Jintao Zhang

Henan Polytechnic University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Yun Pan

Shandong Provincial QianFoShan Hospital

Jiawei Xu

Shandong Provincial QianFoShan Hospital

Liang Dong

First Affiliated Hospital of GuangXi Medical University

Liang Dong

China University of Mining and Technology

Samiksha Wasnik

Loma Linda University

Xiaolei Tang

The Affiliated Hospital to Changchun University of Chinese Medicine

Shengyu Zhou

Chinese Academy of Medical Sciences & Peking Union Medical College

Yonghong Zhang

Soochow University

Chunting Wang

Shandong Provincial Hospital

Dong Zhang

Beijing Chao-Yang Hospital

Cooperative Institutions

Cognitive Neuroimaging Lab

Carrier (United States)

Shandong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Capital Medical University

Peking University

Shandong First Medical University

Sun Yat-sen University

University of Toronto

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Is there any association between asthma and Kawasaki disease? A systematic review and meta‐analysis

Pediatric Pulmonology (2021)

Zihan Wang Jintao Zhang Liang Dong

Abstract Objective Shared immune factors are involved in the pathogenesis of asthma and Kawasaki disease (KD). Consequently, several observational studies have explored an association between KD and asthma. This systematic review and meta‐analysis aimed to explore the association between KD and asthma. Methods PubMed and Embase databases were searched for cross‐sectional, case‐control and cohort studies that investigated the association between KD and asthma. The first author, publication year, study type, sample size, and participant demographics were retrieved. The association between KD and asthma was expressed by the odds ratio (OR) and 95% confidence interval (CI). Results Eleven studies were eligible in the systematic review. The crude ORs (cORs) were extracted from 11 studies, and seven of them also provided adjusted ORs (aORs). The cORs between KD and asthma was 1.53 (95% CI, 1.29–1.81). After adjustment for some confounding factors (age, sex, region), asthma also had an association with KD (aOR, 1.08; 95% CI, 1.00–1.17). The subgroup analyses showed the study design and study location to influence between‐study heterogeneity. Analyses of aOR values revealed that asthma onset before KD onset does not appear to increase KD prevalence, whereas people suffering from KD could increase the prevalence of developing asthma. Conclusion Our meta‐analysis suggested a possible association between preceding KD and asthma onset, but care must be taken when interpreting this result. Prospective cohort studies are needed to assess a causal relationship between these two diseases.

Subgroup analysis

10.1002/ppul.25443

Cite

Citations (3)

An epigenome‐wide DNA methylation study of patients with COVID‐19

Annals of Human Genetics (2021)

Shengyu Zhou Jintao Zhang Jiawei Xu Fayan Zhang Peng Li

Abstract In the early 2000s, emerging SARS‐CoV‐2, which is highly pathogenic, posed a great threat to public health. During COVID‐19, epigenetic regulation is deemed to be an important part of the pathophysiology and illness severity. Using the Illumina Infinium Methylation EPIC BeadChip (850 K), we investigated genome‐wide differences in DNA methylation between healthy subjects and COVID‐19 patients with different disease severities. We conducted a combined analysis and selected 35 “marker” genes that could indicate a SARS‐CoV‐2 infection, including 12 ( ATHL1 , CHN2 , CHST15 , CPLX2 , CRHR2 , DCAKD , GNAI2 , HECW1 , HYAL1 , MIR510 , PDE11A , and SMG6 ) situated in the promoter region. The functions and pathways of differentially methylated genes were enriched in biological processes, signal transduction, and the immune system. In the “Severe versus Mild” group, differentially methylated genes, after eliminating duplicates, were used for PPI analyses. The four hub genes ( GNG7 , GNAS , PRKCZ , and PRKAG2 ) that had the highest degree of nodes were identified and among them, GNG7 and GNAS genes expressions were also downregulated in the severe group in sequencing results. Above all, the results suggest that GNG7 and GNAS may play a non‐ignorable role in the progression of COVID‐19. In conclusion, the identified key genes and related pathways in the current study can be used to study the molecular mechanisms of COVID‐19 and may provide possibilities for specific treatments.

GNAS complex locus

Epigenome

10.1111/ahg.12440

Cite

Citations (21)

Coupling of Indium Clusters with Atomic Fe-N4 on Carbon for Long-term Rechargeable Zn-Air Batteries

Energy & Environmental Science (2024)

Xinxin Shu Xueying Cao Bowen He Xunyi Chen Lanling Zhao

The single atom electrocatalysts with the typical metal-nitrogen-carbon sites possess good oxygen reduction reaction (ORR) activity, yet challenges remain in fabricating rechargeable Zn-air batteries (ZABs) due to their poor oxygen...

