Xiang‐Ling Li

South China Agricultural University

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Jing‐Juan Xu

Nanjing University

Hong‐Yuan Chen

Nanjing University

Jin Wang

Key Laboratory for High Strength Lightweight Metallic Materials of Shandong Province

Meirong Cui

The Synergetic Innovation Center for Advanced Materials

Wei Zhao

Shanghai University

Tingting Zhang

Chengdu University of Traditional Chinese Medicine

Xuejiao Yang

Nanjing Tech University

Bao-Yi Hu

South China Agricultural University

Jing Xie

Dongguk University

Bin Kang

Nanjing University

Cooperative Institutions

Nanjing University

South China Agricultural University

Chinese Academy of Sciences

Sichuan University

Nanjing Tech University

Nanjing University of Posts and Telecommunications

Wuhan University

Sun Yat-sen University

Huazhong University of Science and Technology

Shanghai Jiao Tong University

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Targeted Transmembrane Delivery of Ca²⁺ via FA-Nanogel for Synergistically Enhanced Chemotherapy

ACS Applied Materials & Interfaces (2019)

Shanwen Hu Jin Wang Tingting Zhang Xiang‐Ling Li Hong‐Yuan Chen

Metal ion synergistically enhanced chemotherapy is a promising strategy for cancer treatment. However, targeting delivery of ions toward cancer cells remains challenging for decades. Herein, we developed a novel folic acid-nanogel (termed as FA-nanogel) with alkane chains as diffusion barriers for targeted transmembrane delivery of calcium ions into cancer cells. With the aid of hydrophobic diffusion barriers, the FA-nanogel showed a reduced and sustained speed for release of calcium ions, significantly prolonging the ion effect. Moreover, a pH-sensitive injectable hydrogel-loaded FA-nanogel and chemotherapeutic drug 5-fluorouracil (5-Fu) was synthesized for investigating the synergistic effect of nanogel on chemotherapy. Both in vitro and in vivo experiments confirmed that the intracellular calcium ions were continuously increased because of the targeted delivery ability and ion sustained release ability of the smart FA-nanogel, and the tumor growth was effectively inhibited by the ion synergistic chemotherapy. This study not only provides a powerful nanoplatform for sustained transmembrane delivery of ions into malignant cells but also creates better conditions for improving the therapeutic efficacy of chemotherapy.

Nanogel

10.1021/acsami.9b04967

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Citations (12)

Biodegradable MnO2 nanosheet based DNAzyme-recycling amplification towards: Sensitive detection of intracellular MicroRNAs

Talanta (2019)

Fei Liu Xiang‐Ling Li Hong Zhou

Deoxyribozyme

Nanosheet

Molecular beacon

Hybridization probe

10.1016/j.talanta.2019.120199

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Citations (17)

Synthesis, crystal structure, Hirshfeld surface analyses and antibacterial activity of 2-fluorobenzylpyridinium tetrabromidocuprate(II)

Molecular Crystals and Liquid Crystals (2024)

Yan-Lin Chen Xinran Li Xiang‐Ling Li Bao-Yi Hu Yan Jiang

In this article, novel organic-inorganic hybrid material, 2-fluorobenzylpyridinium tetrabromidocuprate(II) [2FBzPy]2[CuBr4], has been obtained by using a slow evaporation solution-growth method and was characterized by powder X-ray diffraction, infrared spectroscopy, scanning electron microscopy, UV–visible diffuse reflectance spectrum. The compound crystallizes in the monoclinic space group P21/c, and the packing is governed by C − H···Br hydrogen bonding interactions, which was confirmed by the Hirshfeld surface analysis. The results of antimicrobial experiments showed that the compound possessed excellent antimicrobial activity against Staphylococcus aureus and Escherichia coli.

10.1080/15421406.2024.2429177

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Research on the Anti-Tumor Mechanism of Artocarpus Lingnanensis Lectin

Journal of Clinical Medicine Research (2024)

Li Lu Wenya Chen Xiang‐Ling Li Ben Chen

The purpose of this study was to investigate the mechanism of Artocarpus Lingnanensis Lectin (ALL) in inhibiting the growth of tumor cells EL-4. ALL was applied to mouse lymphoma cells EL-4, with PHA (100μg/mL) as a positive control drug. The toxicity of ALL (3.125, 6.25, 12.5, 25, 50, 100, 200μg/mL) on EL-4 cells was evaluated using the CCK-8 assay. Flow cytometry was used to assess the effect of ALL (25, 100 μg/ mL) on apoptosis and cell membrane potential of EL-4 cells. Western blotting was conducted to measure the protein expression levels of BAX, cleaved-Caspase-3, cleaved-Caspase-9, cleaved-PARP1. Fluorescence microscopy was employed to detect the concentration of free calcium ions. Results showed that compared to the control group, ALL had a significant inhibitory effect on EL-4 cells in a dose-dependent manner, with an IC50 value of 105.4μg/mL. Flow cytometry results indicated an increase in apoptosis rate of EL-4 cells with ALL treatment, leading to a higher proportion of depolarized mitochondrial membrane potential. Furthermore, the protein expression levels of BAX, cleaved-Caspase-3, cleaved-Caspase-9, and cleaved-PARP1 were significantly upregulated. In conclusion, ALL can promote apoptosis of EL-4 cells through the mitochondrial apoptosis pathway, inhibit their migration and invasion, and thereby exhibit anti-tumor effects.

