Syeda Sohaila Naz

Abdus Salam Centre for Physics

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Nazar Ul Islam

Sarhad University of Science and Information Technology

Muhammad Raza Shah

International Center for Chemical and Biological Sciences

Sara Qaisar

Abdus Salam Centre for Physics

Syed Sartaj Alam

The University of Agriculture, Peshawar

Fiza Ur Rehman

Abdus Salam Centre for Physics

Kifayat Ullah Shah

Quaid-i-Azam University

Muhammad Nawaz Tahir

University of Agriculture Faisalabad

Sulaiman Sulaiman

Hasanuddin University

J. Sweeney

University of Bradford

Taous Khan

COMSATS University Islamabad

Cooperative Institutions

Quaid-i-Azam University

COMSATS University Islamabad

University of Karachi

University of Peshawar

International Center for Chemical and Biological Sciences

University of Veterinary and Animal Sciences

Military Hospital

National University of Sciences and Technology

University of Lahore

Pakistan Army

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Green synthesis and molecular recognition ability of patuletin coated gold nanoparticles

Biosensors and Bioelectronics (2014)

Muhammad Ateeq Muhammad Raza Shah Noor ul Ain Samina Bano Itrat Anis

10.1016/j.bios.2014.07.076

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Citations (38)

Macrophage targeting with the novel carbopol-based miltefosine-loaded transfersomal gel for the treatment of cutaneous leishmaniasis: in vitro and in vivo analyses

Drug Development and Industrial Pharmacy (2021)

Sibgha Batool Fatima Zahid Fakhar ud Din Syeda Sohaila Naz M. Junaid Dar

The purpose of this study was to develop novel carbopol-based miltefosine-loaded transfersomal gel (HePCTG) for the treatment of cutaneous leishmaniasis (CL) via efficient targeting of leishmania infected macrophages.Miltefosine-loaded transfersomes (HePCT) were prepared by ethanol injection method followed by their incorporation into carbopol gel to form HePCTG. The prepared HePCT were assessed for physicochemical properties including mean particle size, polydispersity index, zeta potential, entrapment efficiency, morphology, and deformability. Similarly, HePCTG was evaluated for physiochemical and rheological attributes. The in vitro release, skin permeation, skin irritation, anti-leishmanial activity, and in vivo efficacy in BALB/c mice against infected macrophages were also performed for HePCT.The optimized HePCT displayed a particle size of 168 nm with entrapment efficiency of 92%. HePCTG showed suitable viscosity, pH, and sustained release of the incorporated drug. Furthermore, HePCT and HePCTG demonstrated higher skin permeation than drug solution. The results of macrophage uptake study indicated improved drug intake by passive diffusion. The lower half maximal inhibitory concentration value, selectivity index and higher 50% cytotoxic concentration value of HePCT compared to that of HePC solution demonstrated the improved anti-leishmanial efficacy and non-toxicity of the formulation. This was further confirmed by the notable reduction in parasite load and lesion size observed in in vivo anti-leishmanial study.It can be stated that the formulated HePCTG can effectively be used for the treatment of CL.

Miltefosine

10.1080/03639045.2021.1890768

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Citations (56)

Laser irradiation effects on structural, morphological and mechanical properties of ZirCAD dental ceramic

Digest Journal of Nanomaterials and Biostructures (2021)

A. Rab K. Siraj M. Irshad A. Latif Syeda Sohaila Naz

In the present study, the effects of laser irradiation on microstructure, morphology and hardness of yttria-stabilized tetragonal zirconia (ZrO2) commercially known as ZirCAD are examined. Three specimen discs were cut from the ZirCAD block. After polishing two of them were irradiated by Nd: YAG pulsed laser, with 100 and 150 laser pulses respectively and the remaining one unexposed specimen was kept as a standard. The XRD analysis confirmed that no phase change occurred after laser irradiation however an increase in dislocation line density (DLD) was observed. The surface morphology was observed by optical and scanning electron microscopy (SEM). Laser irradiation initially caused the upper surface to melt therefore resulting in a smooth and glazed surface. Further increase in laser pulses produced porosity within the sample. The optical microscopy revealed that the crater size decreased and the heat-affected zone increased with the increased number of laser pulses. Vickers hardness was employed to observe the hardness of unirradiated and irradiated samples and a 32% increase in hardness was observed when the material was irradiated by 100 laser pulses. The glazed surface exhibited more hardness as compared to the unirradiated and porous surfaces. The improved surface morphology and high hardness achieved in this work with laser irradiation for ZirCAD ceramic are quite beneficial in dental applications.

