Amanda L. Crow

Children's Hospital at Westmead

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Co-Authors

Jaana Hartiala

University of Southern California

Hooman Allayee

University of Southern California

Rajan Jain

New York University

Zeneng Wang

Cleveland Clinic Lerner College of Medicine

Rommel Cruzado

Children's Hospital at Westmead

Christina Willenborg

University of Lübeck

Brian W. Parks

University of Wisconsin–Madison

Xiaoying Zhou

South China University of Technology

Ishwarya Sankaranarayanan

The University of Texas at Dallas

Mark Tracy

University of Sydney

Cooperative Institutions

University of Southern California

University of California, Los Angeles

Southern California University for Professional Studies

Children's Hospital at Westmead

University of Sydney

University of Pennsylvania

UCLA Health

University of Leicester

Case Western Reserve University

Cleveland Clinic Lerner College of Medicine

Author Statistics

Papers

Citation

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Clinical and Biopsy Specimen Features in Black and White Men With Clinically Localized Prostate Cancer

Southern Medical Journal (2000)

Caleb B. Bozeman Briana J. Williams Terence Whatley Amanda L. Crow James A. Eastham

The incidence of prostate cancer in black men is estimated to be 30% to 50% higher than among age-matched white men, and black men have a twofold higher mortality rate. To determine whether racial differences exist in men with similarly staged disease, we compared clinical and pathologic features in black and white men with clinical stage T1-T2 prostate cancer.We retrospectively reviewed the records of all men who had prostate biopsy at our facilities. Men were included in this study if they were of black or white race, if the clinical stage of their prostate cancer was T1-T2, and if detailed information regarding their prostate biopsy was available.Black men were found to have significantly higher serum prostate-specific antigen (PSA) levels, but no other differences were noted in the other clinical or pathologic features studied.While racial differences in the incidence and mortality of prostate cancer are well known, differences in the clinical and pathologic features between black and white men with similarly staged disease have been poorly studied. Our results suggest that serum PSA levels are higher in black men, but no other differences were noted. This suggests that early detection programs for prostate cancer in black men can potentially decrease prostate cancer mortality.

Negroid

Prostate biopsy

10.1097/00007611-200004000-00010

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Citations (6)

The effects of auditory, tactile, and visual cues on lower extremity running mechanics

Amanda L. Crow Tim Kuhlmann S. Shirk Jean A. Quinn

Sensory cue

Source

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Citations (0)

Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease

Nature Communications (2016)

Jaana Hartiala W.H. Wilson Tang Zeneng Wang Amanda L. Crow Alexandre F.R. Stewart

Abstract Metabolites derived from dietary choline and L -carnitine, such as trimethylamine N -oxide and betaine, have recently been identified as novel risk factors for atherosclerosis in mice and humans. We sought to identify genetic factors associated with plasma betaine levels and determine their effect on risk of coronary artery disease (CAD). A two-stage genome-wide association study (GWAS) identified two significantly associated loci on chromosomes 2q34 and 5q14.1. The lead variant on 2q24 (rs715) localizes to carbamoyl-phosphate synthase 1 ( CPS1 ), which encodes a mitochondrial enzyme that catalyses the first committed reaction and rate-limiting step in the urea cycle. Rs715 is also significantly associated with decreased levels of urea cycle metabolites and increased plasma glycine levels. Notably, rs715 yield a strikingly significant and protective association with decreased risk of CAD in only women. These results suggest that glycine metabolism and/or the urea cycle represent potentially novel sex-specific mechanisms for the development of atherosclerosis.

Genome-wide Association Study

Betaine

Trimethylamine N-oxide

Genetic Association

Choline

10.1038/ncomms10558

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Citations (113)

Neonatologist-performed point-of-care abdominal ultrasound: What have we learned so far?

Frontiers in Pediatrics (2023)

Archana Priyadarshi Sheryl Rogerson Rommel Cruzado Amanda L. Crow Murray Hinder

This review describes the sonographic appearances of the neonatal bowel in Necrotising enterocolitis. It compares these findings to those seen in midgut-Volvulus, obstructive intestinal conditions such as milk-curd obstruction, and slow gut motility in preterm infants on continuous positive airway pressure (CPAP)-CPAP belly syndrome. Point-of-care bowel ultrasound is also helpful in ruling out severe and active intestinal conditions, reassuring clinicians when the diagnosis is unclear in a non-specific clinical presentation where NEC cannot be excluded. As NEC is a severe disease, it is often over-diagnosed, mainly due to a lack of reliable biomarkers and clinical presentation similar to sepsis in neonates. Thus, the assessment of the bowel in real-time would allow clinicians to determine the timing of re-initiation of feeds and would also be reassuring based on specific typical bowel characteristics visualised on the ultrasound.

