Piotr Leszczyński

Poznan University of Medical Sciences

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Katarzyna Pawlak‐Buś

Poznan University of Medical Sciences

Piotr Wiland

Wroclaw Medical University

Maria Majdan

Medical University of Lublin

F Meisel-Mikołajczyk

Medical University of Warsaw

Eugeniusz J. Kucharz

University of Silesia in Katowice

Marek Brzosko

Pomeranian Medical University

Włodzimierz Samborski

Poznan University of Medical Sciences

Marzena Olesińska

National Institute of Geriatrics, Rheumatology and Rehabilitation

Bogdan Batko

Andrzej Frycz Modrzewski Krakow University

Sławomir Jeka

University of Bydgoszcz

Cooperative Institutions

Medical University of Warsaw

Center for Rheumatology

Poznan University of Medical Sciences

University School of Physical Education in Kraków

Medical University of Silesia

Merck & Co., Inc., Rahway, NJ, USA (United States)

National Institute of Geriatrics, Rheumatology and Rehabilitation

Nicolaus Copernicus University

Medical University of Lodz

Wroclaw Medical University

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Kwas zoledronowy w leczeniu wtórnej osteoporozy w przebiegu homocystynurii

DOAJ (DOAJ: Directory of Open Access Journals) (2010)

Piotr Leszczyński Katarzyna Pawlak‐Buś Tomasz Szafrański

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Satisfaction and discontent of Polish patients with biological therapy of rheumatic diseases: results of a multi-center questionnaire study

Reumatologia/Rheumatology (2018)

Anna Kotulska Eugeniusz J. Kucharz Piotr Wiland Marzena Olesińska Anna Felis-Giemza

Objectives Biologics are medications widely applied in the management of inflammatory rheumatic diseases. The drugs were found to be effective but their application is associated with some disadvantages. Medication with biologics is relatively expensive, and in Poland, it is carried out in specialized centers. The study was designed to evaluate various aspects of satisfaction and dissatisfaction of Polish patients treated with biologics. Material and methods An anonymous questionnaire was distributed in 23 Polish rheumatological centers involved in the treatment; 1212 returned questionnaires were used for analysis. Responses were received from 606 patients with rheumatoid arthritis, 427 with ankylosing spondylitis, 117 psoriatic arthritis, and 62 adult patients with juvenile idiopathic arthritis (in whom administration of the drugs had been introduced before they were 18 years old). The investigated group constituted about one-fifth of all rheumatic patients on biologics in Poland. Results A beneficial or very beneficial influence of the medication on the state of physical health was found mostly in patients with rheumatoid arthritis (51.3 and 30.5%) and ankylosing spondylitis (51.0 and 36.8%). Family life was improved by the treatment especially in patients with ankylosing spondylitis (40.7 and 35.6% beneficial and very beneficial, respectively), sleep quality and sexual life mostly in those with ankylosing spondylitis (beneficial/very beneficial influence 41.5/38.4, and 38.7/23.9, respectively). There was a rather small influence of biological treatment on the financial situation of the patients. In general, satisfaction with the treatment was evaluated as positive or very positive in 88% of all investigated patients. In a significant part of the patients, transportation to the medical center was considered as a disadvantage of the treatment. About one-third of the patients considered laboratory and imaging tests to be done before initiation of the medication as a difficulty, and for about 40% waiting time for qualification for the medication was a significant disadvantage. The route of drug administration was without importance for 4/5 of the patients. Conclusions Summing up, the results were similar in the patients suffering from various diseases although those with psoriatic arthritis felt the highest satisfaction (possibly due to the positive aesthetic effect), and those with ankylosing spondylitis had significant improvement in sexual life (probably due to younger age). Relatively low satisfaction was found in patients with juvenile idiopathic arthritis. There was a small influence of medication on financial status of the patients. Application of biologics has few disadvantages and most of them are associated with the organization of health services (waiting time for the tests, transportation to the medical centers).

