Manman Liu

University of Science and Technology of China

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Yangzhong Liu

University of Science and Technology of China

Junjie Cheng

University of Science and Technology of China

Yang Zhu

National University of Singapore

Duo Jin

University of Science and Technology of China

Jiaji Yu

University of Science and Technology of China

Wenxin Yu

University of Science and Technology of China

Yi Dai

Anhui Xinhua University

Xiaoyuan Chen

National University of Singapore

Jianhua Zou

National University of Singapore

David J. Singh

University of Missouri

Cooperative Institutions

University of Science and Technology of China

Chinese Academy of Sciences

Hefei National Center for Physical Sciences at Nanoscale

University of Chinese Academy of Sciences

Hefei University

Collaborative Innovation Center of Chemistry for Energy Materials

National Synchrotron Radiation Laboratory

High Magnetic Field Laboratory

Zhejiang University

Fujian Institute of Research on the Structure of Matter

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Biocompatible Ruthenium Single-Atom Catalyst for Cascade Enzyme-Mimicking Therapy

ACS Applied Materials & Interfaces (2021)

Wenyu Wang Yang Zhu Xiaorong Zhu Yafei Zhao Zhenggang Xue

Rationally constructing single-atom enzymes (SAEs) with superior activity, robust stability, and good biocompatibility is crucial for tumor therapy but still remains a substantial challenge. In this work, we adopt biocompatible carbon dots as the carrier material to load Ru single atoms, achieving Ru SAEs with superior multiple enzyme-like activity and stability. Ru SAEs behave as oxidase, peroxidase, and glutathione oxidase mimics to synchronously catalyze the generation of reactive oxygen species (ROS) and the depletion of glutathione, thus amplifying the ROS damage and finally causing the death of cancer cells. Notably, Ru SAEs exhibit excellent peroxidase-like activity with a specific activity of 7.5 U/mg, which surpasses most of the reported SAEs and is 20 times higher than that of Ru/C. Theoretical results reveal that the electrons of the Ru 4d orbital in Ru SAEs are transferred to O atoms in H2O2 and then efficiently activate H2O2 to produce •OH. Our work may provide some inspiration for the design of SAEs for cancer therapy.

Biocompatibility

Biocompatible material

Thermal Stability

Cancer Therapy

Glucose oxidase

10.1021/acsami.1c12706

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Citations (51)

Nanobody‐Ferritin Conjugate for Targeted Photodynamic Therapy

Chemistry - A European Journal (2020)

Manman Liu Yang Zhu Tiantian Wu Junjie Cheng Yangzhong Liu

Abstract Ferritin is an iron‐storage protein nanocage that is assembled from 24 subunits. The hollow cavity of ferritin enables its encapsulation of various therapeutic agents; therefore, ferritin has been intensively investigated for drug delivery. The use of antibody‐ferritin conjugates provides an effective approach for targeted drug delivery. However, the complicated preparation and limited protein stability hamper wide applications of this system. Herein, we designed a novel nanobody‐ferritin platform (Nb‐Ftn) for targeted drug delivery. The site‐specific conjugation between nanobody and ferritin is achieved by transglutaminase‐catalyzed protein ligation. This ligation strategy allows the Nb conjugation after drug loading in ferritin, which avoids deactivation of the nanobody under the harsh pH environment required for drug encapsulation. To verify the tumor targeting of this Nb‐Ftn platform, a photodynamic reagent, manganese phthalocyanine (MnPc), was loaded into the ferritin cavity, and an anti‐EGFR nanobody was conjugated to the surface of the ferritin. The ferritin nanocage can encapsulate about 82 MnPc molecules. This MnPc@Nb‐Ftn conjugate can be efficiently internalized by EGFR positive A431 cancer cells, but not by EGFR negative MCF‐7 cells. Upon 730 nm laser irradiation, MnPc@Nb‐Ftn selectively killed EGFR positive A431 cells by generating reactive oxygen species (ROS), whereas no obvious damage was observed on MCF‐7 cells. Given that ferritin can be used for encapsulation of various therapeutic agents, this work provides a strategy for facile construction of nanobody‐ferritin for targeted drug delivery.

