided cancer therapy

Journal for ImmunoTherapy of Cancer (2023)

Rui Tang Hongye He Xiaohong Lin Nianhong Wu Li Wan

Background High-intensity focused ultrasound (HIFU) has shown considerable promise in treating solid tumors, but its ultrasonic energy is easily attenuated, resulting in insufficient energy accumulation in the target area. Moreover, HIFU ablation alone may inevitably lead to the presence of residual tumors, which may cause tumor recurrence and metastasis. Here, we describe a synergistic regimen combining HIFU facilitation with immunomodulation based on a novel oxygen-carrying biomimetic perfluorocarbon nanoparticle (M@P-SOP) to stimulate immunogenic cell death in tumor cells while alleviating immune suppression tumor microenvironment. Methods M@P-SOP was prepared by double emulsion and film extrusion method. The anticancer and antimetastatic effects of M@P-SOP were evaluated on a preclinical transplanted 4T1 tumor model by combining HIFU and immunotherapy. Flow cytometry and immunofluorescence were used to clarify the potential mechanism of HIFU+M@P-SOP and their role in anti-programmed death ligand-1 (PD-L1) therapy. Results Guided by photoacoustic/MR/ultrasound (US) multimodal imaging, M@P-SOP was abundantly enriched in tumor, which greatly enhanced HIFU’s killing of tumor tissue in situ, induced stronger tumor immunogenic cell death, stimulated dendritic cell maturation and activated CD8 + T cells. At the same time, M@P-SOP released oxygen to alleviate the tumor hypoxic environment, repolarizing the protumor M2-type macrophages into antitumor M1-type. With concurrent anti-PD-L1 treatment, the antitumor immune response was further amplified to the whole body, and the growth of mimic distant tumor was effectively suppressed. Conclusions Our findings offer a highly promising HIFU synergist for effectively ameliorating acoustic and hypoxia environment, eventually inhibiting tumor growth and metastasis by stimulating host’s antitumor immunity under HIFU ablation, especially in synergizing with PD-L1 antibody immunotherapy.

High-intensity focused ultrasound

Immunogenic cell death

Bioluminescence imaging

Immune checkpoint

10.1136/jitc-2022-006226

Cite

Citations (24)

Covalent Organic Framework-Based Nanocomposite for Synergetic Photo-, Chemodynamic-, and Immunotherapies

ACS Applied Materials & Interfaces (2020)

Sainan Liu Ying Zhou Chunling Hu Lihan Cai Maolin Pang

Cancer deaths are mainly caused by tumor metastases. However, tumor ablation therapies can only target the primary tumor but not inhibit tumor metastasis. Herein, a multifunctional covalent organic framework (COF)-based nanocomposite is designed for synergetic photo-, chemodynamic- and immunotherapies. Specifically, the synthesized COF possesses the ability to produce singlet oxygen under the 650 nm laser irradiation. After being metallized with FeCl3, p-phenylenediamine is polymerized on the surface of COF with Fe3+ as the oxidant. The obtained poly(p-phenylenediamine) can be used for photothermal therapy. Meanwhile, the overexpressed H2O2 in the tumor would be further catalyzed and decomposed into hydroxyl radicals (•OH) by the Fe3+/Fe2+ redox couple via Fenton reaction. Intriguingly, the increase of temperature caused by photothermal therapy can accelerate the production of •OH. Moreover, the tumor-associated antigen induced a robust antitumor immune response and effectively inhibited tumor metastasis in the presence of anti-PD-L1 checkpoint blockade. Such a COF-based multifunctional nanoplatform provides an efficacious treatment strategy for both the primary tumor and tumor metastasis.

Tumor ablation

Covalent organic framework

Immune checkpoint

10.1021/acsami.0c12824

Cite

Citations (53)

Covalent Organic Framework–Titanium Oxide Nanocomposite for Enhanced Sonodynamic Therapy

Bioconjugate Chemistry (2021)

Lihan Cai Chunling Hu Sainan Liu Ying Zhou Zhendong Liu

Sonodynamic therapy (SDT) has attracted wide attention for its high tissue-penetration depth capacity. However, developing new kinds of sonosensitizers that are capable of generating large amounts of reactive oxygen species (ROS) still remains a challenge. Herein, covalent organic framework-titanium oxide nanoparticles (COF-TiO2 NPs) were successfully synthesized by using COF as a template. Under ultrasound (US) irradiation, large quantities of ROS can be generated, and compared with pure TiO2 NPs, the SDT performance of COF-TiO2 nanoparticles was significantly improved due to the narrower band gap. Both in vitro and in vivo experiments demonstrated the great tumor inhibitory effect via COF-TiO2-mediated SDT. This work broadens the biomedical applications of COF-based composites.

Sonodynamic therapy

Covalent organic framework

Titanium oxide

10.1021/acs.bioconjchem.1c00039

Cite

Citations (35)