Murugan Rajan

Universidade Federal de Sergipe

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Narendra Narain

Universidade Federal de Sergipe

Parimelazhagan Thangaraj

Bharathiar University

Maria Terezinha Santos Leite Neta

Universidade Federal de Sergipe

Tamna Joanan Farias Lima Guedes

Universidade Federal de Sergipe

Saikumar Sathyanarayanan

Bharathiar University

Paula Ferreira Barbosa

Universidade Federal de Sergipe

Juliete Pedreira Nogueira

Universidade Federal de Sergipe

Christean Santos de Oliveira

Universidade Federal de Sergipe

Kasipandi Muniyandi

Agricultural Research Organization

S. Saravanan

Universidade Federal de Sergipe

Cooperative Institutions

Universidade Federal de Sergipe

Bharathiar University

Institute of Nuclear Medicine & Allied Sciences

Defence Research and Development Organisation

University of Hawaii at Hilo

Universidade Tiradentes

Purdue University West Lafayette

Chinese Academy of Sciences

University of Johannesburg

All India Institute of Medical Sciences

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Bioactive compounds and antioxidant activities in the agro-industrial residues of acerola (Malpighia emarginata L.), guava (Psidium guajava L.), genipap (Genipa americana L.) and umbu (Spondias tuberosa L.) fruits assisted by ultrasonic or shaker extraction

Food Research International (2021)

Nayjara Carvalho Gualberto Christean Santos de Oliveira Juliete Pedreira Nogueira Mônica Silva de Jesus Hannah Caroline Santos Araujo

Psidium

ABTS

10.1016/j.foodres.2021.110538

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Citations (49)

Phytochemical composition and antioxidant potential of different varieties viz. Flor Branca, Costa Rica and Junco of green unripe acerola (Malphigia emarginata D.C.) fruits

Food Science and Technology (2020)

Tamna Joanan Farias Lima Guedes Murugan Rajan Paula Ferreira Barbosa Elizabete de Santana Silva Tatiane de Oliveira Xavier Machado

Malpighia emarginata D.C is an important crop of Brazil and significant source of antioxidant active compounds with notable health effects. The purpose of this work was to study three varieties of acerola (Malpighia emarginata D.C) at green unripe stage of maturity from the São Francisco Valley of Northeast Brazil. The fruits were evaluated for physico-chemical composition, bioactive compounds, through spectrophotometric analysis and liquid chromatography, as well as the profile of macro and micro minerals and antioxidant capacity. The fruits presented satisfactory results in physico-chemical quality parameters. HPLC-DAD phenolic profile analysis identified kaempferol-3-glucoside (32.68 mg/100 g), p-coumaric acid (28.87 mg/100 g) and isorhamnetin (11.41 mg/100 g) as the major compounds, mainly in the variety of Flor Branca (FB). The results obtained from the profiles of sugars and organic acids were similar among the varieties. The minerals were excellent sources of the elements of K, Ca, Mg and Mn. Moreover, FB variety represents higher antioxidant capacity in ABTS·+ (8613.54 μM Trolox/g) and ORAC (2454.42 μM Trolox/g). Thus, the results show the potential to be applied for variety selection and utilization programs based on their specific nutritive characters, contributing to the development of new products.

Trolox

ABTS

Phytochemical

10.1590/fst.46320

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Citations (11)

Performance of different solvents on extraction of bioactive compounds, antioxidant and cytotoxic activities in Phoenix loureiroi Kunth leaves

Journal of Applied Research on Medicinal and Aromatic Plants (2020)

Murugan Rajan R Gomathi Tamna Joanan Farias Lima Guedes Romy Gleyse Chagas Barros Narendra Narain

ABTS

Petroleum ether

10.1016/j.jarmap.2020.100247

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Citations (28)

Optimization and method validation of determining polyphenolic compounds by UFLC-DAD system using two biphenyl and pentafluorophenylpropyl columns

Journal of Liquid Chromatography &amp Related Technologies (2019)

Murugan Rajan Paula Ferreira Barbosa Nayjara Carvalho Gualberto Christean Santos de Oliveira Maria Terezinha Santos Leite Neta

