1768 Objectives To study the clinical value of the evaluation of therapeutic efficiency and differential diagnosis of benign and malignant lesions in prostate cancer patients with bone metastases, in the use of 99mTc-MDP SPECT whole body and SPECT/CT partial tomographic fusion bone imaging semi-quantitative analysis technology respectively. Methods Analysis the results of bone scans and other clinical data about 34 hospitalized Prostate cancer bone metastasis-positive patients, who had accepted 99mTc-MDP bone imaging at the department of Nuclear Medicine in the First Clinical Hospital of Shanxi Medical University from September 2013 to December 2015. With the pathological examination, review follow-up and other imaging study findings as a reference, analyzing the correlation of imaging agent uptake degree on the 99mTc-MDP whole body bone imaging and prostate cancer-specific antibody (PSA) in 34 Prostate cancer patients. By ROIs technology, we studied the differences of images agent uptake degree (tumour / nontumour, T/NT) among the malignant lesions in Positive patients with bone metastases of prostate cancer and benign lesions in bone metastasis-negative patients and normal bone tissue in normal control group in the tomography fusion imaging. Besides, using the ROC curve to obtain the cutoff between benign and malignant lesions on 99mTc-MDP SPECT /CT partial tomographic fusion bone imaging. Results PSA of Prostate cancer bone metastasis-positive patients is significantly higher than negative patients. The degree of the imaging agent uptake on the 99mTc-MDP whole body bone imaging and prostate cancer-specific antibody (PSA) ratio has correlation in 34 patients. The correlation coefficient r is 0.356. Differences of the imaging agent uptake levels in 99mTc-MDP SPECT local tomography are statistically significant (Bonferoni correction, P Conclusions Differences of PSA are statistically significant in Positive patients with bone metastases of prostate cancer and bone metastasis-negative patients. Along with the increasing of malignant lesions’ imaging agent uptake degree on 99mTc-MDP SPECT whole body bone imaging, the level of serum PSA increases gradually. The imaging agent uptake levels among the malignant lesions in Positive patients with bone metastases of prostate cancer and benign lesions in bone metastasis-negative patients and normal control group of normal bone tissue in 99mTc-MDP SPECT partial tomographic fusion bone imaging is significantly different, and the author believes that T/NT蠅2.94 is much better for the differentiation of benign and malignant lesions. 99mTc-MDP bone imaging semi-quantitative analysis combines with PSA is expected to make a early definite diagnosis of prostate cancer bone metastases specifically, aiding to select reasonable treatment plans and getting More accurate treatment effects and prognosis.
Objective To study the clinical effects of treating advanced colorectal cancer with compound Kushen injection plus chemotherapy.Methods Totally 104 cases of patients who were confirmed as advanced colorectal cancer by cytology or histological were randomly divided into the treatment group(compound Kushen combined group) and the control group(chemotherapy alone) in June 2006 to January 2009,56 cases in the treatment group,48 cases in the control group,compared the difference of effect,quality of life,adverse effects.Results The effective rate of treatment group was 72%,in the control group the effective rate was 65%,so the difference was no statistically significant(P0.05).Quality of life improved after treatment,the effective rate of treatment group was 75%(42/56),the control group was 45.8%(22/48),the quality of life of the treatment group was better than the control group,the difference had significance(P0.01).The effective rate of reduction of white blood cells,diarrhea,peripheral neuritis,nausea,vomiting,anemia,thrombocytopenia in the treatment group was lower than that of the control group,the difference was statistically significant(P0.05).Conclusions Compound Kushen injection can improve the quality of life,and reduce adverse effects of chemotherapy.
Background: Nowadays, mental health problems have become a major concern affecting economic and social development, with severe mental health disorders being the top priority. In 2013, Beijing began to implement the Community Free-Medication Service policy (CFMS). This article aims to evaluate the effect of the policy on medication adherence. Methods: In this study, multi-stage sampling was used to select representative patients as samples. Some of the baseline data were obtained by consulting the archives, and information about patient medication adherence measured by Brooks Medication Adherence Scale was obtained through face-to-face interviews. Logistic regression was used to examine the impact of the policy. Results: Policy participation had a significant positive impact on medication adherence (OR = 1.557). The effect of policy participation on medication adherence in the Medication-only mode and Subsidy-only mode were highly significant, but it was not significant in the Mixed mode. Conclusion: This study found that the CFMS in Beijing as an intervention is effective in improving the medication adherence of community patients. However, the impact of the policy is not consistent among service modes. Reinforcement magnitude and frequency should be considered when designing reinforcement interventions.
