Pigmented villonodular synovitis (PVNS) is a benign proliferative disorder that affects the synovial joints, bursae, and tendon sheaths. To date, few studies have reported on the treatment of postoperative pain and edema in patients with PVNS. Herein, we present the case of a woman who developed pain and edema in the left lower limb 1 wk after synovectomy and arthroscopic partial meniscectomy and was unable to walk due to limited flexion and extension of the left knee.
With its higher rate of morbidity and poor prognosis,heart failure with normal ejection fraction(HFNEF) is attracting increasing amounts of attention.Although the morbidity of HFNEF are increasing in conjunction with the growing aging population,there is still a lack of effective treatment due to controversy surrounding the mechanism and therapy of diastolic heart failure.This article reviews the pathogenesis,diagnosis and treatment of HFNEF.
Abstract Background The elderly are the primary age group of acute kidney injury (AKI). The predictive value of Antithrombin III (ATIII) level in preventing AKI among septic elderly patients has not been studied. The purpose of this study was to evaluate the value of ATIII in predicting AKI nondevelopment and prognosis in septic elderly patients under ICU settings. Materials and methods This is a retrospective study enrolling 107 elderly patients with sepsis who were admitted to ICUs from October 2015 to March 2018. Assessment of renal function was performed daily by measuring serum creatinine level and urine output. The ATIII level was obtained within the first 48 hours of the diagnosis of sepsis (ATIII1). Results Among all enrolled patients, 29 (27.1%) developed AKI. The ATIII level was a predictor of AKI nondevelopment (AUC-ROC =0.729, and sensitivity 0.700and specificity0.714). The ATIII/Cr ratio was also a predictor of AKI nondevelopment (AUC-ROC =0.971, and sensitivity 0.900and specificity1).The accuracy of ATIII and ATIII/Cr in predicting survival was intermediate, with AUC-ROC of 0.681 and 0.804 repectively, sensitivity ranging between 0.802 and 0.596, and specificity between 0.542 and 0.875. The ATIII level demonstrated excellent ability in predicting AKI nondevelopment in septic elderly patients in ICUs. Patients were divided into low ATIII group and high ATIII group using 66.95 or 55.7 as cutoff value. In comparison, ICU stay was significantly lower in the high ATIII group(p=0.020 and 0.049, repectively. Off mechanical ventilation time, off CRRT time, and survival time were significantly higher in high ATIII group(p=0.049,0.048,0.014 using 66.95 as cutoff and 0.041,0.036,0.021 using 55.7 as cutoff). Conclusion This study suggests that ATIII predicts acute kidney injury in septic elderly patients. Lower ATIII predicts worse prognosis .
The torsional vibration of marine diesel engine shafting affects the safety performance of Power device.This paper researches the torsional vibration caused by vibration torque and the vibration characteristics and discusses the hazard produced by torsional vibration.Some methods of preventing and reducing vibration are given in the end.
Wind speed forecasting is an important issue in Marine fisheries. Improving the accuracy of wind speed forecasting is helpful to reduce the loss of fishery economy caused by strong wind. This paper proposes a wind speed forecasting method for fishing harbor anchorage based on a novel deep convolutional neural network. By combining the actual monitoring data of the automatic weather station with the numerical weather prediction (NWP) products, the proposed method constructing a deep convolutional neural network was based wind speed forecasting model. The model includes a one-dimensional convolution module (1D-CM) and a two-dimensional convolution module (2D-CM), in which 1D-CM extracts the time series features of the meteorological data, and 2D-CM is used to mine the latent semantic information from the outputs of 1D-CM. In order to alleviate the overfitting problem of the model, the L2 regularization and the dropout strategies are adopted in the training process, which improves the generalization of the model with higher reliability for wind speed prediction. Simulation experiments were carried out, using the 2016 wind speed and related meteorological data of a sheltered anchorage in Xiangshan, Ningbo, China. The results showed that, for wind speed forecast in the next 1 h, the proposed method outperform the traditional methods in terms of prediction accuracy; the mean absolute error (MAE) and the mean absolute percentage error (MAPE) of the proposed method are 0.3945 m/s and 5.71%, respectively.
Chronic kidney disease (CKD) is a common complication after liver transplantation and is traditionally considered to be secondary to calcineurin inhibitors (CNIs). However, several studies have reported that the etiology of CKD after liver transplantation is broad and may only be assessed accurately by renal biopsy. The current study aimed to explore the usefulness of renal biopsies in managing CKD after liver transplantation in daily clinical practice.This retrospective analysis enrolled all post-liver transplantation patients who had a renal biopsy in a single center from July 2018 to February 2021.Fourteen renal biopsies were retrieved for review from 14 patients at a median of 35.7 (minimum-maximum: 2.80-134.73) months following liver transplantation. The male-to-female ratio was 13:1 (age range, 31-75 years). The histomorphological alterations were varied. The predominant glomerular histomorphological changes included focal segmental glomerular sclerosis (FSGS) (n = 4), diabetic glomerulopathy (n = 4), and membranoproliferative glomerulonephritis (n = 4). Thirteen (92.9%) patients had renal arteriolar sclerosis. Immune complex nephritis was present in six patients, of whom only two had abnormal serum immunological indicators. Despite interstitial fibrosis and tubular atrophy being present in all the patients, only six (42.9%) presented with severe interstitial injury. No major renal biopsy-related complications occurred. After a mean follow-up of 11.8 months (range: 1.2-29.8), three patients progressed to end-stage renal disease (ESRD).The etiology of CKD after liver transplantation might be more complex than originally thought and should not be diagnosed simply as calcineurin inhibitors(CNI)-related nephropathy. Renal biopsy plays a potentially important role in the diagnosis and treatment of CKD after liver transplantation and might not be fully substituted by urine or blood tests. It may help avoid unnecessary changes to the immunosuppressants and inadequate treatment of primary diseases.
Objective To improve MRI operation efficiency by analysis of operation data.Methods The data of MRI operation efficiency was counted from January 2010 to January 2011.Results MRI receipted over 23 persons everyday expect during Spring Festival period,and most persons were receipted during 2:00p.m to 3:00p.m.The head coil,body coil and spine coil were used more often than other coils.Conclusion Efficiency is improved by optimizing process and strengthening maintenance.
Coronary artery disease (CAD) and associated comorbidities such as heart failure (HF) remain the leading cause of morbidity and mortality worldwide attributed to, at least partially, the lack of biomarkers for efficient disease diagnosis. Here, we evaluated the diagnostic potential of serum peptidoglycan recognition protein 1 (PGLYRP1), an important component of the innate immunity and inflammation system, for both CAD and HF. A machine-learning method (random forest) was used to evaluate the clinical utility of circulating PGLYRP1 for diagnosis of CAD and HF in a total of 370 individuals. Causal links of chronic serum PGLYRP1 elevation to both diseases were further explored in ApoE-/- mice. The serum levels of PGLYRP1 were significantly higher in individuals with either chronic CAD or acute coronary syndrome than those in those without coronary artery stenosis (the control group) and even more pronounced in CAD individuals with concomitant HF. Our random forest classifier revealed that this protein performed better than other recommended clinical indicators in distinguishing the CAD from the control individuals. In addition, this protein associates more with the biomarkers of HF including left ventricular ejection fraction than inflammation. Notably, our mice experiment indicated that long-term treatment with recombinant PGLYRP1 could significantly impair the cardiovascular system as reflected from both increased atherogenic lesions and reduced fractional shortening of the left ventricle. Our findings, therefore, supported the circulating levels of PGLYRP1 as a valuable biomarker for both CAD and HF.
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