Yue Sun

Qingdao Institute of Bioenergy and Bioprocess Technology

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Rui Nian

Chinese Academy of Sciences

Zixian Bao

Shandong University

Mo Xian

Chinese Academy of Sciences

Kamal Rai

College of Staten Island

Xiying Fan

Qingdao Institute of Bioenergy and Bioprocess Technology

Xinying Peng

Sun Yat-sen University

Yunlong Liang

Shandong Agricultural University

Wenshuai Liu

Chinese Academy of Sciences

Quan Chen

Central South University

Junqing Yang

Qingdao Institute of Bioenergy and Bioprocess Technology

Cooperative Institutions

Chinese Academy of Sciences

Qingdao Institute of Bioenergy and Bioprocess Technology

University of Chinese Academy of Sciences

Qinghai New Energy (China)

Shandong University

Ocean University of China

Qingdao Center of Resource Chemistry and New Materials

Qingdao University

Peking University

Zhejiang University

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Reduction of chromatin heteroaggregates by acid precipitation of mammalian cell culture and ramification in protein A chromatography for recombinant immunoglobulin G purification

Biochemical Engineering Journal (2018)

Wenshuai Liu Dongyan Zhou Yue Sun Jianli Yu Quan Chen

10.1016/j.bej.2018.12.012

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Citations (0)

Production of α-alkenes catalyzed by the fused lipase and P450 fatty acid de-carboxylase

Chinese Science Bulletin (Chinese Version) (2017)

Yue Sun Li Ma Hui Chen Huifang Xu Zhaofeng Li

The irreversibly diminishing reserves and the fluctuating price of crude oil, together with the serious concerns on the global environment and energy security, all suggests an unpleasant future of fossil fuel. Within this context, it is imperative to find alternative eco-friendly fuel with properties that highly mimic fossil fuel. Aliphatic alka(e)nes generated from renewable resources via biosynthetic pathways perfectly suits the criteria and represents the ideal ″drop-in″ biofuels. α-Alkenes are special microbial natural products. These biohydrocarbons have attracted much attention due to their potential application as biofuels and biomaterials. By coupling the activity of lipase and P450 decarboxylase, lipids (i.e. triglycerides) can be transformed into α-alkenes via free fatty acid intermediates. To improve the conversion efficiency of lipids to α-alkenes, in this study, four different versions of fusion proteins of the lipase TlL from Thermomyces lanuginosus and the P450 decarboxylase OleTJE from Jeotgalicoccus sp. ATCC 8456, including FusA (His6-TlL-linker-OleTJE), FusB (TlL-Linker-OleTJE-His6), FusC (His6-OleTJE-linker-TlL) and FusD (OleTJE- linker-TlL-His6), were constructed and comparatively evaluated. The optimal fusion enzyme FusC was able to convert a number of triacylglycerols including trilaurin (C12), trimyristin (C14) and tripalmitin (C16) into corresponding α-alkenes via the coupled hydrolysis and decarboxylation. The 31.7% yield of 1-tridecene from trimyristin demonstrates good substrate channeling effect. Due to the higher catalytic efficiency compared to the mixed TlL and OleTJE, as well as the simplified enzyme purification and hence the lower cost, this fusion strategy may hold significant potential of application.

Alpha (finance)

10.1360/n972017-00212

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Citations (2)

Identification of alternative splicing variants of the β subunit of human Ca²⁺/calmodulin‐dependent protein kinase II with different activities

FEBS Letters (2000)

Ping Wang Yalan Wu Tianhua Zhou Yue Sun Gang Pei

The β subunit of human Ca 2+ /calmodulin‐dependent protein kinase II (β CaMKII) was identified by searching through an expressed sequence tag database and rapid amplification of cDNA 5′‐ends and was assigned to chromosome 7. Reverse transcription‐polymerase chain reaction and sequencing analysis identified at least five alternative splicing variants of β CaMKII (β, β6, βe, β′e, and β7) in brain and two of them (β6 and β7) were first detected in any species. When expressed in HEK 293 cells, the Ca 2+ /calmodulin‐dependent kinase activity of β7, the shortest variant, was much lower than that of either β (the longest one) or βe (the medium one), suggesting possible regulation of β CaMKII activity by alternative splicing.

10.1016/s0014-5793(00)01634-3

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Persistent hepatocyte secretory failure in lopinavir/ritonavir related to drug-induced liver injury: a case report

Frontiers in Medicine (2025)

Yue Sun Ran Wang C.L. Wang Xiaodong Shao Xiaojie Zheng

Lopinavir/ritonavir, an anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drug, may be associated with the development of liver injury. In this paper, we reported an elderly female patient with drug-induced liver injury secondary to lopinavir/ritonavir, which was evaluated for their causality using the updated Roussel Uclaf Causality Assessment Method (RUCAM) of 2016. She had a RUCAM score of 8 which was equivalent to a probable causality grading. Her clinical course was complicated by persistent hepatocyte secretion failure (PHSF), followed by septic shock and SARS-CoV-2 re-infection during her hospitalization. Her response to any medical intervention, including ursodeoxycholic acid, glutathione, methylprednisolone sodium succinate, rifampicin, artificial liver support, and endoscopic nasobiliary drainage (ENBD) was very poor, and her family members refused liver transplantation. Finally, she died. In summary, this case suggests the possibility that lopinavir/ritonavir can cause DILI and even PHSF in our clinical practice.