Conjugate

Nanocages

10.1002/chem.202000075

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Citations (40)

Enhancing Tumor Immunotherapy by Multivalent Anti‐PD‐L1 Nanobody Assembled via Ferritin Nanocage

Advanced Science (2024)

Manman Liu Duo Jin Wenxin Yu Jiaji Yu Kaiming Cao

Increasing immunotherapy response rate and durability can lead to significant improvements in cancer care. To address this challenge, a novel multivalent immune checkpoint therapeutic platform is constructed through site-specific ligation of anti-PD-L1 nanobody (Nb) on ferritin (Ftn) nanocage. Nb-Ftn blocks PD-1/PD-L1 interaction and downregulates PD-L1 levels via endocytosis-induced degradation. In addition, the cage structure of Ftn allows encapsulation of indocyanine green (ICG), an FDA-approved dye. Photothermal treatment with Nb-Ftn@ICG induces immunogenic death of tumor cells, which improves systemic immune response via maturation of dendritic cells and enhanced infiltration of T cells. Moreover, Nb-Ftn encapsulation significantly enhances cellular uptake, tumor accumulation and retention of ICG. In vivo assays showed that this nanoplatform ablates the primary tumor, suppresses abscopal tumors and inhibits tumor metastasis, leading to a prolonged survival rate. This work presents a novel strategy for improving cancer immunotherapy using multivalent nanobody-ferritin conjugates as immunological targeting and enhancing carriers.

Nanocages

Cancer Immunotherapy

Abscopal effect

10.1002/advs.202308248

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Citations (10)

Ni3S2 nanowires supported on Ni foam as efficient bifunctional electrocatalyst for urea-assisted electrolytic hydrogen production

Catalysis Today (2019)

Manman Liu Yongli Jiao Sihui Zhan Haitao Wang

Overpotential

Nickel sulfide

10.1016/j.cattod.2019.05.032

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Citations (59)

Simulation and experimental study on the aerodynamic characteristics of a high-speed elevator with three-sided arc fairings

Journal of Building Engineering (2023)

Jun Zhang Manman Liu Minzong Li Bei Liu Shenxin Jin

Aerodynamic force

Elevator

10.1016/j.jobe.2023.108172

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Mitochondrial genomes and phylogenomic analysis of Ulva lactuca Linnaeus (Ulvophyceae, Chlorophyta)

Mitochondrial DNA Part B (2020)

Manman Liu Feng Liu Nansheng Chen James T. Melton Luo Min-bo

Two mitogenomes of Ulva lactuca Linnaeus, one from Florida, USA and another nearly complete mtDNA from Chile, had previously been sequenced. Here, the complete mitogenome of U. lactuca from Shantou, China was sequenced and compared with them. The circular-mapping mitogenome of U. lactuca was 62,021 bp in size and 407 bases longer than that from the USA. The average sequence identity in gene sequence regions was 99.8% among these three U. lactuca mtDNAs. Differences in genome size were mainly caused by duplication mutations and insertion/deletion mutations of short DNA sequences. Two intergenic regions (nad6-trnS and trnF-trnG) contained long tandem repeats which displayed a high level of variation in repeat sequences and copy numbers, indicating fast mutation rates in these regions. The phylogenomic analysis revealed that these three samples of U. lactuca formed a strongly supported clade. The mitogenome can be used to understand the phylogeography and population genetics in Ulva on a global scale.

Intergenic region

Ulvophyceae

Ulva lactuca

Phylogenomics

10.1080/23802359.2020.1745712

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Comparative analysis on the photoluminescence properties of Cs₂BF₆:Mn⁴⁺ (B = Ge, Si, Zr, Ti) red phosphors for WLEDs

Journal of the American Ceramic Society (2019)

Manman Liu Peipei Dang Yi Wei Sisi Liang Guofeng Liu

Abstract A series of Cs 2 BF 6 :Mn 4+ (B = Ge, Si, Ti, Zr) red phosphors were synthesized by a precipitation‐cation exchange route. The phase purity, morphology, and constituent were characterized by X‐ray diffraction (XRD) and scanning electron microscopy (SEM). Optical properties were investigated by photoluminescence (PL) spectra and high‐resolution PL. Temperature‐dependent PL examination at the range of both 273‐573 K and 10‐300 K was performed to investigate the emission mechanism of Mn 4+ in these fluorides. The intensity for both zero‐phonon lines (ZPLs) and vibration coupled emission of Mn 4+ in these four systems with different crystal structures was investigated systematically. These phosphors present bright red emission under blue light (467 nm) illumination, among which Cs 2 GeF 6 :0.1Mn 4+ shows the highest emission intensity with ultrahigh quantum efficiency of 94%. The white light‐emitting diodes (WLEDs) fabricated with this sample, blue InGaN chips and commercial YAG:Ce 3+ phosphor exhibited high luminous efficacy beyond 100 lm/w with high color rendering index (~88.6) and low color temperature (~3684 K).

