Qiang Luo

Wenzhou University

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N. D’Angelo

Fermi National Accelerator Laboratory

R. L. Merlino

University of Iowa

Jize Zhao

Lanzhou University

Yi Qiu

Peking University

Heng Yang

Gannan Normal University

Zeng Ling Ran

University of Electronic Science and Technology of China

Zhiwei Ma

Southwest Petroleum University

Zou Jiangfeng

Southwest Petroleum University

Guina Xiao

Shanghai Jiao Tong University

Ran Zeng-Ling

University of Electronic Science and Technology of China

Cooperative Institutions

Chinese Academy of Sciences

Southwest Petroleum University

Shanghai Jiao Tong University

Huazhong University of Science and Technology

Sichuan University

Tsinghua University

Central South University

Fudan University

Zhejiang University

State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation

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Procedure Optimization for Gram Scale Synthesis of Silicon Rhodamine and its Use in Labeling of Protein Kinase Inhibitor

Tao Bi Yanan Zhou Pan Liang Junyu Lai Qiang Luo

Due to its high photo-stability and Near-Infrared (NIR) emission, silicon rhodamine (SiR) has achieved wide applications in visualization of small molecules and biomolecules in living cells by conjugating SiR with a therapeutic drug of interest. However, the synthesis of SiR has proven to be labor tedious and inefficient. In this work, we optimized the procedure for gram-scale synthesis of 5-carboxyl SiR, achieving 1.5 g of 5-carboxyl SiR in one pot with 24% yield for the first time, which was more than two times higher than that of the reported results. Furthermore, we extend the use of SiR for tracing small molecule inhibitors, innovatively introduced SiR into JQ1 to investigate the uptake and distribution of small molecule based kinase inhibitor in breast cancer cells. The molecular docking and further cellular uptake results showed that JQ1-SiR indeed share the same target towards BRD4 protein with JQ1. In vitro toxicity assay indicated that JQ1-SiR conjugate retained the anti-tumor performance of JQ1 to some extent. The improved method could be employed in large-scale synthesis of silicon rhodamine based fluorescent inhibitor, thereby broadening the biological applications of this type of fluorescent inhibitor.

Gram

Rhodamine

10.2139/ssrn.4478550

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Density Functional Theory Calculation of N–H₂S Hydrate

Science of Advanced Materials (2023)

Zhonghua Liu Zou Jiangfeng Qiang Luo Zhiwei Ma Qiu Yi

This study establishes a high-symmetry water cage structure model (structure N) based on the density functional theory first-principles technique. Three high-symmetry H 2 S hydrates (N–H 2 S hydrate) are examined in terms of their geometric structures, electrical characteristics, and optical characteristics. The structure of three N–H 2 S hydrates is most stable when H 2 S is in the center of water cage with small hydrogen bonds, and the molecular orientation of H 2 S has little effect on the structure of hydrate. The energy band of H 2 S enters forbidden band, resulting in the band gap of N–H 2 S hydrate being much less than that of water cage. A formation energy of −0.128 eV is reached when H 2 S DOS shift to the higher energy zone and the water cage DOS shift more to the lower energy region. The three N–H 2 S hydrates also possess various reflectivity characteristic peaks in the energy range of 5–12.5 eV, which might be exploited for electromagnetic detection of N–H 2 S hydrates. The findings of this research may serve as a theoretical foundation for related experiments.

Clathrate hydrate

Cage

10.1166/sam.2023.4413

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First Principles Calculation on Adsorption of S on Fe(100)

Advanced materials research (2011)

Zhi Zhang Qiang Luo Zeng Ling Ran Tai He Shi

Using the first principles method, which is based on the density function theory (DFT), the structures and electronic properties of S atoms are adsorbed on the Fe (100) surface, and their molecular orbital and binding energies were calculated with the generalized gradient approximation. The results show that the S atom is adsorbed hollow site is stable. With partial density of states, we have obtained the interaction of s and p states for S and Fe. It shows that the interaction between the S adsorption on the clean Fe (100) surface does lead to FeS comes into being.

10.4028/www.scientific.net/amr.337.690

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Three-Dimensional Broad Learning Gravity Data Inversion Using Single-Anomaly Training Samples

Applied Sciences (2024)

G. Xu Qiang Zu Xiao-Hui Yang Tao Tao Peng Han

Gravity data inversion is of critical importance in geophysics, encompassing a range of applications, such as the exploration of geological resources, the identification of geological structures, and the detection of groundwater resources. This study proposes a three-dimensional (3D) machine learning approach to enhance the efficiency of the aforementioned exploration tasks by leveraging gravity data. The mapping relationship between gravity data and subsurface density structures is modeled by the broad learning network, distinguished by its high training efficiency and robust modeling capability. Notably, the proposed inversion method obviates the constraints on the number of anomalies prior to the inversion process. This is achieved by setting one anomaly with varied locations for different training samples. Numerical and field data applications demonstrate the efficiency of the proposed 3D machine learning gravity data inversion method, especially in automatically determining the number of anomalies. In particular, the proposed method produced accurate density inversion results in the field application, aiding in the identification of potential oil and gas reservoirs in the target region and offering the potential for broader application in other resource exploration. The proposed inversion method can promote the construction of density structures of subsurfaces based on gravity data.

