Xingliang Zhang

Dalian University of Technology

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i-10 index

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Yuge Huang

Guangdong Medical College

Zhongzhou Chen

China Agricultural University

Haoyu Wang

Shandong Provincial Hospital

Qi Zhang

Australian Regenerative Medicine Institute

Qingqi Meng

Jinan University

Zhencheng Feng

Jinan University

Jianxin Tan

Nanjing Maternity and Child Health Care Hospital

Wei Wu

Chinese Academy of Sciences

Liqiong Hu

Jinan University

Chong Feng

Dalian Minzu University

Cooperative Institutions

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Guangdong Medical College

BGI Group (China)

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

Shenzhen Children's Hospital

Shanghai Jiao Tong University

Shantou University

China Agricultural University

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Association of PKB1 gene polymorphisms and event-related potentials in major depressive disorder

Zhonghua xingwei yixue yu naokexue zazhi (2010)

Li Li Ning Sun Jinzheng Guo Aiping Li Xingliang Zhang

Objective To explore the relationship of protein kinase B1 ( PKB1 ) gene polymorphisms in PI3-K pathway of BDNF and event-related potentials in depression.Methods The design of case-control research was used ,and 91 major depressive patients and 65 normal controls who were made in age and gender matched with patients were measured auditory event-related potential P300 and contingent negative variation ( CNV ) in the day when two groups were collected.Polymerase chain reaction (PCR) and direct DNA sequencing technology were used to detect PKB1 gene polymorphisms.Three SNPs that named rs3001371 ,rs2494738 ,rs1130214 were selected from 3 representative BLOCK Districts of PKB1.Two independent samples t test was used to analysis P300 and CNV between two groups,and the same way to analysis the average level of P300 and CNV and PKB1 SNP genolatency of P2(P＜0.05) and lower amplitude of P3a(P＜0.01 ) ,P3b(P＜0.01 ) and P3 (P＜0.01 ) ;CNV had der had statistical difference (P＜ 0.05 )in PKB1 rs3001371 gene between C/C and C/T genotype combined which included C allele, and T/T genotype.The amplitude of P3a( (5.93 ± 2.35 ) μV, P3b(6.51 ± 3.00) μV, P3 (6.27±2.43) μV) were lower than TT Genotype ( (7.45 ±2.19)μV, (8.63 ±3.57)μV,(8.04 ±2.57)μV,respectively).The mean of CNV indicators were not found different in statistics among the rs3001371 genotypes.Conclusions PKB1 gene rs3001371 polymorphism is associated with the principal component of P300 amplitude in patients with Major depressive disorder which suggest that genetic factors may have a certain impact on cognitive function in the patients with Major depressive disorder. Key words: Protein kinase B1 gene; Gene polymorphism; Major depressive disorder; Event-related potentials

P3a

P3b

SNP

Contingent negative variation

10.3760/cma.j.issn.1674-6554.2010.06.002

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Structural Basis of ABA Perception by PYR/PYL/RCAR Receptors

Springer eBooks (2014)

Lun Jiang Xingliang Zhang Zhongzhou Chen

Subfamily

Dephosphorylation

10.1007/978-94-017-9424-4_7

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Citations (3)

High-resolution Cell Atlas of Domestic Pig Lung and Online Platform Exploring for Lung Single Cell

bioRxiv (Cold Spring Harbor Laboratory) (2020)

Lijing Zhang Jiacheng Zhu Haoyu Wang Jun Xia Ping Liu

Abstract Due to the comparable organ sizes and physiology to human beings, genetically engineered pig is gradually regarded as an optimal source of human for transplantation and an excellent model for human diseases research. The major barrier between pig and human is mainly cellular heterogeneity and immune incompatibilities. Myriad scRNA-seq data of human has been reported, but the counterpart in pig is scarce. Here, we applied scRNA-seq technology to study the cellular heterogeneity of 3 months old pig lungs, generating the single-cell atlas of 13,580 cells covering 16 major cell types. Based on this data, we systematically characterized transcription factor regulatory networks, cell-cell communications in each cell type, and comparison of them and those in human lung. We first presented a comprehensive and openly accessible online platform, ScdbLung, which was composed of three functional modules (Marker, Cluster, and Download) and dedicated to exploiting the valuable resources of lung scRNA-seq data across four mammalian species. Overall, our scRNA-seq atlas of domestic pig lung, conserved transcription factor regulatory networks and cell-cell communications between domestic pig and human, and ScdbLung could provide guidance for porcine lung research and clinical applicability.

Human lung

Cell type

10.1101/2020.12.20.423716

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Citations (1)

Coffee consumption and risk of colorectal cancer: a dose–response analysis of observational studies

Cancer Causes & Control (2013)

Changwei Tian Wenming Wang Zhiqiang Hong Xingliang Zhang

10.1007/s10552-013-0200-6

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Citations (49)

ULK 1 translocates to mitochondria and phosphorylates FUNDC 1 to regulate mitophagy

EMBO Reports (2014)

Wenxian Wu Weili Tian Zhe Hu Chen Guo Lei Huang

10.1002/embr.201438501

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Citations (477)

Structural insights into a novel histone demethylase PHF8

Cell Research (2010)

Lin Yu Yang Wang Shuo Huang Jianjun Wang Zengqin Deng

Demethylase

Demethylation

Histone Methylation

10.1038/cr.2010.8

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Citations (74)