Traditional methods for dielectric characterization and concentration measurements are hindered by technical limitations, the requirement for sample pretreatment, and complex instrument operation. To address these issues, a sensor that combines coplanar waveguide (CPW) and split ring resonator (SRR) technology is proposed in this article, with the resonance frequency of 1.87 GHz and a corresponding transmission coefficient of up to −1.6 dB. This sensor enables nondestructive, real-time, and convenient measurements without the need for sample pretreatment. Organic solvents, including ${n}$ -hexane, carbon tetrachloride, and ethyl acetate, are characterized based on CPW–SRR sensor. The resonance frequency shifts range from 1.4 to 12.2 MHz in the sensor when samples with relative permittivity ranging from 1.89 to 80.1 are measured. In addition, for the volume fractions (0%–100%) of ethanol solution and methanol–ethanol mixed solution, the sensor produces transmission coefficient responses of −1.625 to −1.468 and −1.556 to −1.464 dB, respectively. The sensor offers advantages of low loss, compact size, and cost-effectiveness, making it a promising technical solution for applications in microwave sensors, chemistry analysis, and integrated circuits.
In order to reduce the infrared radiation intensity of supersonic tail nozzles and in response to the increasingly severe battlefield infrared environment, simulations were conducted on axisymmetric expanding tail nozzles to study the effects of air, liquid nitrogen, and dry ice cold flows at different flow rates on the nozzle wall temperature. The results show that when the dry ice flow rate is increased by 1 kg/s, the maximum temperature of the wall surface in the expansion section decreases by about 40 K. At a cold flow rate of 5% in the 0° detection direction, the intensity of infrared radiation was reduced by 20.8% for the liquid nitrogen cold flow and 26.3% for the dry ice cold flow, compared to the cold flow of injected air. The IR suppression of the tail nozzle was significant in the range from α = 0 to 50°. Compared to cooling air, the maximum IR radiation intensity was reduced by 26.5% for dry ice and 20.4% for liquid nitrogen. When the flow rate of the injected cold stream was increased by 4%, the intensity of the infrared radiation from the nozzle was reduced by 52.6%, 55.8%, and 66.2% for the injected air, liquid nitrogen, and dry ice cold streams, respectively.
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) is an intracellular sensor of cytoplasmic viral DNA created during virus infection, which subsequently activates the stimulator of interferon gene (STING)-dependent type I interferon response to eliminate pathogens. In contrast, viruses have developed different strategies to modulate this signalling pathway. Pseudorabies virus (PRV), an alphaherpesvirus, is the causative agent of Aujeszky’s disease (AD), a notable disease that causes substantial economic loss to the swine industry globally. Previous reports have shown that PRV infection induces cGAS-dependent IFN-β production, conversely hydrolysing cGAMP, a second messenger synthesized by cGAS, and attenuates PRV-induced IRF3 activation and IFN-β secretion. However, it is not clear whether PRV open reading frames (ORFs) modulate the cGAS–STING-IRF3 pathway. Here, 50 PRV ORFs were screened, showing that PRV UL13 serine/threonine kinase blocks the cGAS–STING-IRF3-, poly(I:C)- or VSV-mediated transcriptional activation of the IFN-β gene. Importantly, it was discovered that UL13 phosphorylates IRF3, and its kinase activity is indispensable for such an inhibitory effect. Moreover, UL13 does not affect IRF3 dimerization, nuclear translocation or association with CREB-binding protein (CBP) but attenuates the binding of IRF3 to the IRF3-responsive promoter. Consistent with this, it was discovered that UL13 inhibits the expression of multiple interferon-stimulated genes (ISGs) induced by cGAS–STING or poly(I:C). Finally, it was determined that PRV infection can activate IRF3 by recruiting it to the nucleus, and PRVΔUL13 mutants enhance the transactivation level of the IFN-β gene. Taken together, the data from the present study demonstrated that PRV UL13 inhibits cGAS–STING-mediated IFN-β production by phosphorylating IRF3.
Abdominal organs are important organs that sense and respond to ischemia and hypoxia, but there are few evaluation methods. We use ultrasonography to evaluate abdominal organ function and blood flow in patients with mechanical ventilation after cardiopulmonary bypass and to obtain a semiquantitative score for abdominal organ function and blood flow. Patients with cardiopulmonary bypass in the Critical Care Department of Peking Union Medical College Hospital in China from March to July 2021 were enrolled in this prospective observational study. The correlation of the celiac visceral blood flow and function score with the ventilator assistance time, number of days spent in the intensive care unit (ICU), acute physiology and chronic health evaluation II (APACHE-II), sequential organ failure assessment (SOFA), lactate, epinephrine, and norepinephrine use was analyzed at t1 (0–12 h after operation) and t2 (12–24 h after operation), and the results were used to assess the predictive value of the receiver operating characteristic curve (ROC) regression analysis score for the mechanical ventilation time. Of the 92 patients who underwent cardiopulmonary bypass, 41 were finally included. The celiac visceral blood flow and function scores at t1 and t2 were significantly correlated with the ventilator assistance time, number of days spent in the ICU, APACHE-II score, SOFA score, and norepinephrine use time. The scores obtained for the blood flow and function of abdominal organs in a group of patients using ventilators for 36 h or more were significantly higher than those obtained for a group of patients using ventilators for less than 36 h (P <0.05). The evaluation results for the abdominal-visceral-blood-flow-and-function score (t1) were as follows: area under the ROC curve (AUC)=0.876 (95% confidence interval [CI]: 0.767–0.984), cut-off value=2.5, specificity=0.842, and sensitivity=0.773. Abdominal visceral organ function and blood perfusion can be used to evaluate gastrointestinal function. It is related to early and late extubation after cardiac surgery.