Groundwater resources

10.3390/app142311409

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Demonstration of broad photonic crystal stop band in a freely-suspended microfiber perforated by an array of rectangular holes

Optics Express (2014)

Yang Yu Wei Ding Lin Gan Zhi-Yuan Li Qiang Luo

It is shown that photonic crystal (PhC) optical reflectors with reflectance in excess of 60% and fractional bandwidths greater than 10% can be fabricated by ion beam milling of fewer than ten periods of rectangular cross section through-holes in micron-scale tapered fibers. The optical characteristics agree well with numerical simulations when allowance is made for fabrication artefacts and we show that the radiation loss, which is partly determined by optical interference, can be suppressed by design. The freely-suspended devices are compact and robust and could form the basic building block of optical cavities and filters.

Microfiber

Allowance (engineering)

10.1364/oe.22.002528

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Citations (8)

Discussion on development of creative agriculture in Shanghai

Shanghai nongye xuebao (2008)

Qiang Luo

The article analyzed the present situation and problems of developing creative agriculture in Shanghai and put forward several proposals to develop creative agriculture according to the problems in Shanghai.

Source

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Molecular level investigation of methane and carbon dioxide adsorption on SiO2 surface

Computational Materials Science (2019)

Jianfei Zhao Zhouhua Wang Ping Guo Qiang Luo

Langmuir adsorption model

Carbon fibers

10.1016/j.commatsci.2019.05.044

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Citations (34)

Improvement of Surface Morphology and Superconducting Properties of YBCO Coated Conductor on Ni-W Tapes

IEEE Transactions on Applied Superconductivity (2013)

Yijie Li Linfei Liu Guina Xiao Da Xu Ying Wang

High-quality YBCO coated conductors have been deposited on NiW tapes by pulsed laser deposition process. Although thin YBCO films (less than 0.5 $\mu\hbox{m}$ ) have a very high critical current density $J_{\rm c}$ of $4.0 \times 10^{6}\ \hbox{A/cm}^{2}$ (at 77 K, in zero magnetic field), when YBCO film thickness increased over 1.0 $\mu\hbox{m}$ , the $J_{\rm c}$ values of YBCO decreased quickly. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) observations showed that thick YBCO films had micrometer-scale grains and relatively broad grain boundaries that blocked superconducting current paths. In order to control the grain size and grain boundary width of YBCO films as well as improving superconducting properties under applied magnetic field, substrate modification and optimization of cap layer were applied. AFM and SEM images showed that YBCO films on the optimized substrate have smooth surface and higher superconducting critical current density. The maximum $I_{\rm c}$ of YBCO film increased from 280 A/cm to 480 A/cm and $J_{\rm c}$ of 1- $\mu\hbox{m}$ -thick YBCO film increased from $2.3 \times 10^{6}\ \hbox{A/cm}^{2}$ to $3 \times 10^{6}\ \hbox{A/cm}^{2}$ .

10.1109/tasc.2013.2237872

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Micromechanical tangential force measurements between tetrahydrofuran hydrate particles

Fuel (2022)

Qiang Luo Zhihui Liu Fulong Ning Deli Gao Zhichao Liu

Clathrate hydrate

Coulomb friction

Particle (ecology)

10.1016/j.fuel.2021.123073

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Citations (17)

Triple-meron crystal in high-spin Kitaev magnets

arXiv (Cornell University) (2022)

K. Chen Qiang Luo Zongsheng Zhou Saisai He Bin Xi

Spin textures with nontrivial topology hold great promise in future spintronics applications since they are robust against local deformations. The meron, as one of such spin textures, is widely believed to appear in pairs due to its topological equivalence to a half skyrmion. Motivated by recent progresses in high-spin Kitaev magnets, here we investigate numerically a classical Kitaev-$Γ$ model with a single-ion anisotropy. An exotic spin texture including three merons is discovered. Such a state features a peculiar property with an odd number of merons in one magnetic unit cell and it can induce the topological Hall effect.Therefore, these merons cannot be dissociated from skyrmions as reported in the literature and a general mechanism for such a deconfinement phenomenon calls for further studies. Our work demonstrates that high-spin Kitaev magnets can host robust unconventional spin textures and thus they offer a versatile platform not only for exploring exotic states in spintronics but also for understanding the deconfinement mechanism in the condensed-matter physics and the field theory.

Skyrmion

Deconfinement

10.48550/arxiv.2202.02753

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Citations (2)