Carbon fibers

10.1039/d4ee04465g

Cite

Citations (0)

Treatment of superficial hemangioma of the skin in infants with dual-wavelength cynergy laser

Deleted Journal (2013)

Jinping Chen Jun LiHaipian Li Jintao Zhang Xueyi Lin

Objective To evaluate clinical therapeutic efficacy and safety on infant hemangioma of the skin by using dual-wavelength Cynergy laser.Methods A total of 452 cases infant hemangioma of the skin were treated by using dual-wavelength Cynergy laser.Laser parameters were that energy for pulsed dye laser (PDL) ranged from 10-12 J/cm2,and Nd ∶ YAG 35-60 J/cm2,pulse duration for PDL was 10 ms and for Nd ∶ YAG 15 ms,and pulse delay was the long ext.The spot size was 7 mm.Laser was coupled to chilled air-cooling apparatus (Smartcool,Cynosure).The frequency of treatment was two to four times.The interval of the treatment was 1 month.Results Total response was achieved in 326 cases (72.12 ％),good response in 94 cases (20.80 ％),fair response was achieved in 30 cases (7.08 ％) and poor response was 9 cases had recurrence accounting for 2 ％ within 12 months.Temporary side effects included scar formation in 29 cases (6.42 ％),hyper-pigmentation in 53 cases (11.73 ％),hypo-pigmentation in 24 cases (5.31 ％),and they disappeared after 4 to 6 months.Scalp hemangioma was treated using dual wavelength Cynergy laser.PDL and Nd ∶ YAG was more effective than PDL alone in the treament of scalp hemangioma.No significant differences were found in hair loss between the two models.Conclusions Cynergy multiplex pulsed laser systerm emitting both pulsed dye 585 nm and Nd ∶ YAG 1064 nm wavelength,is a good tool to treat infant hemangioma of the skin.It has the advantage of fast efficacy and less side effects. Key words: Hemangioma; Cynergy laser

Hair removal

Nd:YAG laser

Pulsed laser

Infantile hemangioma

10.3760/cma.j.issn.1671-0290.2013.06.012

Cite

Citations (0)

Differentiation of prostate cancer and benign prostatic hyperplasia: comparisons of the histogram analysis of intravoxel incoherent motion and monoexponential model with in-bore MR-guided biopsy as pathological reference

Abdominal Radiology (2019)

Yadong Cui Chunmei Li Ying Liu Yuwei Jiang Lu Yu

Intravoxel incoherent motion

Multiparametric MRI

10.1007/s00261-019-02227-5

Cite

Citations (16)

Comparison of hair follicles between Yuyi curly rats and SD rats

Journal of Zhengzhou University (2007)

Jintao Zhang

Aim:To explore the histological characters of hair follicles of Yuyi curly rats.Methods:Middorsal section through backskin were stained with hematoxylin and eosin.Results:Compared with that of SD rats,backskin from Yuyi curly rats revealed a dramatic disorientation of hair follicles.Others showed no significant difference in the histological characters of skin between curly rats and SD rats.Conclusion:Mutant gene affected hair follicle growth in curly rats.

Source

Cite

Citations (0)

TNFSF11/TNFRSF11A Axis Amplifies HDM-Induced Airway Remodeling by Strengthening TGFβ1/STAT3 Action

Allergy Asthma and Immunology Research (2024)

Dong Zhang Jintao Zhang Qian Qi Yun Pan Rong Zeng

Asthma, an airway inflammatory disease, involves multiple tumor necrosis factors (TNF). TNF ligand superfamily member 11 (TNFSF11) and its known receptor, TNF receptor superfamily 11A (TNFRSF11A), has been implicated in asthma; however, the related mechanisms remain unknown.

10.4168/aair.2024.16.4.399

Cite

Citations (0)

Mutations with Hair Shape Phenotypes Abnormalities—The Morphogenetic Waves and Related Diseases

Journal of Cosmetics Dermatological Sciences and Applications (2013)

Junmin Wang Guannan Wang Jintao Zhang

Hair morphology is one of the most conspicuous features of human variation. The hair follicle has attracted significant attention as a model for the investigation of diverse biological problems. Whereas, very little is known about the genes influencing the morphology and structure of the hair shaft. Curly hair is very common character of hair phenotypes of human, while most congenital curl occurs owing to genetic factors and some are closely related with genetic diseases. This review highlights current related genes reported affecting hair curliness and human diseases which are due to gene mutations.