Spondylitis

10.5114/reum.2018.76901

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P6.16 Efficacy of Glucoprotamin Containing Disinfectant Against Different Bacterial and Fungal Clinical Isolates

Journal of Hospital Infection (2006)

Stefan Tyski Monika Staniszewska Bozena Jakimiak Piotr Leszczyński Wanda Grzybowska

Disinfectant

10.1016/s0195-6701(06)60119-9

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Citations (1)

The physiotherapeutic procedures in patients with or without osteoporotic fractures

Menopausal Review (2013)

Marcin Grześkowiak Piotr Leszczyński Jacek Lewandowski

AMA Grześkowiak M, Leszczyński P, Lewandowski J. The physiotherapeutic procedures in patients with or without osteoporotic fractures. Menopause Review/Przegląd Menopauzalny. 2013;12(2):142-145. doi:10.5114/pm.2013.35072. APA Grześkowiak, M., Leszczyński, P., & Lewandowski, J. (2013). The physiotherapeutic procedures in patients with or without osteoporotic fractures. Menopause Review/Przegląd Menopauzalny, 12(2), 142-145. https://doi.org/10.5114/pm.2013.35072 Chicago Grześkowiak, Marcin, Piotr Leszczyński, and Jacek Lewandowski. 2013. "The physiotherapeutic procedures in patients with or without osteoporotic fractures". Menopause Review/Przegląd Menopauzalny 12 (2): 142-145. doi:10.5114/pm.2013.35072. Harvard Grześkowiak, M., Leszczyński, P., and Lewandowski, J. (2013). The physiotherapeutic procedures in patients with or without osteoporotic fractures. Menopause Review/Przegląd Menopauzalny, 12(2), pp.142-145. https://doi.org/10.5114/pm.2013.35072 MLA Grześkowiak, Marcin et al. "The physiotherapeutic procedures in patients with or without osteoporotic fractures." Menopause Review/Przegląd Menopauzalny, vol. 12, no. 2, 2013, pp. 142-145. doi:10.5114/pm.2013.35072. Vancouver Grześkowiak M, Leszczyński P, Lewandowski J. The physiotherapeutic procedures in patients with or without osteoporotic fractures. Menopause Review/Przegląd Menopauzalny. 2013;12(2):142-145. doi:10.5114/pm.2013.35072.

10.5114/pm.2013.35072

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Corynebacterium coyleae as potential urinary tract pathogen

European Journal of Clinical Microbiology & Infectious Diseases (2019)

Beata Sokół-Leszczyńska Piotr Leszczyński D Lachowicz Olga Rostkowska Mariusz Niemczyk

Corynebacterium coyleae is part of the commensal microflora of the skin, urethra, mucous membranes, and genital tract. Isolates from patients with urinary tract infection (UTI) were reported, but the pathogenic potential of this species has not been defined yet. The aim of the study is to determine whether C. coyleae could be the etiological agent of UTI and to analyze its antibiotic susceptibility. Urine samples were cultured quantitatively according to accepted laboratory procedures. The identification of bacterial isolates was carried out using the Vitek MS (bioMérieux) and antibiotic susceptibility was tested using disc diffusion according to EUCAST guidelines. Between 1 January 2017 and 30 October 2018, a total of 39 C. coyleae strains were isolated. This represented 0.32% of all urine samples cultured in the laboratory during the collection period. The strains were isolated from samples obtained from 35 women and 3 men (age median for all-64 years). One female patient presented with C. coyleae in her urine twice at an interval of 21 months. In six cases of UTI, C. coyleae was isolated in monoculture. The isolates had the same resistance pattern. A total of 11 strains were obtained from cases with a clinical diagnosis of UTI. In 13 cases, the strain was cultured in a monoculture and in 28 cases with accompanying species. All strains were susceptible to vancomycin. However, resistance to ciprofloxacin was observed for 58.4% of the strains. Urine isolates of C. coyleae must be considered as contamination or normal flora in most cases (28/39, 72%). In the remaining cases, it can be considered as potential etiologic agents, mostly in women and especially in the 6 UTI cases where C. coyleae was found as the single culture-positive species. Several of these isolates demonstrate resistance to antibiotics commonly used in empiric treatment of urinary tract infections.

