Bingxian Yang

Zhejiang Sci-Tech University

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Jingkui Tian

Zhejiang Cancer Hospital

Wei Zhu

Zhejiang Cancer Hospital

Zhuoheng Zhong

Zhejiang Sci-Tech University

Qijie Guan

University of Mississippi

Tantan Wang

Zhejiang University

Setsuko Komatsu

Fukui University of Technology

Ji Ma

Obstetrics and Gynecology Hospital of Fudan University

Jingkui Tian

Chinese Academy of Sciences

Ghazala Mustafa

Quaid-i-Azam University

Yaohan Li

Peking Union Medical College Hospital

Cooperative Institutions

Zhejiang University

Zhejiang Sci-Tech University

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Fudan University

Ministry of Agriculture and Rural Affairs

Zhejiang Cancer Hospital

China Agricultural University

Cancer Hospital of Chinese Academy of Medical Sciences

Southwest University

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The complete chloroplast genome sequence of Clematis terniflora DC. (Ranunculaceae)

Mitochondrial DNA Part A (2015)

Mengzhu Li Bingxian Yang Qinyi Chen Wei Zhu Ji Ma

Clematis terniflora DC. is an important medicinal plant used in the treatment of inflammatory symptoms related to respiratory and urinary systems. In this study, we found that the complete cp genome of C. terniflora DC. is 159,528 bp. The phylogenetic analysis of 32 taxa showed a strong sister relationship with Ranunculus macranthus, which also strongly supports the position of Ranunculales. The complete cp genome sequence of Clematis terniflora DC. reported here has the potential to advance population and phylogenetic studies of this medicinal plant.

Clematis

Ranunculaceae

Aconitum

Sister group

Phylogenetic relationship

Ranunculus

10.3109/19401736.2015.1033702

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Citations (8)

RNA-Seq transcriptomic analysis of the Morus alba L. leaves exposed to high-level UVB with or without dark treatment

Gene (2017)

Qijie Guan Jiaojiao Yu Wei Zhu Bingxian Yang Yaohan Li

Flavonoid Biosynthesis

Secondary metabolism

RNA-Seq

10.1016/j.gene.2017.12.045

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Citations (19)

Integrative Omic Analysis Reveals the Dynamic Change in Phenylpropanoid Metabolism in Morus alba under Different Stress

Plants (2023)

Yaohan Li Shengzhi Liu Di Zhang Amin Liu Wei Zhu

Morus alba is used as a traditional Chinese medicine due to its various biological activities. Phenylpropanoid metabolism is one of the most important pathways in Morus alba to produce secondary metabolites and response to stress. From the general phenylpropanoid pathway, there are two metabolic branches in M. alba, including flavonoid and lignin biosynthesis, which also play roles in response to stress. However, the dynamic changes between flavonoid and lignin biosynthesis under Botrytis cinerea infection and UV-B stress in M. alba were unclear. To explore the different regulation mode of flavonoid and lignin biosynthesis in M. alba leaves' response to biotic and abiotic stress, a combined proteomic and metabolomic study of M. alba leaves under UV-B stress and B. cinerea infection was performed. The results showed that most of the proteins involved in the lignin and flavonoid biosynthesis pathway were increased under either UV-B stress or B. cinerea infection in M. alba. This was also confirmed by enzyme assays and metabolomics analysis. Additionally, the abundance of proteins involved in the biosynthesis of jasmonic acid was increased after B. cinerea infection. This suggests that both flavonoid and lignin biosynthesis participate in the responses to abiotic and biotic stress in M. alba, but they might be regulated by different hormone signaling.

Phenylpropanoid

Flavonoid Biosynthesis

Secondary metabolism

Metabolic pathway

Biotic stress

Jasmonic acid

10.3390/plants12183265

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Citations (4)

An in vivo and in vitro assessment of the anti-inflammatory, antinociceptive, and immunomodulatory activities of Clematis terniflora DC. extract, participation of aurantiamide acetate

Journal of Ethnopharmacology (2015)

X.B. Liu Bingxian Yang L. Zhang Yin Lu Min Gong

Clematis

Anti-inflammatory

10.1016/j.jep.2015.04.009

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Citations (36)

Integrative omic analysis reveals the dynamic change of phenylpropanoid metabolism in Morus alba under different stress

Zenodo (CERN European Organization for Nuclear Research) (2023)

Yaohan Li Shengzhi Liu Di Zhang Amin Liu Wei Zhu

Phenylpropanoid

10.5281/zenodo.8284018

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Citations (0)