Hair shaft

Hair disease

Morphology

10.4236/jcdsa.2013.33a1004

Cite

Citations (2)

Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke

Stroke (2021)

Chongke Zhong Zian Lu Bizhong Che Sifan Qian Xiaowei Zheng

Choline metabolism was suggested to play pathophysiological roles in nervous system and atherosclerosis development. However, little is known about the impacts of choline pathway nutrients and metabolites on poststroke cognitive impairment. We aimed to prospectively investigate the relationships between circulating choline, betaine, and trimethylamine N-oxide with cognitive impairment among acute ischemic stroke patients.We derived data from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). Plasma choline, betaine, and trimethylamine N-oxide concentrations at baseline were measured in 617 participants. Cognitive impairment was evaluated using the Mini-Mental State Examination and the Montreal Cognitive Assessment. Reclassification and calibration of models with choline-related biomarkers were evaluated.Plasma choline and betaine were inversely associated with cognitive impairment. Compared with the lowest tertile, adjusted odds ratios of Mini-Mental State Examination-defined cognitive impairment for participants in the highest tertiles of choline and betaine were 0.59 (95% CI, 0.39-0.90) and 0.60 (95% CI, 0.39-0.92), respectively. In addition, both choline and betaine offered incremental predictive ability over the basic model with established risk factors, shown by increase in net reclassification improvement and integrated discrimination improvement. There were similar significant relationships between choline and betaine with cognitive impairment as defined by the Montreal Cognitive Assessment. However, plasma trimethylamine N-oxide was only associated with cognitive impairment evaluated using the Mini-Mental State Examination; the adjusted odds ratio was 1.33 (95% CI, 1.04-1.72) for each 1-SD increment of trimethylamine N-oxide.Patients with higher choline and betaine levels had lower risk of cognitive impairment after ischemic stroke, supporting promising prognostic roles of choline pathway nutrients for poststroke cognitive impairment.

Choline

Trimethylamine N-oxide

Betaine

Montreal Cognitive Assessment

10.1161/strokeaha.120.031903

Cite

Citations (41)

[Relationship between white blood cell count, neutrophils ratio and erythrocyte sedimentation rate and short clinical outcomes among patients with acute ischemic stroke at hospital admission].

PubMed (2012)

Jia-kai Ye Jintao Zhang Yan Kong Tan Xu Tingting Zou

To investigate the relationship between white blood cell count, neutrophils ratio and erythrocyte sedimentation rate and short outcomes among patients with acute ischemic stroke at admission to the hospital.A total of 2675 acute ischemic stroke patients were included in this study. Data on demographic characteristics, life style, history of disease, white blood cell count (WBC), neutrophils ratio (NEUR), erythrocyte sedimentation rate (ESR) and clinical outcomes were collected for all the participants. Poor clinical outcome was defined as neurologic deficiency (NIHSS ≥ 5) at discharge or death during hospitalization.White blood cell count, neutrophils ratio and erythrocyte sedimentation rate were higher in patients with poor outcome than in those without clinical outcome. According to the quartile range, WBC, NEUR and ESR were divided into four levels at admission. After adjustment for multivariate, compared with WBC ≤ 5.6× 10(9)/L, the odds ratio (95% confidence intervals) of poor outcome with ≥ 8.7×10(9)/L was 1.883 (1.306 - 2.716). When compared with NEUR ≤ 0.56, the odds ratio (95% confidence intervals) of poor outcome with 0.57 - 0.64 and with ≥ 0.74 were 1.572 (1.002 - 2.466) and 2.577 (1.698 - 3.910), respectively. When compared with ESR ≤ 4 mm/h, the odds ratio (95% confidence intervals) of poor outcome with ≥ 17 mm/h was 2.426 (1.233 - 4.776). Elevated WBC count and NEUR at admission were significantly and positively associated with poor clinical outcomes among patients with acute ischemic stroke (trend test P < 0.05). Elevated ESR was not significantly or positively associated with poor clinical outcomes among patients with acute ischemic stroke (trend test P > 0.05).There appeared associations between WBC, NEUR, ESR and poor outcome among patients with acute ischemic stroke at admission to the hospital. Both elevated WBC count and NEUR showed significantly positive association with poor clinical outcomes among patients with acute ischemic stroke at admission.

Erythrocyte sedimentation rate

White blood cell

Quartile

Stroke

Source

Cite

Citations (3)