Dharmendra Kumar

IEC University

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Pramod Kumar Sharma

All India Institute of Medical Sciences Bhopal

Yadu Nandan Dey

Ministry of AYUSH

Manish M. Wanjari

Ministry of AYUSH

Rishabha Malviya

Galgotias University

Ankush Jadhav

Swami Ramanand Teerth Rural Medical College

Shivani Mahor

Sakshi Gupta

Manav Rachna International Institute of Research and Studies

Vinay Lomash

Defence Research and Development Establishment

Tinsae Kebede

Haramaya University

Chanchal Tiwari

Chitkara University

Cooperative Institutions

Ministry of AYUSH

Shobhit University

National Institute of Ayurveda

Central Council for Research in Ayurvedic Science

Central Institute for Research on Buffaloes

Karnataka Veterinary Animal and Fisheries Sciences University

Banaras Hindu University

Indian Institute of Science Education and Research Thiruvananthapuram

Patna Medical College and Hospital

Shoolini University

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Preliminary phytochemical, pharmacognostical and physico-chemical evaluation of Cedrus deodara heartwood

Journal of Pharmacognosy and Phytochemistry (2014)

Sourabh Jain Aakanchha Jain Ankur Vaidya Dharmendra Kumar Vikas Jain

Deodar (Cedrus deodara Roxb.) is one of the most useful traditional medicinal plant in India. Each part of the Deodar tree has some medicinal property and is thus commercially exploitable. During the last five decades, apart from the chemistry of the Deodar compounds, considerable progress has been achieved regarding the biological activity and medicinal applications of Deodar. The present study was carried out to investigate morphological, microscopical, physicochemical and phytochemical screening of Cedrus deodara heartwood. Morphological studies showed the presence of various diagnostic characters. In the microscopical studies showed the presence of Collenchyma, Xylem parenchyma, Tracheids and Sclrenchyma. Ash value, extractive value and moisture content were determined for quality standard of drugs. Phytochemical investigation shows the presence of tannins, flavanoids, alkaloids, and terpenoids.

Phytochemical

Tracheid

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Citations (17)

Corona virus affects fertility: A concern

Annals of Antivirals and Antiretrovirals (2020)

Dharmendra Kumar Rishabha Malviya Pramod Kumar Sharma

Nowadays, world suffer from the outbreak of CORONAVIRUS pandemic. New Case of corona infection increases daily. No satisfied treatment or vaccine is available. Another a new concern is thriving in community is that CORONAVIRUS will affect their fertility.

Thriving

Coronavirus

Pandemic

Corona (planetary geology)

Affect

10.17352/aaa.000008

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Citations (1)

Role of Phytoconstituents in Cancer Treatment: A Review

Recent Advances in Food Nutrition & Agriculture (2024)

Manish Kumar Sakshi Gupta Kamini Kalia Dharmendra Kumar

Over the years, natural compounds have become a significant advancement in cancer treatment, primarily due to their effectiveness, safety, bio-functionality, and wide range of molecular structures. They are now increasingly preferred in drug discovery due to these attributes. These compounds, whether occurring naturally or with synthetic modifications, find applications in various fields like biology, medicine, and engineering. While chemotherapy has been a successful method for treating cancer, it comes with systemic toxicity. To address this issue, researchers and medical practitioners are exploring the concept of combinational chemotherapy. This approach aims to reduce toxicity by using a mix of natural substances and their derivatives in clinical trials and prescription medications. Among the most extensively studied natural anticancer compounds are quercetin, curcumin, vincristine, and vinblastine. These compounds play crucial roles as immunotherapeutics and chemosensitizers, both as standalone treatments and in combination therapies with specific mechanisms. This review article provides a concise overview of the functions, potentials, and combinations of natural anticancer compounds in cancer treatment, along with their mechanisms of action and clinical applications.

Anticancer drug

Cancer Treatment

10.2174/012772574x274566231220051254

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Citations (1)

Antidiabetic activity of Passiflora incarnata Linn. in streptozotocin-induced diabetes in mice

Journal of Ethnopharmacology (2011)

Rakesh Kumar Gupta Dharmendra Kumar Amrendra Kumar Chaudhary Mukesh Maithani Ranjit Singh

Glucose tolerance test

Phytotherapy

10.1016/j.jep.2011.12.021

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Citations (61)

Tongue like projection of the left lobe of liver – A case report

Journal of Anatomical Society of India (2017)

Dharmendra Kumar Richa Gurudiwan C. Sarangi C. Mohapatra

Lobe

10.1016/j.jasi.2017.08.293

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Potential Drug Options for Treatment of COVID-19: A Review

Coronaviruses (2020)

Tinsae Kebede Dharmendra Kumar Pramod Kumar Sharma

A virus known as novel corona (SARS-CoV-2) which causes COVID-19 pandemic disease is an invisible enemy, appeared for the first time in the world’s most populous country, China, and became a reason for causing death of many people all over the world. As a result of this, a remarkable investigation and clinical trials are ongoing to discover the treatment for this devastating pandemic disease. Effective vaccines and anti-viral treatments are immediately required in order to control and eradicate the disease. But still, neither vaccine nor any drug is approved for prevention and control of COVID-19 pandemic. Proper and well-designed strategies are needed to reduce social and economic consequences arisen due to this pandemic disease. There are some drugs that are used for other diseases which are showing valuable outcomes to elicit the virus causing COVID-19. However, there are no approved drugs full of clinical evidence. A systematic review literature search was carried out from different electronic databases to identify available articles on the effectiveness of drugs against COVID-19.Four therapies suggested recently via World Health Organization (abbreviated “WHO”) that were later incorporated for under taking efficient clinical trial of the newly established project (European Discovery), comprise remdesivir, combination of anti-viral drugs (lopinavir and ritonavir), lopinavir plus ritonavir with beta interferon, and anti-malarial drugs like hydroxyl chloroquine and chloroquine. On May 25 2020, hydroxychloroquine and chloroquine were suspended by WHO from Solidarity trial because of their safety and efficacy concerns. However, there were neither effective specific antivirals nor drug combinations approved which were supported by great-level of clinical evidence.

