Chengyu Chen

Research Field

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Citations (52)

A Novel Molecularly Imprinted Sensor Based on CuO Nanoparticles with Peroxidase-like Activity for the Selective Determination of Astragaloside-IV

Biosensors (2023)

Guoying Chen Lingxiao Chen Jin Gao Chengyu Chen Jianli Guan

In this work, dopamine (DA) was polymerized on the surface of CuO nanoparticles (CuO NPs) to form a molecularly imprinted polymer (MIP@PDA/CuO NPs) for the colorimetric detection of astragaloside-IV (AS-IV). The synthesis process of MIP is simple and easy to operate, without adding other monomers or initiators. CuO NPs has high peroxidase (POD)-like activity that can catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to generate oxidized TMB (OxTMB) in the presence of H2O2, having a maximum ultraviolet-visible (UV-Vis) absorption peak at 652 nm. The AS-IV can specifically bind to the surface imprinted cavities and prevent the entry of TMB and H2O2, which will lead to the inhibition of the catalytic reaction. Therefore, a new approach based on the POD-like activity of MIP@PDA/CuO NPs for AS-IV detection was developed with a linear range from 0.000341 to 1.024 mg/mL. The LOD and LOQ are 0.000991 and 0.000341 mg/mL, respectively. The developed method can accurately determine AS-IV in Huangqi Granules and different batches of Ganweikang Tablets, which are similar to the results measured by HPLC-ELSD and meet the requirements of Chinese Pharmacopoeia (2020 edition) for the amount of AS-IV in Huangqi Granules. The combination of MIP with CuO NPs not only endows the detection of AS-IV with high selectivity and reliability, but also expands the application of nanozymes in the detection of small-molecule compounds that have weak UV absorption, and do not have reducibility or oxidation properties.

Molecularly imprinted polymer

10.3390/bios13110959

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Citations (3)

Activation of persulfate for tetracycline degradation using the catalyst regenerated from Fenton sludge containing heavy metal: Synergistic effect of Cu for catalysis

Chemical Engineering Journal (2020)

Minxian Shen Zhujian Huang Xuewen Luo Yujia Ma Chengyu Chen

Persulfate

Degradation

10.1016/j.cej.2020.125238

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Citations (125)

A fast and efficient virtual screening and identification strategy for helix peptide binders based on finDr webserver: A case study of bovine serum albumin (BSA)

International Journal of Biological Macromolecules (2025)

J. Bu Na Luo Cheng Shen Chongxin Xu Qing Zhu

Bovine serum albumin

Identification

Helix (gastropod)

10.1016/j.ijbiomac.2025.141118

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"Phosphorus Speciation in the Pearl River Estuary of South China"

Environmental Analysis & Ecology Studies (2018)

Chengyu Chen

Based on information of chemical properties in the water samples in the Pearl River Estuary in South China in prior studies, the speciation of phosphorus in water samples from four sampling sites was calculated and modelled by a MINEQL+4.6 Software, in an effort to quantify the likelihood and reason of eutrophication and algal bloom in the local aquatic environment. Results showed that the dominant forms of phosphorus in local water are hydroxylapatite and H2PO4-, with the minor forms being HPO4 2- and CaHPO4. The total dissolved phosphate is 4.55, 4.59, 7.06, and 7.93, 10-6mol/L for Zones A to D, respectively. Increasing Ca2+ concentration leads to precipitation and removal of phosphorus from water, but its concentration will need to be increased by 9, 10, 14.7, and 13.8 times, respectively, in Zones A to D in order to prevent eutrophication and subsequent algal blooms [1].

Genetic algorithm

Hydroxylapatite

10.31031/eaes.2018.03.000575

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Nano-FeS incorporated into stable lignin hydrogel: A novel strategy for cadmium removal from soil

Environmental Pollution (2020)

Yonglin Liu Yongdong Huang Cong Zhang Wenyan Li Chengyu Chen

10.1016/j.envpol.2020.114739

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Citations (87)

Contaminated soil remediation with nano-FeS loaded lignin hydrogel: A novel strategy to produce safe rice grains while reducing cadmium in paddy field