Jia Yang

Shantou University

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Jinming Yu

Shandong First Medical University

Man Hu

Shandong Tumor Hospital

Xingchen Ding

Shandong First Medical University

Dianbin Mu

Shandong Tumor Hospital

Meilan Xue

Sinai Health System

Shulun Nie

Qilu Hospital of Shandong University

Xianbin Zhang

Shenzhen University

Zihan Zhou

Hebei University of Technology

Xinbin Bai

National University of Defense Technology

Kunpeng Qin

First Affiliated Hospital of Anhui Medical University

Cooperative Institutions

Shandong First Medical University

Shandong Tumor Hospital

Sun Yat-sen University

Shandong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhejiang Chinese Medical University

The First Affiliated Hospital, Sun Yat-sen University

Wuhan University

Chinese Academy of Sciences

Sichuan University

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Overexpression of Ku80 Suggests Poor Prognosis of Locally Advanced Esophageal Squamous Cell Carcinoma Patients

World Journal of Surgery (2015)

Shuai Wang Zhou Wang Xiangyan Liu Yu Liu Jia Yang

Ku80

Univariate analysis

10.1007/s00268-015-3023-7

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Citations (9)

High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites

Gastroenterology (2021)

Jia Yang Hong Wei Yunfei Zhou Chun Ho Szeto Chuangen Li

Dysbiosis

10.1053/j.gastro.2021.08.041

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Citations (314)

Allicin attenuates H2O2-induced cytotoxicity in retinal pigmented epithelial cells by regulating the levels of reactive oxygen species

Molecular Medicine Reports (2016)

Gerile Tu Y.F. Zhang Wei Wei Langen Li Yanmei Zhang

Retinal pigmented epithelial cell (RPE) oxidative stress is known to have a vital role in the etiology of age‑related macular degeneration (AMD). The present study aimed to investigate whether allicin, a natural product with antioxidant activity, was able to protect RPEs (ARPE‑19) from hydrogen peroxide (H2O2)‑induced damage, and to determine the underlying mechanisms. The 3-(4,5-dimethylthiazol-2-yl)-2,5‑diphenyl tetrazolium bromide assay was used to determine cellular viability, and reactive oxygen species (ROS) were detected using a ROS Assay kit. The results demonstrated that allicin was able to protect ARPE‑19 cells from H2O2‑induced damage in a dose‑dependent manner. In addition, allicin attenuated oxidative stress by reducing the levels of intracellular ROS and malondialdehyde (MDA), and enhancing the glutathione/glutathione disulfide (GSSG) ratio. With regards to the underlying mechanism, allicin was able to markedly modulate the expression levels of ROS‑associated enzymes, including superoxide dismutase, NADPH oxidase 4 and NAD(P)H dehydrogenase quinone 1, and elevate the activity of nuclear factor erythroid 2‑related factor 2 in the H2O2‑stimulated ARPE‑19 cells. These results suggested that allicin may exert protective effects against H2O2‑induced cytotoxicity in RPEs via ROS regulation.

Viability assay

Malondialdehyde

Glutathione disulfide

10.3892/mmr.2016.4797

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Citations (27)

Histopathologic validation of 18F-fluorothymidine PET for detecting tumor repopulation during radiotherapy of human FaDu squamous cell carcinoma in nude mice

Journal of Nuclear Medicine (2014)

Jia Yang Jing Liu Jason T. Lee Daniel Cabrera Jinming Yu

Repopulation

Source

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Relationship Between Microbiome and Colorectal Cancer

Elsevier eBooks (2019)

Jia Yang Jun Yu

Fusobacterium nucleatum

Gut microbiome

10.1016/b978-0-08-100596-5.22881-3

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Citations (1)

RETRACTED: Comparison of efficacy and side effects of Fixed-dose combination of Aclidinium/Formoterol and Monotherapy of Aclidinium or Formoterol in COPD: A meta-analysis

Heart & Lung (2021)

Kaiwen Ni Jia Yang Huan Yang Shiming Zhu Zhen Wang

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

Formoterol Fumarate

10.1016/j.hrtlng.2021.07.005

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Citations (2)

