Cuijuan Zhang

Shandong University

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Qing Liang

Xuzhou Medical College

Longgang Hu

Shanghai Cancer Institute

Kejia Wang

Amgen (United States)

Yunzhen Shi

Sichuan University

Dan Li

East China University of Science and Technology

Weiwei Yang

Weifang Medical University

Qingyou Xu

Hebei University of Chinese Medicine

Bin Wang

Shandong First Medical University

Yi Chang

Hebei University of Chinese Medicine

Fan Yang

Chinese Academy of Medical Sciences & Peking Union Medical College

Cooperative Institutions

Sun Yat-sen University

Hebei University of Chinese Medicine

Shandong University

Weifang Medical University

Chinese Academy of Sciences

Chongqing Medical University

Qingdao University

Chinese Academy of Medical Sciences & Peking Union Medical College

Fujian Normal University

Shanghai Jiao Tong University

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UUO induces lung fibrosis with macrophage-myofibroblast transition in rats

International Immunopharmacology (2021)

Fan Yang Yi Chang Cuijuan Zhang Yunzhao Xiong Xiangting Wang

Myofibroblast

Eplerenone

10.1016/j.intimp.2021.107396

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Citations (38)

Expression of miR-125b in the plasma and placentas from preeclampsia patients (PE) and normal control pregnancies (NC).

Weiwei Yang Anning Wang Chunling Zhao Qinghua Li Pan Zhifang

10.1371/journal.pone.0166940.g001

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Citations (0)

MOESM4 of Peripheral T cell receptor beta immune repertoire is promptly reconstituted after acute myocardial infarction

Figshare (2019)

Dan Li Longgang Hu Qing Liang Cuijuan Zhang Yunzhen Shi

Additional file 4: Table S3. The distribution of V-J combinations in each sample.

10.6084/m9.figshare.7686380

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Citations (0)

Decreased levels of serum nesfatin-1 in patients with preeclampsia

Biomarkers (2014)

Cuijuan Zhang Ying Wang Yunhai Wang Jie Li Ruxin Liu

Objective: The aim of our study is to investigate whether abnormal serum levels of nesfatin-1 are associated with the presence and severity of preeclampsia.

10.3109/1354750x.2014.919027

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Citations (14)

Influence of Standardized Nursing Intervention Combined with Mindfulness Stress Reduction Training on the Curative Effect, Negative Emotion, and Quality of Life in Patients with Chronic Gastritis and Gastric Ulcer

Evidence-based Complementary and Alternative Medicine (2021)

Hong‐Mei Xiao Zhibin Zhao Cuijuan Zhang Jimin Wang

Objective. To explore the curative effect of standardized nursing intervention combined with mindfulness stress reduction training in patients with chronic gastritis and gastric ulcer and its influence on negative emotion and quality of life. Methods. Total of 146 patients with chronic gastritis and gastric ulcer admitted to our hospital from August 2018 to February 2020 were collected and divided into the control group (n = 73) and study group (n = 73) according to patients’ wishes and the random number method. The control group received traditional nursing measures. The study group received standardized nursing intervention combined with mindfulness stress reduction training. The general data, nursing efficiency, negative emotions, self-efficacy, quality of life, and nursing satisfaction of the two groups were recorded. Results. The nursing effective rate of the study group (91.78%) was higher than the control group (79.45%) ( P < 0.05 ). After intervention, the self-rating anxiety scale score and self-rating depressive scale score of the study group were lower than the control group ( P < 0.05 ). After intervention, the general self-efficacy scale score and the generic quality of life inventory-74 scores of the study group were higher than the control group ( P < 0.05 ). The nursing satisfaction rate of the study group (89.04%) was higher than the control group (75.34%) ( P < 0.05 ). Conclusion. Standardized nursing intervention combined with mindfulness stress reduction training has a good curative effect in patients with chronic gastritis and gastric ulcer, which is beneficial to reduce negative emotions, increase self-efficacy, improve quality of life, and improve nursing satisfaction.