Color temperature

Quantum Efficiency

10.1111/jace.16806

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Citations (16)

Complete Sets of Material Constants of [001]-Poled 0.72Pb(Mg_1/3Nb_2/3)O_3- 0.28PbTiO₃ Single Crystals Using Alternating Current Poling

IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control (2022)

Manman Liu Haiyue Tang Wenjie Zhang Zujian Wang Xiaoming Yang

Alternating current poling (ACP) is an effective method to improve the piezoelectric performance of relaxor-PbTiO3 (PT) ferroelectric single crystal. 0.72Pb(Mg1/3Nb2/3)O3-0.28PbTiO3 (PMN-PT) single crystals have been used to fabricate piezoelectric transducers for medical imaging. Up to date, there are no reports about the full matrix material constants of PMN-0.28PT single crystals poled by ACP. Here, we report the complete sets of elastic, dielectric, and piezoelectric properties of [001]-poled PMN-0.28PT single crystals by direct current poling (DCP) and ACP through the resonance method. The results show that [001]-poled rhombohedral PMN-0.28PT single crystals exhibit the enhancement of longitudinal and transverse piezoelectric properties ( d33 ∼ 2000 pC/N, d31 ∼ -1010 pC/N) after ACP. Compared with DCP samples ( d33 ∼ 1660 pC/N, d31 ∼ -780 pC/N), the values of d33 and d31 increase 20% and 29%, respectively. While the d15 value decrease from 110 pC/N for DCP sample to 90 pC/N for ACP sample, showing the decrease in transverse shear piezoelectric properties. In addition, the elastic stiffness coefficients c11 , c12 , c13 , the elastic compliance coefficients s11 , s12 , and the dielectric constants ε11 , ε33 have great change compared with DCP and ACP samples. This variation of the property matrices provides a reference for high-performance piezoelectric device design.

Poling

10.1109/tuffc.2022.3141461

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Citations (5)

Resonance Emission Enhancement (REE) for Narrow Band Red-Emitting A₂GeF₆:Mn⁴⁺ (A = Na, K, Rb, Cs) Phosphors Synthesized via a Precipitation–Cation Exchange Route

Inorganic Chemistry (2017)

Hongzhou Lian Qingming Huang Yeqing Chen Kai Li Sisi Liang

Narrow band red-emitting A2GeF6:Mn4+ (A = Na, K, Rb, Cs) phosphors were prepared through a two-step precipitation–cation exchange route using a K2MnF6 precursor as the Mn4+ source. The phase purity, morphology, and constituent were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectric spectroscopy (XPS), and electron paramagnetic resonance (EPR) examination. Optical properties were investigated by photoluminescence spectra (PL and PLE) and high-resolution PL. A temperature-dependent PL examination was performed to investigate the electron–phonon coupling emission mechanism of Mn4+ in these alkali fluorogermanates. The PL data show that both ordered distribution and appropriate distance between Mn4+ ions are propitious for enhancement of the emission intensity. A resonance emission enhancement (REE) mechanism has been proposed to explain the intensity increment among these products. These phosphors present bright red emission under blue light (467 nm) illumination, among which Cs2GeF6:0.03Mn4+ exhibits the most excellent optical properties with a quantum yield (QY) of 93%. A WLED (white light-emitting diode) fabricated with blend of commercial YAG:Ce3+ and this phosphor emits intense warm white light with low color temperature (CCT = 3385 K) and high color rendering index (Ra = 90.5), implying its potential application as red phosphor in WLEDs.

Quantum yield

Color temperature

10.1021/acs.inorgchem.7b01890

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Citations (91)

Stimuli‐Responsive Manganese Single‐Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions

Angewandte Chemie (2021)

Yang Zhu Wenyu Wang Junjie Cheng Yunteng Qu Yi Dai

Abstract The single‐atom enzyme (SAE) is a novel type of nanozyme that exhibits extraordinary catalytic activity. Here, we constructed a PEGylated manganese‐based SAE (Mn/PSAE) by coordination of single‐atom manganese to nitrogen atoms in hollow zeolitic imidazolate frameworks. Mn/PSAE catalyzes the conversion of cellular H 2 O 2 to . OH through a Fenton‐like reaction; it also promotes the decomposition of H 2 O 2 to O 2 and continuously catalyzes the conversion of O 2 to cytotoxic . O 2 − via oxidase‐like activity. The catalytic activity of Mn/PSAE is more pronounced in the weak acidic tumor environment; therefore, these cascade reactions enable the sufficient generation of reactive oxygen species (ROS) and effectively kill tumor cells. The prominent photothermal conversion property of the amorphous carbon can be utilized for photothermal therapy. Hence, Mn/PSAE exhibits significant therapeutic efficacy through tumor microenvironment stimulated generation of multiple ROS and photothermal activity.

10.1002/ange.202017152

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Citations (63)