10.32629/jcmr.v5i1.1805

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Crystal structures, Hirshfeld surface analysis, antimicrobial activity, and optical properties based on DFT calculations of two new organic-inorganic hybrids: [nClBzPy]2[MnCl4] (n = 2, 4)

Journal of Molecular Structure (2024)

Shiyu Hu Yan Jiang Bao-Yi Hu Shanshan Liu Xinran Li

Crystal (programming language)

10.1016/j.molstruc.2024.138694

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Integration of DNA bio-gates and duplex-specific nuclease signal amplification: towards electrochemiluminescence detection of survivin mRNA

Chemical Communications (2015)

Jing Wang Xiang‐Ling Li Jia-Dong Zhang Nan Hao Jing‐Juan Xu

Based on the integration of DNA bio-gates and duplex-specific nuclease assisted target recycling, a facile electrochemiluminescence assay was developed for the sensitive detection of survivin mRNA.

Nuclease

Electrochemiluminescence

Survivin

Duplex (building)

10.1039/c5cc03693c

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Citations (32)

Plasmonic nanohalo optical probes for highly sensitive imaging of survivin mRNA in living cells

Chemical Communications (2016)

Guangsheng Qian Bin Kang Zhuo-Lei Zhang Xiang‐Ling Li Wei Zhao

A novel strategy for sensitive detection of survivin mRNA based on Rayleigh light scattering spectroscopy of AuNP nanohalo probes.

Survivin

10.1039/c6cc02831d

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Long‐Lived Charge Carriers in Mn‐Doped CdS Quantum Dots for Photoelectrochemical Cytosensing

Chemistry - A European Journal (2015)

Peng Wu Jian‐Bing Pan Xiang‐Ling Li Xiandeng Hou Jing‐Juan Xu

Abstract Photoelectrochemical (PEC) biosensing with semiconductor quantum dots (QDs) has received great attention because it integrates the advantages of both photo‐excitation and electrochemical detection. During the photon‐to‐electricity conversion in PEC processes, electron–hole (charge) separation competes with electron–hole recombination, and the net effect essentially determines the performance of PEC biosensors. Herein, we propose a new approach for slowing down electron–hole recombination to increase charge separation efficiency for PEC biosensor development. Through doping with Mn 2+ , a pair of d bands ( 4 T 1 and 6 A 1 ) is inserted between the conduction and valence bands of CdS QDs, which alters the electron–hole separation and recombination dynamics, allowing the generation of long‐lived charge carriers with ms‐scale lifetime that decay about 10 4 –10 5 ‐fold more slowly than in the case of undoped QDs. Photocurrent tests indicated that Mn 2+ doping resulted in an approximately 80 % increase in photocurrent generation compared with undoped CdS QDs. For application, the Mn‐doped CdS QDs were coated on the surface of a glassy carbon electrode and functionalized with a cell surface carbohydrate‐specific ligand (3‐aminophenylboronic acid). In this way, a sensitive cytosensor for K562 leukemia cells was constructed. Moreover, the sugar‐specific binding property of 3‐aminophenylboronic acid allowed the electrode to serve as a switch for the capture and release of cells. This has been further explored with a view to developing a reusable PEC cytosensing platform.

Photocurrent

Charge carrier

Photoelectrochemistry

10.1002/chem.201405798

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Citations (69)

Biogated mesoporous silica nanoagents for inhibition of cell migration and combined cancer therapy

Microchimica Acta (2024)

Yu Wu Xiaojie Shi Xinyi Dai Tian shun Song Xiang‐Ling Li

Cancer Therapy

10.1007/s00604-024-06401-5

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Tumor-Marker-Mediated “on-Demand” Drug Release and Real-Time Monitoring System Based on Multifunctional Mesoporous Silica Nanoparticles

Analytical Chemistry (2014)

Xiang‐Ling Li Nan Hao Hong‐Yuan Chen Jing‐Juan Xu

“On-demand” drug release can maximize therapeutic efficacy for specific states of malignancies and minimize drug toxicity to healthy cells. Meanwhile, there is lack of a real-time monitoring platform to accurately investigate the amount of anticancer drugs released, especially nonfluorescent ones. So it is significant to integrate both issues in one ideal drug delivery system. To achieve this, here we present a novel stimuli-responsive controlled drug delivery system toward the tumor marker survivin mRNA, using a real-time monitoring approach based on the fluorescence resonance energy transfer (FRET) strategy to quantify the process of drug release. First, 7-amino-4-methlcoumarin (AMCA) dye terminated short oligonucleotide (FlareA) will hybridize with fluorescein isothiocyanate (FITC) labeled long oligonucleotide (S1F), which contains a recognition element to a specific RNA transcript, to form a FRET pair capped on the pores of mesoporous silica nanoparticles (MSNs). Following a target-recognition reaction, the target with a longer strand displaces the FlareA strand to form a longer and more stable duplex with S1F, which leads to the removal of the capped oligonucleotide from the MSNs and triggers the release of the entrapped cargo while FRET between AMCA and FITC is broken. The relevant change in donor and acceptor fluorescence signal can be used to monitor the unlocking and release event in real-time. Further investigations have also demonstrated that this release system possesses the capacity of modulating the extent of drug release according to the cell states, giving the platform an equally broad spectrum of applications in anticancer therapy.

Fluorescein isothiocyanate

10.1021/ac502553u

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Citations (38)