Effects of labeling methods on the biodistribution of 99mTc-labeled HSA complexes

Applied Radiation and Isotopes (2004)

Jia Yang

Biodistribution

10.1016/j.apradiso.2004.09.002

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Citations (0)

Repopulation of tumor cells during fractionated radiotherapy and detection methods (Review)

Oncology Letters (2014)

Jia Yang Jinbo Yue Jing Liu Jinming Yu

Repopulation of tumor cells during radiotherapy is believed to be a significant cause for treatment failure. The phenomenon of tumor repopulation during fractionated radiotherapy was found from clinical observations that identified that the local control rate decreased with a prolonged treatment time. A series of animal experiments with varied overall treatment time and fractionated doses were performed to demonstrate tumor cell repopulation during radiotherapy in various mouse xenograft models. However, conventional detection methods are challenging, as it is difficult to separate viable cells from those destined for apoptosis during fractionated radiotherapy. In essence, the mechanism of tumor repopulation involves the continuing proliferation of clonogenic tumor cells. In vivo imaging, tracking and targeting of the repopulation of these cells has been of clinical interest so as to administer a higher dose to the tumor repopulation regions. Currently, functional imaging methods, including 3'-deoxy-3'-18F-fluorothymidine positron emission tomography (18F-FLT PET), are showing promise in assessing the proliferation activity of tumors in vivo. This review mainly focuses on the phenomenon of tumor repopulation during radiotherapy and its conventional and novel detection methods, particularly on the feasibility of 18F-FLT PET for the detection of tumor-cell repopulation.

Repopulation

Clonogenic assay

Radiobiology

10.3892/ol.2014.1990

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Citations (35)

The Association Between the Change of Soluble Programmed Cell Death Ligand-1 (sPD-L1) and the Radiosensitivity in Patients With Hypopharyngeal Squamous Cell Carcinoma

International Journal of Radiation Oncology*Biology*Physics (2021)

Zihan Zhou Xiangdong Bai Jia Yang Xuanfeng Ding Jianing Xu

Radiosensitivity

10.1016/j.ijrobp.2021.07.1086

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The relationship of the geriatric nutritional risk index to mortality and length of stay in elderly patients with acute respiratory failure: A retrospective cohort study

Heart & Lung (2021)

Xiawei Shi Yueqian Shen Jia Yang Wurong Du Junchao Yang

Elderly people with acute respiratory failure (ARF) have prolonged length of hospital stay (LOS) and high mortality rates. Malnutrition is negatively correlated with these LOS and mortality. However, no tools have been used to detect the risk of malnutrition and assist in designing nutritional support for these patients. The geriatric nutritional risk index (GNRI) is reported as a novel tool for evaluating the risk of malnutrition. The aim of this study is to explore the relationship of the GNRI score with mortality and LOS in elderly patients with ARF.Data of elderly patients diagnosed with ARF were retrieved from the Medical Information Mart for Intensive Care III (MIMIC-III) database. A total of 1250 patients were divided into two groups based on their GNRI score: the malnutrition risk group (GNRI ≤ 98) and no risk group (GNRI > 98). The primary endpoints of this study were hospital mortality and hospital LOS.The higher GNRI score was associated with lower hospital mortality and shorter hospital LOS. Odds ratio (OR) for hospital mortality of patients with nutritional risk (GNRI ≤ 98) was 1.264 (95% CI:1.067-1.497) in the adjusted model. Patients with GNRI ≤98 had longer hospital LOS (adjusted OR: 1.142, 95%CI: 1.044-1.250) compared with those with GNRI > 98. Subgroup analysis showed that higher GNRI was only significantly associated with lower hospital mortality in the patients that did not undergo mechanical ventilator (MV) treatment (adjusted OR: 0.985, 95% CI: 0.977-0.992, P < 0.01). Kaplan-Meier curve analysis showed that the 90-day survival was significantly lower in the group with nutrition risk (GNRI≤98) compared with the no risk group (GNRI > 98, p < 0.05).These findings imply that GNRI is a useful prognostic tool in elderly patients with ARF.

Subgroup analysis

Risk of mortality

10.1016/j.hrtlng.2021.07.012

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Citations (15)