Mindfulness-based stress reduction

Chronic gastritis

Self-Efficacy

10.1155/2021/2131405

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Citations (9)

Spatial Transcriptomic Study Reveals Heterogeneous Metabolic Adaptation and a Role of Pericentral PPARα/CAR/Ces2a Axis During Fasting in Mouse Liver

Advanced Science (2024)

Shiguan Wang Bowen Xu Jinyuan Liang Yawei Feng Penghu Han

Abstract Spatial heterogeneity and plasticity of the mammalian liver are critical for systemic metabolic homeostasis in response to fluctuating nutritional conditions. Here, a spatially resolved transcriptomic landscape of mouse livers across fed, fasted and refed states using spatial transcriptomics is generated. This approach elucidated dynamic temporal‐spatial gene cascades and how liver zonation—both expression levels and patterns—adapts to shifts in nutritional status. Importantly, the pericentral nuclear receptor Nr1i3 (CAR) as a pivotal regulator of triglyceride metabolism is pinpointed. It is showed that the activation of CAR in the pericentral region is transcriptionally governed by Pparα. During fasting, CAR activation enhances lipolysis by upregulating carboxylesterase 2a, playing a crucial role in maintaining triglyceride homeostasis. These findings lay the foundation for future mechanistic studies of liver metabolic heterogeneity and plasticity in response to nutritional status changes, offering insights into the zonated pathology that emerge during liver disease progression linked to nutritional imbalances.

10.1002/advs.202405240

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Chronic intermittent hypoxia induces renal fibrosis through MR activation

Experimental Gerontology (2022)

Cuijuan Zhang Hui Li Yunzhao Xiong Yi Chang Fan Yang

Hypoxia

Eplerenone

Myofibroblast

10.1016/j.exger.2022.111780

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Citations (7)

MOESM7 of Peripheral T cell receptor beta immune repertoire is promptly reconstituted after acute myocardial infarction

Figshare (2019)

Dan Li Longgang Hu Qing Liang Cuijuan Zhang Yunzhen Shi

Additional file 7: Table S6. The distribution of AA usage in CDR3.

BETA (programming language)

10.6084/m9.figshare.7686404

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Eplerenone Attenuates Fibrosis in the Contralateral Kidney of UUO Rats by Preventing Macrophage-to-Myofibroblast Transition

Frontiers in Pharmacology (2021)

Yunzhao Xiong Yi Chang Juan Hao Cuijuan Zhang Fan Yang

Severe renal fibrosis often occurs in obstructive kidney disease, not only in the obstructed kidney but also in the contralateral kidney, causing renal dysfunction. Although the mechanisms of injury in obstructed kidney have been studied for years, the pathogenesis of fibrosis in the contralateral kidney remains largely unknown. Here, we examined long-term unilateral ureteral obstruction (UUO) model in male Sprague-Dawley rats and found that macrophage-to-myofibroblast transition (MMT) is contributing to renal fibrosis in the contralateral kidney of UUO rats. Interestingly, this process was attenuated by treatment of eplerenone, a specific blocker of the mineralocorticoid receptor (MR). In-vitro, stimulating MR in primary cultured or cell line macrophages enhances MMT, which were also inhibited by MR blockade. Collectively, these findings provide a plausible mechanism for UUO-induced injury in the contralateral kidney, suggesting the benefit of using MR blockage as a part of treatment to UUO to protect the contralateral kidney thereby preserve renal function.

Eplerenone

Myofibroblast

Cardiac Fibrosis

10.3389/fphar.2021.620433

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Citations (27)

Preliminary approach to the diagnosis of byssinosis

American Journal of Industrial Medicine (1987)

Dehong Li Lu Shixuan Ding Maobo Cuijuan Zhang

The prevalence of byssinosis was studied in two cotton mills by a standardized questionnaire and pulmonary function measurements (forced expiratory volume in 1 second; FEV1). In mill A, the dust level was high (57-159 mg/m3). Among 90 participants, 80 were interviewed twice at an interval of 4 months, and disagreement on actual presence or absence of byssinosis was 7.5 percent. Twenty out of ninety workers had complaints of Monday symptoms and the prevalence was 22.2 percent. In mill B, the dust control (6.8 mg/m3) was relatively good. Among 173 participants from the carding room, two had complaints of Monday symptoms and the prevalence was 1.2 percent. A significant correlation was found between duration of employment and prevalence of byssinosis in mill A. FEV1 was measured in 9 byssinotics, 29 nonbyssinotics, and 30 controls before and after work on Mondays and Wednesdays. A significant decrease of 177 ml on average (7.8%) was found in byssinotics after work on Monday, whereas in nonbyssinotics, the decrease of FEV1 was nonsignificant. In controls, a slight increase in FEV1 after work was observed.

Byssinosis

Pneumoconiosis

10.1002/ajim.4700120611

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Citations (1)