Shengbo Zhang

Inner Mongolia University

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i-10 index

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Stephen L. Nutt

Walter and Eliza Hall Institute of Medical Research

Michaël Chopin

Walter and Eliza Hall Institute of Medical Research

Andrew M. Lew

University of Melbourne

Yifan Zhan

Walter and Eliza Hall Institute of Medical Research

Yuxia Zhang

Shandong Academy of Agricultural Sciences

Yue You

Walter and Eliza Hall Institute of Medical Research

Nicolas Jacquelot

Princess Margaret Cancer Centre

Enbo Cai

Jilin Agricultural University

Xiaoman Zheng

South China Agricultural University

Jai Rautela

Walter and Eliza Hall Institute of Medical Research

Cooperative Institutions

University of Melbourne

Walter and Eliza Hall Institute of Medical Research

Shanghai Jiao Tong University

Peter MacCallum Cancer Centre

Monash University

Chinese Academy of Medical Sciences & Peking Union Medical College

Heinrich Heine University Düsseldorf

Düsseldorf University Hospital

Guangzhou Medical University

Capital Medical University

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Bamboo-inspired 3D printed continuous fiber-reinforced vascular composites

Composites Communications (2024)

Qifeng Li Dou Zhang Shengbo Zhang Jeroen Soete Stepan Vladimirovitch Lomov

Fiber-reinforced composite

3d printed

10.1016/j.coco.2024.102219

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Citations (1)

Comparative analysis of active ingredients and effects of the combination of Panax ginseng and Ophiopogon japonicus at different proportions on chemotherapy-induced myelosuppression mouse

Food & Function (2019)

Shengbo Zhang Hengyu Sun Chunyun Wang Xiaoman Zheng Xiaohuan Jia

In this study, we aimed to investigate the effects of the combination of Panax ginseng and Ophiopogon japonicus (PG-OJ) herbs at different ratios on myelosuppression induced by chemotherapy. The myelosuppression model was established using an intraperitoneal injection of 100 mg kg-1 cyclophosphamide (CTX) in mice. The mice were administered the PG-OJ extract or Shengmaiyin (SMY) at different proportions (1 : 0, 1 : 1, 1 : 2, 2 : 1, 2 : 3, 3 : 2, and 0 : 1). The changes in the chemical composition caused by decocting the herbs together were analyzed by HPLC. The parameters i.e. the number of bone marrow nucleated cells and peripheral blood cells and the thymus and spleen indices were determined after administration. The results indicated that the co-decoction of PG and OJ, especially at the ratio of 2 : 3, was more conducive to the conversion of conventional ginsenosides (Rg1, Re, Rb1, Rg2, Rc, Rb2, Rb3 and Rd) to rare ginsenosides (Rg5, Rk3, S-Rg3, R-Rg3, Rk1 and Rh1) and the dissolution of ophiopogonin D. In addition, PG-OJ has an excellent synergistic effect on myelosuppression induced by CTX in mice. PG-OJ could significantly increase the numbers of the bone marrow nucleated cells and peripheral blood cells; moreover, it increased the thymus index and decreased the spleen index. The herb pair with a ratio of 2 : 3 showed the best therapeutic effect. By combining the results of the chemical composition changes and pharmacological activities, it can be concluded that rare ginsenosides and ophiopogonin D may be the main material basis of PG-OJ for the treatment of bone marrow suppression after chemotherapy.

Decoction

Blood stasis

Phytotherapy

10.1039/c8fo02354a

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Citations (14)

Transcriptional regulation of dendritic cell development and function

Frontiers in Immunology (2023)

Shengbo Zhang Cindy Audiger Michaël Chopin Stephen L. Nutt

Dendritic cells (DCs) are sentinel immune cells that form a critical bridge linking the innate and adaptive immune systems. Extensive research addressing the cellular origin and heterogeneity of the DC network has revealed the essential role played by the spatiotemporal activity of key transcription factors. In response to environmental signals DC mature but it is only following the sensing of environmental signals that DC can induce an antigen specific T cell response. Thus, whilst the coordinate action of transcription factors governs DC differentiation, sensing of environmental signals by DC is instrumental in shaping their functional properties. In this review, we provide an overview that focuses on recent advances in understanding the transcriptional networks that regulate the development of the reported DC subsets, shedding light on the function of different DC subsets. Specifically, we discuss the emerging knowledge on the heterogeneity of cDC2s, the ontogeny of pDCs, and the newly described DC subset, DC3. Additionally, we examine critical transcription factors such as IRF8, PU.1, and E2-2 and their regulatory mechanisms and downstream targets. We highlight the complex interplay between these transcription factors, which shape the DC transcriptome and influence their function in response to environmental stimuli. The information presented in this review provides essential insights into the regulation of DC development and function, which might have implications for developing novel therapeutic strategies for immune-related diseases.

