Nidhi Dwivedi

Hindu Rao Hospital

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Satyen Saha

Banaras Hindu University

Sumit Kumar Panja

Uka Tarsadia University

Sailaja S. Sunkari

Banaras Hindu University

Jitendra K. Thakur

National Institute of Plant Genome Research

Sourobh Maji

University of Delhi

Mohd Waseem

National Institute of Plant Genome Research

Abhineet Verma

Banaras Hindu University

Pallabi Thakur

National Institute of Plant Genome Research

Katharina Hopp

University of Colorado Denver

Sandeep Sachdeva

Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences

Cooperative Institutions

National Institute of Plant Genome Research

Banaras Hindu University

University of Colorado Anschutz Medical Campus

University of Colorado Denver

Indian Agricultural Research Institute

All India Institute of Medical Sciences

Academy of Scientific and Innovative Research

Institute of Medical Sciences

Creative Commons

University of Delhi

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Finite Element Modeling of Human Femur Using CT Data: A Biomechanical Analysis

Lecture notes in bioengineering (2012)

Amrita Francis Ashwani Shrivastava Chetna Masih Nidhi Dwivedi Priyanka Tiwari

Biomechanics

10.1007/978-81-322-0970-6_8

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Citations (1)

AN IN SILICO APPROACH TO IDENTIFY LEAD MOLECULES AMONG GC-MS ANALYZED COMPOUNDS OF MIMUSOPS ELENGI AGAINST GLYCOSYL TRANSFERASE OF STREPTOCOCCUS MUTANS

Egyptian Journal of Chemistry (2023)

Hemavathy Ekambaram Kiragandur Manjunath Kadabagere Narayanaswamy Hemavathi Avijit Maity Korthusheril Ajayakumar Akshaya

Transferase

10.21608/ejchem.2023.178301.7295

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Tetrabutylammonium Hydrogensulphate Catalyzed Efficient Synthesis of Glycosyl(aryl) Dihydropyrimidinones

Letters in Organic Chemistry (2005)

Nidhi Dwivedi Rupesh K. Mishra Renu Tripathi

An efficient synthesis of glycosyl dihydropyrimidinones using a three-component reaction of a α- keto ester, glycosyl aldehyde, urea (or thiourea) in the presence of tetrabutylammonium hydrogensulphate and diethylene glycol as eco-friendly solvent has been reported. The reaction has been extended to the synthesis of aryl dihydropyrimidinones also. The glycosyl dihydropyrimidinones were obtained in excellent yields in less time than the methods already reported. Keywords: aldehydes, phase transfer catalyst, dihydropyrimidinone

Diethylene glycol

10.2174/1570178054405986

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Convergence of Stress‐Induced Hormone Signaling Pathways on a Transcriptional Co‐Factor

Nidhi Dwivedi Vinay Kumar Jitendra K. Thakur

Mediator is a massive and flexible complex involved in eukaryotic gene regulation. Basically, it acts as a bridge between a transcription factor and transcriptional machinery. However, latest reports suggest that Mediator is involved in almost all the aspects of gene transcription including initiation of transcription, elongation of transcript, splicing of transcript, gene looping, and termination of transcription. The Mediator complex consists of several subunits, which are arranged in different modules named Head, Middle, Tail, and Kinase. Few subunits have not yet been assigned to any module. In Arabidopsis, it seems that different compositions of subunits might form functional complexes in different contexts and scenarios as different stresses and phytohormones affect transcript abundance of specific set of these subunit genes. Although the Mediator complex is required in the basic mechanism of transcription initiation and regulation of almost all the class II genes, several individual subunits have been found to be important in specific transcriptional responses. In this chapter, we discuss involvement of Mediator subunits in stress responses. Since hormones play an important role in stress responses, we explain the known and probable involvement of Mediator in phytohormone mediated transcriptional responses evoked by different biotic and abiotic stresses in plants.

Mediator

Transcription

RNA polymerase II

Eukaryotic transcription

10.1002/9781118889022.ch28

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The Relationships of Paranormal Beliefs and Locus of Control among Students of Medical College, Delhi

Indian Journal of Public Health Research & Development (2023)

Sujata Gupta Neha Taneja Nidhi Dwivedi Sandeep Sachdeva

Background: The phenomenon of Paranormal beliefs has puzzled scientific community. Studies on this subjecthave been hindered by conceptual and methodological issues. There is little evidences found between locus ofcontrol and paranormal. This constituted rationale of current study. We studied relationships between paranormalbeliefs, as measured by Paranormal Belief Scale (Tobacyk& Milford, 1983) and locus of control as measured byROT-IE scale among medical students of Delhi.Methodology: The study population consists of medical undergraduate students in Delhi who were enrolled atcollege during the time of the study. All undergraduate students who gave consent were included in study. A pretestedand predesigned questionnaire asking their socio-demographic information and relationship between theirsense of personal control(locus of control measured by the ROT-IE scale) and paranormal beliefs(using revisedform of the Paranormal Belief Scale) was administered. Chi-square test and Pearson’s correlation test were usedto test significanceResults: Means and standard deviations for the PBS-R and the IELOC Scales were reported separately for sociodemographicparameters. Females scored higher than males on all subscale except extraordinary life formsand precognition but it was statistically significant. Bi-variate correlation between locus of control and revisedparanormal belief scale revealed that as persons tend towards internal locus of control, their paranormal beliefbecome low.Conclusion: In our study it was shown that there was significant relationships among paranormal beliefs and locusof control.