The development of efficient analytical methods for the identification and quantification of polyphenols in natural products is needed. The present study was aimed to optimize the polyphenols by UFLC using two different Ascentis express columns. Chromatographic separation was performed using UFLC-DAD connected with Ascentis Express Biphenyl column (system I) and Ascentis Express F5 pentafluorophenylpropyl (PFP) column (system II). Multistep gradient elution program was used in both analytical instruments to detect 34 compounds of different classes (phenolic acids, flavonoids, isoflavones, flavanols, flavonols and flavanones). The detection wavelength, linear calibration range, theoretical plate, tailing factor, limits of detection and of quantification were determined. The results were validated and the optimized method was proven to be precise, revealing good separation in the UFLC system II using Ascentis Express F5 PFP column. In conclusion, this study shows analytical preciseness and is useful in determining polyphenols in natural products.

Flavonols

Gradient elution

Biphenyl

10.1080/10826076.2019.1598429

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Citations (10)

Study of intestinal anti-inflammatory activity of Phoenix loureiroi Kunth (Arecaceae) fruit

Biomedicine & Pharmacotherapy (2017)

Murugan Rajan S. Saravanan Parimelazhagan Thangaraj

Sulfasalazine

Antispasmodic

10.1016/j.biopha.2017.06.028

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Citations (14)

Volatile profiling and UHPLC-QqQ-MS/MS polyphenol analysis of Passiflora leschenaultii DC. fruits and its anti-radical and anti-diabetic properties

Food Research International (2020)

S. Saravanan Rafael Donizete Dutra Sandes Murugan Rajan Maria Terezinha Santos Leite Neta Bruno dos Santos Lima

Twenty-four phenolic compounds including daidzein, epicatechin and artepillin C were identified in Passiflora leschenaultii DC. fruit by UHPLC-QqQ-MS/MS analysis. The aroma profile has been studied using the HS–SPME/GC–MS which revealed 67 volatile compounds including 13 terpenes, 18 alcoholics, 15 esters, ketones and phenolic acids. Further, the proximate composition, anti-radical and anti-diabetic activities of fruit pulp were also determined. The fresh fruit pulp of P. leschenaultii registered higher total phenolic (691.90 mg GAE/g extract) and tannin (313.81 mg GAE/g extract) contents and it also exhibited maximum DPPH (IC50 of 6.69 µg/ml) and ABTS+ (9760.44 µM trolox equivalent/g extract) scavenging activities. The fresh fruit pulp showed a strong inhibition towards the α-Amylase and α-Glucosidase (IC50 of 32.20 and 19.81 µg/mL, respectively) enzymes. Thus, the work stipulates that phenolic compounds rich P. leschenaultii fruit can serve as a potential nutraceutical, antioxidative and anti-diabetic agent in food and pharmaceutical formulations.

Trolox

ABTS

Nutraceutical

Terpene

10.1016/j.foodres.2020.109202

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Citations (24)

Anti-oxidant, hypoglycemic and anti-hyperglycemic properties of Syzygium calophyllifolium

Bangladesh Journal of Pharmacology (2015)

Rahul Chandran Saikumar Sathyanarayanan Murugan Rajan Kasipandi Muniyandi Parimelazhagan Thangaraj

The article discusses anti-oxidant oral glucose tolerance and anti-hyperglycemic potentials of Syzygium calophyllifolium. Extracts from successive solvent extraction were tested for the total phenolic, tannin, flavonoid content and free radical scavenging property using DPPH, ABTS+, phosphomolyb-denum, FRAP, superoxide and metal chelating assays. Ethyl acetate extract of bark responded well against DPPH (IC50 4.13), ABTS+ (36832.29 µM TE/ g extract),phosphomolybdenum (100.4 g AAE/100g extract), superoxide and metal ion radicals. The methanol extract of bark was also found as an effective radical scavenger. The leaf methanol extract also showed significant anti-oxidant ability. The bark methanol extract could potentially reduce the blood glucose level in glucose loaded and diabetic rats. The immense anti-oxidant potential of S. calophyllifolium leaf and bark extracts could be taken as a good source of natural anti-oxidant supplement in food to defend oxidative stress related disorders like diabetes.