An Adenosine A1 Agonist 2-Chloro-N6 Cyclopentyladenosine Inhibits the Angiotensin II-Induced Cardiomyocyte Hypertrophy through the Calcineurin Pathway

Cardiology (2014)

Xingliang Zhang Juan Xia Dandan Qian Yang Wang Yongwen Lin

Objectives: The aim of this investigation was to study the underlying mechanism of an adenosine A1 receptor agonist 2-chloro-N6 cyclopentyladenosine (CCPA) inhibiting cardiomyocyte hypertrophy induced by angiotensin II (AngII). Methods: Neonatal rat cardiomyocytes were treated with AngII to generate a cardiomyocyte hypertrophy model. Cardiomyocyte cultures were randomized into 5 groups: control; AngII; AngII + cyclosporin A (CsA); AngII + CCPA, and AngII + CCPA + DPCPX. Cardiomyocyte viability was measured by MTT assay. Protein synthesis was assessed by the application of 3H leucine (3H-Leu) incorporation into protein. The mRNA expressions of atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), β-myosin heavy chain (β-MHC) and calcineurin Aβ (CnAβ) were measured by real-time quantitative PCR. The protein level of CnAβ was dissected by Western blotting. Results: AngII administration at lower concentrations increased the cardiomyocytes viabilities gradually. Surface area, mRNA expressions of ANP, BNP and β-MHC, and 3H-Leu incorporation of AngII-induced cardiomyocytes were increased in a dose-dependent manner. As a calcineurin-specific inhibitor, CsA inhibited 3H-Leu incorporation, surface area, mRNA expressions of ANP, BNP, β-MHC, CnAβ and protein expression of CnAβ of AngII-induced cardiomyocytes. CCPA also suppressed the mRNA and protein expressions of CnAβ and exerted antihypertrophic effects to a greater degree than CsA. The inhibition of CCPA on cardiomyocyte hypertrophy was counteracted by the A1 receptor antagonist DPCPX. Conclusion: The A1 receptor agonist CCPA could significantly inhibit AngII-induced cardiomyocyte hypertrophy via the calcineurin signaling pathway.

CCPA

Atrial natriuretic peptide

Adenosine A1 receptor

10.1159/000364995

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Citations (6)

Silk sericin-decorated supramolecular photothermal nanocatalyst-based ferric sulfide for boosting high therapeutic performance of tumor cells

Journal of Drug Delivery Science and Technology (2022)

Jie Zhao Yingying Li Yuxin Wang Xingliang Zhang Xiaoli Zhang

10.1016/j.jddst.2022.103104

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Citations (3)

Combined Rosiglitazone and Forskolin Have Neuroprotective Effects in SD Rats after Spinal Cord Injury

PPAR Research (2018)

Qingqi Meng Wei Lei Hao Chen Zhencheng Feng Liqiong Hu

The peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist rosiglitazone inhibits NF-κB expression and endogenous neural stem cell differentiation into neurons and reduces the inflammatory cascade after spinal cord injury (SCI). The aim of this study was to explore the mechanisms underlying rosiglitazone-mediated neuroprotective effects and regulation of the balance between the inflammatory cascade and generation of endogenous spinal cord neurons by using a spinal cord-derived neural stem cell culture system as well as SD rat SCI model. Activation of PPAR-γ could promote neural stem cell proliferation and inhibit PKA expression and neuronal formation in vitro. In the SD rat SCI model, the rosiglitazone + forskolin group showed better locomotor recovery compared to the rosiglitazone and forskolin groups. MAP2 expression was higher in the rosiglitazone + forskolin group than in the rosiglitazone group, NF-κB expression was lower in the rosiglitazone + forskolin group than in the forskolin group, and NeuN expression was higher in the rosiglitazone + forskolin group than in the forskolin group. PPAR-γ activation likely inhibits NF-κB, thereby reducing the inflammatory cascade, and PKA activation likely promotes neuronal cell regeneration.

Rosiglitazone

10.1155/2018/3897478

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Citations (10)

Acidic microenvironment responsive polymeric MOF-based nanoparticles induce immunogenic cell death for combined cancer therapy

Journal of Nanobiotechnology (2021)

Xiaoli Zhang Yi Lu Die Jia Wei Qiu Xianbin Ma

Abstract Background The complex tumor microenvironment and non-targeting drugs limit the efficacy of clinical tumor therapy. For ensuring the accurate delivery and maximal effects of anticancer drugs, it is important to develop innovative drug delivery system based on nano-strategies. Result In this study, an intracellular acidity-responsive polymeric metal organic framework nanoparticle (denoted as DIMP) has been constructed, which can co-deliver the chemotherapy agent of doxorubicin (DOX) and phototherapy agent of indocyanine green (ICG) for breast carcinoma theranostics. Specifically, DIMP possesses a suitable and stable nanometer size and can respond to the acidic microenvironment in cells, thus precisely delivering drugs into target tumor sites and igniting the biological reactions towards cell apoptosis. Following in vivo and in vitro results showed that DIMP could be effectively accumulated in tumor sites and induced powerful immunogenic cell death (ICD) effect. Conclusion The designed DIMP displayed its effectiveness in combined photo-chemotherapy with auxiliary of ICD effect under a multimodal imaging monitor. Thus, the present MOF-based strategy may offer a potential paradigm for designing drug-delivery system for image-guided synergistic tumor therapy. Graphical Abstract

Indocyanine Green

10.1186/s12951-021-01217-4

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Citations (28)