Jiayao Xu

Yulin Normal University

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i-10 index

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Shulin Zhao

Guangxi Normal University

Yong Huang

Xinjiang University

Shulong Wang

Guangxi Normal University

Zhihui Luo

Yulin Normal University

Xiaohong Zhong

Guangxi Normal University

Hong Liang

Guangxi Normal University

Lifang Yao

Women's Hospital, School of Medicine, Zhejiang University

Ming Shi

Xuzhou Medical College

Huakui Huang

Guangxi Normal University

Mingzhu Fan

Westlake University

Cooperative Institutions

Guangxi Normal University

Fudan University

Shanghai Jiao Tong University

Yulin Normal University

Chinese Academy of Sciences

East China University of Science and Technology

First Affiliated Hospital of Zhengzhou University

China Medical University

Sun Yat-sen University

Central South University

Author Statistics

Papers

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Stability of SARS-CoV-2 on inanimate surfaces: A review

Microbiological Research (2023)

Jiayao Xu Chengyin Xu Ruilin Chen Yun Yin Zengliang Wang

2019-20 coronavirus outbreak

Sars virus

10.1016/j.micres.2023.127388

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Citations (10)

A MnO_x-nucleic acid nanoprobe with enzyme-free cascade signal amplification for ultrasensitive intracellular microRNA imaging

Chemical Communications (2022)

Jiayao Xu Yuxin Qin Qiuyi Liang Xiaohong Zhong Li Hou

A novel MnOx-nucleic acid nanoprobe was constructed for catalytic imaging of microRNA in living cells based on the combination of catalytic hairpin assembly, hybridization chain reaction, and DNAzyme amplification. This nanoprobe exhibited ultrahigh sensitivity and specificity, and could distinguish tumor cells and normal cells by live cell microRNA imaging.

Nanoprobe

Deoxyribozyme

Chain reaction

10.1039/d2cc03980j

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Citations (2)

A ratiometric fluorescent probe with dual near infrared emission for in vivo ratio imaging of cysteine

Talanta (2025)

Bing Zheng Shulong Wang Jiayao Xu Lixian Huang Shulin Zhao

10.1016/j.talanta.2025.127564

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Citations (0)

Rational design of a near-infrared dual-emission fluorescent probe for ratiometric imaging of glutathione in cells

Microchimica Acta (2024)

Shulong Wang Zhifang Li Jiayao Xu Qingyan Lin Wenfang Huang

Emission intensity

SIGNAL (programming language)

Nanoclusters

10.1007/s00604-024-06179-6

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Citations (6)

Correction to: Real-Time FPGA Design for OMP Targeting 8K Image Reconstruction

Lecture notes in computer science (2024)

Jiayao Xu Chen Fu Zhiqiang Zhang Jinjia Zhou

10.1007/978-3-030-98358-1_50

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Citations (0)

Peroxidase-Mimicking Dna-Ag/Pt Nanoclusters Mediated Visual Biosensor for Cea Detection Based on Rolling Circle Amplification and Crispr/Cas 12a

SSRN Electronic Journal (2022)

Xiaomei Mu Jinshen Li Shixiu Xiao Jiayao Xu Yong Huang

As a new type of nano-catalytic materials, silver-platinum nanoclusters have attracted more and more attention in the fields of biosensors and catalysis. A novel colorimetric method for CEA was developed based on the catalytic activity of peroxidase of DNA-Ag/Pt nanoclusters (NCs) and rolling circle amplification (RCA) and CRISPR/Cas12a. In this paper, DNA-Ag/Pt NCs can catalyze H2O2 to oxidize 3,3,5',5'-tetramethyl benzidine (TMB) to form blue substance ox-TMB. Target CEA can specifically bind to the aptamer and releases the primer chain, which initiates the RCA reaction and activates the trans-cleavage activity of the Cas12a/crRNA, and the signal probe DNA-Ag/Pt NCs is hydrolyzed immediately, thus causing signal changes in the system. Due to signal amplification by combining RCA with CRISPR/Cas 12a system, the visual sensor has a high sensitivity for CEA with a linear range of 2.5 pg/mL to 2.0 ng/mL and a detection limit of 0.94 pg/mL (S/N=3). Furthermore, the sensor has the advantages of good specificity, satisfactory results for the detection of actual samples and simple operation, indicating that this method has a potential application prospect in clinical detection.

Rolling circle replication

Nanoclusters

Aptamer

10.2139/ssrn.4201068

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Citations (1)

A smart mRNA-initiated DNAzyme nanogenerator for precise imaging and gene therapy in vivo

Sensors and Actuators B Chemical (2024)

Mingzhu Fan Xiaohong Zhong Yanshi Wei Rong Wang Yifang He

Deoxyribozyme

10.1016/j.snb.2024.135742

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Citations (1)

Rational design of biomimetic-inspired nanoenzyme probes based on metal–organic frameworks (MOFs) for NIR-II window photoacoustic imaging of ultra-trace H2O2 activation in vivo

Microchemical Journal (2024)

Wenfang Huang Shulong Wang Min Wu Xinping Huang Q. Mo

TRACE (psycholinguistics)

Rational design

Therapeutic window

10.1016/j.microc.2024.112261

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Citations (0)

A biodegradable and cofactor self-sufficient aptazyme nanoprobe for amplified imaging of low-abundance protein in living cells

Talanta (2022)

Jiayao Xu Lifang Yao Xiaohong Zhong Kun Hu Shulin Zhao

Nanoprobe

Deoxyribozyme

Nuclease

10.1016/j.talanta.2022.123983

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Citations (4)

Lysosomes Initiating and DNAzyme-Assisted Intracellular Signal Amplification Strategy for Quantification of Alpha-Fetoprotein in a Single Cell

Analytical Chemistry (2023)

Sheng-Yu Chen Jingjin Zhao Chunhuan Xu Bingfang Shi Jiayao Xu

Cellular trace proteins are critical for maintaining normal cell functions, with their quantitative analysis in individual cells aiding our understanding of the role of cell proteins in biological processes. This study proposes a strategy for the quantitative analysis of alpha-fetoprotein in single cells, utilizing a lysosome microenvironment initiation and a DNAzyme-assisted intracellular signal amplification technique based on electrophoretic separation. A nanoprobe targeting lysosomes was prepared, facilitating the intracellular signal amplification of alpha-fetoprotein. Following intracellular signal amplification, the levels of alpha-fetoprotein (AFP) in 20 HepG2 hepatoma cells and 20 normal HL-7702 hepatocytes were individually evaluated using microchip electrophoresis with laser-induced fluorescence detection (MCE-LIF). Results demonstrated overexpression of alpha-fetoprotein in hepatocellular carcinoma cells. This strategy represents a novel technique for single-cell protein analysis and holds significant potential as a powerful tool for such analyses.

Nanoprobe

Alpha-fetoprotein

Single-Cell Analysis

10.1021/acs.analchem.3c03152

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Citations (3)