Medical microbiology

Corynebacterium

10.1007/s10096-019-03565-4

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Efficacy and safety of guselkumab in patients with active psoriatic arthritis: a randomised, double-blind, placebo-controlled, phase 2 study

The Lancet (2018)

Atul Deodhar Alice B. Gottlieb Wolf‐Henning Boehncke Bin Dong Yuhua Wang

Ustekinumab

Placebo-controlled study

10.1016/s0140-6736(18)30952-8

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Citations (166)

Successful eradication of methicillin-resistantStaphylococcus aureus (MRSA) intestinal carrier status in a healthcare worker — Case report

Folia Microbiologica (2006)

Piotr Leszczyński Beata Weber‐Dąbrowska M. Kohutnicka M. Łuczak A Górecki

10.1007/bf02932128

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Citations (65)

[Bacterial diarrhea in small children treated in the clinic during the winter months 1986/1987].

PubMed (1990)

E Torbicka F Meisel-Mikołajczyk E Czerniak E Kurkiewicz K Rafałowska

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Enterotoxin-producing Bacteroides fragilis (ETBF) Strains in Stool Samples Submitted for Testing ofClostridium difficile and its Toxins

Anaerobe (1999)

F Meisel-Mikołajczyk Piotr Leszczyński Alex van Belkum Hanna Pituch Piotr Obuch-Woszczatyński

Bacteroides fragilis

Bacteroidaceae

10.1006/anae.1999.0246

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CLOSTRIDIUM DIFFICILE INFECTION IN KIDNEY OR LIVER GRAFT RECIPIENTS

Transplantation (2004)

Mariusz Niemczyk Piotr Leszczyński J Wyzgał L Pąaczek Marcin Krawczyk

A258 Aims: Antibiotic-associated diarrhea is defined as otherwise unexplained diarrhea which occurs in association with the administration of antibiotics and Clostridium difficile is the most common identifiable pathogen leading to it. We were interested in characteristics of this infection in recipients of kidney or liver graft. Methods: The retrospective analysis of infections caused by Clostridium difficile that occurred during first six months of 2003 in our Department was performed. Results: In this period 18 infections in 16 patients: 9 kidney, 6 liver and 1 kidney and liver graft recipients were diagnosed. Average age was 50.8 years, and frequency of infections increased with age. Ten (62.5 %) infections appeared during first 6 months after transplantation, including 6 (37.5 %) in first month. Most common immunosupressive regimen in infected patients was prednisone + tacrolimus. All patients received antibiotics during 2 months preceding infection, and eleven (68.75 %) individuals were applied more than one antibiotic during that period. In some patients there were several indications for therapy. In most cases one of them was antibiotic cover before an invasive procedure. Most commonly engaged antibiotics are cephalosporins, ciprofloxacin and amoxicillin-clavulanate. Most patients had concomitant diseases, too. Severe or fatal course of infection was not observed most probably due to immediate diagnostics and treatment. Test of feces for toxin presence is the crucial diagnostic procedure. Infections were treated with metronidazole in 14 patients, with good effects in 13 cases, 1 person needed vancomycin then. Two patients got vancomycin as drug of choice in simultaneous infection. Preventive procedures included: analysis of risk factors in new patients, isolation of infected individuals, cleaning and disinfection of rooms and toilets with preparation of proven sporicidal activity, training of personnel, and modification of antibiotic policy of the Department. As result, in third quarter of 2003 the number of Clostridium difficile infections in our Department decreased. No case of Clostridium difficile diarrhea occurred in personnel or their families during analysed period. Conclusions: Therefore, it seems that measures taken in our Department should be recommended in case of suspected or diagnosed Clostridium difficile infection in transplant recipients.

10.1097/00007890-200407271-01984

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