Objective To determine the effect of restriction of third-generation cephalosporin use on antibiotic resistance and the outcome of patients with infection. Design A prospective, before–after comparative study. Setting A general intensive care unit with 14 beds at a university-affiliated teaching hospital. Patients All patients admitted to the intensive care unit within 2 yrs. Interventions A new antibiotic treatment strategy was implemented during phase II. All patients with confirmed or suspected Gram-negative bacterial infections were treated mainly with antibiotics other than third-generation cephalosporins. Measurements and Main Results Antibiotic resistance among common Gram-negative bacilli and infection-related hospital mortality during phase I were compared with phase II. A 26.6% reduction in third-generation cephalosporin use (from 168.2 ± 48.0 to 123.5 ± 39.3 g/month, p = .021), accompanied by a 277.7% increase in cefepime use (from 10.3 ± 19.2 to 38.9 ± 31.7 g/month, p = .014) occurred in phase II compared with phase I. This was accompanied by a significant decrease in reduced susceptibility of Gram-negative bacilli to third-generation cephalosporins (p < .05), mainly because of the improved susceptibility of Escherichia coli and Klebsiella species (p < .05). Infection-related hospital mortality was significantly lower in phase II (19.3% vs. 36.3%, p = .014). Multiple logistic regression analysis demonstrated lower respiratory tract infection, the status of immunocompromise, and continuous veno-venous hemofiltration as independent risk factors for infection-related hospital mortality (p < .05), whereas infection with E. coli or Klebsiella species (p = .039) and restriction of third-generation cephalosporin use (p = .025) were associated with a significantly lower mortality rate. Conclusions Restriction of third-generation cephalosporin use may improve the antibiotic susceptibility and reduce infection-related hospital mortality in critically ill patients.
Abstract Background: CZT-SPECT has good agreement in the evaluation of mechanical synchronization compared with conventional SPECT.Theaim of this study was to evaluate the correlation between left ventricular mechanical contraction synchrony and left ventricular systolic function by gated myocardial perfusion imaging (GMPI) using Cadmium-Zine-Telluride(CZT)single photon emission computed tomography (SPECT).Methods: This retrospective study involved 371 patients （239 malesand 132 females, mean age 61.06 ± 11.78 years old）who underwent GMPI at the Nuclear Medicine Department of Shanxi Cardiovascular Hospital from January 2020 to August 2020. Systolic synchrony parameters and left ventricular systolic function parameters were calculated via Emory Cardiac Toolbox，includingPP, PSD, PHB, HS, HK, EDV, ESV, and LVEF. Based on LVEF value, patients were divided into the severe reduction group (group 1,127cases, EF<35%), moderate reduction group (group 2, 47 cases, 35% ≤ EF < 45%), mild reduction group (group 3,50 cases, 45%≤EF < 50%) and normal group (group 4 ,147 cases, EF≥50%).Differencesin PP, PSD, PHB, HS and HK between the four groups were compared using one-way ANOVA. Differences between two groups were compared usingLSD-ttest. The correlation among functional and mechanical contraction synchronism factors were analyzed using Pearson test.Results: PP, PSD, PHB, HS and HK were significantly different betweenthe four groups (F=5.20, 188.72, 202.88, 171.05, 101.36, P<0.001). Pairwise comparison tests showed significant differences in PSD and PHB in each two groups, and HS and HK in each two groups except for group 2 and 3 (t=0.28 and 0.39, both P> 0.001). PP was significantly higher in group 1, relative to group 3 (t=2.43, P<0.001) and group 4 (t=3.67, P<0.001). Pearson correlation analysis revealed that LVEF negatively correlats with PP, PSD, PHB (r = 0.194, -0.790, -0.799, all P<0.001). HS and HK showed positive correlation for LVEF (r=0.778 and 0.795, P<0.001), PSD, PHB and ESV were had good positive correlation (r=0.778, 0.795, P<0.001), PSD, PHB and EDV had good positivecorrelation (r=0.722, 0.732, P<0.001). However, PP had poor correlation with EDV (r=0.095, P>0.001). HS and HK were negatively correlated with EDV and ESV (r=-0.700～ -0.594,P<0.001).Conclusion: CZT SPECT GMPI provided left ventricular mechanical contraction synchrony parameters that correlated well with left ventricular systolic function. Worse left ventricular mechanical contraction synchrony lead to decreased LVEF , making the systolic synchrony parameters valuable in the prediction of left ventricular systolic function．
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