Vickers hardness test

10.15251/djnb.2021.162.677

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Citations (4)

Analysis of the essential work of fracture method as applied to UHMWPE

Journal of Materials Science (2009)

Syeda Sohaila Naz J. Sweeney Phil Coates

Hyperelastic material

Tension (geology)

Ultra-high-molecular-weight polyethylene

10.1007/s10853-009-3961-2

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Citations (12)

Synthesis of zinc oxide based etoricoxib and montelukast nanoformulations and their evaluation through analgesic, anti-inflammatory, anti-pyretic and acute toxicity activities

Journal of King Saud University - Science (2022)

Sulaiman Sulaiman Shabir Ahmad Syeda Sohaila Naz Sara Qaisar Sayyar Muhammad

The current study described the synthesis of novel low dose PVA capped Etoricoxib (ET) and montelukast (MT) conjugated Zinc Oxide (ZnO) nanomaterials (NMs) as potential anti-inflammatory, analgesic and antipyretic agents. A facile coprecipitation protocol was used for synthesis of NMs by combination of ET, MT and ZnO NP. The efficient synthesis of ET and MT conjugated ZnO NMs were confirmed through UV–visible, XRD, FTIR and DLS analysis. Data of in vivo anti-inflammatory activity indicated that potency of ZnO NMs was found to be greater than drugs (ET and MT). Analgesic potency of NMs was much higher than that of drugs (ET and MT). The in vivo antipyretic activity indicates that the results of NMs and drugs (ET and MT) are of similar effect but that of NMs are more potent based on per weight basis. A wide therapeutic window was shown by the acute toxicity study carried out via LD50 method. It is concluded that the novel low dose PVA capped ET and MT conjugated ZnO NMs were potential analgesic, antipyretic and anti-inflammatory agents.

Etoricoxib

Antipyretic

Anti-inflammatory

10.1016/j.jksus.2022.101938

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Citations (9)

5-Carboxy-2,4-dihydroxyanilinium chloride dihydrate

Acta Crystallographica Section E Structure Reports Online (2011)

Syeda Sohaila Naz Nazar Ul Islam Muhammad Nawaz Tahir

In the title compound, C(7)H(8)NO(4) (+)·Cl(-)·2H(2)O, the organic mol-ecule is almost planar with an r.m.s. deviation of 0.0164 Å for all non-H atoms. An S(6) ring motif is formed due to an intra-molecular O-H⋯O hydrogen bond. In the crystal, the mol-ecules are linked into a three-dimensional network by N-H⋯Cl, N-H⋯O, O-H⋯Cl and O-H⋯O hydrogen bonds.

Crystal (programming language)

10.1107/s1600536811000559

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Citations (2)

Surface modified multifaceted nanocarriers for oral non-conventional cancer therapy; synthesis and evaluation

Materials Science and Engineering C (2021)

Fiza Ur Rehman Kehkashan Mazhar Annum Malik Syeda Sohaila Naz Kifayat Ullah Shah

Nanocarriers

Cancer Therapy

10.1016/j.msec.2021.111940

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Citations (14)

Cerium oxide nanoparticles improve the post-thaw quality and in-vivo fertility of Beetal buck spermatozoa

Theriogenology (2023)

Mubashir Ali Khalique Syed Murtaza Hassan Andrabi Khalid Abdul Majeed Muhammad Shahbaz Yousaf Nisar Ahmad

Semen quality

10.1016/j.theriogenology.2023.10.022

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Citations (7)

Biological and Pharmacological Properties of the Sweet Basil (Ocimum basilicum)

British Journal of Pharmaceutical Research (2015)

M Ch Syeda Sohaila Naz Asifa Sharif Maimoona Akram Muhammad Saeed

Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers in all areas of pharmaceutical Science including pharmaceutical drugs, community pharmacy, hospital pharmacy, clinical pharmacy, compounding pharmacy, consultant pharmacy, internet pharmacy, veterinary pharmacy, nuclear pharmacy, military pharmacy, pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, clinical pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics, pharmacoepidemiology, toxicology, theoretical pharmacology, posology, pharmacognosy, behavioral pharmacology, environmental pharmacology, medicine development and safety testing, drug legislation and safety, pharmaceutical microbiology, pharmaceutical molecular biology, pharmaceutical biotechnology. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer reviewed, open access INTERNATIONAL journal.

Sweet Basil

10.9734/bjpr/2015/16505

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Citations (72)

Stable and reproducible synthesis of gold nanorods for biomedical applications: a comprehensive study

IET Nanobiotechnology (2017)

Uzma Azeem Awan Shaukat Ali Mehreen Rehman Nashmia Zia Syeda Sohaila Naz

Gold nanorods (GNRs) are ideal choice in biomedical research due to their amenability of synthesis, tunable plasmonic properties, less toxicity and ease of detection but their diverse biological applications necessitate stable structure. Despite two decades' efforts made towards reproducible anisotropic structures synthesis, still the kinetic control during GNRs growth has not been achieved. This study is an attempt to apprehend thermodynamic and kinetic parameters for synthesising mono-disperse, reproducible and highly stable GNRs with desired aspect ratios. Effects of various growth parameters and assay steps on the facile and reproducible synthesis of GNRs are analysed. GNRs' environmental and biological colloidal stability is studied through UV–Vis spectroscopy based particle instability parameter (PIP < 0.1). The authors hereby report GNRs with tunable longitudinal surface plasmon resonance (682–906 nm) having different aspect ratios (2.5–4.6) that are stable at 28–60°C; however, prolonged high temperature ( > 60°C) and alkaline pH can trigger colloidal instability. GNRs remain stable at higher salt concentration, physiological and slightly acidic pH. GNRs can be stored in 0.001 M cetyltrimethylammonium bromide for 3 months without compromising their stability. PEGylated GNRs are quite stable in cellular media solution (PIP < 0.1). With current optimised growth conditions, no aggregation at physiological pH and stability at high temperatures make GNRs an ideal candidate in biomedical applications.

Nanorod

Biomolecule

Chemical Stability

10.1049/iet-nbt.2016.0220

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Citations (19)