Ritonavir

Lopinavir

Lopinavir/ritonavir

10.3389/fmed.2025.1492002

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Improved stability of liposome-stabilized emulsions as a co-encapsulation delivery system for vitamin B₂, vitamin E and β-carotene

Food & Function (2022)

Yue Sun Wenting Tang Chuanfen Pu Risheng Li Qingjie Sun

To realize the co-encapsulation of multiple nutraceuticals with different solubilities, Pickering emulsions stabilized by freshly-prepared liposome suspension stabilized emulsion (Fre-Lip-Sus-E) and hydrated lyophilized liposome stabilized emulsion (Hyd-Lyo-Lip-E) were prepared, in comparison with the phospholipid stabilized emulsion (Pho-E). The particle size, zeta-potential, emulsification activity (EAI), emulsion stability (ESI), morphology, environmental stability and rheological properties of the three emulsions were compared. In addition, the in vitro digestive stability and bioaccessibility of three emulsions loaded with vitamin B2, vitamin E and β-carotene were assessed. The results showed that the Fre-Lip-Sus-E and Hyd-Lyo-Lip-E were characterized by smaller particles and higher environmental stability than the Pho-E. The slight difference between the Hyd-Lyo-Lip-E and Fre-Lip-Sus-E might be due to the partial destruction of the phospholipid bilayer during the lyophilization of lyophilized liposomes. Rheological analysis demonstrated that all emulsions had high interfacial viscosity and significant shear thinning characteristics of pseudoplastic fluids. Compared with the Pho-E, the liposome-stabilized emulsions demonstrated good environmental stability and antioxidant properties, and the Fre-Lip-Sus-E and Hyd-Lyo-Lip-E exhibited comparable stabilising effects. Higher bioaccessibility of vitamin B2 and vitamin E in the Fre-Lip-Sus-E and Hyd-Lyo-Lip-E was observed, while β-carotene had higher bioaccessibility in Pho-E. These results provide valuable insight into the potential for designing emulsion co-encapsulation delivery systems using liposomes as stabilizers.

Zeta potential

10.1039/d1fo03617c

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Citations (17)

Phosphatidylinositol 4,5‐bisphosphate: Targeted production and signaling

BioEssays (2013)

Yue Sun Narendra Thapa Andrew C. Hedman Richard A. Anderson

Abstract Phosphatidylinositol 4,5‐bisphosphate (PI4,5P 2 ) is a key lipid signaling molecule that regulates a vast array of biological activities. PI4,5P 2 can act directly as a messenger or can be utilized as a precursor to generate other messengers: inositol trisphosphate, diacylglycerol, or phosphatidylinositol 3,4,5‐trisphosphate. PI4,5P 2 interacts with hundreds of different effector proteins. The enormous diversity of PI4,5P 2 effector proteins and the spatio‐temporal control of PI4,5P 2 generation allow PI4,5P 2 signaling to control a broad spectrum of cellular functions. PI4,5P 2 is synthesized by phosphatidylinositol phosphate kinases (PIPKs). The array of PIPKs in cells enables their targeting to specific subcellular compartments through interactions with targeting factors that are often PI4,5P 2 effectors. These interactions are a mechanism to define spatial and temporal PI4,5P 2 synthesis and the specificity of PI4,5P 2 signaling. In turn, the regulation of PI4,5P 2 effectors at specific cellular compartments has implications for understanding how PI4,5P 2 controls cellular processes and its role in diseases.

Pleckstrin homology domain

Second messenger system

10.1002/bies.201200171

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Citations (98)

A novel fish collagen scaffold as dural substitute

Materials Science and Engineering C (2017)

Qing Li Lanlan Mu Fenghua Zhang Yue Sun Quan Chen

Biocompatibility

Carbodiimide

10.1016/j.msec.2017.05.102

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Citations (36)

Histone-dependent IgG conservation in octanoic acid precipitation and its mechanism

Applied Microbiology and Biotechnology (2016)

Quan Chen Phyllicia Toh Yue Sun Sarah Maria Abdul Latiff Aina Hoi

10.1007/s00253-016-7719-x

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Citations (3)

Exploring pyrimidine-substituted curcumin analogues: Design, synthesis and effects on EGFR signaling

Bioorganic & Medicinal Chemistry (2013)

Peiju Qiu Lingling Xu Lei Gao Meng Zhang Shixi Wang

Epidermal growth factor receptor (EGFR) is an effective molecular target of anti-cancer therapies. Curcumin inhibits cancer cell growth in vitro by suppressing gene expression of EGFR and reduces tumor growth in various animal models. To overcome instable and insoluble properties of curcumin as therapeutics, we designed and synthesized six novel pyrimidine-substituted curcumin analogues with or without a hydroxyl group originally present in curcumin. The cell viability tests indicated that IC50 of the analogues containing hydroxyl group were 3 to 8-fold lower than those of the analogues without hydroxyl group in two colon cancer cell lines tested. Western blot analysis indicates the analogues containing hydroxyl group inhibited expression and tyrosine phosphorylation of EGFR. Further protein analyses showed that the analogues had anti-cellular proliferation, pro-apoptosis, and cell cycle arrest properties associated with suppressed EGFR expression. These results indicate that the hydroxyl groups in curcumin and the analogues were critical for observed biological activities.

EGFR Inhibitors

10.1016/j.bmc.2013.06.053

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Citations (33)

Mussel-inspired chemistry in producing mechanically robust and bioactive hydrogels as skin dressings

Materials Today Chemistry (2022)

Wen Yu Yang Cui Mingcai Han Pengxiang Jia Yuyue Zhao

Ductility (Earth science)

10.1016/j.mtchem.2022.101272

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Citations (7)