当科において経験した血管性病変74例 (1983～1996年) の治療法, 予後, 臨床経過における問題点について動静脈奇形を中心に検討した。治療方針としては外科的切除を第一選択とした。しかし動静脈奇形における広範囲進展例では, 顎顔面特有の機能・審美性の温存や患者の意向を考慮すると根治的治療の遂行が困難であり, 塞栓術を適用した。塞栓物質の選択は予後に大きく影響した。ゼルフォーム, アイバロン, 金属コイルを用いた症例の中には, 栄養動脈の再開通や側副血管路開通に加えて追加塞栓が徐々に困難となり, 病変部の疾痛増強と出血を繰り返した後, 出血性ショックにて死亡した1例を経験した。一方, シアノアクリレートは重合時間の調節が困難であったが, 永久塞栓物質としての塞栓効果は高かった。動静脈奇形は病巣部の拡大に伴い著明な歯周疾患と歯牙喪失がみられ, 大量出血の誘因になっていたことから, 積極的な歯牙, 歯周管理は不可欠と考える。

Arteriovenous malformation

Vascular malformation

10.5981/jjhnc1974.23.131

Cite

Citations (0)

The microbiome of the “sterile” pustules in palmoplantar pustulosis

Experimental Dermatology (2018)

Kana Masuda‐Kuroki Masamoto Murakami Naohito Tokunaga Mari Kishibe Hideki Mori

The skin microbiome influences skin pathophysiology. Palmoplantar pustulosis (PPP) is a chronic skin disease characterized by infectious-like pustules on the palms and soles. These pustules are thought to be sterile because bacterial cultures obtained from the pustules are negative. However, culture methods are limited in their ability to identify all bacteria on the skin. We hypothesized that the "sterile" pustules of PPP do not lack bacteria, but rather contain a microbiome. To test this hypothesis, we identified bacteria in "sterile" pustules using non-culture methods. We conducted Sanger and 16S rRNA sequencing using primers specific to the V1-V2 region in PPP-pustulovesicles (PVs) (n = 43) and pompholyx vesicle fluids (n = 15). Sanger sequencing identified some Staphylococcus, Propionibacterium, Streptococcus and Pyrinomonas species in PPP-PVs but failed to identify any bacteria in most of the pompholyx vesicles. 16S rRNA sequencing of PPP-PVs indicated the presence of a microbiome that included various phyla, including Firmicutes, Proteobacteria, Actinobacteria and Bacteroidetes. At the genus level, smokers had higher levels of Staphylococcus in PPP-PVs compared with non-smokers. These results indicate that a microbiome exists in "sterile" pustules of PPP and that PPP smokers had higher levels of Staphylococcus in pustules. It is therefore necessary to reconsider the pathogenesis of PPP from the perspective of the microbiome.

Palmoplantar pustulosis

Fusobacteria

10.1111/exd.13791

Cite

Citations (16)

Five-level inverter having only double DC power supplies

European Conference on Power Electronics and Applications (2005)

Isamu Yamamoto Kunihiko Matsui S. Yamaguchi Hideki Mori Fukashi Ueda

The five-level PWM inverter has many advantages such as ability to operate the AC motors or the power compensator with very large capacity in nearly sinusoidal current waveforms. For these reasons, these applications have just begun to study. However, this circuit must provide four DC power supplies for supplying the active power. In this paper, we propose a novel double power supply method, in which both power supplies are interconnected by DC capacitors. The voltages of the interconnected DC capacitor are controlled by a novel third order harmonic injection method, where the phase of modified third order harmonic signal having positive or negative polarity is controlled individually

Harmonic

Polarity (international relations)

SIGNAL (programming language)

10.1109/epe.2005.219206

Cite

Citations (0)

Capacitor voltage controls of novel five-level inverter having only double DC power supplies

Isamu Yamamoto Kunihiko Matsui S. Yamaguchi M. Hasegawa Hideki Mori

The five-level PWM inverter has many advantages such as ability to operate the AC motors or the power compensator with very large capacity in nearly sinusoidal current waveforms. For these reasons, these applications have just begun to study. However, this circuit must provide four DC power supplies for supplying the active power. In this paper, we propose a novel double power supply method, in which both power supplies are inter-connected by DC capacitors. The voltages of the inter-connected DC capacitor are controlled by a novel third order harmonic injection method, where the phase of modified third order harmonic signal having positive or negative polarity is controlled individually