Neonatology

Necrotizing Enterocolitis

Presentation (obstetrics)

Short Bowel Syndrome

Gastroschisis

10.3389/fped.2023.1173311

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Citations (5)

The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2015)

Xiaoying Zhou Amanda L. Crow Jaana Hartiala Tassja J. Spindler Anatole Ghazalpour

Hematopoietic stem cell

10.17615/h0v8-jg41

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Citations (0)

Transcranial Doppler in children with sickle cell disease: Five years of screening experience

Australasian Journal of Ultrasound in Medicine (2020)

Amanda L. Crow

Abstract Introduction Sickle cell disease (SCD) is an autosomal recessive, inherited disorder of haemoglobin. Children with sickle cell disease (SCD) are at risk of vascular occlusions. If this occurs in the brain, it can result in stroke. Stroke is the leading cause of death and disability in children with SCD. Transcranial Doppler (TCD) has been shown to accurately predict those children at risk of stroke so appropriate preventative treatment can commence. Method TCD screening with a non‐imaging Doppler machine to assess stroke risk has been in operation at our institution for 5 years. Eighty‐eight patients attending the haematology clinic for SCD are scanned annually. If abnormal velocities are found, repeat scans are performed at close interval to ensure results are reproducible. Results No child has had a stroke since the start of our screening. Seven of the eighty‐eight patients have shown high velocities on annual screening. Conclusion The introduction of a TCD programme at out institution has identified children at risk of stroke so they can be closely monitored and potentially receive prophylactic treatment.

Transcranial Doppler

Stroke

Stroke risk

10.1002/ajum.12192

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Citations (4)

Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice

Scientific Reports (2019)

Nicholas C. Woodward Amanda L. Crow Yang Zhang Sam Epstein Jaana Hartiala

Emerging evidence from epidemiological and animal studies suggests that exposure to traffic-related air pollutants and particulate matter less than 2.5 µm in diameter (PM2.5) contributes to development of obesity and related metabolic abnormalities. However, it is not known whether nanoscale particulate matter (nPM) with aerodynamic diameter ≤200 nm have similar adverse metabolic effects. The goal of the present study was to determine the effects of prenatal and early life exposure to nPM on metabolic homeostasis in mice. C57BL/6 J mice were exposed to nPM or filtered air from gestation until 17 weeks of age and characterized for metabolic and behavioral parameters. In male mice, nPM exposure increased food intake, body weight, fat mass, adiposity, and whole-body glucose intolerance (p < 0.05). Consistent with these effects, male mice exposed to nPM displayed alterations in the expression of metabolically-relevant neuropeptides in the hypothalamus and decreased expression of insulin receptor signaling genes in adipose (p < 0.05). There were no differences in exploratory behavior or motor function, fasting lipid levels, or the inflammatory profile of adipose tissue. Our results provide evidence that chronic nPM exposure from gestation to early adulthood in male mice promotes metabolic dysregulation in part through modulation of feeding behavior and in the absence of an obesogenic diet.

Homeostasis

Energy homeostasis

10.1038/s41598-018-37704-2

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Citations (27)

0457: Liver Transplant in Children

Ultrasound in Medicine & Biology (2009)

Amanda L. Crow

Cadaveric spasm

10.1016/j.ultrasmedbio.2009.06.244

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Citations (2)

Sonography for the investigation of a child with a limp

Australasian Journal of Ultrasound in Medicine (2010)

Amanda L. Crow A. Cheung A. Lam Esther Sui Chu Ho

Abstract Hip pain is a common paediatric presentation and is potentially serious. While hip pain can be attributed to primary hip pathology, the hip area is also a common site for referred pain. This often poses a diagnostic challenge particularly in the young child who may not verbalise the point of pain and may not report an injury. Differential diagnoses for paediatric hip joint pain range from fracture, transient synovitis, septic arthritis with or without osteomyelitis, juvenile idiopathic arthritis (JIA, previously juvenile rheumatoid arthritis JRA), Legg‐Calve‐Perthes' disease (LCP), slipped capital femoral epiphysis (SCFE) to haemarthrosis in patient with a clotting disorder. Referred pain from abdominal pathology, for example; appendicitis, psoas abscess or haematoma should also be considered. The evaluation and management of hip pain requires a thorough history and physical examination. A radiograph is usually indicated to rule out any bony injury. Septic arthritis is a medical emergency requiring urgent surgical as well as medical treatment. Ultrasound of the hip joint plays a role in helping to differentiate which hips require early intervention and to guide a needle aspiration of joint fluid if indicated. In this article, we aim to review the anatomy of the hip, techniques in ultrasonographic examination and some common pathologies in the paediatric hip.

Limp

Juvenile rheumatoid arthritis

Hip pain

10.1002/j.2205-0140.2010.tb00160.x

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Citations (13)