Xiaochuan Zhang

Harbin Medical University

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Xinmiao Liang

Shanghai Innovative Research Center of Traditional Chinese Medicine

Chunsheng Zhu

First Affiliated Hospital of Zhengzhou University

Zheng Zhou

Henan University of Science and Technology

Caiping Wang

Xi'an University of Science and Technology

Zhengwen Shuang

Lan Zhang

Kunming Medical University

Gonghai Zhang

Jinchuan (China)

Kaiwen W. Chen

National University of Singapore

Xiaopeng An

Northwest A&F University

Haidong Ma

Lanzhou University

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First Affiliated Hospital of Zhengzhou University

Nantong University

Harbin Medical University

Northwest A&F University

First Affiliated Hospital of Harbin Medical University

Shanghai Jiao Tong University

Jilin University

Peking University

Zhejiang University

Beijing University of Chinese Medicine

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Additional file 4: of Chi-miR-3031 regulates beta-casein via the PI3K/AKT-mTOR signaling pathway in goat mammary epithelial cells (GMECs)

Figshare (2018)

Kaiwen W. Chen Jinxing Hou Yuxuan Song Xiaochuan Zhang Yuhan Liu

Table S2. Pathway annotations of differentially expressed genes. (XLSX 13 kb)

BETA (programming language)

10.6084/m9.figshare.7391972

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Citations (0)

Current Study of RhoA and Associated Signaling Pathways in Gastric Cancer

Current Stem Cell Research & Therapy (2020)

Haiping Liu Yiqian Liu Xiaochuan Zhang Xiaodong Wang

Gastric cancer (GC) is the fourth-most common cancer in the world, with an estimated 1.034 million new cases in 2015, and the third-highest cause of cancer deaths, estimated at 785,558, in 2014. Early diagnosis and treatment greatly affect the survival rate in patients with GC: the 5‐year survival rate of early GC reaches 90%‐95%, while the mortality rate significantly increases if GC develops to the late stage. Recently, studies for the role of RhoA in the diseases have become a hot topic, especially in the development of tumors. A study found that RhoA can regulate actin polymerization, cell adhesion, motor-myosin, cell transformation, and the ability to participate in the activities of cell movement, proliferation, migration, which are closely related to the invasion and metastasis of tumor cells. However, the specific role of RhoA in tumor cells remains to be studied. Therefore, our current study aimed to briefly review the role of RhoA in GC, especially for its associated signaling pathways involved in the GC progression.

10.2174/1574888x15666200330143958

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Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons

Journal of Physiology and Biochemistry (2014)

Caiping Wang Guicai Li Yunwei Shi Xiaochuan Zhang Jianlong Li

Cortical neurons

10.1007/s13105-014-0342-3

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Citations (52)

Chi-miR-3031 regulates beta-casein via the PI3K/AKT-mTOR signaling pathway in goat mammary epithelial cells (GMECs)

BMC Veterinary Research (2018)

Kaiwen W. Chen Jinxing Hou Yuxuan Song Xiaochuan Zhang Yuhan Liu

MicroRNAs can regulate gene expression at the posttranscriptional level through translational repression or target degradation. Our previous investigations examined the differential expression levels of chi-miR-3031 in caprine mammary gland tissues in colostrum and common milk stages.The present study detected the role of chi-miR-3031 in the lactation mechanisms of GMECs. High-throughput sequencing was used to analyze transcriptomic landscapes of GMECs transfected with chi-miR-3031 mimics (MC) and a mimic negative control (NC). In the MC and NC groups, we acquired 39,793,503 and 36,531,517 uniquely mapped reads, respectively, accounting for 85.85 and 81.66% of total reads. In the MC group, 180 differentially expressed unigenes were downregulated, whereas 157 unigenes were upregulated. KEGG pathway analyses showed that the prolactin, TNF and ErbB signaling pathways, including TGFα, PIK3R3, IGF2, ELF5, IGFBP5 and LHβ genes, played important roles in mammary development and milk secretion. Results from transcriptome sequencing, real-time PCR and western blotting showed that chi-miR-3031 suppressed the expression of IGFBP5 mRNA and protein. The expression levels of β-casein significantly increased in the MC and siRNA-IGFBP5 groups. We observed that the down-regulation of IGFBP5 activated mTOR at the Ser2448 site in GMECs transfected with MC and siRNA-IGFBP5. Previous findings and our results showed that chi-miR-3031 activated the PI3K-AKT-mTOR pathway and increased β-casein expression by down-regulating IGFBP5.These findings will afford valuable information for improving milk quality and contribute the development of potential methods for amending lactation performance.

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10.1186/s12917-018-1695-6

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Antiparasitic effects of oxymatrine and matrine against Toxoplasma gondii in vitro and in vivo

Experimental Parasitology (2016)

Xiaochuan Zhang Lili Jin Zhe Cui Changhao Zhang Xue Wu

Oxymatrine

Spiramycin

Toxoplasmosis

10.1016/j.exppara.2016.03.020

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