Lopinavir

Hydroxychloroquine

Pandemic

Ritonavir

10.2174/2666796701999200701131604

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Citations (12)

Investigation of Softer Lattice Dynamics in Defect Engineered GeTe Crystals

arXiv (Cornell University) (2025)

Saptak Majumder Pintu Singha Sharath Kumar Channarayappa Mayanak K. Gupta Dharmendra Kumar

In this paper, we investigated the low-temperature lattice dynamics in two GeTe crystals with varying Ge defect stoichiometry. The X-ray Diffraction (XRD) of the as-cleaved ingots indicate that the orientation is mainly along the h0l direction. From the Raman spectra, a comparison of the linewidth variation with temperature for the in-plane (E-mode) vibrations reveals a subtle enhancement around 170 K for the less stoichiometric crystal, depicting a more anharmonic nature, via the 4-phonon scattering processes. Furthermore, a comparison of the out-of-plane A_T^1 mode indicates a sensitivity of a weaker Raman signal ( about 239 cm -1) from disordered GeTe4 tetrahedra that has adversely affected the mode dynamics in the less stoichiometric sample (S1). However, this weaker signal is not observed for the more stoichiometric sample (S2) below 200 K. The Machine Learned Molecular Dynamics (MLMD) simulations performed to calculate the phonon spectral densities reveal that the heavier atom, Te dominate below 100 cm-1, while, the lighter Ge has more significant contribution above 100 cm-1. Thus, the change observed only in the 120 cm-1 (A_T^1) mode is justified by defects at the Ge sites. Specific heat capacity measurements are performed that show a broad hump near 14 K, when plotted as Cp/T^3 versus T indicative of a non-Debye nature. Hence, considering the two optical modes in the Raman spectra, a Debye and two-Einstein modes model is conceptualized to explain the low-temperature specific heat. These calculations reveal a softer bonding vis-a-vis lowering of Debye temperature in S1. Lower Einstein temperatures are also observed in S1, which is attributed to the easy activation of these localized modes that affect the harmonicity of the lattice. Finally, the low-temperature resistivity measurements reveal a reduction in the effective phonon frequency (w_e) through the estimation of Te.

Lattice (music)

Dynamics

10.48550/arxiv.2502.10745

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Corona Virus: A Review of COVID-19

Eurasian Journal of Medicine and Oncology (2020)

Dharmendra Kumar

Corona virus causes respiratory infection including pneumonia, cold, sneezing and coughing while in animal it causes diarrhea and upper respiratory diseases. Corona virus transmitted human to human or human to animal via airborne droplets. Corona virus enters in human cell through membrane ACE-2 exopeptidase receptor. WHO and ECDC advised to avoid public place and close contact to infected persons and pet animals. Firstly Corona virus (2019-nCoV) was isolated from Wuhan market China at 7 Jan. 2020. Keywords: Corona virus, COVID-19, MERS-CoV, SARS-CoV, Wuhan

Corona (planetary geology)

Virus diseases

2019-20 coronavirus outbreak

Common cold

10.14744/ejmo.2020.51418

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Citations (223)

Advancement in Nano Pharmaceutical Formulations and their Biomedical Use

Nanoscience &amp Nanotechnology-Asia (2020)

Dharmendra Kumar Rishabha Malviya Pramod Kumar Sharma Akanksha Sharma Vineet Bhardwaj

Nanoparticles and modified nanoparticles are used in biological and medical sciences as liposomes, polymeric micelles, block ionomer complexes, dendrimers, inorganic and organic nanoparticles. Nanoparticles and surface-modified nanoparticles show good stability and water solubility and can be used efficiently as drug delivery carriers. This paper summarizes the advancement in nanoparticles/surface-modified nanoparticles and patents based on them.

10.2174/2210681210999200723165456

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ASSESSMENT OF CAUSES FOR UNNATURAL DEATHS AMONGST FEMALE CHILDREN AND ADOLESCENTS IN BIHAR

International Journal of Medical and Biomedical Studies (2018)

Ritu Ritu Dharmendra Kumar Sohan Prasad Choudhary Anil Shandil Ramanand Choudhary

If a person dies naturally, then there lies no suspicion so as to the death of the person. But in case of unnatural death, the death is caused due to circumstances which needs to be explained and examined. This study is aimed at describing the contribution of social conditions and violence against women towards the main causes of unnatural deaths among the females. The main objectives of the study are to: a) Ascertain the various aspects of unnatural female deaths, b) Analyze the probable reasons for the same c) Contribution of social conditions and violence against women towards the main causes of unnatural deaths. Total 50 cases of unnatural deaths referred for autopsy in the Patna Medical College Patna from April 2018 to Nov 2018, were evaluated in the present study. Only female’s cases of childrens and adolescents with the age group of 5 to 20 years were enrolled in the present study. The approval of the institutional ethics committee was taken before starting the study. Majority of the victims of 'unnatural deaths belonged to the lower socioeconomic category. Suggestions relating to road safety, decreasing the stress of the modern mechanical life-style, educating the public in general and regarding. The availability, use and storage of poisonous substances in particular have been put forward, while highlighting the social evil of dowry system prevailing in India. Keywords: Unnatural female deaths, dowry deaths, bride burning, social aspects.

Dowry

Verbal autopsy

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