The Comprehensive Research Facility for Fusion Technology (CRAFT) serves as a pivotal pilot research project of the China Fusion Engineering Test Reactor (CFETR). The superconducting conductor experiment testing platform (Super-X) is a part of CRAFT to assess the performance of future superconducting components. The Direct Current (DC) magnet generates the background field in the Super-X facility. A “wind and react” process is employed in the fabrication of Nb3Sn coils for DC magnet. We designed and constructed a circulating atmosphere heat treatment system for the completion of Nb3Sn coil heat treatment. Given the significant influence of heat treatment temperature, particularly in terms of temperature uniformity, on the critical properties of Nb3Sn, it is imperative to analyze the temporal evolution of temperatures within Nb3Sn coils during the heat treatment process. In this study, the coil temperature field distribution during heat treatment process has been analyzed using finite element method. Additionally, thermocouples are placed on coil's surface to monitor temperature changes during heat treatment. Both simulation results and experimental data demonstrate that the uniformity of heat treatment temperature satisfies technical requirements.
Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any SNPs are associated with some traits and those tests are correlated. When test statistics are correlated, false discovery control becomes very challenging under arbitrary dependence. In the current paper, we propose a novel method based on principal factor approximation, which successfully subtracts the common dependence and weakens significantly the correlation structure, to deal with an arbitrary dependence structure. We derive an approximate expression for false discovery proportion (FDP) in large scale multiple testing when a common threshold is used and provide a consistent estimate of realized FDP. This result has important applications in controlling FDR and FDP. Our estimate of realized FDP compares favorably with Efron (2007)'s approach, as demonstrated in the simulated examples. Our approach is further illustrated by some real data applications. We also propose a dependence-adjusted procedure, which is more powerful than the fixed threshold procedure.
The hydraulic servo control system of the ground motion parameter field test system is introduced in this paper. The hydraulic servo control system mainly includes the seismic wave generating equipment system and the servo control system. And the equipment system consists of the P-wave and the S-wave generator. The main advantage of the hydraulic servo control system is that P-wave and S-wave generator can generate both p-wave and S-wave. The seismic waves produced are characterized by strong stability and high energy, which can overcome the shortcomings of instability, less energy and poor repeatability of the on-site wave generating device. It is necessary to generate the waveform of different types of seismic waves, such as sine wave, cosine wave, square wave and random wave. The vibration frequency of the seismic wave can be controlled to meet the actual demand of the seismic wave in engineering. The hydraulic servo control system can be run stably for a long time, without interference and unreliable operation in various environments and states, which can be of great significance for the seismic safety evaluation of the engineering site.
775 Background: Current treatment for high-risk non-muscle invasive bladder cancer (HR-NMIBC) involves Bacillus Calmette-Guérin (BCG) therapy, or radical cystectomy (RC) especially for patients with very-high-risk features. However, 40%-60% HR-NMIBC pts will relapse after BCG treatment. Moreover there are a high incidence of postoperative complications and a negative impact on health-related quality of life after RC. Disitamab Vedotin (DV) is a novel antibody drug conjugate (ADC) that targets the HER2 protein, however its efficacy and safety in HR-NMIBC are limited.We conducted a prospective, open label, single-center study to evaluate the value of RC48 combined with BCG in HR-NMIBC pts. Methods: In this study, two cohorts of BCG-naive pts with very-high-risk features who refused to undergo RC or did not meet the requirements of RC with HER2 expression (IHC 1+/2+/3+) were enrolled (Cohort A:pts were unable to undergo complete tumor resection or have CIS. Cohort B: pts underwent complete tumor resection). All pts will receive eight cycles of intravenous injection of DV (2mg/kg, once every three weeks) and at least one year of BCG intravesical instillation. The Primary endpoints included the 3-month cCR rate in Cohort A and the 6-month EFS rate in Cohort B. The secondary endpoints were to evaluate additional efficacy end points and safety. Results: From Dec 2023 to Aug 2024, twenty eligible pts(16 male;4 female)were enrolled, with 15 pts in Cohort A and 5 pts in Cohort B. 17 of pts had HER2 high expression (2+ or 3+), and 3 of them had HER2 low expression (1+). As a cut-off date (12-Sep-2024), the cCR rate at 3 months and 6 months were both 100% in 11 and 5 pts of Cohort A and the EFS rate at 6 months was also 100% in 3 pts of Cohort B. 65% (13/20) pts experienced treatment-related adverse events (TRAEs). The most common TRAEs included AST/ALT increase 40%(8/20) ,alopecia 45% (9/20), peripheral sensory neuropathy 35% (7/20), anorexia 10% (2/20) and rash 5% (1/20). Grade 3 TRAEs occurred in 10% (2/20) pts with one peripheral sensory neuropathy caused by DV and one hematuria caused by BCG. 60% (12/20) pts had BCG-related AEs including bladder irritation, fever, arthralgia, conjunctivitis and hematuria. Conclusions: This was the first study to evaluate DV in combination with BCG in the treatment for HR-NMIBC. Preliminary results showed the combination had promising efficacy with a manageable safety profile. This may potentially provide a new bladder-sparing therapy for very HR-NMIBC pts with HER2 expression who refused RC or did not meet the requirements of RC. Clinical trial information: NCT06187506 .
