Meng Yu

Chinese Academy of Medical Sciences & Peking Union Medical College

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Zhong‐Mei Zou

Chinese Academy of Medical Sciences & Peking Union Medical College

Hong‐Mei Jia

Chinese Academy of Medical Sciences & Peking Union Medical College

Hongwu Zhang

Ludong University

Gang Ding

Hubei University

Hai Shang

Chinese Academy of Medical Sciences & Peking Union Medical College

Yong Yang

Chinese Academy of Medical Sciences & Peking Union Medical College

Tao Zhang

Chinese Academy of Medical Sciences & Peking Union Medical College

Chao Zhou

Chinese PLA General Hospital

Li-Yan Ma

Chinese Academy of Medical Sciences & Peking Union Medical College

Lingyu Li

Chinese Academy of Medical Sciences & Peking Union Medical College

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Chinese Academy of Medical Sciences & Peking Union Medical College

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Peking Union Medical College Hospital

Chinese Academy of Sciences

State Administration of Traditional Chinese Medicine of the People's Republic of China

Academy of Medical Sciences

University of Chinese Academy of Sciences

Peking University

Institute of Medicinal Plant Development

Huazhong University of Science and Technology

Guangzhou University of Chinese Medicine

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Metabolism of glycerophospholipid, bile acid and retinol is correlated with the early outcomes of autoimmune hepatitis

Molecular BioSystems (2016)

Chao Zhou Hong‐Mei Jia Yuetao Liu Meng Yu Xing Chang

This study first reports the metabolic variations at the early stage of the liver injury related to autoimmune hepatitis.

Glycerophospholipids

Autoimmune Hepatitis

10.1039/c6mb00092d

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Citations (47)

Silencing Tautomerization to Isolate Unstable Physalins fromPhysalis minima

Journal of Natural Products (2022)

Jiangping Wu Lingyu Li Jing‐Rong Li Meng Yu Jianping Zhao

The inherent structural instability of some physalins has hampered the isolation and identification of these compounds for approximately 50 years, and an effective method to overcome these challenges remains unavailable. In the present study, the unprecedented tautomerization mechanism of unstable physalins was elucidated by performing isotopic labeling experiments and DFT calculations, which led to the successful separation of tautomers and isolation of highly pure products for the first time. As a result, 15 new physalins, physaminins A–O (1–15), as well as 17 known analogues (16–32), were isolated from the whole plants of Physalis minima L. The chemical structures of the new compounds were established by performing a comprehensive analysis of spectroscopic data, and their absolute configurations were confirmed by using computational ECD calculations and/or single-crystal X-ray diffraction analyses. All obtained isolates were evaluated for their antiproliferative effects against four human cancer cell lines (A549, HepG2, MCF-7, and SCG-7901) and two noncancerous cell lines (RAW 264.7 and human normal hepatocytes L02), as well as their anti-inflammatory activities by measuring their abilities to inhibit NO production in LPS-stimulated murine RAW 264.7 cells in vitro. Compounds 1–5, 13, 16, 18, 19, 23, and 30 exerted significant antiproliferative effects on the four human cancer lines, with IC50 values ranging from 0.2(0) to 24.7(2) μM, and these compounds were not toxic to the two noncancerous cell lines at a concentration of 10 μM. Moreover, compounds 7, 10, 11, 12, 14, 17, 22, and 27 significantly inhibited NO production, with IC50 values ranging from 2.9(1) to 9.5(2) μM.

Physalis

10.1021/acs.jnatprod.2c00101

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Systematical NMR analysis of swainsonine, a mycotoxin from endophytic fungus Alternaria oxytropis

Magnetic Resonance in Chemistry (2020)

Xiang‐Mei Tan Yanduo Wang Zhenliang Liu Liu Liliang Meng Yu

Abstract Swainsonine (SW, 1 ), a unique indolizine with poly‐hydroxyl groups, was re‐isolated from the plant endophytic fungus Alternaria oxytropis. The structure (including planar structure and relative configuration) was systematically elucidated by NMR spectra (including 1 H, 13 C, 1 H‐ 1 H COSY, HMQC, HMBC, and NOESY spectra in DMSO‐ d 6 and in CD 3 OD); 1 H NMR spectra of the modified Mosher's products were first used to determine the absolute configuration of SW. More importantly, the complex coupled features of H‐7α, H‐7β, and H‐6α in the 1 H NMR spectrum of ( 1 ) were analyzed in details, which will provide aids for the planar and relative configuration determination of analogs.

Swainsonine

Proton NMR

Indolizine

Absolute Configuration

10.1002/mrc.5098

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Neuroprotective Effect of Cyperi rhizome against Corticosterone-Induced PC12 Cell Injury via Suppression of Ca2+ Overloading

Metabolites (2019)