Melatonin elevated Sclerotinia sclerotiorum resistance via modulation of ATP and glucosinolate biosynthesis in Brassica rapa ssp. pekinensis

Journal of Proteomics (2021)

Zhiyan Teng Youjian Yu Zhujun Zhu Seung‐Beom Hong Bingxian Yang

Sclerotinia Sclerotiorum

Brassica rapa

Sclerotinia

Stem rot

10.1016/j.jprot.2021.104264

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Citations (33)

The complete chloroplast genome sequence of Sapindus mukorossi

Mitochondrial DNA Part A (2014)

Bingxian Yang Mengzhu Li Ji Ma Zheng-Zheng Fu Xiaobao Xu

The complete chloroplast genome sequence of Sapindus mukorossi, a critical Chinese medicine, was reported here. The total length of the chloroplast genome is 160,481 bp long with 37.7% overall GC content. A pair of IRs (inverted repeats) of 27,979 bp were separated by SSC (18,873 bp) and LSC (85,650 bp). It contains 78 protein-coding genes, 30 tRNA genes and four rRNA genes. Sixteen genes contain one or two introns.

Inverted repeat

GC-content

10.3109/19401736.2014.971243

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Citations (10)

The complete chloroplast genome sequence of Fatsia japonica (Apiales: Araliaceae) and the phylogenetic analysis

Mitochondrial DNA Part A (2015)

Qinyi Chen Xiao Feng Mengzhu Li Bingxian Yang Cuixia Gao

In this study, we have sequenced the complete chloroplast genome of Fatsia japonica, a well-known ornamental and potential medicinal plant. The complete chloroplast genome of F. japonica is 155 613 bp in length with 62.09% AT content, has a typical quadripartite structure with large (LSC 86 487 bp) and small (SSC 17 866 bp) single-copy regions separated by a pair of inverted repeats (IRs 25 929 bp) and contains 114 unique genes with 18 genes duplicated in the IR making a total of 132 genes. The phylogenetic analysis indicated the position of F. japonica in Apiales and has the potential to facilitate a better understanding of the intergeneric relationships in the family.

Inverted repeat

Araliaceae

10.3109/19401736.2015.1063129

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Citations (7)

Proteomics and metabolomics reveal the mechanism underlying differential antioxidant activity among the organs of two base plants of Shiliang tea (Chimonanthus salicifolius and Chimonanthus zhejiangensis)

Food Chemistry (2022)

Bingxian Yang Qi Li Kaisen Cheng Jie Fang Ghazala Mustafa

Phenylpropanoid

10.1016/j.foodchem.2022.132698

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Citations (20)

Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo by inhibiting autophagic flux

Journal of Cellular and Molecular Medicine (2015)

Yi Yang Lihui Zhang Bingxian Yang Jin‐kui Tian Lin Zhang

Abstract We aim to investigate the effect of aurantiamide acetate isolated from the aerial parts of C lematis terniflora DC against gliomas. Human malignant glioma U87 and U251 cells were incubated with different concentrations (0–100 μM) of aurantiamide acetate. Aurantiamide acetate greatly decreased the cell viability in a dose‐ and time‐dependent manner. It induced moderate mitochondrial fragmentation and the loss of mitochondrial membrane potential. No significant difference was found in the alternation of other intracellular organelles, although F‐actin structure was slightly disturbed. Apparent ultrastructure alternation with increased autophagosome and autolysosome accumulation was observed in aurantiamide acetate‐treated cells. The expression of LC 3‐ II was greatly up‐regulated in cells exposed to aurantiamide acetate ( P < 0.05 compared with control). The cytoplasmic accumulation of autophagosomes and autolysosomes induced by aurantiamide acetate treatment was confirmed by fluorescent reporter protein labelling. Administration of chloroquine ( CQ ), which inhibits the fusion step of autophagosomes, further increased the accumulation of autophagosomes in the cytoplasm of U87 cells. Autophagy inhibition by 3‐methyladenine, Bafilomycin A1 or CQ had no influence on aurantiamide acetate‐induced cytotoxicity, whereas autophagy stimulator rapamycin significantly suppressed aurantiamide acetate‐induced cell death. The anti‐tumour effects of aurantiamide acetate were further evaluated in tumour‐bearing nude mice. Intratumoural injection of aurantiamide acetate obviously suppressed tumour growth, and increased number of autophagic vacuoles was observed in tumour tissues of animals receiving aurantiamide acetate. Our findings suggest that aurantiamide acetate may suppress the growth of malignant gliomas by blocking autophagic flux.

10.1111/jcmm.12498

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Citations (24)