Molecular prognostic factors for individualized treatment of squamous cell carcinoma (SCC) are poorly defined. Our study developed and validated a novel molecular tools aid in preinguinal and postinguinal lymphadenectomy risk stratification in node-positive penile SCC. Patients with node-positive penile SCC who underwent inguinal or ilioinguinal lymphadenectomy were divided into three cohorts: a discovery set, a development set and a validation set. The local ethics committee approved the study. The primary endpoint was cancer-specific survival (CSS). At the discovery stage, 17 CpG sites were significantly associated with CSS. In the development set, we constructed a 3-CpG-based prognostic score for survival prediction. The hazard ratio (HR) of the panel (dichotomized using the optimal cutoff) was 5.8 in the multivariate analyses (P < .001). The addition of the methylation score significantly improved the pN-stage C-index from 0.70 to 0.79 (incremental C = 0.09, P < .001). In the validation set, the methylation panel showed a HR of 9.9 in the multivariate analyses. The addition of the molecular marker improved the pN-stage C-index from 0.69 to 0.78 (incremental C = 0.09, P < .001). The methylation score remarkably separated survival curves in different pN stages, which indicate that the tool can be applied to tailor the treatment in both preinguinal and postinguinal lymphadenectomy settings. We developed and validated a prognostic methylation panel for node-positive penile SCC. The tool may aid in the risk stratification of the population with heterogeneous outcomes and needs prospective validation. Patients in high-risk group may benefit from more aggressive therapy or clinical trials.
Industrial control systems (ICS) are widely used in critical infrastructure such as national water resources, power, transportation, energy and so on. These important industrial systems have a profound impact on national security and economic development. In recent years, the occurrence of various security incidents and their serious consequences further reflect the seriousness of the information security situation of industrial control systems. In this paper, the current situation of information security in industrial control systems is summarized and analyzed. The existing problems in ICS information security and the corresponding measures taken are focused on. Furthermore, the problems to be solved and the development direction are pointed out.
Semi-circle bending (SCB) test is an important test in the field of rock fracture. In order to investigate the propagation process of 3-D internal cracks under semi-circular bending, numerical simulations of SCB specimens were carried out based on the finite element method and adaptive mesh technique. The results show that the numerical simulation results of this method are in good agreement with the previous laboratory test. The symmetrical loading model belongs to the pure I loading where the value of KI is positively related to the bottom load span S/R. The asymmetric loading model belongs to mix-mode loading. With the increase of unilateral load span S2/R, there is a decline and then a rise of the value of SIF at the same point at the crack tip. The S2/R is an important factor affecting the mechanical properties of rock specimens. The crack propagation path was obtained based on the maximum tensile stress (MTS) criterion. In-plane propagation of the internal crack in the symmetrically loading model leads to failure of the specimen. Wing propagation of the internal crack in the asymmetrically loading model causes the specimen to fracture into two asymmetrical parts. Quantitative analysis of the internal crack propagation of the symmetrical loading model shows that the growth rate of the lower end of the crack is the largest, and the upper end of the crack is the smallest. The above results can provide a reference for the research on the propagation of 3-D internal cracks of SCB specimens.
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