ABTS

Tannin

10.3329/bjp.v10i3.23361

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Citations (11)

Profiles of nutritional, bioactive compounds and cytotoxic activity of Dwarf date palm (Phoenix loureiroi) fruit

Journal of Food Measurement & Characterization (2020)

Murugan Rajan S. Saravanan Tamna Joanan Farias Lima Guedes Parimelazhagan Thangaraj Paula Ferreira Barbosa

Dry weight

Dried fruit

10.1007/s11694-020-00753-1

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Citations (2)

Babassu Oil (Orbynia phalerata), an Artisanal Product: Process Optimization of Seed Roasting on Yield, Phenolic Compounds, and Antioxidant Capacity

European Journal of Lipid Science and Technology (2020)

Iago Hudson da Silva Souza Juliete Pedreira Nogueira Murugan Rajan Maria Terezinha Santos Leite Neta Narendra Narain

Abstract Babassu oil has high concentrations of phenolic compounds. When seeds are preheated, these compounds tend to migrate to the oil depending on the degree of roasting applied. This study aims to optimize the roasting conditions of babassu seeds using response surface methodology (RSM) and the desirability functions. A central composite rotational design (CCRD) is employed to investigate the effects of two independent variables, temperature ( X 1 ) and roasting time ( X 2 ) which significantly affected response variables, namely yield (%), total phenolics content (TPC), number of phenolic compounds, oxygen radical absorbance capacity, acid value and peroxide value. The quadratic model is adjusted for most responses. The roasting temperature of 222 °C and the roasting time of 43 min are standardized as ideal conditions. Thus, the oil produced at the optimized conditions shows a yield of 54.47% and TPC of 91.53 mg GAE/100 g. In the control oil sample, the presence of phenolic compounds analyzed by HPLC‐DAD is not observed while under optimized conditions, seven phenolic compounds are observed. The model of optimized conditions shows a good correlation between the predicted and experimental values. In general, these results demonstrate the effectiveness of optimum roasting conditions in improving the quality of bioactive compounds in babassu oil. Practical Applications : This work aims to optimize the babassu seeds roasting process to obtain oil with a greater number of phenolic compounds and better antioxidant capacity. As the first study on babassu seeds roasting, it contributes to the generation of important data in relation to the identification and quantification of phenolic compounds in the oil. Finally, the optimum roasting conditions established in this work can be explored commercially in babassu oil extraction.

Roasting

Central composite design

Peroxide value

10.1002/ejlt.202000163

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Citations (6)

Comparative evaluation of volatile profile of tomato subjected to hot air, freeze, and spray drying

Drying Technology (2020)

R Gomathi Murugan Rajan Hannah Caroline Santos Araujo Mônica Silva de Jesus Maria Terezinha Santos Leite Neta

Tomato (Lycopersicon esculentum Mill.) is an important vegetable crop cherished all over the world for consumption as a raw vegetable or as processed products. They are subjected to various drying processes to increase product stability and decrease postharvest loss. However, this can cause a loss in volatile compounds due to process conditions. Present study aims to gain an insight into the volatile profile of tomatoes when subjected to hot air, freeze, and spray drying processes. In this regard, the analysis of headspace - solid phase microextraction (HS-SPME) in conjunction with gas chromatography–mass spectroscopy (GC–MS) revealed that the volatile profile, namely compounds belonging to aldehydes, alcohols, terpenes, ketones, and furans varied greatly between the fresh and dehydrated tomatoes. The aroma of dehydrated tomato products that retained volatiles followed the following order: freeze-drying >/≥spray drying > hot air drying. An increase in contents of compounds such as dimethyl sulfide, 2-ethyl furan, hydroxymethyl furfural, acetaldehyde, and α-terpineol was found in all dehydrated products. Interestingly, compounds such as 3-methyl furan, hexanol and terpinyl acetate were found to occur only in dehydrated products. The presence of γ-undecalactone (fruity odor note) is identified for the first time in our study in fresh and all dehydrated tomatoes. From the results obtained and with chemometric analysis as principal component analysis and hierarchical cluster analysis on the volatile profile, it could be concluded that dehydrated tomatoes serve suitable products that could be extensively commercialized world-wide to achieve overall consumer acceptability.

Dimethyl trisulfide

Furan

Furfuryl alcohol

Solid-Phase Microextraction

Terpene

10.1080/07373937.2020.1842441

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Citations (13)