Paranormal

Locus of control

10.37506/ijphrd.v14i4.19825

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CCDC 1849101: Experimental Crystal Structure Determination

The Cambridge Structural Database (2018)

Priyanka Pandey Nidhi Dwivedi Goulven Cosquer Masahiro Yamashita Sailaja S. Sunkari

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2024fp

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Autophagy Inhibition Ameliorates Polycystic Kidney Disease

Journal of the American Society of Nephrology (2021)

Daniel Atwood Deepak Pokhrel Nidhi Dwivedi Katharina Hopp Charles L. Edelstein

Atwood, Daniel; Pokhrel, Deepak; Dwivedi, Nidhi; Hopp, Katharina; Edelstein, Charles L. Author Information

10.1681/asn.20213210s1395a

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Author response for "Mediator<scp>W</scp>eb: a protein–protein interaction network database for the <scp>RNA</scp> polymerase <scp>II</scp> Mediator complex"

Sourobh Maji Mohd Waseem Manish Kumar Sharma Maninder Singh Anamika Singh

Mediator

10.1111/febs.17225/v2/response1

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Association of Catechol-O-Methyltransferase Gene rs4680 Polymorphism and Levodopa Induced Dyskinesia in Parkinson’s Disease: A Meta-Analysis and Systematic Review

Journal of Geriatric Psychiatry and Neurology (2022)

Archana Dwivedi Nidhi Dwivedi Anand Kumar Varun Kumar Singh Abhishek Pathak

Introduction Long-term levodopa therapy for Parkinson’s disease (PD) can cause levodopa induced dyskinesia (LID). Genetic predisposition has a significant role to play in inter-individual heterogeneity in the clinical manifestation of LID. Despite accumulating evidence for the role of COMT gene polymorphism (rs4680) as a genetic basis for LID, to date results have been inconsistent. Early assessment of the Catechol-O-Methyltransferase (COMT) genotype might be helpful to stratify PD patients concerning their individual risk for LID. Method In this meta-analysis, we have used 9 studies, which were selected through online databases. Statistical analysis was performed using R (v-3.6) software. 5 genetic models have been used in the present study: Allele model (A vs. G), Dominant model (AA+AG vs. GG), Homozygote model (AA vs. GG), Co-dominant/heterozygote model (AG vs. GG), and Recessive model (AA vs. AG + GG). Results The results indicated a significant association between COMT rs4680 (Val158Met) polymorphism and LID risk. The genotype AA of COMT rs4680 is a risk factor for LID in PD patients under the recessive model (AA vs GG+AG) in the random-effect model. Analysis based on ethnicity showed that COMT rs4680 SNP allele A is a risk factor for LID development in Asian PD patients, while GG genotype is a risk factor for LID development in non-Asian PD patients using different genetic models. Conclusion The results of the present meta-analysis support that the COMT Val158Met polymorphism is a risk factor for the development of LID in PD patients having ethnic variations.

rs4680

genetic model

SNP

10.1177/08919887221103580

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KIX domain of AtMed15a, a Mediator subunit of Arabidopsis, is required for its interaction with different proteins

Figshare (2018)

Vinay Kumar Mohd Waseem Nidhi Dwivedi Sourobh Maji Angad Kumar

Med15 is an important subunit of Mediator Tail module and is characterized by a KIX domain present towards amino terminal. In yeast and metazoans, Med15 KIX domain has been found to interact with various transcription factors regulating several processes including carbohydrate metabolism, lipogenesis, stress response and multidrug resistance. Mechanism of Med15 functioning in Arabidopsis is largely unknown. In this study, interactome of KIX domain of Arabidopsis Med15, AtMed15a, was characterized. We found 45 proteins that interact with AtMed15a KIX domain, including 11 transcription factors, 3 single strand nucleic acid-binding proteins and 1 splicing factor. The third helix of the KIX domain was found to be involved in most of the interactions. Mapping of the regions participating in the interactions revealed that the activation domain of a transcription factor, UKTF1 interacted with AtMed15a KIX domain. Thus, our results suggest that in Arabidopsis, activation domain of transcription factors target KIX domain of AtMed15a for their transcriptional responses.

Mediator

10.6084/m9.figshare.5794983

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