10.3389/fimmu.2023.1182553

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Citations (10)

Type 1 conventional dendritic cells: ontogeny, function, and emerging roles in cancer immunotherapy

Trends in Immunology (2021)

Shengbo Zhang Michaël Chopin Stephen L. Nutt

Cancer Immunotherapy

10.1016/j.it.2021.10.004

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Citations (26)

Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients

Signal Transduction and Targeted Therapy (2021)

Xiang-Na Zhao Yue You Xiaoming Cui Huixia Gao Guolin Wang

Abstract While some individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present mild-to-severe disease, many SARS-CoV-2-infected individuals are asymptomatic. We sought to identify the distinction of immune response between asymptomatic and moderate patients. We performed single-cell transcriptome and T-cell/B-cell receptor (TCR/BCR) sequencing in 37 longitudinal collected peripheral blood mononuclear cell samples from asymptomatic, moderate, and severe patients with healthy controls. Asymptomatic patients displayed increased CD56 bri CD16 − natural killer (NK) cells and upregulation of interferon-gamma in effector CD4 + and CD8 + T cells and NK cells. They showed more robust TCR clonal expansion, especially in effector CD4 + T cells, but lack strong BCR clonal expansion compared to moderate patients. Moreover, asymptomatic patients have lower interferon-stimulated genes (ISGs) expression in general but large interpatient variability, whereas moderate patients showed various magnitude and temporal dynamics of the ISGs expression across multiple cell populations but lower than a patient with severe disease. Our data provide evidence of different immune signatures to SARS-CoV-2 in asymptomatic infections.

Profiling (computer programming)

2019-20 coronavirus outbreak

10.1038/s41392-021-00753-7

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Citations (43)

Longitudinal single-cell immune profiling revealed distinct innate immune response in asymptomatic COVID-19 patients

bioRxiv (Cold Spring Harbor Laboratory) (2020)

Xiang-Na Zhao Yue You Guolin Wang Huixia Gao Xiao-Ming Cui

SUMMARY Recent studies have characterized the single-cell immune landscape of host immune response of coronavirus disease 2019 (COVID-19), specifically focus on the severe condition. However, the immune response in mild or even asymptomatic patients remains unclear. Here, we performed longitudinal single-cell transcriptome sequencing and T cell/B cell receptor sequencing on 3 healthy donors and 10 COVID-19 patients with asymptomatic, moderate, and severe conditions. We found asymptomatic patients displayed distinct innate immune responses, including increased CD56 bri CD16 − NK subset, which was nearly missing in severe condition and enrichment of a new Th2-like cell type/state expressing a ciliated cell marker. Unlike that in moderate condition, asymptomatic patients lacked clonal expansion of effector CD8 + T cells but had a robust effector CD4 + T cell clonal expansion, coincide with previously detected SARS-CoV-2-reactive CD4 + T cells in unexposed individuals. Moreover, NK and effector T cells in asymptomatic patients have upregulated cytokine related genes, such as IFNG and XCL2 . Our data suggest early innate immune response and type I immunity may contribute to the asymptomatic phenotype in COVID-19 disease, which could in turn deepen our understanding of severe COVID-19 and guide early prediction and therapeutics.

CD16

10.1101/2020.09.02.276865

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Open distal gastrectomy versus laparoscopic distal gastrectomy for early gastric cancer: a retrospective study

Journal of Gastrointestinal Oncology (2021)

Feng Wang Shengbo Zhang Wei Zhao Deyou Wang Tang Sifeng

Although the early results of most randomized clinical trials on early gastric cancer have demonstrated the shortterm benefits and safety of laparoscopic procedures (7-10), data associated with the long-term safety and effects of this approach have been limited.Therefore, to fill this research gap and provide more information for clinicians to make decisions, we searched the prospectively maintained database

10.21037/jgo-21-782

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Citations (4)

Protective effects of Acanthopanax senticosus - Ligustrum lucidum combination on bone marrow suppression induced by chemotherapy in mice

Biomedicine & Pharmacotherapy (2018)

Chunyun Wang Hongbo Gao Enbo Cai Lianxue Zhang Xiaoman Zheng

This study investigated the combination effects of the Acanthopanax senticosus - Ligustrum lucidum (AS-LL) herb pair on bone marrow suppression caused by chemotherapy. A bone marrow suppression model was established by intraperitoneal injection (i.p.) of cyclophosphamide (CTX, 100 mg/kg). The changes in chemical composition between the AS-LL decocted together and single were analyzed, and their effects on the bone marrow nucleated cells, peripheral blood, thymus and spleen indices, in vitro hematopoietic cell culture, ELISA and cell cycle were detected. The results showed that the contents of the main active components, such as salidroside, isofraxidin and specnuezhenide in the sample of AS-LL decocted together, increased significantly compared to singles. Moreover, AS-LL decocted together exhibited a significantly better therapeutic effect on myelosuppression induced by CTX than AS and LL alone. AS-LL decocted together significantly increased the number of bone marrow nucleated cells and displayed a good regulatory effect on peripheral blood (p < 0.01), while significantly increased the thymus index (p < 0.01) and decreased the spleen index (p < 0.01). AS-LL significantly promoted the formation of cell colonies (p < 0.05), the proliferation and differentiation of hematopoietic progenitor cells, and played a positive regulatory role in hematopoietic factors. AS-LL also reduced the proportion of G0/G1 cells, increased the ratio of S and G2/M cells, and increased the cell proliferation index (PI). All these results implied that AS-LL decocted together might be a promising food additives and therapeutic agent for myelosuppression induced by chemotherapy.

10.1016/j.biopha.2018.11.071

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Citations (19)

Bortezomib inhibits C2C12 growth by inducing cell cycle arrest and apoptosis

Biochemical and Biophysical Research Communications (2014)

Shanshan Xing Congcong Shen Michael P. Godard J.J. Wang Yingying Yue

C2C12

Viability assay

10.1016/j.bbrc.2014.02.008

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Citations (9)

Effect of Panax ginseng combined with Angelica sinensis on the dissolution of ginsenosides and in chemotherapy mice hematopoietic function