Hong‐Mei Jia Yang Liu Meng Yu Hai Shang Hongwu Zhang

Cyperi Rhizoma (CR) is a well-known functional food and traditional herbal medicine in Asian countries for the treatment of menstrual or emotional disturbances in women. Recent studies have shown the pharmacological effects of CR on neuronal diseases, such as Parkinson's disease (PD) and depression. Thus, the neuroprotective effect of CR might play a vital role in exerting its effect. Here, corticosterone-induced PC12 cells were applied to screen the active fraction of CR and evaluate its neuroprotective effect. The results indicated that the fraction containing medium-polarity chemical constituents (CR-50E) displayed the best protection effect. CR-50E could increase the cell viability and reduce cell apoptosis through inhibiting oxidative stress and decreasing the lactate dehydrogenase LDH release induced by corticosterone. Further, the mechanism of action was explored by cell metabolomics. The result showed CR-50E mediated the sphingolipids metabolism of corticosterone-induced PC12 cells, which suggested inhibition of Ca2+ overloading may involve the protection of CR-50E against cell damage. The expression levels of three key proteins in calcium transport, including phospholipase A2 (PLA2), calcium/calmodulin independent protein kinase II (CaMK II), and caspase-3, confirmed the above result by Western blot. The findings suggest that CR-50E can suppress the disequilibrium of calcium homeostasis-mediated apoptosis by improving the abnormal sphingolipids metabolism as well as remedying the damage of the cell membrane.

Corticosterone

Viability assay

10.3390/metabo9110244

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Citations (7)

Protective effect of Chaihu-Shu-Gan-San on corticosterone-induced lesion in cultured PC12 cells

European Journal of Integrative Medicine (2014)

Ming‐Fang Wu Hong‐Mei Jia Xing Chang Meng Yu Zhuo Ma

Corticosterone

10.1016/j.eujim.2014.09.123

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Sesquiterpenoids and mycotoxin swainsonine from the locoweed endophytic fungus Alternaria oxytropis

Phytochemistry (2019)

Xiang‐Mei Tan Xiaoyan Zhang Meng Yu Yu YongTao Zhe Guo

Swainsonine

HeLa

Terpene

10.1016/j.phytochem.2019.05.012

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Citations (31)

Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus Rhinocladiella similis

Molecules (2019)

Luying Li Xiaoyan Zhang Xiang‐Mei Tan Bing‐Da Sun Bin Wu

Seven resorcylic acid lactones (RALs) including five new analog rhinoclactones, A-E (1, 2, 4-6), were isolated from an endophytic fungus Rhinocladiella similis in the plant Agriophyllum squarrosum collected from the Tengger Desert of the Ningxia Province, China. The structures of these new compounds were determined by HR-ESI-MS (High Resolution Electrospray Ionization Mass Spectrometry), NMR data, modified Mosher's method, and X-ray diffraction experiments. All compounds isolated from this fungus possessed the 16-OMe/14-OH, not the common 16-OH/14-OH or 16-OH/14-OMe groups on the aromatic ring, which are rarely found in nature. Compound 7 displayed cytotoxic activities against HCT116 and HeLa cancer cell lines. The possible biosynthesis of 1-7 is suggested, and the potential ecological roles of these fungal secondary metabolites is discussed.

HeLa

Cancer cell lines

10.3390/molecules24071405

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Citations (11)

Advances in understanding of health‐promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics

Food Frontiers (2020)

Minmin Yang Tao Yan Meng Yu Jie Kang Ruoxi Gao

The health-promoting benefits of medicine and food homology (MFH) are known for thousands of years in China. However, active compounds and biological mechanisms are unclear, greatly limiting clinical practice of MFH. The advent of gut microbiota analysis and metabolomics emerge as key tools to discover functional compounds, therapeutic targets, and mechanisms of benefits of MFH. Such studies hold great promise to promote and optimize functional efficacy and development of MFH-based products, for example, foods for daily dietary supplements or for special medical purposes. In this review, we summarized pharmacological effects of 109 species of MFH approved by the Health and Fitness Commission in 2015. Recent studies applying genome sequencing of gut microbiota and metabolomics to explain the activity of MFH in prevention and management of health consequences were extensively reviewed. We discussed the potentiality in future to decipher functional activities of MFH by applying metabolomics-based polypharmacokinetic strategy and multiomics technologies. The needs for personalized MFH recommendations and comprehensive databases have also been highlighted. This review emphasizes current achievements and challenges of the analysis of gut microbiota and metabolomics as a new avenue to understand MFH.

Nutrigenomics

Health Benefits

Limiting

Personalized Medicine

10.1002/fft2.49

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Citations (29)

Chaihu-Shu-Gan-San regulates phospholipids and bile acid metabolism against hepatic injury induced by chronic unpredictable stress in rat

Journal of Chromatography B (2017)

Hong‐Mei Jia Meng Yu Li-Yan Ma Hongwu Zhang Zhong‐Mei Zou

Amino acid metabolism

10.1016/j.jchromb.2017.08.003

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Citations (42)

Trematosphones A and B, Two Unique Dimeric Structures from the Desert Plant Endophytic Fungus Trematosphaeria terricola

Organic Letters (2019)

Bo Song Lingyu Li Hai Shang Liu Yang Meng Yu

Trematosphones A (1) and B (2), two unique dimers with novel structural features, were isolated from the special bioenvironmental desert plant endophytic fungus Trematosphaeria terricola. Their structures were assigned on the basis of spectroscopic approaches including NMR, calculated electronic circular dichroism data, and X-ray diffraction analysis. Possible biosynthetic pathways of these two compounds were proposed. Trematosphone A (1) exhibited protective activities against the corticosterone-induced damages in PC12.

10.1021/acs.orglett.9b00454

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Citations (26)