Harmonic

Polarity (international relations)

SIGNAL (programming language)

10.1109/iecon.2005.1568994

Cite

Citations (0)

A Case of Perineal Endometriosis with Findings Similar to Deeply Infiltrating Endometriosis by MRI

Nihon Daicho Komonbyo Gakkai Zasshi (2019)

Kaori Tanaka Takuo Nishina Noriaki Kojima T. Mase Hideki Mori

症例は45歳女性で，4年前に第2子を出産後，肛門膣間に疼痛を伴う硬結を自覚していた．最近疼痛が増悪してきたため当科受診した．肛門膣間右側に分娩時の会陰切開痕を認め，直下に可動性のない径4cmの硬結を触知した．会陰部痛は月経周期に付随していた．CA125が高値を示し，MRI（T2WI）では低信号の腫瘤の内部に点状の高信号域を認めた．生検にて会陰部子宮内膜症と診断した．腫瘍が肛門括約筋に広く浸潤していたため，肛門機能を温存した腫瘍全摘は困難と判断．45歳と閉経に近く挙児希望がないことより，ホルモン療法を選択した．治療開始半年後のMRIでは明らかに腫瘍の縮小を認め，CA125も著減し，会陰部痛も消失した．会陰部異所性子宮内膜症はまれな疾患であるが，肛門診察で遭遇する可能性がある疾患である．本症例が非典型的なMRI所見を呈したこともあり，会陰部子宮内膜症のMRI所見についても考察する．

10.3862/jcoloproctology.72.439

Cite

Citations (0)

Selective epitaxial growth of GaAs by low-pressure MOVPE

Journal of Crystal Growth (1985)

Koichi Kamon Shigenori Takagishi Hideki Mori

Torr

Deposition

10.1016/0022-0248(85)90332-x

Cite

Citations (93)

Multi-output chopper circuit for input power supplies of five-level inverter

Kunihiko Matsui Isamu Yamamoto Hideki Mori

In the fields such as various electric power compensators and ac motor drives, large capacity and high-performance converters are wished to be put into practical applications. For these converters, since the upper limit of the switching frequency is low and capacity of device is insufficient, method of connecting the device in series and parallel would be effective. From such reasons, for improving the harmonic characteristics, various multi-level inverters have been reported, in which it is necessary to provide some dc power supplies connected in series that is disadvantage for this inverter. We propose a simple dc-dc converter for adjusting the power supply voltages of this inverter. By means of this dc-dc converter circuit, the voltages of four dc power supplies of five-level inverter can be suitably controlled towards a desired value. The circuit characteristics are discussed by theoretical and simulated procedures. The theoretical results and the simulated ones agree with each other.

Chopper

Grid-tie inverter

Harmonic

10.1109/mwscas.2004.1354147

Cite

Citations (2)

Chemoprevention of Colon Carcinogenesis by Dietary Non-nutritive Compounds.

PubMed (2001)

Takuji Tanaka Hiroyuki Kohno Hideki Mori

In addition to mutagens and/or carcinogens a number of modulators of carcinogenesis are present in our environment. Some of them are contained in our regular foods and therefore dietary factors play a role in the development of some types of cancers including colon cancer. Epidemiological studies have suggested that a diet rich in fruits and vegetables is associated with reduced risk for a number of common cancers. There are still many unknown constituents and/or factors in foods that could either enhance or reduce the possibility of developing cancer. Animal studies of experimental chemical carcinogenesis have indicated that several non-nutritive components in foods, belonging to different chemical groups, protect against certain types of cancers including colonic neoplasms. These chemicals are known as "chemopreventive agents". Many of them are antioxidants and might suppress carcinogenesis through: (I) inhibiting Phase I enzymes; (ii) induction of Phase II enzymes; (iii) scavenging DNA reactive agents; (iv) suppression of hyper-cell proliferation induced by carcinogens; and/or (v) inhibition of certain properties of neoplastic cells. With the continuing increase in the incidence of colon cancer, there is an ever increasing need to determine the most effective means for prevention and to understand the underlying mechanism(s). Previous studies in our laboratory demonstrated protective effects of several naturally occurring products against rat colon tumorigenesis. This article will introduce our recent studies in our search for chemopreventive effects of flavonoids (diosmin and hesperidin) and other phytochemicals in edible plants on rat colon carcinogenesis.

Diosmin

Anticarcinogen

Source

Cite

Citations (55)